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A Pilot Clinical Study of the Efficacy and Safety of Phellinus Linteus (Sanghuang) Extract Treatment for Knee Osteoarthritis

  • Ryu, Hwa yeon;Lee, Hyun;Kang, Jae Hui
    • Journal of Acupuncture Research
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    • v.39 no.2
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    • pp.115-121
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    • 2022
  • Background: To evaluate the efficacy and safety of Phellinus linteus (PL) extract for the treatment of knee osteoarthritis (KOA) a pilot clinical study was performed. Methods: There were 24 patients with KOA who enrolled in this double-blind, randomized, controlled, clinical trial. There were 3 groups: PL 1,000 mg/day (PL 1,000), PL 1,500 mg/day (PL 1,500), and dextrin 3,000 mg/day (placebo). Patients took capsules twice a day, 3 capsules at a time, over 8 weeks. Patients were monitored prior to treatment (Visit 1: Week 0), and followed up every 4 weeks (Visit 2: Week 4 and Visit 3: Week 8) where outcome measurements were taken. The primary outcome measure was the score from the Korean version of the Western Ontario and McMasters Universities from baseline to Week 8. The secondary outcomes were measurements from the visual analog scale, quality of life scale, erythrocyte sedimentation, and c-reactive protein. Adverse events were recorded at every visit. Results: The Korean version of the Western Ontario and McMasters Universities score showed the greatest improvement in symptoms of KOA in the PL 1,500 group compared with the placebo group. The erythrocyte sedimentation tended to decrease in the PL 1,500 group compared with the placebo group (which was within the normal range). The visual analog scale score decreased in all groups, with no significant differences between groups. No adverse events related to PL were reported. There were no abnormal hematological or physical findings. Conclusion: This pilot clinical trial was the first step to assess the efficacy and safety of PL used in the treatment of patients with KOA.

A Case Study of Home Health Care for Postpartum Women and their Newborns (산욕부와 신생아의 가정간호 사례연구)

  • Jun, Eun-Mi
    • 모자간호학회지
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    • v.4 no.1
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    • pp.3-11
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    • 1994
  • Presently there is an increasing demand for home health care services due to changes in the demographic structure as a result of an increasing elderly population, socio-economic improvements, and changes in the family structure, as well as the growing number of people with degenerative diseases. In addition to these reasons, rising medical costs and there a shortage of patient beds space in the hospital, particularly since introduction of national medical insurance. There has been an increasing demand for health care health care services. This study was done to identify the basic data for home health care management. It focused on developing client selection criteria, assessment tools, and recording methods. This was accomplished by the researchers visiting the patients in their homes. The research process included preparation investigation, tool development, training of the project researcher, and visiting the clients in their homes. The research tools are as follows : 1. Record development : a) The selection criteria tool for home health care of postpartum women was a structured tool and consisted of four parts. b) The structured assessment tool consisted of a general items, obstetric history, past medical history, methods of feeding, medications taken before admission, laboratory test results, discharge instructions, discharge medications, family tree, economic status, environmental status, a map, health assessment of postpartum women and their newborns. c) The visit note I consisted of the frequency of visits. Visit note II consisted of the date ; nursing problems ; nursing process including the initial assessment ; nursing goal ; visit plan ; postpartum women and their neonate health status, diagnosis, goal, implementation, evaluation, summary, next plan, for visit revision. d) Problem note consisted of the date, problem numbers, nursing diagnosis, problem appearance date problem resolution date. The research results are as follows : 1. Nursing problems : The nursing problems of the postpartum women and their neonates were evaluated by the number of nursing diagnoses and the change in the pattern of nursing diagnosis related to the number of visits. a) Nursing diagnosis The nursing diagnosis was classified according to physical function, psychosocial function, family system maintained function. b) The changes of nursing diagnosis related to the number of visits. As the type of nursing diagnosis changed related to the number of visits the number of nursing diagnoses decreased. 2. Contents of home health care : The content was categorized according to assessment, direct care, counseling, education, family care, reporting to with the attending doctor. The recommendations based on the research results are as follows : 1. Tool development Replication of this study is needed to test the validity of the assessment tools used. 2. Home visit a) Home health care nurses should be licensed and qualified. A referral form from the attending doctor is needed for legal protection of nurses. b) The first home visit need to be within 24 hours of discharge from the hospital to decrease the anxiety of frightened postpartum women. c) When the changes occur in the newborn's status, home health care nurses should consult a pediatrician. Communication within the home healthcare team is essential and needs to consistent and done smoothly. 3. Home health care A Study is required to develop protocols for education of staff and for operation of all aspects of this program.

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The Effect of Using Massage Chair with Acupoint and Meridian Muscle Massage Program on Back Pain: A Single Arm Pre-post Comparison Study (경혈 및 경근 안마 프로그램이 적용된 안마의자 사용이 요통에 미치는 영향)

  • Choi, Su-Ji;Kim, Dong-Il
    • Korean Journal of Acupuncture
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    • v.35 no.2
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    • pp.82-90
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    • 2018
  • Objectives : The purpose of this study is to investigate the effect of acupoint and meridian muscle massage given by automatic massage chair. Methods : We recruited 30 patients with back pain who met inclusion criteria. Two weeks were given as a waiting period, and the massage intervention was applied 12 times for 4 weeks. The programmed automatic massage chair was used to provide effective stimulus on acupoints and meridians for 20 minutes. We used Visual analog scale(VAS) and Korean Oswestry Disability Index(KODI) to quantify pain and function. We also recorded patients' all of vital signs and abnormal reactions during the trial to asses to assess safety. Results : Two participants dropped out due to personal reasons and 28 participants completed the clinical trial. We found that the degree of back pain (VAS, KODI) decreased significantly after the trial. As a result, VAS score decreased from $6.44{\pm}0.85$(Visit 2) to $4.59{\pm}1.52$ (Visit 14)(p<0.001), and KODI score was also reduced from $14.79{\pm}5.13$(Visit 14) to $9.04{\pm}4.52$ (Visit 2) (p<0.001). Also, we did not find any adverse effects in this study. Conclusions : We found that the acupoint and meridian muscle massage can effectively decrease back pain. This proves that the massage program designed by Korean medicine can be a good option to patients with back pain. However, further study with controlled design is still needed to verify its effectiveness.

Positive impact of integrated amrita meditation technique on heart rate, respiratory rate and IgA on young healthy adults

  • Vandana, Balakrishnan;Saraswathy, Lakshmiammal;Suseeladevi, Gowrikutty K.;Sundaram, Karimassery Ramaiyer;Kumar, Harish
    • CELLMED
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    • v.3 no.2
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    • pp.13.1-13.6
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    • 2013
  • The objective of the current study was to find out the effect of Integrated Amrita Meditation Technique (IAM) on blood pressure (BP), heart rate (HR), respiratory rate (RR) and IgA. One hundred and fifty subjects were randomized into three groups IAM, Progressive Muscle Relaxation (PMR) and Control. Baseline values were collected before giving the training for all the subjects and the IAM and PMR groups were given training in the respective techniques. BP, HR, RR and IgA were recorded manually at 0 h, 48 h, 2 months and 8 months after the first visit. HR was found to be reduced in the IAM group 48 h onwards and the fall sustained till 8 months (p < 0.05). IAM group showed significant drop when compared to the PMR group and control group in all the subsequent visits (p < 0.05). RR decreased significantly in the IAM group in the third and fourth visits (p < 0.05). RR of IAM showed significant decrease when compared to PMR and control from the third visit onwards. IgA showed significant increase in comparison with PMR and control in the third and fourth visits. BP did not show any difference in any of the visits. There was subject dropout from randomization to completion of the study, in all the three groups. The significant decrease in HR and RR and increase in IgA in the IAM group when compared to the PMR and control group shows the efficacy of the technique in reducing the physiological stress indicators for up to 8 months.

Impact of Coronavirus Disease 2019 on Dental Service Utilization of Korean Children and Adolescents (코로나 바이러스 감염증-19가 한국 소아청소년의 치과 이용에 미치는 영향)

  • Joo-Hee, Kim;Hoi-In, Jung;Ik-Hwan, Kim;Jaeho, Lee;Chung-Min, Kang
    • Journal of the korean academy of Pediatric Dentistry
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    • v.49 no.2
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    • pp.206-216
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    • 2022
  • This study aimed to investigate the frequency of dental visits after coronavirus disease 2019 (COVID-19) in children and adolescents in comparison to that of adults. The data on the number of dental visits on the basis of different classification and treatment codes for all the age groups were provided by the Health Insurance Review and Assessment Service from January 2017 to December 2020. To reduce the impact of the population change, dental visits per 1000 people was used. After the start of the pandemic, dental visits per 1000 people decreased in all age groups when analyzed for the diseases of pulp and periapical tissues classification code and dental visits per 1000 people decreased over 5 years age groups when analyzed for the pulp treatment code. Regarding the restorative treatment code, visits in the 0 - 19 years age group decreased after the pandemic. Based on the comparison of the number of confirmed COVID-19 cases to that of monthly dental visits by treatment codes, the change rate of pulp and restorative treatments gradually decreased after the waves of the pandemic in February and August 2020 in Korea. Furthermore, dental visits per 1000 people for gingivitis and periodontal disease classification code increased after the pandemic in all age groups. The rate of decrease in dental visits per 1000 people for restorative treatments in children and adolescents was higher than that in adults. The rate of decrease in the number of dental visits for multi-visit pulp treatments showed a rapid decrease as compared to that of 1-visit pulp treatments after the pandemic. This study identified changes in the number of dental visits of children and adolescents after COVID-19 transmission in comparison to that observed in adults.

Influence of Usual Source of Care on Outpatient Visit and Expense of Hypertension Patients (상용치료원 보유여부가 고혈압 환자의 외래이용횟수 및 외래의료비에 미치는 영향)

  • Yoon, Hyo Jung;Choi, Jae Woo;Lee, Sang Ah;Park, Eun-Cheol
    • Korea Journal of Hospital Management
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    • v.22 no.1
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    • pp.1-9
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    • 2017
  • Purpose : Many studies showed that having a usual source of care improved the efficient access of healthcare service. However in Korea there have been few studies on the usual source of care. So this study aims to find whether having a usual source of care affect the medical utilization and expense. Methodology/Approach : We used the Korean Health Panel data in 2012, 2013 to examine the change of utilization and expenses in ambulatory care affected by having a usual source of care. We selected 1,215 hypertension patients without usual source of care in 2012 and performed linear regression analysis to identify the difference between treatment group(with usual source of care in 2013) and control group(without usual source of care in 2013). Then we performed analysis again separated by the age group. Findings : Among study population, 711(58.5%) reported that they have a usual source of care in 2013. Treatment group reported 1.85 less increase in outpatient visits and 69,234 won less increase in expense than control group with weak significance(visit ${\beta}$ -1.85 p-value 0.0807, expense ${\beta}$ -69,234 p-value 0.0541). People under the age of 65 showed significant change in outpatient visits for tertiary hospital (visit ${\beta}$ -0.78 p-value 0.0154, expense ${\beta}$ -91,462 p-value 0.0168). The analysis which focused outpatient for mild disease showed similar trend. Practical Implications : This study supports the positive effect of having usual source of care which decrease inefficient outpatient utilization. Promoting physician-patient relationships is important for efficiency of healthcare service.

The Effects of Joint Mobilization and TENS on Pain Threshold and Hormonal Changes in Patients with Chronic Low Back Pain (관절가동술과 TENS가 만성요통환자의 통증역치 및 호르몬 변화에 미치는 영향)

  • Lee, Seung-byung;Jeong, Seong-gwan;Lee, Ho-jun
    • The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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    • v.26 no.1
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    • pp.65-72
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    • 2020
  • Background: The purpose of this research is to investigate the effects of joint mobilization and transcutaneous electrical nerve stimulation (TENS) on pain threshold and hormonal changes in patients with chronic LBP. Methods: 14 patients with chronic LBP were divided into the experimental group and the control group with 7 patients each, and both groups of patients were evaluated on pain duration, blood tests, and pressure pain threshold (PPT) on their first visit. On their second visit, joint mobilization was applied to the experimental group for 10 min and TENS to the control group for 20 min. Results: Pain threshold and duration of analgesia increased from after treatment in the experimental group. Serotonin and Cortisol decreased after treatment in the experimental group. Conclusion: Joint mobilization in patients with chronic LBP caused an increase in pain duration and pain thresholds and a decrease in serotonin, whereas there was little difference in cortisol.

The Effects of Sobieum on Decrease of Body Mass Index (BMI) and Obesity Index of Obese Children (소비음(消肥飮)이 비만아의 체질량지수와 비만도 감소에 미치는 영향)

  • Lee, Dong-Hyung;Kim, Deog-Gon
    • The Journal of Pediatrics of Korean Medicine
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    • v.23 no.1
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    • pp.195-203
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    • 2009
  • Objectives The purpose of this study is to evaluate the effects of Sobieum on decrease of BMI and obesity index of obese children. Methods 66 children (33 boys, 33 girls) were involved in this study. We measured height and weight for each time their visit, and calculated BMI and obesity index. Results After medication, BMI level and obesity index were significantly reduced (p<0.001). Conclusions We speculate that Sobieum is effective in the treatment of childhood obesity, and further controlled studies are needed with clinical cases of hematological evaluation.

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Efficacy and Safety of Codonopsis lanceolata (S. et Z.) Trautv. Extract on the Improvement of the Hypersensitivity Reaction in Allergic Rhinitis Patients (알레르기 비염 질환자를 대상으로 한 더덕(Codonopsis lanceolata (S. et Z.) Trautv.) 추출물의 과민면역반응 개선에 대한 유효성 및 안전성 평가)

  • Ahn, Ha-Young;Boo, Hee-Ock;Kim, Hyeong-Jun
    • The Korea Journal of Herbology
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    • v.34 no.1
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    • pp.13-21
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    • 2019
  • Objectives : This clinical trial is performed to investigate the effect of improving the hypersensitivity reaction and the safety of powdered ethanol extract Codonopsis lanceolata (S. et Z.) Trautv. for allergic patients. Methods : This study was randomized, double blinded, placebo-controlled clinical trial. 60 allergic rhinitis subjects were randomly assigned to Treatment group(n=30) and Control group(n=30). They were received the test substance or placebo in their $1^{st}$ and $2^{nd}$ visit, and took it once a day, 1 powder bag per 1 time, for 8 weeks. The freeze dried powder of Codonopsis lanceolata (S. et Z.) Trautv. was mixed with 30% ethanol and the filtrate was collected thrice with constant stirring of the mixture. The placebo was prepared in the same form as the test substance by replacing with corn starch. Total Nasal Symptom Score(TNSS) questionnaires and laboratory tests were performed at the screening and last visit to evaluate the efficacy. And to assess safety, vital signs and adverse events were confirmed at every visit. Statistical analysis about the result was performed using SAS 9.4. Results : In treatment group, there was a significant decrease in B cell after taking the test substance(p<0.005). And there was a statistically significant difference between groups(p<0.005). Changes in nasal symptoms were not statistically significant between groups, and both groups showed statistically significant differences before and after the test(p<0.0001). Also there were no adverse events associated with the clinical trial product. Conclusions : This clinical trial showed that Codonopsis lanceolata (S. et Z.) Trautv. extract was helpful in improving the hypersensitivity reaction in allergic patients without significant side effects.

Relationship between inclusion level of Vachellia tortilis leaf meal and behavioral activities of finishing pigs

  • Thabethe, Fortune;Khanyile, Mbongeni;Ncobela, Cyprial Ndumiso;Chimonyo, Michael
    • Asian-Australasian Journal of Animal Sciences
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    • v.33 no.1
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    • pp.177-185
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    • 2020
  • Objective: The study was conducted to establish a relationship between inclusion level of Vachellia tortilis (V. tortilis) leaf meal and time spent on different behavioral activities by finishing pigs. Methods: A total of forty-eight male Large White×Landrace finishing pigs with a mean (±standard deviation) body weight of 63.8±3.28 kg aged 14 wks were assigned to individual pens in a completely randomized design. Pigs were fed on diets containing 0, 30, 60, 90, 120, and 150 g/kg dry matter of V. tortilis leaf meal ad libitum with fresh water provided throughout the trial. There were eight pigs in each experimental diet. The behavior of pigs was observed for three wks twice a wk from 0600 to 1800 h using six closed circuit television cameras. Results: Increasing levels of V. tortilis leaf meal caused a linear decrease (p<0.05) in time spent eating, lying down and the number of visit to the feeder. Time spent standing and biting objects increased linearly (p<0.05) with increasing inclusion level of V. tortilis leaf meal. The was a negative linear relationship (p<0.05) between condensed tannins versus time spent eating, lying down and number of feeder visits. Condensed tannins showed a positive linear relationship (p<0.05) with time spent standing and biting objects. Neutral detergent fiber caused a linear decrease (p<0.05) in number of feeder visits, time spent eating, time spent standing. Conclusion: Inclusion level of V. tortilis leaf meal reduces time spent eating, lying down and the number of feeder visit while prolonging time spent standing and biting of objects. Condensed tannins and dietary fiber are among nutritional factors affecting behavioral activities displayed by finishing pigs.