• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2015년도 춘계학술대회
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• pp.947-950
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• 2015

우리나라 전체 교통사고 원인에 있어서 졸음운전은 음주운전보다도 더 큰 비중을 차지하고 있는 위험요소로 나타나고 있다. 따라서 사전에 졸음운전사고를 예방하기 위하여 운전자의 졸음을 인식하고 경고해주는 시스템 개발과 관련된 연구가 활발하게 이루어지고 있는 추세이며, 졸음의 지표는 뇌파의 알파파를 분석하는 것이 효과적이라는 선행 연구결과들이 발표되었다. 본 연구에서는 LabView 프로그램을 이용하여 졸음지표를 검출할 수 있는 신호처리 알고리즘을 적용시킨 뇌파측정 장치를 자체 개발하였다. 소수의 실험자를 대상으로 졸음유도 실험을 실시한 결과 알파파의 상대 파워스펙트럼 변화를 기준으로 졸음상태를 의미하는 뇌파의 패턴을 검출 할 수 있었다. 이후 기존의 뇌파측정 장비들을 사용하여 측정한 졸음패턴과 비교분석한 결과 유사한 패턴을 나타내는 것을 확인 할 수 있었다. 이러한 결과를 바탕으로 차후 운전자의 졸음예방 시스템에 활용한다면 졸음운전 사고로 인한 사망률을 낮추는데 기여할 수 있을 것으로 기대된다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.3151-3154
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• 2013

Introduction: Colorectal cancers are in the top of the cancer-related causes of death in the world and lymph node metastasis is accepted as the primary prognostic factor. In this study, correlations of FGF19 staining pattern with local invasion and lymph node metastasis in a series of colorectal cancers were investigated. Methods: This studyincluded 81 colorectal cancer patients who underwent surgery in our hospital with no evidence of preoperative radiological distant metastasis. Routine pathological examination of the resection material was performed in order to identify vascular, perineural and serosal infiltration, regional lymph node metastasis and the degree of differentiation. Tumor tissue samples were stained with an immunohistochemistry method for FGF 19 evaluation and the staining pattern was statistically compared with the above mentioned characteristics of the tumors. Results: The patient population consisted of 47 females and 34 males with a median age of 70 years. In 40 patients regional lymph nodes were positive and 51%, 32% and 38% had serosal, perineural and vascular invasion. While 64 cases were moderately-differentiated, 11 cases were well-differentiated and 6 poorlydifferentiated, there was no association with FGF 19 staining, including intensity. Conclusion: No evidence of significant statistically correlation was found between FGF 19 staining pattern and serosal, perineural, vascular invasion, lymph node involvement and degree of differentiation.

• 한국인구학
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• 제29권2호
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• pp.89-113
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• 2006

본 연구는 개발도상국의 지역별 인구변천 유형과 특징을 검토하는데 그 목적이 있다. 이를 위해 본 연구는 개발도상국의 인구변천 유형을 인구변천 단계와 관련시키고 있다. 그 다음으로 출산력과 사망력이 지난 40년간 어떻게 변화되어 왔는지를 다양한 지표를 활용하여 검토하고 있다. 분석결과 출산력의 경우 아프리카 지역은 최근까지도 비교적 높은 출산율을 보여 인구변천의 제2단계에 돌입한 것으로 보인다. 이 지역은 또한 알제리, 리비아, 모로코 등 아프리카 북부지역의 국가와 나머지 국가들이 인구변천 과정에서 뚜렷한 차이를 보인다. 서남아시아의 국가들 역시 인구변천의 제2단계에 있다고 볼 수 있다. 서남아시아 국가 증 아프카니스탄과 예맨은 지난 40년 간 출산력 수준의 변화는 거의 없고 사망력 수준만 약간 감소하는 전형적인 아프리카 형태를 보이고 있다. 이에 반해 동아시아 지역은 출산력의 감소 속도가 사망률의 감소 속도보다 훨씬 빠르게 나타나서 인구의 증가폭이 둔화되는 양상을 보이는 인구변천의 제3단계에 속한다고 볼 수 있다. 중남미 지역 국가들도 동남아시아 국가들의 경우와 비슷하게 출산력의 감소 속도가 사망력의 감소 속도보다 빠르게 나타나 인구의 증가 폭이 둔화되는 인구변천의 제3단계에 속한다. 특히 동남아시아의 한국과 싱가포르는 매우 빠른 속도로 출산력 감소를 보였으며 최근에는 오히려 저출산이 문제가 될 정도로 낮은 출산력 수준을 보이고 있다. 사망력의 경우 특히 평균수명은 지역별로 큰 차이를 보인다. 평균수명이 가장 높은 국가 중의 하나인 싱가포르가 78.0세인데 반해 르완다는 39.9세에 머무르고 있다. 아프리카의 평균수명이 낮은 것은 여러 가지 설명이 가능하나 최근에 크게 확산되고 있는 에이즈의 영향이 가장 클 것으로 판단된다.

• Journal of Preventive Medicine and Public Health
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• 제31권4호
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• pp.604-615
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• 1998

Although previous studies revealed the association of physical activity with mortality rate, it is unclear whether there is a linear trend between physical activity and mortality rate. In this study, the association of physical activity with the risk of all-cause mortality was analysed using Cox's proportional hazard model for a cohort of 14,204 healthy Korean men aged 40-59 years followed up for 4 years(Jan. 1993-Dec. 1996). Physical activity and other life style were surveyed by a postal questionnaire in December 1992. Total of 14,204 subjects were grouped into quartiles by physical activity. Using death certificate data, 123 deaths were identified. The second most active quartile had a lowest mortality .ate with relative risk of 0.44(95% C.I. : 0.23-0.84) compared with most sedentary quartile, showing a J-shape pattern of physical activity-mortality curve. By examining the difference in proportion of cause of the death between most active quartile and the other quartiles, there was no significant difference of proportional mortality from cardiovascular deaths, cerebrovascular deaths or deaths from trauma. The covariates were stratified into two group between which the trend of RR was compared to test the effect modification. There was no remarkable effect modification by alcohol intake, smoking, body mass index, calorie consumption, percent fat consumption. In conclusion, moderate activity was found to have more protective effect on all-cause mortality than vigorous activity and that the J-shape pattern of physical activity-mortality curve was not due to the difference of mortality pattern or effect modification by alcohol intake, smoking, body mass index, calorie consumption and percent fat consumption.

• The Plant Pathology Journal
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• 제32권4호
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• pp.340-346
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• 2016

To understand how Bursaphelenchus xylophilus kills pine trees, the differences between the effects of B. xylophilus and B. mucronatus on pine trees are usually compared. In this study, the migration and attacking ability of a non-pathogenic B. mucronatus in Pinus thunbergii were investigated. The distribution of B. mucronatus and the number of dead epithelial cells resulting from inoculation were compared with those of the pathogenic B. xylophilus. Although B. mucronatus is non-pathogenic in pines, its distribution pattern in P. thunbergii was the same as that of B. xylophilus. We therefore concluded that the non-pathogenicity of B. mucronatus could not be attributed to its migration ability. The sparse and sporadic attacking pattern of B. mucronatus was also the same as that of B. xylophilus. However, the number and area of the dead epithelial cells in pine cuttings inoculated with B. mucronatus were smaller than in those cuttings inoculated with B. xylophilus, meaning that the attacking ability of B. mucronatus is weaker than that of B. xylophilus. Therefore, we concluded that the weaker attacking ability of B. mucronatus might be the factor responsible for the non-pathogenicity.

• International Journal of Advanced Culture Technology
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• 제9권3호
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• pp.181-187
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• 2021

According to Joseph Campbell, there is always a similar pattern in the hero myth, which is called hero's journey. The legends about Cuchulain, the great Irish warrior, also follow this pattern. W. B. Yeats adapts the legends into his plays with Cuchulain as the protagonist. This paper discusses the protagonist's heroic journey in the five Cuchulain plays written by Yeats. In the five plays, Cuchulain grows, matures, weakens, dies, and resurrects, completing and meanwhile sublimating his heroic journey. In At the Hawk's Well, Cuchulain shows potential qualities of a hero. The Green Helmet displays his self-growth through the depiction of his heroic merits which make him a true hero. In On Baile's Strand, the hero suffers from the major frustrations and tribulations in his heroic journey and is stricken down consequently. The Only Jealousy of Emer reflects the hero's inner struggle and vulnerability. The last play, The Death of Cuchulainn, marks the end and reincarnation of the hero's life. Through the depiction of Cuchulain's heroic journey in the five plays, his heroic qualities are well demonstrated. Meanwhile, Yeats's views of heroism can be found as well.

• IMMUNE NETWORK
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• 제20권1호
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• pp.8.1-8.15
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• 2020

Immune checkpoint blockade targeting PD-1 and PD-L1 has resulted in unprecedented clinical benefit for cancer patients. Anti-PD-1/PD-L1 therapy has become the standard treatment for diverse cancer types as monotherapy or in combination with other anticancer therapies, and its indications are expanding. However, many patients do not benefit from anti-PD-1/PD-L1 therapy due to primary and/or acquired resistance, which is a major obstacle to broadening the clinical applicability of anti-PD-1/PD-L1 therapy. In addition, hyperprogressive disease, an acceleration of tumor growth following anti-PD-1/PD-L1 therapy, has been proposed as a new response pattern associated with deleterious prognosis. Anti-PD-1/PD-L1 therapy can also cause a unique pattern of adverse events termed immune-related adverse events, sometimes leading to treatment discontinuation and fatal outcomes. Investigations have been carried out to predict and monitor treatment outcomes using peripheral blood as an alternative to tissue biopsy. This review summarizes recent studies utilizing peripheral blood immune cells to predict various outcomes in cancer patients treated with anti-PD-1/PD-L1 therapy.

• Radiation Oncology Journal
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• 제21권4호
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• pp.306-314
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• 2003

목적: K562 세포의 방사선에 의한 세포 사망은 mitotic catastrophe 현상이 위주로 나타나지만 herbimycin A (HMA)에 의하여 apoptosis 반응이 촉진되는 반면 genisteln에 의하여 두 가지 형태의 세포사망이 모두 억제된다. 본 연구에서는 HMA와 genistein에 의한 K562세포의 방사선 유도 세포주기 조절 변화와 세포 사망 양상의 연관성을 조사하였다. 대상 및 방법: 지수증식기의 KS62 세포에 6 MV 선형가속기(Clinac 1,m C, Varian)를 이용하여 200~300 cGy/min의 선량률로 10 Gy를 균일하게 조사하였다. HMA와 genistein은 각각 250 nM와 25$\mu$M농도로 방사선 조사 후 즉시 투여하였다. 실험에서는 세포주기, 오절인자의 발현 및 활성, 노화 및 분화정도 등에 있어서의 시간에 따른 변화를 조사하였다. 결과: 방사선 단독조사에서 KS62세포는 G2기의 정체를 보였으나 정상적인 053을 가지는 세포와는 달리 지속적인 세포주기의 정체를 보이지 않았다. G2정체가 유지되는 동안 cyclin Bl의 점진적인 증가를 관찰할 수 있었으며, 이는 염색체의 복제가 완료되지 않은 상태에서 M기로 진행하여 미성숙한 염색체 응축과 mitotic catastrophe 현상이 나타나는 것과 일치한다. 방사선 조사와 함께 HMA를 투여한 경우에는 G2정체가 빠르게 해소되었으며 동시에 Gl기에서 세포가 정체되는 양상을 보였다. 세포주기 조절인자 cdc2 kinase 활성 증가와 cyclln I와 A 발현 및 CDK2 활성의 감소 등의 현상으로 설명되며, 이는 apoptosis의 증가와 연관성을 갖는다. 반면 genistein의 경우에는 cyclin Bl과 떨cfsc 발현 및 cdc2활성이 모두 감소하는 등 G2정체를 계속 유지하였다. 이와 함께 방사선에 의한 노화와 megakaryocyte로의 분화도 지속되는 것을 관찰할 수 있었다. 결론: HMA와 genistein에 의한 KS62세포의 방사선 유도 세포사망의 변화는 세포주기 조절과 밀접하게 연관되어 있음을 확인하였다. 이는 다양한 방사선 유도 세포사망의 기전을 이해하는 데 독창적인 모델을 제공하며, 방사선을 이용한 암 치료법의 개발에 새로운 표적을 제공할 수 있을 것이다.

• 대한한방내과학회지
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• 제21권1호
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• pp.65-73
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• 2000

Objectives : The effects of cotreatment of adriamycin and ethanol extract of herb (Palgin-tang hab Hwajuck-hwan a traditional medicine for cancer treatment in oriental medicine) on the induction of apoptotic cell death were investigated in human liver origin cell lines, Chang. Methods : Chang(ATCC) liver cells were cultured in RPMI-1640(Gibco SRL Co, Gaithersburg, MD) badge including 10% fetal bovine serum. Chang liver cells were treated with various concentrations(from 10 to $0.16{\mu}l$) of adriamycin and herb extract(from 500 to $31.25{\mu}l$) After 48h later, the cells were tested for viability by Crystal violet staining assay. Adriamycin and Herb extract induced ladder pattern of DNA fragmentation in Chang cells. Genomic DNA was isolated and separated on 1.5% agarose gels. The DNA was stained with ethidium bromide and visualized under UV light. Results : The death of Chang cells was synergistically induced by the cotreatment of adriamycin and ethanol extract of herb. In addition, the cotreatment-induced cell death of Chang cells was mediated by apoptotic death signal processes. The phosphotransferase activity of JNK1 remained in a basal level in Chang cells which was treated individually with the adriamycin and ethanol extract of herb. However, it was markedly increased in Chang cells which was cotreated with adriamycin and ethanol extract of herb. In addition, the expression of Fas and FasL was markedly induced by the cotreatment of adriamycin and herb extract. For a while, the expression of Sax was a eminently increased by the ethanol extract of herb. However, Scl2 expression was not affected by the individual or cotreatment of adriamycin and herb extract. Conclusions : our results suggest that the cotreatment of adriamycin aM ethanol extract of herb induces synergistic apoptotis of human liver origin Chang cells via the upregulation of JNK, Fas, FasL and Bax.

• 대한의생명과학회지
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• 제18권2호
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• pp.169-174
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• 2012

The placenta is an extraembryonic tissue that is formed between mother and fetus and mediates delivery of nutrients and oxygen from the mother to the fetus. Because of its essential role in sustaining the growth of the fetus during gestation, defects in its development and function frequently result in fetal growth retardation or intrauterine death, depending on its severity. Vertebrate Hox genes are well known transcription factors that are essential for the proper organization of the body plan during embryogenesis. However, certain Hox genes have been known to be expressed in placenta, implying that Hox genes not only play a crucial role during embryonic patterning but also play an important role in placental development. So far, there has been no report that shows the expression pattern of the whole Hox genes during placentation. In this study, therefore, we investigated the Hox gene expression pattern in mouse placenta, from day 10.5 to 18.5 of gestation using real-time RT-PCR method. In general, the 5' posterior Hox genes were expressed more in the developing placenta compared to the 3' Hox genes. Statistical analysis revealed that the expression of 15 Hox genes (Hoxa9, -a11, -a13/ -b8, -b9/ -c6, -c9, -c13/ -d1, -d3, -d8, -d9, -d10, -d11, -d12) were significantly changed in the course of gestation. The majority of these genes showed highest expression at gestational day 10.5, suggesting their possible role in the early stage during placental development.