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Effects of adenosine receptor agonist on the rocuronium-induced neuromuscular block and sugammadex-induced recovery

  • Kim, Yong Beom;Lee, Sangseok;Choi, Hey Ran;In, Junyong;Chang, Young Jin;Kim, Ha Jung;Ro, Young Jin;Yang, Hong-Seuk
    • Korean Journal of Anesthesiology
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    • v.71 no.6
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    • pp.476-482
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    • 2018
  • Background: Several types of receptors are found at neuromuscular presynaptic membranes. Presynaptic inhibitory $A_1$ and facilitatory $A_{2A}$ receptors mediate different modulatory functions on acetylcholine release. This study investigated whether adenosine $A_1$ receptor agonist contributes to the first twitch tension (T1) of train-of-four (TOF) stimulation depression and TOF fade during rocuronium-induced neuromuscular blockade, and sugammadex-induced recovery. Methods: Phrenic nerve-diaphragm tissues were obtained from 30 adult Sprague-Dawley rats. Each tissue specimen was randomly allocated to either control group or 2-chloroadenosine (CADO, $10{\mu}M$) group. One hour of reaction time was allowed before initiating main experimental data collection. Loading and boost doses of rocuronium were sequentially administered until > 95% depression of the T1 was achieved. After confirming that there was no T1 twitch tension response, 15 min of resting time was allowed, after which sugammadex was administered. Recovery profiles (T1, TOF ratio [TOFR], and recovery index) were collected for 1 h and compared between groups. Results: There were statistically significant differences on amount of rocuronium (actually used during experiment), TOFR changes during concentration-response of rocuronium (P = 0.04), and recovery profiles (P < 0.01) of CADO group comparing with the control group. However, at the initial phase of this experiment, dose-response of rocuronium in each group demonstrated no statistically significant differences (P = 0.12). Conclusions: The adenosine $A_1$ receptor agonist (CADO) influenced the TOFR and the recovery profile. After activating adenosine receptor, sugammadex-induced recovery from rocuronium-induced neuromuscular block was delayed.

Reliability and Validity of an Electronic Inspiratory Loading Device for Assessing Pulmonary Function in Patients with COPD

  • Lee, Seugcheol;You, Seongkwang;Yang, Subin;Park, Daesung
    • Physical Therapy Rehabilitation Science
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    • v.10 no.1
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    • pp.40-47
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    • 2021
  • Objective: The purpose of this study is to prove the reliability and validity of the Power breath K5 and to compare it with pony FX. Power breathe K5 is one type of device can assess automatically Maximum inspiratory pressure (MIP), Peak inspiratory pressure, Peak inspiratory flow (PIF). Design: Cross-sectional study. Methods: Thirty-five COPD patients participated in the test to investigate for the intra relater reliability and concurrent validity. The tests MIP, Vital capacity (VC), PIF were measured by Powerbreathe K5 and Pony Fx. Data was analyzed by intraclass correlation reliability (ICC) value and a standard error of measurement and Bland-Altman plots for reliability and pearson correlation for validity. Results: Intra rater reliability of the Powerbreathe K5 was very high at MIP (ICC=0.977 95%CI 0.956~0.989, SEM=8.665, MDC=0.295), PIF (ICC=0.966 95%CI 0.933~0.93, SEM=8.665, MDC=0.295), VC (ICC=0.949 95CI 0.902~0.974, SEM=0.042, MDC=0.116). The Powerbreath K5 was significant correlation compared with Pony Fx in assessment for MIP (r=0.971, p<0.05) and vital capacity (r=0.534, p<0.05). Conclusion: In this study, We investigated the clinical usefulness of the Powerbreath K5 in evaulating the MIP, VC and PIF with COPD patients with high reliability and validity.

Economic construction management of composite beam using the head stud shear connector with encased cold-formed steel built-up fix beam via efficient computer simulation

  • Yin, Jinzhao;Tong, Huizhi;Gholizadeh, Morteza;Zandi, Yousef;Selmi, Abdellatif;Roco-Videla, Angel;Issakhov, Alibek
    • Advances in concrete construction
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    • v.11 no.5
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    • pp.429-445
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    • 2021
  • With regard to economic efficiency, composite fix beams are widely used to pass longitudinal shear forces across the interface. The current knowledge of the composite beam load-slip activity and shear capability are restricted to data from measurements of push-off. Modelling and analysis of the composite beams based on Euro-code 4 regarding to shear, bending, and deflection under differing loads were carried out using Finite Element through an efficient computer simulation and the final loading and sections capacity based on the failure modes was analysed. In bending, the section potential was increased by an improvement of the strength in both steel and concrete, but the flexural and compressive resistance growth is very weak (3.2% 3.1% and 3.0%), while the strength of the concrete has increased respectively from 25 N/mm2 to 30, 35, and 40 N/mm2 compared to the increment of steel strength by 27% and 21% when it was raised from 275 to 355 and 460 N/mm2, respectively. It was found that the final flexural load capacity of fix beams was declined with increase in the fix beam span for both three steel strength. The shear capacity of sections was remained unchanged at constant steel strength and different length, but raised with final yield strength increment of steel sections by 29%, and 67% when it was raised from 275 N/mm2 to 355 N/mm2 and 460 N/mm2, respectively.

Dynamic Deformation Behavior of Ultra-Fine-Grained Pure Coppers Fabricated by Equal Channel Angular Pressing (ECAP으로 제조된 초미세립 순동의 동적 변형거동)

  • Kim, Yang Gon;Hwang, Byoungchul;Lee, Sunghak;Lee, Chul Won;Shin, Dong Hyuk
    • Korean Journal of Metals and Materials
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    • v.46 no.9
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    • pp.545-553
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    • 2008
  • Dynamic deformation behavior of ultra-fine-grained pure coppers fabricated by equal channel angular pressing (ECAP) was investigated in this study. Dynamic torsional tests were conducted on four copper specimens using a torsional Kolsky bar, and then the test data were analyzed by their microstructures and tensile properties. The 1-pass ECAP'ed specimen consisted of fine dislocation cell structures elongated along the ECAP direction, which were changed to very fine, equiaxed subgrains of 300~400 nm in size as the pass number increased. The dynamic torsional test results indicated that maximum shear stress increased with increasing ECAP pass number. Adiabatic shear bands were not found at the gage center of the dynamically deformed torsional specimen of the 1- or 4-pass ECAP'ed specimen, while some weak bands were observed in the 8-pass ECAP'ed specimen. These findings suggested that the grain refinement according to the ECAP was very effective in strengthening of pure coppers, and that ECAP'ed coppers could be used without serious reduction in fracture resistance under dynamic torsional loading as adiabatic shear bands were hardly formed.

Research on Mac OS X Physical Memory Analysis (Mac OS X 물리 메모리 분석에 관한 연구)

  • Lee, Kyeong-Sik;Lee, Sang-Jin
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.21 no.4
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    • pp.89-100
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    • 2011
  • Physical memory analysis has been an issue on a field of live forensic analysis in digital forensics until now. It is very useful to make the result of analysis more reliable, because record of user behavior and data can be founded on physical memory although process is hided. But most memory analysis focuses on windows based system. Because the diversity of target system to be analyzed rises up, it is very important to analyze physical memory based on other OS, not Windows. Mac OS X, has second market share in Operating System, is operated by loading kernel image to physical memory area. In this paper, We propose a methodology for physical memory analysis on Mac OS X using symbol information in kernel image, and acquire a process information, mounted device information, kernel information, kernel extensions(eg. KEXT) and system call entry for detecting system call hooking. In additional to the methodology, we prove that physical memory analysis is very useful though experimental study.

Analytical post-heating behavior of concrete-filled steel tubular columns containing tire rubber

  • Karimi, Amirhossein;Nematzadeh, Mahdi;Mohammad-Ebrahimzadeh-Sepasgozar, Saleh
    • Computers and Concrete
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    • v.26 no.6
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    • pp.467-482
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    • 2020
  • This research focused on analyzing the post-fire behavior of high-performance concrete-filled steel tube (CFST) columns, with the concrete containing tire rubber and steel fibers, under axial compressive loading. The finite element (FE) modeling of such heated columns containing recycled aggregate is a branch of this field which has not received the proper attention of researchers. Better understanding the post-fire behavior of these columns by measuring their residual strength and deformation is critical for achieving the minimum repair level required for structures damaged in the fire. Therefore, to develop this model, 19 groups of confined and unconfined specimens with the variables including the volume ratio of steel fibers, tire rubber content, diameter-to-thickness (D/t) ratio of the steel tube, and exposure temperature were considered. The ABAQUS software was employed to model the tested specimens so that the accurate behavior of the FE-modeled specimens could be examined under test conditions. To achieve desirable results for the modeling of the specimens, in addition to the novel procedure described in this research, the modified versions of models presented by previous researchers were also utilized. After the completion of modeling, the load-axial strain and load-lateral strain relationships, ultimate strength, and failure mode of the modeled CFST specimens were evaluated against the test data, through which the satisfactory accuracy of this modeling procedure was established. Afterward, using a parametric study, the effect of factors such as the concrete core strength at different temperatures and the D/t ratio on the behavior of the CFST columns was explored. Finally, the compressive strength values obtained from the FE model were compared with the corresponding values predicted by various codes, the results of which indicated that most codes were conservative in terms of these predictions.

A Study of Corporate CSR Effects on Corporate Crisis Management

  • LEE, Jae-Min;QUAN, Zhixuan
    • The Journal of Economics, Marketing and Management
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    • v.8 no.2
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    • pp.13-17
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    • 2020
  • Purpose: In modern corporate management, the establishment of a crisis management system that minimizes damage through measures used to respond to corporate crises is no longer an option. The importance of corporate reputation and brand asset management in modern enterprise management cannot be overemphasized and negative events that might arise from a number of different causes can cause brand crises. Research design, data and methodology: More than half of the questionnaire respondents were female (252 or 53%). More than a fourth of the respondents were aged 20 (122 or 26%) and the number of married participants was 196 (41%). Of the participants, 32% (153) had graduated from college. Only 18% (87) were employees and the monthly household income was 121. In this study, we conducted factor analysis in order to extract the variables that may enhance the explanation capability of each variable. For the method of factor extraction, an Eigen value of at least 1 was used as was factor loading. An analysis was performed using the Cronbach's alpha coefficient to verify the reliability of the measurement scale. Results: First, the analysis of the impact of the social responsibility activities on brand image revealed that the social, economic, philanthropic, ethical, and environmental responsibility activities significantly affected brand image, but legal responsibility activities were not statistically significant. Second, the analysis of the impact of brand image on loyalty showed that brand image had a significant impact on loyalty. Third, the analysis of the impact of social responsibility activities on loyalty showed that they had a significant impact on loyalty. Conclusions: The pro-social enterprise image is not only a brand asset that can be shared, but also a heavy proposition followed by a corresponding social responsibility, it will have to practice transparent corporate management based on clear principles through the establishment of various systems and the implementation of a strict code of conduct within the enterprise.

Generation of Time Series Data from Octave Bandwidth SPL of Acoustic Loading Using Interpolation Method (보간법을 이용한 옥타브 밴드폭 음향 하중 SPL의 시계열 데이터 생성)

  • Go, Eun-Su;Kim, In-Gul;Jeon, Minhyeok;Cho, Hyun-Jun;Park, Jae-Sang;Kim, Min-Sung
    • Journal of the Korea Institute of Military Science and Technology
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    • v.24 no.1
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    • pp.1-11
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    • 2021
  • Thermal protection system structures such as double-panel structures are used on the skin of the fuselage and wings to prevent the transfer of high heat into the interior of an high supersonic/hypersonic aircraft. The thin-walled double-panel skin can be exposed to acoustic loads by high power engine noise and jet flow noise, which can cause sonic fatigue damage. In order to predict the fatigue life of the skin, the octave bandwidth SPL should be calculated as narrow bandwidth PSD or acoustic load history using interpolation method. In this paper, a method of converting the octave bandwidth SPL acoustic load into a narrow bandwidth PSD and reconstructed acoustic load history was investigated. The octave bandwidth SPL was converted to the narrow bandwidth PSD using various interpolation methods such as flat, log and linear scale, and the probabilistic characteristics and fatigue damage results were compared. It was found that average error of fatigue damage index by the log scale interpolation method was relatively small among three methods.

A Study on the make Fire Scenario for Residential Facility Combustible Materials

  • Kim, Dong-Eun;Lee, Dong-Yeol
    • Journal of the Korea Society of Computer and Information
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    • v.26 no.6
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    • pp.137-143
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    • 2021
  • In the case of residential facilities, general fire scenarios cannot be applied. Becauseit is difficult to quantify due to the types of combustibles and various fire loads. Existing research conducting surveys of combustibles, but research on fire characteristics is insufficient. Therefore, in this study, an Excel macro that can be quantified by experimenting with the HRR experiments of sofa, drawer, mattress, chair, desk and TV, which are typical combustibles. As a result of experimenting 6 loading combustibles in domestic residential facilities by using a furniture calorimeter, values of 2,391.26kW appeared from the sofa, 1,891.80kW from the drawer, 1,778.95kW from the mattress, 1,104kW from the chair, 291kW from the desk, and 135.09kW from the TV. Also, by applying the α value of the fire growth rate by classifying fire-growing speeds at NFPA 72 (National Fire Alarm Code 2007, Annex B), the mattress can be defined as Very Fast, the sofa and drawer Fast, the TV Slow, the desk Slow, and the chair Medium.

Electrode Fabrication of MWCNT-PDMS Strain Sensors by Wet-etching (습식 식각을 이용한 MWCNT-PMDS 변형율 센서 전극 생성에 관한 연구)

  • Jung, La-Hee;Hwang, Hui-Yun
    • Composites Research
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    • v.34 no.6
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    • pp.387-393
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    • 2021
  • This paper investigated the electrical properties of multiwall carbon nanotube reinforced polydimethylsiloxane (CNT-PDMS) strain sensors with copper electrodes on the wet-etched surface. MWCNT-PDMS strain sensors were fabricated according to the wt% of MWCNT. Surfaces on the electrode area were wet-etched with various etching duration and silver epoxy adhesives were spread on the wet-etched surface. Finally, we attached the copper electrodes to the MWCNT-PMDS strain sensors. We checked the electric conductivities by the two-probe method and sensing characteristics under the cyclic loading. We observed the electric conductivity of MWCNT-PDMS strain sensors increased sharply and the scattering of the measured data decreased when the surface of the electrode area was wet-etched. Initial resistances of MWCNT-PDMS strain sensors were inversely proportion to wt% of MWCNT and the etching duration. However, the resistance changing rates under 30% strain increased as wt% of MWCNT and the etching duration increased. Decreasing rate of the electric resistance change after 100 repetitions was smaller when wt% of MWCNT was larger and the etching duration was short. This was due to the low initial resistance of the MWCNT-PMDS strain sensors by the wet-etching.