• 보존과학회지
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• 제38권2호
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• pp.166-179
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• 2022

본 연구에서는 목판 문화재의 보존처리를 위해 열화된 소나무를 이용하여 시험편을 제작하고 Dammar, Beeswax, Paraloid B-72, 아교, H.P.C 처리제 적용에 따른 시험편의 중량변화와 수축률, 색 변화, 침투확산 특성을 관찰하였다. 그 결과 목재 본래의 색을 유지하며 재질 강화에 효과적인 처리제로 Dammar이 가장 적합한 것으로 확인되었다. 위 결과를 토대로 목판 문화재와 손상 상태가 유사하며 목판 문화재의 주요수종과 유사한 열화된 산공재 수종을 이용하여 시험편을 제작하고 Dammar의 적용농도 및 처리 방법을 알아보고자 Dammar 농도별(2%, 5%) 도포와 Dammar 농도별(10%, 15%) 함침을 진행하였으며 중량변화, 침투확산 특성 등을 관찰하였다. 그 결과 목재 본연의 색을 유지하면서 재질 강화에 효과적인 방법으로 Dammar 2% 도포가 가장 우수한 것으로 나타났다. 따라서, 충해 및 열화가 심한 목판 문화재의 강화처리에는 Dammar 2% 도포가 가장 적합한 것으로 판단된다.

• 보존과학회지
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• 제20권
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• pp.81-88
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• 2007

무령왕릉 목관재의 보존 처리를 위하여 목관재의 물리적 특성과 유사한 시편을 제작하여 Dammar, Paraloid B72, H.F.C 처리제의 침투에 따른 시편의 중량변화와 수축률, 색변화, 침투확산 특성 등을 관찰하였다. 그 결과 수축변형을 방지하고 유물 원래의 색을 살리면서 재질을 강화시키는 처리제로 Dammar 2%(in xylene)가 가장 우수한 것으로 나타났다. 따라서 건조 열화 된 목관재의 강화처리제로 Dammar이 적합한 것으로 확인되었다.

• Journal of Ginseng Research
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• 제44권3호
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• pp.405-412
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• 2020

Background: Root rot is a serious destructive disease of Panax notoginseng, a famous cultivated araliaceous herb called Sanqi or Tianqi in Southwest China. Methods: The chemical substances of Sanqi rot roots were explored by chromatographic techniques. MS, 1D/2D-NMR, and single crystal X-ray diffraction were applied to determine the structures. Murine macrophage RAW264.7 and five human cancer cell lines were used separately for evaluating the antiinflammatory and cytotoxic activities. Results and Conclusion: Thirty dammarane-type triterpenes and saponins were isolated from the rot roots of P. notoginseng. Among them, seven triterpenes, namely, 20(S)-dammar-25-ene-24(S)-hydroperoxyl-3β,6α,12β,20-tetrol (1), 20(S)-dammar-3-oxo-23-ene-25-hydroperoxyl-6α,12β,20-triol (2), 20(S)-dammar-12-oxo-23-ene-25-hydroperoxyl-3β,6α,20-triol (3), 20(S)-dammar-3-oxo-23-ene-25-hydroperoxyl-12β,20-diol (4), 20(S),24(R)-epoxy-3,4-seco-dammar-25-hydroxy-12-one-3-oic acid (5), 20(S),24(R)-epoxy-3,4-seco-dammar-25-hydroxy-12-one-3-oic acid methyl ester (6), and 6α-hydroxy-22,23,24,25,26,27-hexanordammar-3,12,20-trione (7), are new compounds. In addition, 12 known ones (12-16 and 19-25) were reported in Sanqi for the first time. The new Compound 1 showed comparable antiinflammatory activity on inhibition of NO production to the positive control, whereas the known compounds 9, 12, 13, and 16 displayed moderate cytotoxicities against five human cancer cell lines. The results will provide scientific basis for understanding the chemical constituents of Sanqi rot roots and new candidates for searching antiinflammatory and antitumor agents.

• 약학회지
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• 제40권2호
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• pp.163-169
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• 1996

Glycosidation of 20(S)-protopanaxadiol obtained by the alkaline hydrolysis of total ginsenosides with 2,3,4,6-tetra-O-acetyl-${\alpha$-D-glucopyranosyl bromide in the presence of $CdCO_3$ in benzene-dioxane gave a mixture of acetylated monoglucosides and diglucosides in a total yield of 68%. Under the same condenstion condition, 20-dehydroxyglucosides were formed by dehydration of 12-O-glucosides. The structures of produced glycosides were elucidated as 3-O-${\beta$-D-glucopyranosyl-20(S)-protopanaxadiol, 12-O-${\beta$-D-glucopyranosyl-dammar-20(22), 24-dien-$3{\beta},12{\beta}$-diol, 3,12-di-O-${\beta}$-D-glucopyranosyl-dammar-20(22), 24-dien-$3{\beta},\;12{\beta}$-diol, respectively.

• Archives of Pharmacal Research
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• 제20권2호
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• pp.191-193
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• 1997

A new nortriterpene, rhombenone (1) was isolated from the leaves of Hedera rhombea Bean (Araliaceae). The structure of this compound was established as 27-demethyl-20(S)-dammar-23-ene-$6{\alpha}$, 20-diol-3, 25-dione on the basis of spectral analysis including HMQC and HMBC techniques. Rhombenone (1) was the first 27-demethyl nortriterpene of dammarane type isolated from natural sources.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1993년도 학술대회지
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• pp.74-83
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• 1993

In an attempt toward the synthesis of the difficulty accessible ginseng saponins the four dammarane glycosides identical to the natural $ginsenosides-Rh_2,$ - F2, compound K and chikusetsusaponin - LT8 have been prepared from betulafolienetriol(=dammar-24-ene-$3{\alpha},12{\beta}\;20(S)-triol).\;3-O-{\beta}-D-Glucopyranoside$ of 20(S) - protopanaxadiol $(=ginsenoside-Rh_2)$ have been obtained by the regio - and stereoselective glycosylation of the $12-O-acetyldammar-24-ene-3{\beta},\;12{\beta},$ 20(S)-triol. The 12-ketoderivative of 20(S)-protopanaxadiol has been used as aglycon in synthesis of chikusetsusaponin - LT8. Attempted regio - and stereoselective glycosylation of the less reactive tertiary C - 20 - hydroxyl group in order to synthesize the $20-O-{\beta}-D-glucopyranoside$ of 20(S)-protopanaxadiol(=compound K) using 3, 12 - di - O - acetyldammar - 24 - ene - $3{\beta},12{\beta},20(S)$-trial as aglycon was unsuccessful. Glycosylation of 3, 12 - diketone of betulafolienetriol followed by $NaBH_4$ reduction yielded the $20-O-{\beta}-D-glucopyranoside\;of\;dammar-24-ene-3{\beta},12{\alpha},$ 20(S)-triol, the $12{\alpha}-epimer$ of 20(S) - protopanaxadiol. Moreover, a number of semisynthetic ocotillol - type glucosides, analogs of natural pseudoginsenosides, have been prepared.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1998년도 Advances in Ginseng Research - Proceedings of the 7th International Symposium on Ginseng -
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• pp.115-126
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• 1998

Four new dammarnae-glycosides named ginsenosides Rgs, Rh4, RsB and Rf2 have been isolated 1'rom Korean red ginseng, the root of Panax ginseng C. A. Meyer (Araliaceae) and their chemical structures have been elucidated by chemical and spectroscopic methods, including'H-'H COSY, HMQC, HMBC, NOESY, as 3-0- [$\beta$-D-glucopyranosyl(1 ~2)-$\beta$-D-glucopyranosyl] dammar-20(22) , B4-diene-3P,12P-diol (ginsenoside Rgs),6-0-$\beta$-D-glucopyranosyl-dammar-20(22),24-diene-3P,6P, 12P-triol (ginsenoside Rh4),3-0- [6" -0-acetyl-D-glucopyranosyl(1 ~2)--D-glucopyranosyl] 20(5)- protopanaxadiol (ginsenoside Rs3) and 6-0- [u-L-rhamno-pyranosyl(1 ~2)-$\beta$-D-glucopyranosyl] dammarane -3$\beta$, 6a, 12 $\beta$, 20(R),25-pentol(ginsenoslde Rfa). The absolute stereo structure of a double bond at C-20(22) was determined as entgegen type by applying NOESY.OESY.

• 보존과학연구
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• 통권35호
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• pp.45-55
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• 2014

태안 마도1호선에서 출수된 대나무 소반은 해양에 매장되어 있는 동안 열화되어 매우 취약한 상태였다. 따라서 치수안정화처리를 위해 약품 4종(Sucrose, Dammar gum, Cetyl alcohol, Polyethylene glycol 4000)을 사용하여 예비실험을 진행했다. 실험 결과 수용성 PEG 4000 함침 후 진공동결건조법을 적용한 시료가 형태를 잘 유지하고 처리 후 색상이 밝게 표현되어 수침대나무를 보존처리하는데 적합한 방법으로 평가되었다. 대나무 소반 2점 중 1점은 수용성 PEG 4000을 10%에서 40%까지 함침처리 한 후 진공동결건조하였다. 다른 한 점은 수용성 PEG 4000을 10%에서 70%까지 함침처리하였다. 그 후 대나무 소반의 편을 모두 해체한 후 각각의 부재를 폴리카보네이트판으로 진공동결건조하였다. 또한 형태유지 및 강도부여를 위해 아크릴을 사용하여 유물 형태에 맞추어 틀을 제작한 후 그 위에 소반을 복원함으로써 원형을 찾고 전시 및 보관이 용이하도록 하였다.

• Natural Product Sciences
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• 제23권4호
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• pp.291-298
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• 2017

Six dammarane-type triterpenoids, dammar-24-en-$3{\beta}$-ol (1), $3{\beta}$-epicabraleahydroxy lactone (2), (E)-25-hydroperoxydammar-23-en-$3{\beta}$,20-diol (3), dammar-24-en-$3{\beta}$,20-diol (4), $3{\beta}$-acetyl-20S,24S-epoxy-25-hydroxydammarane (5), and $3{\beta}$-epiocotillol (6) were isolated from the methanolic extract of the bark of Aglaia elliptica. The chemical structure were identified on the basis of spectroscopic evidence and by comparison with those spectra previously reported. Compounds 1 - 6 were isolated first time from this plant. Compounds 1 - 6, along with a known synthetic analog, cabraleone (7) were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds $3{\beta}$-acetyl-20S,24S-epoxy-25-hydroxydammarane (5) showed strongest cytotoxic activity with $IC_{50}$ value of $8.02{\pm}0.06{\mu}M$.

• 약학회지
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• 제39권1호
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• pp.85-93
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• 1995

Acidic and alkaline hydrolysis of diol-type ginseng saponins produced a new glycoside, (20E)-ginsenoside Rh$_{3}$, and its stereoisomer (20Z)-, which were further subjected to alkaline by drolysis to give their aglycones, (20E)- and (20Z)-3$\beta$, 12$\beta$-dihydroxy-dammar-20(22),24-diene. The ratio of stereoisomeric mixtures was estimated to be ca. 5:1 from intensities of the peaks in $^{1}$H- and $^{13}$C-NMR spectra. The $^{1}$H- and $^{13}$C-NMR signals of ginsenoside Rh$_{3}$, which have remained unclarified, were completely assigned by the extensive application of modern NMR techniques.