• Journal of Applied Biological Chemistry
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• v.55 no.2
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• pp.109-115
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• 2012

The aim of this study was to determine hepatoprotective effects of pig placenta hydrolysates (PLA) on liver damage-induced rats. Sprague Dawley rats were subcutaneously injected with carbon tetrachlorides and divided into 4 groups: negative control (DMSO treated), two PLA treated groups, low dosage of PLA (LPLA; 300 mg/kg body weight) and high dosage of PLA (HPLA; 1000 mg/kg body weight), and silymarin treated group (80 mg/kg body weight). Rats in each group orally received assigned compounds for 3 weeks. For the normal control group vehicle (corn oil) was injected. After 3 weeks, liver and spleen weights were greater in the two PLA and silymarin groups than the negative control group. After bromosulfalein (BSP) treatment, the clearance rates were in the descending order of negative control > LPLA > HPLA = silymarin and serum BSP levels exhibited the opposite trends of the clearance rates. Serum levels of aspartate aminotransferase, alanine aminotransferase, triglyceride, and cholesterol lowered with PLA in a dose-dependent manner. The decrease with HPLA was similar to that with silymarin. In addition, triglyceride, cholesterol, lipid peroxides levels in the liver decreased in HPLA and silymarin compared to the negative control. The liver morphometry was improved in HPLA- or silymarin-treated rats in comparison to the negative control. In conclusion, HPLA administration ameliorated the hepatotoxicity as much as silymarin in rats injected with carbon tetrachlorides.

• Korean Journal of Heritage: History & Science
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• v.46 no.1
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• pp.176-187
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• 2013

A study has been carried out on metal materials in order to identify the quantitative relation between the concentration and damage characteristics after evaluation of the damage characteristics according to the $SO_2$ concentration. The prepared metal samples, which were categorized according to the material (silver, copper, iron, lead, brass) were exposed to 0.01, 0.12, 1, 10, 100, 1,000, and 5,000ppm of $SO_2$ for 24 hours and the optical, physical, chemical deterioration rates both before and after testing were evaluated. The results showed optical deterioration, a loss of gloss on silver specimen with $SO_2$ 100ppm, an increase of color difference on brass, iron, copper and lead specimens with $SO_2$ 5,000ppm, as well as physical changes such as an increase of thickness and corrosion rate on iron sample with $SO_2$ 5,000ppm. In the case of chemical changes such as an increase sulfate ion ($SO{_4}^{2-}$) concentration and decrease of pH on iron and brass specimens were identified. These results suggest that $SO_2$ 100ppm caused clear optical deterioration on some metals such as silver and physicochemical and optical deterioration were identified at $SO_2$ 5,000ppm regardless of metal type. Also, It was concluded that iron and brass are the most susceptible of the metal specimens to $SO_2$.

• The Journal of Society for e-Business Studies
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• v.23 no.1
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• pp.47-63
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• 2018

This study suggested quantitative models to calculate a royalty rate as an important input factor of the relief from royalty method which has the characteristics of income approach method and market approach method that are generally used in the valuation of intangible assets. This study built a royalty rate regression model by referring to the patent infringement damages cases based on royalties, i.e., by using the royalty rates as a dependent variable and the patent indexes of the corresponding patent right as independent variables. Then, a logistic regression model was constructed by referring to inter-partes review cases of patent rights, i.e. by using not-unpatentable results as a dependent variable and the patent indexes of the corresponding patent right as independent variables. A final royalty rate was calculated by matching the royalty rate from the royalty rate regression model with a not-unpatentable probability from the logistic regression model. The suggested royalty rate was compared with the royalty rate obtained by the traditional methods to check its reliability.

• Journal of Embryo Transfer
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• v.32 no.4
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• pp.257-265
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• 2017

Ferulic Acid (FA) is a metabolite of phenylalanine and tyrosine, a phenolic compound commonly found in fruits and vegetables. Several studies have shown that FA has various functions such as antioxidant effect, prevention of cell damage from irradiation, protection from cell damage caused by oxygen deficiency, anti-inflammatory action, anti-aging action, liver protective effect and anti-cancer action. In this study, we investigated the maturation rate, intracellular glutathione (GSH) and reactive oxygen species (ROS) of porcine oocytes by adding FA to the in vitro maturation (IVM) medium and examined subsequent embryonic developmental competence at 5% oxygen through parthenogenesis. There is no significant difference between the control group ($0{\mu}M$) and treatment groups ($5{\mu}M$, $10{\mu}M$, $20{\mu}M$) on maturation rates. Intracellular GSH levels in oocyte treated with $5{\mu}M$ of FA significantly increased (P < 0.05), and $20{\mu}M$ of FA revealed significant decrease (P < 0.05) in intracellular ROS levels compared with the control group. Oocytes treated with FA exhibited significantly higher cleavage rates (79.01% vs 89.19%, 92.20%, 90.89%, respectively) than the control group. Oocytes treated with $10{\mu}M$ showed significantly higher blastocyst formation rates (28.3% vs 40.3%, respectively) after PA than the control group. Total cell numbers in blastocyst of $10{\mu}M$ FA displayed significantly higher (39.4 vs 51.9, respectively) than the control group. In conclusion, these results suggested that treatment with FA during IVM improved the developmental potential of porcine embryos by increasing intracellular GSH synthesis and reducing ROS levels. Also, there was an improvement of cleavage rate, blastocyst formation and total cell numbers in blastocysts. It might be associated with Keap1-Nrf2 pathway as an antioxidant regulate pathway that plays a crucial role in determining the sensitivity of cells to oxidative damages by regulating the basal and inducible expression of enzymes which is related to detoxification and anti-oxidative effects, stress response enzymes and/or proteins and ABC transporters.

• Journal of Nutrition and Health
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• v.29 no.6
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• pp.578-589
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• 1996

This study was performed to invstigate the effect of dietary protein level and source on cadmium intoxicification in rats. Forty-eight male rats of Sprague-Dawley strain weighing 171$\pm$3g were blocked into 8 groups of 6 animals according to body weigth, and were raised for 30days. Eight experimental diets different with cadmium(0ppm, 400ppm)and protein(15%, 40%) levels and protein source[casien, I.S.P.(isolated soy protein)] were given to animals for 30days. Food intake, weight gain, food efficiency ratio, liver weight, kidney weight and femur weight were lower in cadmium added group, and higher in high protein groups(40% protein) than medium protein groups(15% protein). But, dietary protein source had no influence on them. Cadmium concerntration of liver was higher in rats fed casein than I.S.P. groups, and cadmium concentration in intestine was higher in high protein groups. In femur both high protein and I.S.P.diets increased cadmium concentrations. MT concdentrations in liver, kidney and intestine were higher in cadmium added group, and kidney intestine MT concentration were higher in high protein group. Absorption and retention rates of cadmium were lower in rat fed I.S.P. than animal fed casein among medium protein groups and cadmium concentration in blood and liver of I.S.P groups were lower than casein groups. But absorption and retention rates of cadmium were similar in high casein and I.S.P. groups. Renal damage by cadmium administration was not seen in all groups. Absorption rates of zinc and copper competing with cadmium in absorption process were lower in high protein groups than medium protein groups and lower in rats fed I.S.P. than casein. In conclusion, weight gain, F.E.R, and MT concentraion of high protein groups were higher than those of medium protein groups and absorption and retention rates of cadmium were lower in high protein groups. From these results, it was shown that cadmium toxicity was alleviated by high dietary protein. Meanwhile, the effect of dietary source on the cadmium toxicity was different with protein level. In medium protein groups absorption and retention rates of cadmium were much lower in rats fed I.S.P. than casein. In high protein groups, cadmium toxicity was not influenced by protein source and absorption and retention rates of cadmium were not different between casein and I.S.P. groups.

• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.25-25
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• 2022

Drought becomes frequent and severe because of continuous global warming, leading to a significant loss of crop yield. In soybean (Glycine max [L.]), most of quantitative trait loci (QTLs) analyses for drought tolerance have conducted by investigating yield changes under water-restricted conditions at the reproductive stages. More recently, the necessity of QTL studies to use physiological indices responding to drought at the early growth stages besides the reproductive ones has arisen due to the unpredictable and prevalent occurrence of drought throughout the soybean growing season. In this study, we thus identified QTLs conferring wilting scores and moisture contents of soybean subjected to drought stress in the early vegetative stage using an recombinant inbred line (RIL) population derived from a cross between Taekwang (drought-sensitive) and SS2-2 (drought-tolerant). For the two traits, the same major QTL was located on chromosome 10, accounting for up to 11.5% of phenotypic variance explained with LOD score of 12.5. This QTL overlaps with a reported QTL for the limited transpiration trait in soybean and harbors an ortholog of the Arabidopsis ABA and drought-induced RING-D UF1117 gene. Meanwhile, one of important features of plant drought tolerance is their ability to limit transpiration rates under high vapor pressure deficiency in response to mitigate water loss. However, monitoring their transpiration rates is time-consuming and laborious. Therefore, only a few population-level studies regarding transpiration rates under the drought condition have been reported so far. Via employing an Arduino-based platform, for the reasons addressed, we are measuring and recording total pot weights of soybean plants every hour from the 1^st day after water restriction to the days when the half of the RILs exhibited permanent tissue damage in at least one trifoliate. Gradual decrease in moisture of soil in pots as time passes refers increase in the severity of drought stress. By tracking changes in the total pot weights of soybean plants, we will infer transpiration rates of the mapping parents and their RILs according to different levels of VPD and drought stress. The profile of transpiration rates from different levels of severity in the stresses facilitates a better understanding of relationship between transpiration-related features, such as limited maximum transpiration rates, to water saving performances, as well as those to other drought-responsive phenotypes. Our findings will provide primary insights on drought tolerance mechanisms in soybean and useful resources for improvement of soybean varieties tolerant to drought stress.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.25 no.5
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• pp.276-284
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• 2013

A stochastic expected cost model has been suggested by combining the nonlinear cumulative damage model with the expected cost model together which can be useful for doing the preventive optimal-maintenance of the armor units of rubble-mound breakwaters. The suggested model has been satisfactorily calibrated by comparison of the results from others models, also the sensitivity analysis has been carried out in detail under the variation of the associated parameters with the model. The optimal repair times can be directly evaluated by minimizing the expected cost rates that depend on the social importances, damage intensity functions and resistance limits. Finally, the present cost model has been straightforwardly applied to the armor units of rubble-mound breakwaters. Based on the assumption of turning the damaged structure back to the state as good as new after repairs, the required optimal repair times and magnitudes can be determined quantitatively in terms of the optimum balance between the costs and benefits on the preventive maintenance.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.35 no.4
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• pp.769-777
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• 2015

In this study, the rheological models were introduced and developed to reflect rate dependent tensile behaviour of concrete. In general, mechanical properties(e.g. strength, elasticity, and fracture energy) of concrete are increased under high loading rates. The strength of concrete shows high rate dependency among its mechanical properties, and the tensile strength has higher rate dependency than the compressional strength. To simulate the rate dependency of concrete, original spring set of RBSN(Rigid-Body- Spring-Network) model was adjusted with viscous and friction units(e.g. dashpot and Coulomb friction component). Three types of models( 1) visco-elastic, 2) visco-plastic, and 3) visco-elasto- plastic damage models) are considered, and the constitutive relationships for the models are derived. For validation purpose, direct tensile test were simulated, and characteristics of the three different rheological models were compared with experimental stress-strain responses. Simulation result of the developed visco-elasto-plastic damage(VEPD) model demonstrated well describing and fitting with experimental results.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.45 no.6
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• pp.405-410
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• 2000

This experiment was conducted to investigate to the degree of damage by stink bugs at the soybean fields of Kyong-buk Agricultural Research and Extension Services from 1997 to 1998. Thirty different soybean varieties including Hwangkeumkong were used. Stink bugs collected in the soybean fields were Riptortus clavatus, Nazara antennata, Piezodorus hybneri, Dolycoris baccarum, and Halyomorpha halys, etc. The damage rates by stink bug were 5.0-12.5% in determinate types and 36.1-50.0% in indeterminate ones, which indicated that stink bugs preferred indeterminate types to determinate ones. The control values to sting bugs by fenitrothion, triaazophos, and carbaryl, were 83.4%, 69.5%, and 87.0%, respectively.

• International Journal of Highway Engineering
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• v.7 no.2 s.24
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• pp.69-76
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• 2005

While the repeated traffic loading accumulates the damage of asphalt pavement, the damage has being healed during rest periods. And then, this healing enhances the fatigue life of asphalt pavement. A method was developed to determine the healing rate of asphalt mixture in terms of recovered dissipated creep strain energy (DCSE) per unit time, and the healing properties of four different asphalt mixtures were evaluated. The test procedure consists of repeated loading test and periodical resilient modulus tests. A normalized healing rate in terms of $DCSE/DCSE_{applied}$ was defined to evaluate the healing properties independently of the amount of damage incurred in the mixture. From the test results, it was concluded that the healing rates of asphalt mixtures were increased exponentially as the temperature was increased and more affected by the structural characteristics of mixture such as asphalt content than the binder characteristics such as the polymer modification.