• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5311-5316
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• 2013

A functional polymorphism in the NQO1 gene, featuring a 609C>T substitution,leading to proline to serine amino-acid and enzyme activity changes, has been implicated in cancer risk. However, individually published investigations showed inconclusive results, especially for leukemia. In this study, we therefore performed a meta-analysis of 21 publications with a total of 3,634 cases and 4,827controls, mainly for leukemia. We summarized the data on the association between the NQO1 609C>T polymorphism and risk of leukemia and performed subgroup analyses by ethnicity and leukemia type. We found that the variant TT homozygous genotype o was associated with a modestly increased risk of leukemia (TT versus CT/CC: OR=1.23, 95%CI=1.00-1.51, heterogeneity=0.76; $I^2$=0%). Following further stratified analyses, increased risk was only observed in subgroups of Caucasians. This meta-analysis suggests that the NQO1 609T allele is a high-penetrance risk factor for leukemia in Caucasians. The effect on leukemia may be modified by ethnicity and leukemia type, and the small sample sizes of the subgroup analyses suggest that further larger studies are needed.

• Investigative Magnetic Resonance Imaging
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• 제19권1호
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• pp.37-46
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• 2015

Purpose: This report compared the diagnostic effectiveness between ultrasmall superparamagnetic iron oxide (USPIO) and gadolinium (Gd) based magnetic resonance imaging (MRI) for differentiation of axillary status in breast cancer patients. Materials and Methods: The present authors performed a meta-analysis of previous studies that compared USPIO or Gd based MRI with histological diagnosis after surgery or biopsy. We searched PubMed, EMBASE, Cochrane Library, ScienceDirect, SpringerLink, Ovid databases and references of articles to identify studies reporting data until December 2013. Pooled sensitivity and specificity were calculated for every study; summary receiver operating characteristic and subgroup analysis was done. Analyses of study quality and heterogeneity were also assessed. Results: There were 14 publications that met the criteria for inclusion in our meta-analysis. USPIO based MRI showed 0.83 (95% CI: 0.75-0.89) and 0.97 (95% CI: 0.94-0.98) for pooled sensitivity and specificity, respectively. Gd based MRI represented pooled sensitivity and specificity of 0.61 (95% CI: 0.55-0.67) and 0.90 (95% CI: 0.87-0.92) for each. Overall weighted area under the curve for USPIO and Gd based MRI were 0.9563 and 0.9051, respectively. Conclusion: USPIO based MRI had a tendency toward high pooled sensitivity and specificity in detection of axillary metastases for breast cancer. This result may mean that USPIO based MRI could be used as complementary modality to differentiate axillary status more precisely, and assist in the decision-making process regarding possible invasive procedures, such as sentinel node biopsy.

• 정보처리학회논문지D
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• 제12D권4호
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• pp.553-568
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• 2005

분산된 생물 정보원을 물리적으로 혹은 가상적으로 통합하기 위해서는 정보원들의 이질성을 해결해야 하며, 사용자의 다양한 요구를 수용할 수 있도록 범용성과 적응력이 뛰어나야 한다 본 논문에서는 데이터는 물론 응용 프로그램의 통합을 위한 미들웨어를 설계함에 있어서 랩퍼 시스템에서의 융통성 있는 범용 XML 질의 처리 엔진을 제시한다. 제시된 질의 처리 엔진은 사용자 정의 XML 뷰를 지원함으로서 융통성 있는 통합 질의 구성을 가능하게 한다. 질의 처리 과정은 뷰 합성, 지역 정보원에 대한 질의 변환, 그리고 결과 문서 생성과정을 동반하는데, 이를 위해 XML 뷰와 XML 질의어를 뷰 트리로 표현하는 XML 뷰 트리 기반의 질의 처리 모델을 제시한다. 그리고 제시된 질의 처리 모델의 범용성을 확인하기 위해 관계형 데이터베이스와 웹 정보원, 그리고 응용 프로그램에 대하여 정보원의 질의 결과 형이 관계형 튜플과 XML 문서인 경우에 대한 질의 처리 방법을 제시한다.

• 한국조사연구학회지:조사연구
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• 제12권1호
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• pp.65-88
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• 2011

본 연구는 패널조사에 기초한 다중상태 생명표 모형을 활용하여 우리나라 중고령층의 근로와 은퇴 그리고 사망으로 이어지는 생애과정을 분석하고 있다. 또한 기존의 생명표 분석이 성별 차이만을 고려하였음에 비해 본 연구는 교육수준을 추가적으로 고려하여 생명표를 작성함으로써 근로 및 은퇴 생애과정에서 관측되는 사회계층별 이질성을 추가적으로 고려하고자 하였다. 분석 결과는 근로 및 은퇴 생애과정이 성별 그리고 교육수준별로 매우 이질적인 패턴을 보이고 있음을 보여 주었다. 성별 차이와 관련하여 여성은 남성에 비해 생존기간이 길지만 취업 기대여명이 낮음과 동시에 미취업 기대여명이 높게 나타남으로써 전체 생존 기간에서 미취업 기간이 차지하는 비중이 매우 높은 모습을 보여 주었다. 교육수준별 차이와 관련한 분석 결과는 전반적으로 취업 기대여명에서는 뚜렷한 차이가 관측되지 않는 반면, 미취업 기대여명에서의 격차가 유의미하게 나타남으로써 교육수준별 근로생애 차이는 대체로 미취업 기대여명에서의 차이임을 보여 주었다. 보다 구체적으로, 교육수준이 낮은 개인들은 교육수준이 높은 개인들과 유사한 수준의 취업 기대여명을 갖고 있지만, 미취업 기대여명이 유의미하게 낮음으로 인해 생존 기간의 보다 큰 비중을 노동시장에서 체류하고 있음을 보여 주었다.

• 응용통계연구
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• 제26권3호
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• pp.453-470
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• 2013

본 논문에서는 카드뮴의 반응-용량 모형에 대한 베이지안 분석을 실시하고 기준용량에 대한 추정값들을 유도하고 비교한다. 이를 위하여 독성물질에 대한 용량반응곡선에서 많이 활용되는 두 가지 모형을 사용하고, 카드뮴의 독성연구에 관련한 기존의 문헌으로 수집된 자료에 대한 성별, 연령, 인종, study code 등과 같은 소집단 간의 개별적 형질을 반영할 수 있는 베이지안 메타분석 관점에서의 모형분석을 실시한다. 이러한 두 가지 모형에 대한 베이지안 분석을 위하여 WinBUGS를 이용한 마르코프 연쇄 몬테칼로(Markov chain Monte Carlo; MCMC) 방법을 통하여 모수를 추정하고 이에 따른 다양한 기준용량들을 계산하고 비교해보았다. 베이지안 모형 적합뿐만 아니라 편차정보기준을 통해서 주어진 자료를 더 잘 설명하는 모형을 선택하는 베이지안 모형 선택을 고려하였고, 이를 실제 자료에 적용해본다.

• Journal of Preventive Medicine and Public Health
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• 제41권3호
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• pp.159-164
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• 2008

Objectives : The purpose of this systematic review was to investigate the association between dietary intake of citrus fruits and prostate cancer risk. Methods : Authors searched electronic databases and the reference lists of publications of diet and prostate cancer studies until August 2007. All of the epidemiological studies that obtained individual data on dietary intake of citrus fruits and presented risk estimates of the association between intake of citrus fruits and risk of prostate cancer were identified and included. Using general variance-based methods, study-specific odds ratios (OR)/ relative risk (RR) and associated confidence interval (CI)/ standard error (SE) for highest versus lowest intake of citrus fruits level were extracted from each paper. Results : Eleven articles including six case-control studies, one nested case-control study and four cohort studies, proved eligible. Overall summary OR using random effect model did not show an association in risk of prostate caner with intake of citrus fruits (summary OR=1.03, 95% CI=0.89-1.19) with large heterogeneity across studies that we were unable to explain ($I^2$=67.88%). The summary ORs in case-control studies and cohort studies were 1.10 (95% CI=0.97-1.22) and 1.05 (95% CI=0.96-1.14), respectively. Conclusions : Pooled results from observational studies did not show an association between intake of citrus fruits and the risk of prostate cancer, although results vary substantially across studies.

• 보건행정학회지
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• 제30권1호
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• pp.26-36
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• 2020

Background: The purpose of this study was to analyze the relationship between the regional characteristics and the age-adjusted cardio-cerebrovascular disease mortality rates (SCDMR) in 229 si·gun·gu administrative regions. Methods: SCDMR of man and woman was used as a dependent variable using the statistical data of death cause in 2017. As a representative index of regional characteristics, health behavior factors, socio-demographic and economic factors, physical environment factors, and health care factors were selected as independent variables. Ordinary least square (OLS) regression and geographically weighted regression (GWR) were performed to identify their relationship. Results: OLS analysis showed significant factors affecting the mortality rates of cardio-cerebrovascular disease as follows: high-risk drinking rates, the ratio of elderly living alone, financial independence, and walking practice rates. GWR analysis showed that the regression coefficients were varied by regions and the influence directions of the independent variables on the dependent variable were mixed. GWR showed higher adjusted R² and Akaike information criterion values than those of OLS. Conclusion: If there is a spatial heterogeneity problem as Korea, it is appropriate to use the GWR model to estimate the influence of regional characteristics. Therefore, results using the GWR model suggest that it needs to establish customized health policies and projects for each region considering the socio-economic characteristics of each region.

• Restorative Dentistry and Endodontics
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• 제22권1호
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• pp.413-427
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• 1997

Porphyromonas endodontalis and Prevotella intermedia are black-pigmented anaerobic gram negative rods which have been isolated from infected root canals and submucous abscesses of endodontic origin. And they are associated with clinical symptoms such as pain, percussion, and foul odor. It has been reported that there are 3 serotypes according to capsule membrane in P. endodontalis and 2 DNA homology groups and 3 serotypes in P. intermedia, but there is no data available regarding genetic diversity for the species P. endodontalis and P. intermedia. The purpose of this study is to investigate genetic diversities between individual strains of P. endodontalis and P. intermedia which are indistinguishable by serotyping and biotyping using bacterial DNA restriction endonuclease analysis. 45 teeth with at least one clinical symptoms, with single canal, and with pulp necrosis were sampled. For sampling bacteria, access cavity was prepared after disinfecting tooth and its surroundings. Then the paper point was inserted to the apex of the canal, leave there for 15 seconds, and finally it was placed into PRAS Ringer's solution and PBS solution. P. endodontalis and P. intermedia were identified by biochemical test and IIF after subculturing black and brown colonies which were produced after 7 days of incubation on BAP in anaerobic chamber. P. endodontalis and P. intermedia strains were grown in BHI broth and whole genomic DNA was extracted by phenol-chloroform extraction technique and digested by restriction endonuclease, Eco RI and Pst I. The resulting DNA fragments were separated by agarose gel electrophoresis, stained with EtBr and photographed under UV light. The results were as follows : 1. In both P. endodontalis and P. intermedia, different serotypes could be found within a root canal of same patient. 2. There were obvious genetic heterogeneity within a patient and within a serotype in both P. endodontalis and P. intermedia. 3. P. endodontalis serotype c, isolated from different patients, exhibited limited genotypic diversity.

• 디지털융복합연구
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• 제12권11호
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• pp.617-623
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• 2014

본 연구는 전통의학문헌에 나타난 재래닭 관련 의안을 분석하여 재래닭의 약리작용 성분을 정리하는데 목표를 두고 있다. 민간치료 자료의 처방과 기존의 한의서에 기술된 다양한 재래 닭 처방과의 상이성 및 공통점을 찾아 분석하여 과학적 검증이 가능한 내용에 대하여 정리하고자 한다. 분석된 내용을 구분 정리하여 DB를 구축하고, 전통의서에 수재된 처방, 한약, 생약 및 특수 치료 방법에 대한 유용성 평가를 통하여 닭 관련 제품개발과 다양한 기능성 식품개발의 근거를 마련하고자 한다. 또한, 국가 지식자원의 지속적인 확충과 전문인력 양성 및 지식문화 관련사업의 부가가치 창출을 통한 미래 신성장 동력산업을 육성하고자 한다. 재래닭 관련 처방지식에 대한 검색 및 정보 관리체계의 정형화가 난해하므로 규격화, 개념화, 형식화한 전통의학 재래닭 처방지식 DB를 구축하여 다학제간의 연구시스템을 통한 고의학 서적의 약학적 유용성을 평가하고 대체의학이나 기능성 식품개발의 실용화 방안을 제시하고자 한다.

• Journal of Microbiology
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• 제45권5호
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• pp.466-472
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• 2007

A total of 98 vancomycin-resistant Enterococcus faecium (VREF) isolates (58 isolates from patients and 40 isolates from poultry) were compared based on their antimicrobial susceptibility, Tn1546 element organization, and pulsed-field gel electrophoresis (PFGE) patterns. This comparison aided in determining the relationships between the groups of isolates. All the VREF isolates harbored the vanA gene; however, 29 (29.6%) of the isolates exhibited the VanB phenotype-vanA genotype. Furthermore, the VREF isolates from humans and poultry exhibited distinct antimicrobial resistance patterns. The PCR mapping of the Tn1546 elements exhibited 12 different transposon types (A to L). The VREF isolates of poultry were classified into types A to D, whereas the human isolates were classified into types E to L. A PFGE analysis demonstrated a high degree of clonal heterogeneity in both groups of isolates; however, the distinct VREF clones appeared in each group of isolates. The deletion of the vanX-vanY genes or insertion of IS1216V in the intergenic region from the vanX-vanY genes is directly associated with the incongruence of the VanB phenotype-vanA genotype in human VREF isolates. These data suggest that the VREF isolates exhibit distinct phenotypic and genotypic traits according to their origins, which suggests that no evidence exists to substantiate the clonal spread or transfer of vancomycin resistance determinants between humans and poultry.