• 대한인간공학회:학술대회논문집
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• 대한인간공학회 1995년도 추계학술대회논문집
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• pp.208-213
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• 1995

The vehicle navigation system is developed for helping driver to retrieve driving information more easily and lastly. Navigation System informs driver many pieces of driving information - roadway structure and system, on-line traffic condition, the position of vehicle, route guidance, destination and other infor- mation service. As the style of information is diverse and the amount of information is large, driver may have mental and visual overload. The display of information can disturb the driver's attention and this can cause accidents. This state is caused by the defect of human-machine interactions. When the navigation system is designed, human factors - cognitive, judgment, operating -must be considered. The display style must be designed simply and easily, not to be obstacle of human - machine interface. In this study, outside- in view display style and inside-out view display style are compared each other. Tow factors are measured. One is cognitive factor-time of cognition on information that is displayed by screen display, cognition error rate. The other is image of screen display - subject's feeling about several styles of display, degree of subject's preference. The prototype of roadway is four kinds -Cross, T-cross and O-cross. Roadway display for test is taken from paper maps. Traffic condition display style, vehicle position display style and route guidance display style are taken from current display style. Traffic condition display style is symbol. vehicle position display style and route guidance display style are described as color and symbol. The test on screen display is implemented doing given tasks. Then the test is analyzed statistically. The result of test analysis gives the guideline to the designer for the map display of the vehicle navigation system.

• 대한지리학회지
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• 제39권3호
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• pp.473-493
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• 2004

김정호는 19세기를 살아간 인물 중에서 지도와 지지에 대해 가장 광범위한 자료를 수집하고 검토한 인물이다. 그는 이러한 검토의 과정에서 그 이전까지 존재하던 지도의 장단점을 체계적으로 연구하여 정리할 수 있었다. 그리고 그러한 연구 성과를 바탕으로 $\boxDr$청구도$\boxUl$라는 뛰어난 지도책을 만들어낼 수 있었다. $\boxDr$청구도$\boxUl$는 내용적으로 보았을 때 김정호가 검토한 모든 지도가 아니라 특정한 지도 계통을 중요한 저본으로 삼고 있다. 그것이 바로 정조 때 만들어진 전국 군현지도책인 $\boxDr$해동여지도$\boxUl$이다 또한 $\boxDr$해동여지도$\boxUl$ 자체도 새롭게 제작된 것이 아니라 영조 때 신경준의 주도에 의해 제작된 것으로 추정되는 $\boxDr$조선지도$\boxUl$를 약간만 바꾸어 놓은 것이다. 따라서 김정호의 $\boxDr$청구도$\boxUl$는 조선 후기 내내 이루어진 정확한 지도 제작의 결과물을 새로운 형식과 내용을 가미하여 탄생된 것이라고 볼 수 있다. $\boxDr$청구도$\boxUl$에는 지도의 제작과 이용에 관한 일반적인 내용뿐만 아니라 지도의 교정에 관한 방법도 서술되어 있다. 이것은 $\boxDr$청구도$\boxUl$를 개정하려는 김정호 자신의 의지를 표현한 것이다.

• 산업경영시스템학회지
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• 제18권36호
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• pp.49-59
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• 1995

The vehicle navigation system is developed for helping driver to retrieve driving information more easily and fastly. Navigation System informs driver many pieces of driving information - roadway structure and system, on-line traffic condition, the position of vehicle, route guidance, destination and other information service. As the style of information is diverse and the amount of information is large, driver may have mental and visual overload. The display of information can disturb the driver's attention and this can cause accidents. This state is caused by the defect of human-machine interactions. When the navigation system is designed, human factors - cognitive, judgment, operating - must be considered. The display style must be designed simply and easily, not to be obstacle of human -machine interface. In this study, outside-in view display style and inside-out view display style are compared each other. Two factors are measured. One is cognitive factor-time of cognition on information that is displayed by screen display, cognition error rate. The other is image of screen display - subject's feeling about several styles of display, degree of subject's preference. The prototype of roadway is four kinds - Cross, T-cross, Y-cross and O-cross. Roadway display for test is taken from paper maps. Traffic condition display style, vehicle position display style and route guidance display style are taken from current display style. Traffic condition display style is symbol. Vehicle position display style and route guidance display style are described as color and symbol. The test on screen display is implemented doing given tasks. Then the test is analyzed statistically, The result of test analysis gives the guideline to the designer for the map display of the vehicle navigation system.

• 대한핵의학회지
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• 제27권1호
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• pp.59-64
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• 1993

To evaluate the usefulness and differences in diagnosing coronary artery disease (CAD) between men and women of intravenous dipyridamole $^{99m}Tc$-MIBI myocardial SPECT, we obtained $^{99m}Tc$-MIBI myocardial SPECT and compared with the findings of coronary angiographies. Ninety eight male and 37 female patients who underwent dipyridamole $^{99m}Tc$-MIBI myocardial imaging within one month of cardiac catheterization were studied. Scans were considered abnormal if perfusion defect was detected and the defect size was more than 12% for left anterior descending artery (LAD) and circumflex (LCX) and 8% for right coronary artery (RCA) territories. Lesions${\geqq}$50% luminal diameter narrowing were considered significant CAD. Overall sensitivity for detection of CAD was 94.3% in men and 96.4% in women; specificity was 70% in men and 52.6% in women (P=not significant, ns). Vessel-matched sensitivity was 75.3% in men and 72.7% in women (P=ns): specificity was 84.6% in men and 67.9% in women (P < 0.025). For individual coronary artery, the sensitivity in men and women was 87.7%, 81.8% for LAD; 78%, 83.3% for RCA and 52.2%, 46.7% for LCX (P=ns): the specificity was 80%, 40% for LAD (P<0.01), 82.5%, 68.4% for RCA, 88.9%, 86.4% for LCX (P=ns). The hemodynamic parameter after intravenous dipyridamole in men and women were significantly changed; the heart rate was increased and systolic, diastolic blood pressure was decreased. Adverse effects were reported in 58.8% of men and 72.7% in women (P=ns). The incidence of chest pain and headache were higher in women. There was no significant difference in the incidences of nausea, abdominal pain, dizziness, facial flushing, dyspnea. In conclusion, dipyridamole $^{99m}Tc$-MIBI myocardial SPECT is a safe, noninvasive test for evaluation of CAD. There was no gender difference to detect CAD, but more false-positive rate in women especially in the territory of LAD.

• 한국정밀공학회지
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• 제26권1호
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• pp.97-104
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• 2009

There is a many kinds with nondestructive testing such as RT and UT representatively. Referred before two testing methods there is a limit which is spatial such as nuclear pipe, small vessel, sealing up vessel. So a new technique needs to overcome the limit which is spatial. shearography will be able to overcome the limit which is spatial. This paper introducing shearography which was known as non-contact full-field testing method and It is an interferometric technique for measurement of surface deformation such as displacement or displacement gradient. Also, a research about internal defect of the flange welding zone was accomplished. About variation with method pressurized with the Gaseous Nitrogen. Phase map where is various were measured according to changing a sheared direction, size of crack and loaded pressure. Consequently, crack quantitatively to be detected qualitatively was measured by using shearography.

• BMB Reports
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• 제46권12호
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• pp.617-622
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• 2013

Rac1 plays a key role in neurite outgrowth via reorganization of the actin cytoskeleton. The molecular mechanisms underlying Rac1-mediated actin dynamics in the cytosol and plasma membrane have been intensively studied, but the nuclear function of Rac1 in neurite outgrowth has not yet been addressed. Using subcellular fractionation and immunocytochemistry, we sought to explore the role of nuclear Rac1 in neurite outgrowth. bFGF, a strong agonist for neurite outgrowth in PC12 cells, stimulated the nuclear accumulation of an active form of Rac1. Rac1-PBR (Q) mutant, in which six basic residues in the polybasic region at the C-terminus were replaced by glutamine, didn't accumulate in the nucleus. In comparison with control cells, cells expressing this mutant form of Rac1 displayed a marked defect in extending neurites that was concomitant with reduced expression of MAP2 and MEK-1. These results suggest that Rac1 translocation to the nucleus functionally correlates with bFGF-induced neurite outgrowth.

• 한국기계가공학회지
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• 제20권1호
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• pp.16-24
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• 2021

A laser-engineered net shaping (LENS) process is a representative directed energy deposition process. Deposition characteristics of the LENS process are greatly dependent on the process parameters. The present paper preliminarily investigates deposition characteristics of Inconel 718 superalloy on S45C structural steel using a LENS process. The influence of process parameters, including the laser power and powder feed rate, on the characteristics of the bead formation and the dilution in the vicinity of the deposited region is examined through repeated experiments. A processing map and feasible deposition conditions are estimated from viewpoints of the aspect ratio, defect formation, and the dilution rate of the deposited bead. Finally, an appropriate deposition condition considering side angle, deposition ratio, and buy-to-fly (BTF) is predicted.

• 한국의학물리학회지:의학물리
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• 제22권1호
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• pp.42-51
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• 2011

전통적으로 심근 생존능을 식별하고 심근 관류를 정확히 평가하기 위한 도구로 핵의학영상이 이용되고 있으나 경색영역을 정의하기에는 어려움이 있다. 이에 본 연구에서는 극성지도의 분포를 분석하여 특성에 맞는 적응적 임계값을 이용하여 심근경색 모델을 정량적으로 평가하고자 하였다. 쥐 심근경색 모델은 왼쪽 관상동맥을 결찰시켜 제작하였다. 소동물PET 영상은 37 MBq $^{18}F$-FDG를 쥐의 꼬리정맥에 주사한 후 60분 섭취 후 Siemens Inveon SPECT/PET 스캐너를 이용하여 20분 동안 ECG 신호와 함께 획득하였고, OSEM 2D 알고리즘을 이용하여 재구성하였다. PET 영상의 심근 극성지도는 Siemens QGS 소프트웨어에 적합한 형식으로 변환 후 자동으로 심근 벽을 설정하여 작성하였다. 심근경색영역의 기준데이터는 TTC 염색으로 설정하였으며 전체 좌심실대비 염색된 영역의 백분율로 획득하였다. 최적의 임계값 설정을 위해 절대치 설정 방법, Otsu 알고리즘, 다중가우시안혼합모델(Multi Gaussian mixture model, MGMM)을 이용하여 평가하였다. 절대치 설정 방법은 10~90%까지 10%단위로 미리 정의 된 임계값을 이용하였고, Otsu 알고리즘은 영상 내에서 두 군집의 분산을 최대로 하는 임계값으로 설정하였다. MGMM 방법은 영상의 화소 강도를 분석하여 여러 개의 가우시안 분포함수(MGMM2, $\cdots$ MGMM4)로 반복 수행하여 최적의 가우시안 분포를 구하여 적응적 임계값을 설정하였다. 극성지도 평가지표는 각각의 알고리즘에서 측정된 임계값을 이용하여 이진화하고 전체 극성지도와 경색영역의 백분율로 획득한 후, TTC 염색으로 획득된 기준데이터와의 차이를 비교하였다. 그 차이는 절대치 방법의 20%에서 $7.04{\pm}3.44%$, 30%에서 $3.87{\pm}2.09%$, 40%에서 $2.15{\pm}2.07%$이었다. Otsu 방법은 $3.56{\pm}4.16%$이었으며 MGMM 방법은 $2.29{\pm}1.94%$이었다. 소동물 PET 극성지도에서는 30% 임계값이 조직학적 데이터와 비교하여 가장 작은 차이를 보였다. 그러나 TTC 염색으로 측정한 크기가 10% 이하에서는 MGMM 방법이 절대치 방법보다 작은 차이를 보였다(MGMM: 0.006%, 절대치방법: 0.59%). 이 연구에서는 심근경색 모델 평가를 위하여 생체영상 극성지도에서 다중가우시안혼합모델을 이용하여 평가하고자 하였다. MGMM은 사용자의 선택 없이도 자동적으로 영상 특성을 고려하여 적응적 임계값을 찾아주는 방법으로 극성지도에서 심근경색을 평가하는데 도움이 될 것으로 기대된다.

• 대한핵의학회지
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• 제25권2호
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• pp.165-176
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• 1991

The purpose of this study was to assess the ability of quantitative Tl-201 tomography to identify and localize coronary artery disease (CAD). The study population consisted of 41 patients (31 males, 10 females; mean age $55{\pm}7$ yr) including 14 with prior myocardial infarction who underwent both exercise Tl-201 myocardium SPECT and coronary angiography for the evaluation of chest pain. From the short axis and vertical long axis tomograms, stress extent polar maps were generated by Cedars-Sinai Medical Center program, and the % stress defect extent (SDE) was quantified for each coronary artery territory. For the purpose of this study, the coronary circulation was divided into 6 arterial segments, and the "myocardial ischemic score" (MIS) was calculated from the coronary angiogram. Sensitivity for the detection of CAD ($\geq50%$ coronary stenosis by angiography) by angiography) by stress extent polar map was 95% in single vessel disease, and 100% in double and triple vessel deseases. Overall sensitivity was 97%. Sensitivity and specificity for the detection of individual diseased vessels were, respectively, 87% and 90% for the left anterior descending artery (LAD), 36% and 93% for the left circumflex artery (LCX), and 71% and 70% for the right coronary artery (RCA). Concordance for the detection of individual diseased vessels between the coronary angiography and stress polar map was fair for the LAD (kappa=0.70), and RCA (kappa=0.41) lesions, whereas it was poor for the LCX lesions (kappa : 0.32). There were siginificant correlations between the MIS and SDE in LAD (rs=0.56, p=0.0027), and RCA territory (rs=0.60, p=0.0094). No significant correlation was found in LCX territory. When total vascular territories were combined, there was a significant correlation between the MIS and SDE (rs=0.42, p=0.0116). In conclusion, the quantitative analysis of Tl-201 tomograms appears to be accurate for determining the presence and location of CAD.

• Journal of Yeungnam Medical Science
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• 제11권1호
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• pp.146-152
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• 1994

저자들은 14명의 관상동맥질환이 의심되지 않는 건강한 젊은 남자를 대상으로 dipyridamole 부하 $^{99m}Tc$-MIBI 심근 SPECT를 시행하였다. 이를 이용하여 Cedars-Sinai방법으로 극성지도를 구하고 전체 심근을 9부분으로 나누어 각 부위의 상대적인 방사능 세기를 조사하고 분석하였다. 이와 함께 dipyridamole 부하 전후의 혈역동학적인 변화와 부작용을 알아보았다. 극성지도에서 부하기와 휴식기 모두 방사능 계수치가 가장 높은 부위는 Latero-anterior wall이었고, 가장 낮은 부위는 Infero-septal wall이었다. 부하기와 휴식기사이의 각 부위의 방사능세기는 서로간에 유의한 차이가 없었다. dipyridamole 투여후 심박수와 이완기 혈압 및 Double product는 유의한 변화를 보였다. dipyridamole에 의한 부작용은 14명 중 12명에서 나타나 비교적 높은 비율을 보였으나 중한 부작용은 관찰되지 않았다. 이상의 결과로 $^{99m}Tc$-MIBI 심근 SPECT에서 구한 극성지도에서 관상동맥질환을 판정할 때는 부위별로 혈류 저하를 판정하는 기준이 달라야만 할 것으로 생각된다.