• Archives of Pharmacal Research
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• 제24권4호
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• pp.323-326
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• 2001

Previous studies have demonstrated that CW252053, a quinazoline antifolate, exhibits potent inhibitory activity against thymidylate synthase (TS) as well as cytotoxic activity against tumor cell lines in vitro. In this studys, we evaluated the in vivo antitumor efficacy of CW252053 in the mouse tumor model. Female B6D2F$_1$ mice were injected with LY3.7. 2C TK-/- (thymidine kinase deficient mouse Iymphoma) cells into the gastrocnemius muscle. Then, CW252053 was administered twice daily by intraperitoneal injection for 10 days, and tumor growth was monitored daily by leg diameter measurement. All animals in the vehicle, 5-FU, and low dose (30mgmg/kg CW252053 treated groups died between days 12 and 23 because of the tumor burden. In contrast, dosing with 60 mg/kg of CW252053 produced a cure rat against tumor growth of 37.5% and a survival rate of 50%. Even more significantly, a higher dose of CW252053 (120 mg/kg) elicited both a 100% cure rate and a 100% survival rate at the termination of the study, confirming that this compound has very potent in vivo antitumor activity against tumor growth. During the experimental period of this study no signs of toxicity were observed even at the high CW252053 dosage rate of 120 mg/kg.

• ETRI Journal
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• 제44권3호
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• pp.426-437
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• 2022

To understand the multilateral characteristics of human behavior and physiological markers related to physical, emotional, and environmental states, extensive lifelog data collection in a real-world environment is essential. Here, we propose a data collection method using multimodal mobile sensing and present a long-term dataset from 22 subjects and 616 days of experimental sessions. The dataset contains over 10 000 hours of data, including physiological, data such as photoplethysmography, electrodermal activity, and skin temperature in addition to the multivariate behavioral data. Furthermore, it consists of 10 372 user labels with emotional states and 590 days of sleep quality data. To demonstrate feasibility, human activity recognition was applied on the sensor data using a convolutional neural network-based deep learning model with 92.78% recognition accuracy. From the activity recognition result, we extracted the daily behavior pattern and discovered five representative models by applying spectral clustering. This demonstrates that the dataset contributed toward understanding human behavior using multimodal data accumulated throughout daily lives under natural conditions.

• Physical Therapy Rehabilitation Science
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• 제13권1호
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• pp.106-112
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• 2024

Objective: This study aimed to evaluate the validity of a depth camera-based system for monitoring physical function, assessing its feasibility for accurately monitoring activities of daily living. Design: A cross-sectional study. Methods: Twenty-three participants were enlisted to perform fifteen activities of daily living within a living laboratory designed to simulate a home environment. Activities were monitored using a depth camera system capable of classifying actions into standing, sitting, and lying down, with a conventional video camera employed for activity recording. The duration of each activity, as measured by the system, was compared to direct observations made by a physical therapist which were analyzed using a motion analysis software. The association between these two measurement approaches was assessed through correlation analysis, coefficient of determination, intraclass correlation coefficient (ICC), and Bland-Altman plots. Results: Our findings indicated that standing activities exhibited the highest correlation (r=0.847) between the system measurements and physical therapist observations, followed by sitting (r=0.817) and lying down (r=0.734), which demonstrated lower correlations. However, the ICC and Bland-Altman plots revealed notable variances between the two measurement methods, particularly for activities involving lying down. Conclusions: In this study, the depth camera-based physical monitoring system showed promise feasibility in distinguishing standing, sitting, and lying down activities at home environments. However, the current study also underlined some necessities of enhancements in capturing lying down activities.

• 대한물리의학회지
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• 제6권3호
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• pp.257-266
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• 2011

Purpose : To assess the relationship between post-stroke shoulder pain, motor function, and pain-related quality of life(QOL) Methods : Volunteer sample of 62 chronic stroke survivors with post-stroke shoulder pain and glenohumeral subluxation. The patients answered the question in shoulder pain with the Brief Pain Inventory question 12 (BP1-12), Pain-related Quality of life(BPI-23). Therapists measured the performance of combined upper-limb movement including the hand-behind-neck(HBN), hand-behind-beck(HBB) maneuver, added passive pain-free shoulder external rotation range of motion, and Modified Ashworth Scale(MAS) score of the elbow flexors. Physical performance assessments were used to measure basic activity daily living(Modified Barthel Index-self care, MBI-S/C), motor function of upper limb(Fugl-Meyer Upper/Lower Extremity, FM-U/E). Results : Stepwise regression analyses indicated that post-stroke shoulder pain is associated with the BPI 23, but not with the FM-U/E, MBI-S/C. Thus, the presence of shoulder pain is more important predicting pain-related QOL than its degree in predicting motor function of upper limb and basic activity daily living. Conclusion : Post-stroke shoulder pain was associated with reduced quality of life related to pain. The pain was not associated with the motor function of upper limb and basic activity daily living. The result imply that management of shoulder pain & anatomical position of shoulder joint after stroke should be emphasized. This provides a further incentive to develop effective rehabilitation prevention and treatment strategies for post-stroke shoulder pain.

• Archives of Reconstructive Microsurgery
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• 제10권2호
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• pp.75-80
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• 2001

Purpose : We have evaluated the morbidity of donor site after transfer of free fibular osseous and osteocutaneous flap to defect site of bone and soft tissue due to chronic osteomyelitis of long tubular bone, open fracture with bony defect, bone or soft tissue tumor and congenital anomaly. Materials and methods : The 54 cases of 79 cases to be carried out from May, 1982 to May, 2001 which could be followed up were reviewed. There were forty nine in male and five in female. The mean age was 35(4 to 66)years old and mean follow up period is 21.3 month(12 to 72). We have retrospectively analyzed the various postoperative complications such as compartment syndrome, donor site infection, skin defect, hypesthesia, hammer toes, ankle instability and activity of daily living by help of questionnaire, telephone, physical examination, follow up x-ray study and chart. Results : In the total 54 cases the medication period for pain control after operation were classified into three groups under 2 weeks(49 cases), from 2 weeks to 6 weeks(3 cases) and over 6 weeks(2 cases). The postoperative morbidity were occurred in total 12 cases(compartment syndrome: 0, infection : 2, skin defect: 1, hypesthesia: 5, hammer toe: 2 ankle pain: 2 discomfort in activity of daily living: 0), and also the morbidity rates of donor site were 23.5% in osseous flap and 21.6% in osteocutaneous flap were occurred. There was no statistical significonce in morbidity between osseous and osteocutaneous free fibular flap transfer(P>0.05). Discussion : In general the morbidity of free fibular flap transfer was relatively high but it did not have any effect on daily activity of living. We think that the meticulous operation technique, detailed wound care and early range of motion exercise will reduce the morbidity of donor site of flap.

• Journal of Nutrition and Health
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• 제38권10호
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• pp.847-855
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• 2005

This study investigated and compared the daily activities and energy expenditure of normally-weighted and obese elementary school children. The participants were 115 boys and 115 girls (6th grade) at ten elementary schools in Busan. Time spent on each activity was evaluated using the twenty-four hour recall method. 1) The general characteristics of the normally-weighted and obese children did not differ, although the normally-weighted children exercised and used stairs more than the obese children.2) Among their classified activities, the children spent most of their time resting, study, leisure, physiology and hygiene, commuting, and housework in that decreasing order. Normally-weighted children spent less time tying down and in conversation with family and friends than obese ones. 3) The children's average activity factors were 1.47 - 1.50. The normally-weighted children's rest energy expenditure (REE) (1391.4 kcal,1264.7 kcal) was less than that of the obese children (1711.4 kcal. 1461.0 kcal) . The normally-weighted children's daily energy expenditure was less than that of the obese, but energy expenditure per body weight was less in obese children than in the normally-weighted. In conclusion, sedentary activities and energy expenditure per body weight was less in the obese compared to the normally-weighted children. Programs to help children perceive and practice desirable physical activities should be suggested for prevention of obesity in children. (Korean J Nutrition 38(10): 847$\sim$855,2005)

• 재활복지공학회논문지
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• 제12권1호
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• pp.29-37
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• 2018

본 연구에서는 독거노인과 비독거노인의 건강상태에 관하여 생활활동능력, 신체통증 그리고 정서상태의 3가지 요소로 나누어 그룹간에 차이를 비교하고 고령자의 건강상태에 관여하는 요인에 대한 관련성을 확인해 보았다. 연구에는 총 88명의 고령자를 대상으로 조사를 실시하여 분석에 사용하였다. 비독거노인에 비해, 독거노인의 경우 생활활동능력이 낮고, 신체적통증이 높으며, 정서상태가 부정적인 것으로 나타났다. 그리고 3요소간 유의미한 상관관계가 있었는데, 세부 분석 결과 이는 거주형태(독거/비독거)이외에도 생활활동패턴(실내/실외 활동)이 동시에 관여하고 있음을 확인하였다. 본 연구결과는 독거노인 돌봄서비스와 고령자의 건강상태를 객관적으로 측정하기 위한 생리학적 지표개발에 기초자료로 활용되어 질 수 있을 것으로 예상한다.

• 디지털융복합연구
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• 제12권11호
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• pp.415-426
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• 2014

본 연구는 실증적 검증을 통해 노인의 건강상태가 수면의 질과 삶의 질에 미치는 영향을 파악하여 요양병원에서 노인 간호의 질적인 개선을 위한 간호중재 방안을 제시하고자 하였다. 경기도와 부산광역시에 위치한 5개의 요양병원에 입원한 60세 이상의 노인 170명을 대상으로 2013년 5월 8일부터 28일까지 설문조사를 실시하였다. 요인 분석 결과 노인의 건강상태는 정서적 기능, 체력, 일상생활활동, 사회적 역할, 몸의 변화, 사회적 기능, 통증으로 구분되었으며, 정서적 기능과 통증은 수면의 질에 부적 영향을 미쳤고, 몸의 변화와 일상생활활동은 삶의 질에 긍정적인 영향을 미쳤다. 요양병원 노인 간호의 질적인 향상을 위해서는 입원한 노인의 통증과 정서적 문제를 조기에 발견하여 수면의 질을 향상시키기 위한 노력이 필요하며, 노화에 따른 몸의 변화와 일상생활 활동을 살펴 적절히 대처하기 위해서 요양병원 특성을 고려한 신체사정 및 건강증진 간호중재전략을 개발하는 것이 필요하다.

• 대한간호학회지
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• 제43권1호
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• pp.1-10
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• 2013

Purpose: The purpose of this study was to develop a prediction model for the characteristics of older adults with depression using the decision tree method. Methods: A large dataset from the 2008 Korean Elderly Survey was used and data of 14,970 elderly people were analyzed. Target variable was depression and 53 input variables were general characteristics, family & social relationship, economic status, health status, health behavior, functional status, leisure & social activity, quality of life, and living environment. Data were analyzed by decision tree analysis, a data mining technique using SPSS Window 19.0 and Clementine 12.0 programs. Results: The decision trees were classified into five different rules to define the characteristics of older adults with depression. Classification & Regression Tree (C&RT) showed the best prediction with an accuracy of 80.81% among data mining models. Factors in the rules were life satisfaction, nutritional status, daily activity difficulty due to pain, functional limitation for basic or instrumental daily activities, number of chronic diseases and daily activity difficulty due to disease. Conclusion: The different rules classified by the decision tree model in this study should contribute as baseline data for discovering informative knowledge and developing interventions tailored to these individual characteristics.

• 동아시아식생활학회지
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• 제17권2호
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• pp.192-197
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• 2007

The purpose of this study was to evaluate the energy intake and energy expenditure of obese children. The body weight and height were measured, and the daily energy intake and activity pattern assessed for one day, using the 24 hour recall method and interviews in 83 elementary school children (59 boys and 24 girls). The average age, height, weight, ideal body weight and obesity index in boys and girls were 11.8 years, 144.8 cm, 54.2 kg, 39.9 kg and 35.9% and 11.5 years, 140.8 cm, 48.9 kg, 36.9 kg and 33.7%, respectively. The mean daily energy intakes of boys and girls were 1,670.5 and 1,656.5 kcal; these being 76.4 and 88.5% of estimated energy requirement for Koreans, respectively. The energy intake ratio from carbohydrates, proteins and fats in boys and girls were 61.5:14.7:23.6 and 62.0:14.7:23.7, respectively. The resting energy expenditure, as estimated by the Harris-Benedict, WHO/NAO/FAO and Korean DRI formulae in boys and girls were 1,452.7, 1,239.2 and 1,629.2 kcal and 1,323.9, 1,156.0 and 1,252.4 kcal, respectively. The activity coefficient for both the boys and girls was 1.39. The daily energy expenditure of boys (1,990.7 kcal) was significantly higher than that of girls (1712.1 kcal). No significant correlations were found between the obesity index, energy intake and energy expenditure. These results suggested that a nutrition and exercise program is required to increase the energy expenditure of elementary school children. Further research will be needed to assess multiple dietary factors and dove]lop a standard method for assessing the energy expenditure of obese children.