• 보존과학회지
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• 제36권5호
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• pp.326-332
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• 2020

본 연구에서는 서울 화계사 대웅전의 목부재에 대한 수종과 연륜연대분석을 진행하여 재질과 정확한 건축역사를 조사하고자 하였다. 대웅전 목부재(27점)의 수종은 대부분 소나무속 중 경송류로 식별되었고, 대보 1점만 전나무속으로 식별되었다. 연륜연대분석은 코어링법을 이용하여 시료 채취하였으며, TSAP 프로그램을 이용하여 크로스데이팅 하였다. 연륜연대분석 결과, 보와 기둥과 같은 구조재 20점들에 대한 최외각 연도는 1839년에서 1870년으로 확인되었다. 그 중 수피가 존재하는 5점의 벌채연도는 1869년과 1870년으로 나타내어, 2012년 실측조사에서 종도리 복장물에서 확인된 중건기록(1870년)과 일치하는 것을 확인할 수 있었다.

• Journal of Pharmaceutical Investigation
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• 제36권2호
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• pp.137-142
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• 2006

A bioequivalence of Daewoong $Alendronate^{TM}$ (Daewoong Pharmaceutical Co., Ltd., Korea) and $Fosamax^{TM}$ tablets (MSD Korea) was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). A single 70 mg dose of sodium alendronate of each medicine was administered orally to 56 healthy male volunteers. This study was performed in a $2\;{\time}\;2$ crossover design. Concentrations of alendronate in the urine were monitored by a high-performance liquid chromatography (HPLC). $A_{et}$ (cumulative urinary excreted amount from time 0 to last sampling interval) was calculated by the accumulation of the urinary excreted alendronate. $U_{max}$ (maximum urinary excretion rate) and $T_{max}$ (time to reach $U_{max}$) were compiled from the urinary excretion rate - time data. Analysis of variance was performed using logarithmically transformed $A_{et}$ and $U_{max}$. No significant sequence effect was found for all of the bioavailability parameters. The 90% confidence intervals of the $A_{et}$ and $U_{max}$ for Daewoong $Alendronate^{TM}/Fosamax^{TM}$ were 0.89-1.12 and 0.82-1.02, respectively. This study demonstrated the bioequivalence of Daewoong $Alendronate^{TM}$ and $Fosamax^{TM}$ with respect to the rate and extent of absorption.

• 한국염색가공학회지
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• 제31권4호
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• pp.332-340
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• 2019

Due to the change in lifestyle, new sensible materials for sportswear and outdoor are needed. This study is conducted in order to obtain the data for sensible materials through nylon twist process. 1-step nylon twisting machine was used to set the optimum twist process. DSC measurements of twisted nylon yarn showed crystallization temperatures around 170℃ and melting temperatures around 220℃. Nylon 40D/13F DTY and Nylon 50D/48F DTY showed optimal results at 160℃, 1,500 T/M(Turns per meter), and Nylon 70D/68F DTY at 160℃, 1,200 T/M(Turns per meter) after 1-step twist process. Also, Nylon 40D/13F DTY was confirmed to have inter-layer property deviation of ±5 percent.

• 한국콘텐츠학회논문지
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• 제11권7호
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• pp.142-152
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• 2011

21세기는 디자인의 시대다. 디자인은 세계적으로 다양하게 발전하고 있으며 또 변하고 있다. 그와 동시에 각국에서는 자신의 정체성을 나타내는 디자인에 대한 원형을 찾기 위한 노력이 동시에 진행되고 있다. 본 연구의 목적은 한국 디자인의 원형을 단청 분석을 통해서 찾고자 한다. 단청은 우리 문화의 조형성을 이해하는 중요한 단서이다. 이를 위해 본 논문에서는 전라남도 해남 미황사의 단청을 분석하였다. 대웅전 천정화에 시문된 천불도와 범자문양, 학문양, 모란문양, 연화문양을 디자인적인 측면에서 살펴본바 첫째, 시각적 차원뿐 만아니라 공간적, 상징적, 조형적 차원에서 새로운 문화적 가치를 엿 볼 수 있었다. 둘째, 미황사 단청은 디자인의 형상을 통해 당시의 미학을 고스란히 보여주는 시각적 표현의 결정체였다. 셋째, 단청은 불교에서 유교로 전환한 종교적 의식에 구애받지 않고 우리의 디자인 원형은 자연스럽게 이어져 오고 있음을 보여주고 있다. 본 연구를 통하여 단청은 우리의 삶을 묻어나게 하는 미의 원형으로서 존재하며 우리 민족의 의식을 연결하는 혼합체라는 것을 보여주었다.

• 한국임상약학회지
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• 제22권1호
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• pp.9-12
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• 2012

Background: Cefcapene pivoxil hydrochloride, is an ester-type oral cephem antibiotic. This study was performed to compare the pharmacokinetics and evaluate the bioequivalence of two cefcapene pivoxil hydrochloride 75 mg formulations. Method: In a randomized $2{\times}2$ crossover study, sixty healthy male volunteers were randomly assigned into two groups. After a single dose of 75 mg cefcapene pivoxil hydrochloride oral administration, blood samples were collected at specific time intervals from 0-12 hours. The plasma concentrations of cefcapene pivoxil hydrochloride were determined by LC-MS/MS. The pharmacokinetic parameters were determined from the plasma concentration-time profiles of both formulations. The pharmacokinetic parameters such as $AUC_{last}$, $AUC_{inf}$ and $C_{max}$, were calculated and the 90% confidence intervals for test/reference ratio for pharmacokinetic parameters were obtained by analysis of variance on logarithmically transformed data. Results: The mean value for $AUC_{last}$ in test and reference drug was $4053.1{\pm}876.5\;ng{\cdot}hr/mL$ and $3595.7{\pm}1029.1\;ng{\cdot}h/mL$, respectively. The mean value for $C_{max}$ in test and reference drug was $1324.9{\pm}321.4$ ng/mL and $1159.1{\pm}335.9$ ng/mL, respectively. The 90% confidence intervals of the $AUC_{last}$ and $C_{max}$ ratio for test drug and reference drug were log 1.09-log1.22 and log 1.09-log1.24, respectively. No adverse events were reported by subjects or found on analysis of vital signs or laboratory tests. Conclusion: This single dose study found that the test and reference products met the regulatory criteria for bioequivalence in these health volunteers. Both formulations were safe and well tolerated in 75 mg of cefcapene pivoxil hydrochloride.

• Journal of Ginseng Research
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• 제44권2호
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• pp.229-237
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• 2020

Background: We investigated the tolerability and pharmacokinetic properties of various ginsenosides, including Rb1, Rb2, Rc, Rd, and compound K, after single or multiple administrations of red ginseng extract in human beings. Methods: Red ginseng extract (dried ginseng > 60%) was administered once and repeatedly for 15 days to 15 healthy Korean people. After single and repeated administration of red ginsengextract, blood sample collection, measurement of blood pressure and body temperature, and routine laboratory test were conducted over 48-h test periods. Results: Repeated administration of high-dose red ginseng for 15 days was well tolerated and did not produce significant changes in body temperature or blood pressure. The plasma concentrations of Rb1, Rb2, and Rc were stable and showed similar area under the plasma concentration-time curve (AUC) values after 15 days of repeated administration. Their AUC values after repeated administration of red ginseng extract for 15 days accumulated 4.5- to 6.7-fold compared with single-dose AUC. However, the plasma concentrations of Rd and compound K showed large interindividual variations but correlated well between AUC of Rd and compound K. Compound K did not accumulate after 15 days of repeated administration of red ginseng extract. Conclusion: A good correlation between the AUC values of Rd and compound K might be the result of intestinal biotransformation of Rb1, Rb2, and Rc to Rd and subsequently to compound K, rather than the intestinal permeability of these ginsenosides. A strategy to increase biotransformation or reduce metabolic intersubject variability may increase the plasma concentrations of Rd and compound K.