• Tuberculosis and Respiratory Diseases
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• v.79 no.2
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• pp.85-90
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• 2016

Background: Lung cancer is the most common cause of cancer related death. Alterations in gene sequence, structure, and expression have an important role in the pathogenesis of lung cancer. Fusion genes and alternative splicing of cancer-related genes have the potential to be oncogenic. In the current study, we performed RNA-sequencing (RNA-seq) to investigate potential fusion genes and alternative splicing in non-small cell lung cancer. Methods: RNA was isolated from lung tissues obtained from 86 subjects with lung cancer. The RNA samples from lung cancer and normal tissues were processed with RNA-seq using the HiSeq 2000 system. Fusion genes were evaluated using Defuse and ChimeraScan. Candidate fusion transcripts were validated by Sanger sequencing. Alternative splicing was analyzed using multivariate analysis of transcript sequencing and validated using quantitative real time polymerase chain reaction. Results: RNA-seq data identified oncogenic fusion genes EML4-ALK and SLC34A2-ROS1 in three of 86 normal-cancer paired samples. Nine distinct fusion transcripts were selected using DeFuse and ChimeraScan; of which, four fusion transcripts were validated by Sanger sequencing. In 33 squamous cell carcinoma, 29 tumor specific skipped exon events and six mutually exclusive exon events were identified. ITGB4 and PYCR1 were top genes that showed significant tumor specific splice variants. Conclusion: In conclusion, RNA-seq data identified novel potential fusion transcripts and splice variants. Further evaluation of their functional significance in the pathogenesis of lung cancer is required.

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.902-904
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• 2003

The main objective of this paper is to investigate the potential utility of multisensor remotely sensed data for improved coastal wetland mapping. Five data fusion models, three algebraic models (Multiplicative (MT), Brovey (BT) and Wavelet transform (WT)) and two spectral domain models (Principals component transform (PCT) and Intensity-Hue-Saturation (IHS)) were implemented and tested over the multisensor data. The fused images were then compared based on visual and statistical approaches. The results show that the wavelet transform provides greater flexibility for combining optical data sets and has good potential for preserving the spatial and spectral content of the original images . However, this model yields poor information when combining optical and microwave data. Brovey transform is more reliable for fusing optical and microwave image data and yields improved information about different wetland features of the coastal zone.

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.773-775
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• 2003

From the view point of data fusion, we integrate LIDAR data and digital aerial images to perform 3D building modeling in this study. The proposed scheme comprises two major parts: (1) building block extraction and (2) building model reconstruction. In the first step, height differences are analyzed to detect the above ground areas. Color analysis is then performed for the exclusion of tree areas. Potential building blocks are selected first followed by the refinement of building areas. In the second step, through edge detection and extracting the height information from LIDAR data, accurate 3D edges in object space is calculated. The accurate 3D edges are combined with the already developed SMS method for building modeling. LIDAR data acquired by Leica ALS 40 in Hsin-Chu Science-based Industrial Park of north Taiwan will be used in the test.

• Korean Journal of Remote Sensing
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• v.22 no.3
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• pp.211-219
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• 2006

A random forests classifier is applied to multi-sensor data fusion for supervised land-cover classification in order to account for the importance of variable. The random forests approach is a non-parametric ensemble classifier based on CART-like trees. The distinguished feature is that the importance of variable can be estimated by randomly permuting the variable of interest in all the out-of-bag samples for each classifier. Two different multi-sensor data sets for supervised classification were used to illustrate the applicability of random forests: one with optical and polarimetric SAR data and the other with multi-temporal Radarsat-l and ENVISAT ASAR data sets. From the experimental results, the random forests approach could extract important variables or bands for land-cover discrimination and showed reasonably good performance in terms of classification accuracy.

• Journal of Korea Entertainment Industry Association
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• v.4 no.2
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• pp.58-63
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• 2010

The varieties of situated cognition applications provide various information to a user in a ubiquitous computing environment. In this paper, We propose a system that provides an optimized output using a fusion of temporal data and spatial data from sensing devices.

• Bulletin of the Korean Space Science Society
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• 2000.04a
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• pp.34-34
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• 2000

No Abstract, See Full Text

• Korean Journal of Remote Sensing
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• v.36 no.5_1
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• pp.807-821
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• 2020

The objective of this study is to evaluate the applicability of representative spatio-temporal fusion models developed for the fusion of mid- and low-resolution satellite images in order to construct a set of time-series high-resolution images for crop monitoring. Particularly, the effects of the characteristics of input image pairs on the prediction performance are investigated by considering the principle of spatio-temporal fusion. An experiment on the fusion of multi-temporal Sentinel-2 and RapidEye images in agricultural fields was conducted to evaluate the prediction performance. Three representative fusion models, including Spatial and Temporal Adaptive Reflectance Fusion Model (STARFM), SParse-representation-based SpatioTemporal reflectance Fusion Model (SPSTFM), and Flexible Spatiotemporal DAta Fusion (FSDAF), were applied to this comparative experiment. The three spatio-temporal fusion models exhibited different prediction performance in terms of prediction errors and spatial similarity. However, regardless of the model types, the correlation between coarse resolution images acquired on the pair dates and the prediction date was more significant than the difference between the pair dates and the prediction date to improve the prediction performance. In addition, using vegetation index as input for spatio-temporal fusion showed better prediction performance by alleviating error propagation problems, compared with using fused reflectance values in the calculation of vegetation index. These experimental results can be used as basic information for both the selection of optimal image pairs and input types, and the development of an advanced model in spatio-temporal fusion for crop monitoring.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.36 no.5
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• pp.413-422
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• 2018

Many applications using satellite data from high-resolution multispectral sensors require an image fusion step, known as pansharpening, before processing and analyzing the multispectral images when spatial fidelity is crucial. Image fusion methods are to improve images with higher spatial and spectral resolutions by reducing spectral distortion, which occurs on image fusion processing. The image fusion methods can be classified into MRA (Multi-Resolution Analysis) and CSA (Component Substitution Analysis) approaches. To suggest the efficient image fusion method for Pleiades and KOMPSAT (Korea Multi-Purpose Satellite) 3 satellites, this study will evaluate image fusion methods for multispectral and panchromatic images. HPF (High-Pass Filtering), SFIM (Smoothing Filter-based Intensity Modulation), GS (Gram Schmidt), and GSA (Adoptive GS) were selected for MRA and CSA based image fusion methods and applied on multispectral and panchromatic images. Their performances were evaluated using visual and quality index analysis. HPF and SFIM fusion results presented low performance of spatial details. GS and GSA fusion results had enhanced spatial information closer to panchromatic images, but GS produced more spectral distortions on urban structures. This study presented that GSA was effective to improve spatial resolution of multispectral images from Pleiades 1A and KOMPSAT 3.

• Journal of Korean Society of Transportation
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• v.23 no.5 s.83
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• pp.135-146
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• 2005

Up to now studies on the fusion of travel time from various detectors have been conducted based on the variance raito of the intermittent data mainly collected by GPS or probe vehicles. The fusion model based on the variance ratio of intermittent data is not suitable for the license plate recognition AVIs which can deal with vast amount of data. This study was carried out to develop the fusion model based on travel time acquired from the license plate recognition AVIs and the point detectors. In order to fuse travel time acquired from the point detectors and the license plate recognition AVIs, the optimized fusion model and the proportional fusion model were developed in this study. As a result of verification, the optimized fusion model showed the superior estimation performance. The optimized fusion model is the dynamic fusion ratio estimation model on real time base, which calculates fusion weights based on real time historic data and applies them to the current time period. The results of this study are expected to be used effectively for National Highway Traffic Management System to provide traffic information in the future. However, there should be further studies on the Proper distance for the establishment of the AVIs and the license plate matching rate according to the lanes for AVIs to be established.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.2
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• pp.528-544
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• 2015

Base Station Cooperation (BSC) has been a promising technique for combating the Inter-Cell Interference (ICI) by exchanging information through a high-speed optical fiber back-haul to increase the diversity gain. In this paper, we propose a novel pilot symbol assisted data fusion scheme for distributed Uplink BSC (UBSC) based on Differential Evolution (DE) algorithm. Furthermore, the proposed scheme exploits the pre-defined pilot symbols as the sample of transmitted symbols to constitute a sub-optimal Weight Calculation (WC) model. To circumvent the non-linear programming problem of the proposed sub-optimal model, DE algorithm is employed for searching the proper fusion weights. Compared with the existing equal weights based soft combining scheme, the proposed scheme can adaptively adjust the fusion weights according to the accuracy of cooperative information, which remains the relatively low computational complexity and back-haul traffic. Performance analysis and simulation results show that, the proposed scheme can significantly improve the system performance with the pilot settings of the existing standards.