• Journal of Veterinary Science
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• 제24권4호
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• pp.52.1-52.13
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• 2023

Background: Mesenchymal stem cells (MSCs) have been investigated as therapeutic agents for inflammatory bowel disease (IBD). Stimulation of MSCs with pro-inflammatory cytokines is an approach to enhance their immunomodulatory effects. However, further investigation is required to support their application in immune-mediated disorders and companion animals. Objectives: This study aimed to assess the therapeutic effect of tumor necrosis factor (TNF)-α-stimulated feline adipose tissue-derived MSCs (fAT-MSCs) in a dextran sulfate sodium (DSS)-induced colitis mouse model. Methods: Colitis mice was made by drinking water with 3% DSS and fAT-MSCs were injected intraperitoneally. Colons were collected on day 10. The severity of the disease was evaluated and compared. Raw 264.7 cells were cultured with the conditioned medium to determine the mechanism, using quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay. Results: TNF-α-stimulated fAT-MSCs more improved severity of DSS-induced colitis in disease activity, colon length, histologic score, and inflammatory cytokine. In sectionized colon tissues, the group comprising TNF-α-stimulated fAT-MSCs had higher proportion of CD11b⁺CD206⁺ macrophages than in the other groups. In vitro, TNF-α-stimulation increased cyclooxygenase-2 (COX-2) expression and prostaglandin E₂ (PGE₂) secretion from fAT-MSCs. The conditioned medium from TNF-α-stimulated fAT-MSCs enhanced the expression of interleukin-10 and arginase-1 in LPS-activated Raw 264.7 cells. Conclusions: These results represent that TNF-α-stimulated fat-mscs ameliorate the inflamed colon more effectively. Furthermore, we demonstrated that the effectiveness was interlinked with the COX-2/PGE₂ pathway.

• 한국심리학회지 : 문화 및 사회문제
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• 제24권3호
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• pp.473-489
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• 2018

최근 한국 사회는 연일 쏟아져 나오는 아동방임 및 학대 사건으로 충격 속에서 헤어나지 못하고 있다. 이러한 학대를 경험한 피해아동은 정서적, 정신적, 신체적 외상으로 불완전한 아동보호체계 아래 또 다른 사회문제의 중심에 서있을 수밖에 없는 현실 속에 있다. 이러한 아이들을 보호하기 위해서 미국에서는 CASA(Court Appointed Special Advocates: 법원임명특별옹호자) 프로그램이 실시되고 있다. 이 CASA 프로그램의 효과는 수많은 연구를 통해 학대아동을 위한 질높은 옹호 가능성이 증가하였고, 그들을 위한 더 나은 서비스 제공이 가능해졌으며, 아동복지비용을 절감하는 효과를 가져올 수 있었다. 한국에서도 2014년 아동학대 범죄 등의 처벌에 관한 특례법 제정(이하 '아동학대처벌법')으로, 학대아동이 공적체계 보호로 들어온 것은 사실이나, 이들의 안정적인 보호를 위한 지속적인 정서적 지원은 미흡한 현실이다. 하지만, 현재 한국에서도 아동학대에 대한 공적체계의 개입이 증가하고 있고, 또한 아동학대 재발방지를 위한 적극적인 모니터링을 통한 국가의 개입 강화와 아동권리에 대한 인식이 증가되고 있다. 한국사회의 이러한 변화들은 미국의 CASA 프로그램을 적극적으로 검토하여 한국 사회에 국가적인 사업으로 정착시킬 수 있는 가능성을 보여준다. 이것을 통해 아동학대 피해아동의 안전과 권리가 보호받을 수 있는 체계와 학대 피해아동이 방치되어 더 큰 사회적 문제가 발생되지 않도록 사전에 예방할 수 있는 방안이 될 것으로 기대된다.

• Journal of Trauma and Injury
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• 제36권4호
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• pp.441-446
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• 2023

Inferior vena cava (IVC) injuries, while accounting for fewer than 0.5% of blunt abdominal trauma cases, are among the most difficult to manage. Despite advancements in prehospital care, transportation, operative techniques, and perioperative management, the mortality rate for IVC injuries has remained at 20% to 66% for several decades. Furthermore, 30% to 50% of patients with IVC injuries succumb during the prehospital phase. A 65-year-old male patient, who had been struck in the back by a 500-kg excavator shovel at a construction site, was transported to a regional trauma center. Injuries to the right side of the infrarenal IVC and the right external iliac vein (EIV) were suspected, along with fractures to the right iliac bone and sacrum. The injury to the right side of the infrarenal IVC wall was repaired, and the right internal iliac artery was ligated. However, persistent bleeding around the right EIV was observed, and we were unable to achieve proximal and distal control of the right EIV. Attempts at prolonged manual compression were unsuccessful. To decrease venous return, we ligated the right superficial femoral vein. This reduced the amount of bleeding, enabling us to secure the surgical field. We ultimately controlled the bleeding, and approximately 5 L of blood products were infused intraoperatively. A second-look operation was performed 2 days later, by which time most of the bleeding sites had ceased. Orthopedic surgeons then took over the operation, performing closed reduction and external fixation. Five days later, the patient underwent definitive fixation and was transferred for rehabilitation on postoperative day 22.

• 대한한방내과학회지
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• 제44권4호
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• pp.751-756
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• 2023

목적: 본 연구는 임상에서 많은 빈도로 사용되고 있는 향정신성 약물이 간독성을 발생시킬 수 있음을 임상 예를 통해 보여줌으로써, 한의진료현장에서 이에 대한 경각심과 더불어 약인성간손상에 대한 최신 정보를 제공하고자 한다. 방법: 본 임상 예의 논문은 향정신성 약물을 사용한 후 약인성간독성의 의심과 진단 및 약물의 중단 후 증상과 간손상 효소의 개선과정을 자세히 제시하였다. 결과: 평소 혼합결합조직병으로 한방병원에서 수년 동안 침과 뜸 치료 등으로 잘 유지되고 있던 56세의 여성 환자가, 어느날부터 갑자기 심한 피로감과 전신적 불편편함을 호소하였다. 혈액검사를 시행한 결과, 혈청 AST, ALT가 정상 경계의 2.5-배 이상 증가하였고, 촤근 복용한 향정신성약물에 대한 RUCAM score가 9점으로 약인성간손상 진단에 부합하였다. 이 의심 약물들을 중지한 뒤에 주관적 불편함이 빠르게 개선되었으며, 혈청 간손상 효소 수치 또한 2주 안에 정상화되었다. 결론: 본 증례는 향정신성약물로 생길 수 있는 간손상의 전형적인 임상 예로서, 향정신성약물의 일반화된 상황에 비추어 한의원에서 환자의 진료 과정에서 하나의 중요한 고려사항을 암시한다.

• Journal of Chest Surgery
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• 제57권1호
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• pp.62-69
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• 2024

Background: Cervical esophageal cancer is a rare malignancy that requires specialized care. While definitive chemoradiation is the standard treatment approach, surgery remains a valuable option for certain patients. This study examined the surgical outcomes of patients with cervical esophageal cancer. Methods: The study involved a retrospective review and analysis of 24 patients with cervical esophageal cancer. These patients underwent surgical resection between September 1994 and December 2018. Results: The mean age of the patients was 61.0±10.2 years, and 22 (91.7%) of them were male. Furthermore, 21 patients (87.5%) had T3 or T4 tumors, and 11 (45.8%) exhibited lymph node metastasis. Gastric pull-up with esophagectomy was performed for 19 patients (79.2%), while 5 (20.8%) underwent free jejunal graft with cervical esophagectomy. The 30-day operative mortality rate was 8.3%. During the follow-up period, complications included leakage at the anastomotic site in 9 cases (37.5%) and graft necrosis of the gastric conduit in 1 case. Progression to oral feeding was achieved in 20 patients (83.3%). Fifteen patients (62.5%) displayed tumor recurrence. The median time from surgery to recurrence was 10.5 months, and the 1-year recurrence rate was 73.3%. The 1-year and 3-year survival rates were 75% and 33.3%, respectively, with a median survival period of 17 months. Conclusion: Patients with cervical esophageal cancer who underwent surgical resection faced unfavorable outcomes and relatively poor survival. The selection of cases and decision to proceed with surgery should be made cautiously, considering the risk of severe complications.

• 대한화장품학회지
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• 제50권2호
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• pp.153-161
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• 2024

비타민 D는 주로 자외선에 의해 피부에서 만들어지는 지용성 비타민이다. 멜라토닌과 함께 대표적인 '크로노바이오틱(chronobiotic)' 물질로써 피부가 낮과 밤을 구분하는데 중요한 역할을 한다. 하지만 비타민 D는 조효소 역할을 하는 비타민이자 여러 종류의 유전자 발현을 조절하는 호르몬적 역할을 하기 때문에 화장품에 직접적으로 사용할 수 없다. 따라서 화장품에 사용할 수 있는 비타민 D 전구체인 프로 비타민 D (7-dehydrocholesterol)의 피부 효능에 대해서 알아보고자 하였다. 그 결과, 프로 비타민 D는 멜라닌 생성 효소인 타이로시네이즈(tyrosinase)의 단백질 발현을 억제하여 멜라닌 생성을 억제할 수 있음을 확인할 수 있었다. 이와 같은 피부톤 케어 효과는 인공 피부에서도 검증되었다. 또한 프로 비타민 D는 피부 염증을 일으키는 TNFa의 발현을 억제하고, 자외선에 의해 비타민 D로 전환되면 항균 펩타이드인 CAMP (LL-37)의 발현을 증가시킨다는 것이 확인되었다. 프로 비타민 D가 멜라닌 생성을 억제하는 것은 멜라닌이 자외선을 흡수하여 프로 비타민 D가 비타민 D로 전환되는 것을 억제하기 때문인 것으로 보인다. 따라서 화장품 제형에 프로 비타민 D를 활용한다면 피부톤을 조절하고 피부 면역을 증진시킴과 동시에 일상 생활 속에서 자외선에 의해 비타민 D 전환되면 다른 피부 효능, 즉 피부 항노화, 장벽 기능 향상 등도 기대할 수 있을 것으로 생각한다.

• 한국항해항만학회지
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• 제48권3호
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• pp.221-231
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• 2024

본 연구의 목적은 여객선 작업공간에서 활동하는 선원의 안전 및 정신건강 증진을 위하여 색차계를 사용한 작업공간의 밝기, 색채 값, 색 분포도, 선원의 인터뷰를 통해 문제점 및 개선 방향을 조사하는 것이다. 첫째, 선행 연구, 참고 문헌, 현행 제도 및 규격, 준사고 사례조사를 검토한 뒤 현재 운행 중인 M Ship의 조타실과 기관실을 대상으로 색차계를 사용하여 각 공간의 색상 값을 분석하였다. M Ship의 조타실과 기관 구역에 분포된 밝기와 색채 측정 결과 각 구역의 천장, 벽, 바닥의 밝기는 전체적으로 어두운 편이고 특히 기관 구역은 매우 어두운 편으로 나타났다. 색채에 관하여 각 구역의 천장엔 Green과 Blue가 분포되어 있으며 벽과 바닥엔 Red와 Blue가 분포되어 있었다. 작업공간에 근무하는 선원의 인터뷰 결과 노후한 실내환경과 어두운 작업환경, 미끄럽고 밝은 바닥재, 국내 사용자에게 맞지 않은 계단으로 인한 준사고 경험에 대해 응답하였다. 이에 따라 추후 조명 설치 시 밤과 낮을 구분하여 공간의 밝기 체크, 조명의 위치, 그림자 형성 수준 및 대비 정도, 시설의 반사율, 눈부심, 빛의 색을 고려한 조명 계획, 바닥의 색채계획 및 자재 선정, 국내 사용자에게 적합한 시설 설계에 관해 제안한다.

• 대한지역사회영양학회지
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• 제29권2호
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• pp.129-143
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• 2024

Objectives: The objective of this study is to compare a nutritionally balanced soft blend diet (SBD) with a soft fluid diet (SFD) on the health of inpatients who have undergone oral and maxillofacial (OMF) surgery, ultimately aiming to enhance care outcomes, improve health-related quality of life (QOL), and increase satisfaction with the hospital. Methods: Thirty-two patients were randomized into two groups: sixteen received SFD and sixteen received SBD. Anthropometric, laboratory evaluations were conducted upon admission and discharge. Patients filled out questionnaires on demographics, diet satisfaction, food intake amount, and health-related QOL on the day of discharge, assessed using the EuroQoL 5 Dimensions 3 Level and EuroQoL Visual Analogue Scale (EQ-VAS) instruments. Data were analyzed with descriptive statistics, χ² tests for group differences, and paired nonparametric t-tests for within-group comparisons. The Mann-Whitney U test evaluated inter-group differences in preoperative weight and body mass index (BMI), postoperative changes, meal satisfaction, intake, health-related QOL, and self-assessed health status. P-values were set at a significance level of 0.05. Results: The SBD group had higher dietary intake (63.2% vs. 51.0%) and greater diet satisfaction (80.6 vs. 48.1, P < 0.0001) compared to SFD group. Health-related QOL, measured by EQ-VAS, was better in SBD group (70.3 vs. 58.8, P < 0.05). Postoperative weight and BMI decreased in SFD group but increased in SBD group (P < 0.01). Changes in laboratory results showed more stability in the SBD group. No postoperative infections were reported in SBD group, whereas SFD group had a 31.25% complication rate. Conclusions: While SFD is often recommended after OMF surgery to protect oral wound healing process, our study reveals that SBD not only enhances physical and psychological outcomes but also, somewhat unexpectedly, supports wound healing and reduces complications. Essentially, SBD promotes physical recovery and enhances health-related QOL than SFD by supporting both somatic and mental healing aspects.

• 대한유전성대사질환학회지
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• 제24권1호
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• pp.37-42
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• 2024

선천성 부신 과형성증, 21-수산화효소 결핍증은 부신스테로이드 생성에 영향을 미치는 상염색체 열성 질환으로, 무기질코르티코이드와 글루코코르티코이드의 합성이 저하됩니다. 선천성 부신 과형성증은 저혈압, 무기력, 구토, 저혈당과 같은 증상을 유발할 수 있으며, 염분소실형에서 심각한 경우 생명을 위협하는 부신 위기를 초래할 수 있습니다. 이 보고는 전형적인 부신 위기 증상 없이 지속되는 황달로 내원하여 염분소실형의 복합 이형접합체로 진단받은 드문 사례를 제시합니다. 선천성 부신 과형성증의 신속한 진단과 치료가 심각한 합병증을 예방하는 데 필요함을 강조하며, 신생아 선별검사와 철저한 임상 관찰의 중요성을 강조하는 바 입니다.

• 농촌의학ㆍ지역보건
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• 제13권1호
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• pp.3-18
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• 1988

The general objective of this research is to study behavioral pattern of health care utilization and to measure the level of utilization of the traditional medicine. The specific objective is to study utilization pattern and content of folk medicine which is the indegenous medical technology recognized part of traditional medicine. This research was under taken to generate valid information that will provide basis data for formulating general direction for health education activities and for designing service package for general population. A social survey method was employed to obtain required information for the research activities, The survey field team consisted of 20 surveyors who all participated is an intensive 2 day training course. A total of 3091 households were visited and interviewed by the field team during the period 7 September to 6 October 1987. The major findings obtained from the information collected by the field survey are as follows ; 1) General characteristics of the study households 2562 households out of 3091 households visited were selected for final data process, 80.2 of the selected households were nuclear families ; 17.4%, extended families ; others 2.4%. Only 4.3 percent of the study population in the urban households indicated "no schooling" whereas 14.2% of the rural household members falls within this category. Study population in the urban areas are more protected against diseases by the national medical insurance system than those in rural areas. In their self appraisal of living standard, those who responded with low group are 39.6% and 50.3% respectively by urban and rural households. 2) Morbidity status Period prevalence rate for all diseases during the preceding 15 days before the date of the household interview v as 243,0 per 1,000 study population. For cases with the illness duration of within 15 days, the initial points of medical entry were diversied ; 56.9%, drug stores ; 30.9%, clinics and hospitals ; 4.6% folk medicine ; 1.7% clinics of Korean oriental medicine. Among the chronic case; with illness duration of over 90 days, 34.6% of these people utilized clinics and hospitals of modern medicine ; 31.6%, drug stores ; 18.6% clinics of Korean oriental medicine ; 6.8% folk medical techniques. Noticeable is the almost ten fold increase from the mere 0.9% in the utilization of Korean oriental medicine, whereas in the utilization of folk medicine, it is short of two-fold increase. 3) Folk medicine and its utilization Households that use folk medicine for relief and care of signs and symptoms commonly encountered in daily life, number 1969 households, which accounts for 76.9% of all the study households. This rather high level use of folk medicine is not different from rural to urban areas. The order of frequency of utilizing folk medicine among the study people are : the highest 14.3% for the relief of indigestion ; 8.6% for burns ; 5.1% for common cold ; 4.7% for hiccough ; and 4.2% for hordeolum. A present various procedures of folk medicine is being used to relieve all kinds of symptoms. 192 symptoms are identified at present. The most frequently used procedures of folk medicine appear to be based either on principles of the Korean oriental medicine or of scientific knowledge. Based on these survey findings, proposals for utilizing folk medicine are as follows First, this survey's findings will be feed back to both on the job training and on the spot guidance of community health practitioners, public health nurses and other peripheral work force in the health field, who are in daily contacts with community. This feed back will assure that the health personnel carry out their health education and information activities that are based on the utilization pattern of folk medicine as found in the survey result. Second, studies will be soon implemented that are designed to measure the efficiency and potency of these procedures and to improve these procedures of folk medicine were most frequently used by the community. Third, studies will continue to systematize medicinal plants and skills of Korean oriental medicine that are easily available at minimal cost in daily life for the prevention of diseases and management of emergency cases.