• Journal of Conservation Science
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• v.36 no.5
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• pp.326-332
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• 2020

The this study's objective was to conduct species identification and tree-ring dating for the wood elements of Daewoong-jeon(main temple), Hwagye-temple, Seoul, Korea. Most of the wood elements were made from Pinus spp.(hard pine). However, one large beam was constructed from Abies spp.. For the tree-ring dating, cores were taken from the elements using a drill, and ring-width plots of individual samples were produced with the TSAP software program. The tree-ring dating results showed that, the date of the outermost ring of most elements (20 elements), including beams and pillars, were from AD 1839 to 1870. Among them, five elements had bark, and felling dates were AD 1868 and 1869. These dates confirmed the historical records that Daewoongjeon was rebuilt in AD 1870 from the records of hidden materials(Bokjangmul) in Jongdori by the survey 2012.

• Journal of Pharmaceutical Investigation
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• v.36 no.2
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• pp.137-142
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• 2006

A bioequivalence of Daewoong $Alendronate^{TM}$ (Daewoong Pharmaceutical Co., Ltd., Korea) and $Fosamax^{TM}$ tablets (MSD Korea) was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). A single 70 mg dose of sodium alendronate of each medicine was administered orally to 56 healthy male volunteers. This study was performed in a $2\;{\time}\;2$ crossover design. Concentrations of alendronate in the urine were monitored by a high-performance liquid chromatography (HPLC). $A_{et}$ (cumulative urinary excreted amount from time 0 to last sampling interval) was calculated by the accumulation of the urinary excreted alendronate. $U_{max}$ (maximum urinary excretion rate) and $T_{max}$ (time to reach $U_{max}$) were compiled from the urinary excretion rate - time data. Analysis of variance was performed using logarithmically transformed $A_{et}$ and $U_{max}$. No significant sequence effect was found for all of the bioavailability parameters. The 90% confidence intervals of the $A_{et}$ and $U_{max}$ for Daewoong $Alendronate^{TM}/Fosamax^{TM}$ were 0.89-1.12 and 0.82-1.02, respectively. This study demonstrated the bioequivalence of Daewoong $Alendronate^{TM}$ and $Fosamax^{TM}$ with respect to the rate and extent of absorption.

• Textile Coloration and Finishing
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• v.31 no.4
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• pp.332-340
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• 2019

Due to the change in lifestyle, new sensible materials for sportswear and outdoor are needed. This study is conducted in order to obtain the data for sensible materials through nylon twist process. 1-step nylon twisting machine was used to set the optimum twist process. DSC measurements of twisted nylon yarn showed crystallization temperatures around 170℃ and melting temperatures around 220℃. Nylon 40D/13F DTY and Nylon 50D/48F DTY showed optimal results at 160℃, 1,500 T/M(Turns per meter), and Nylon 70D/68F DTY at 160℃, 1,200 T/M(Turns per meter) after 1-step twist process. Also, Nylon 40D/13F DTY was confirmed to have inter-layer property deviation of ±5 percent.

• The Journal of the Korea Contents Association
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• v.11 no.7
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• pp.142-152
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• 2011

The 21st century is an age of design. The design has been developed and changed globally. At the same time, each country tries to find the archetype of its own design which represents its own identity. The object of this research is to show the identity of Korean design through the analysis of dancheong, Korean traditional decorative coloring on wooden buildings and artifacts for the purpose of style. Dancheong is an important clue through which alows us to understand Korean modelling. For the purpose, dancheong of Daewoong-jeon of Mihwang-sa, Haenam, Jeollanam-do, was analyzed. This study shows that, first, dancheong has a cultural value in terms of visual as well as space, symbolic, and figurative aspect. Second, dancheong at Mihwang-sa is an essence of the visual expression which shows the aesthetics of the age. Third, dancheong does not belong to any specific religions or beliefs but shows Korean's design archetype. This study shows that dancheong exists as an archetype of our beauty and it also links national identity.

• Korean Journal of Clinical Pharmacy
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• v.22 no.1
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• pp.9-12
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• 2012

Background: Cefcapene pivoxil hydrochloride, is an ester-type oral cephem antibiotic. This study was performed to compare the pharmacokinetics and evaluate the bioequivalence of two cefcapene pivoxil hydrochloride 75 mg formulations. Method: In a randomized $2{\times}2$ crossover study, sixty healthy male volunteers were randomly assigned into two groups. After a single dose of 75 mg cefcapene pivoxil hydrochloride oral administration, blood samples were collected at specific time intervals from 0-12 hours. The plasma concentrations of cefcapene pivoxil hydrochloride were determined by LC-MS/MS. The pharmacokinetic parameters were determined from the plasma concentration-time profiles of both formulations. The pharmacokinetic parameters such as $AUC_{last}$, $AUC_{inf}$ and $C_{max}$, were calculated and the 90% confidence intervals for test/reference ratio for pharmacokinetic parameters were obtained by analysis of variance on logarithmically transformed data. Results: The mean value for $AUC_{last}$ in test and reference drug was $4053.1{\pm}876.5\;ng{\cdot}hr/mL$ and $3595.7{\pm}1029.1\;ng{\cdot}h/mL$, respectively. The mean value for $C_{max}$ in test and reference drug was $1324.9{\pm}321.4$ ng/mL and $1159.1{\pm}335.9$ ng/mL, respectively. The 90% confidence intervals of the $AUC_{last}$ and $C_{max}$ ratio for test drug and reference drug were log 1.09-log1.22 and log 1.09-log1.24, respectively. No adverse events were reported by subjects or found on analysis of vital signs or laboratory tests. Conclusion: This single dose study found that the test and reference products met the regulatory criteria for bioequivalence in these health volunteers. Both formulations were safe and well tolerated in 75 mg of cefcapene pivoxil hydrochloride.

• Journal of Ginseng Research
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• v.44 no.2
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• pp.229-237
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• 2020

Background: We investigated the tolerability and pharmacokinetic properties of various ginsenosides, including Rb1, Rb2, Rc, Rd, and compound K, after single or multiple administrations of red ginseng extract in human beings. Methods: Red ginseng extract (dried ginseng > 60%) was administered once and repeatedly for 15 days to 15 healthy Korean people. After single and repeated administration of red ginsengextract, blood sample collection, measurement of blood pressure and body temperature, and routine laboratory test were conducted over 48-h test periods. Results: Repeated administration of high-dose red ginseng for 15 days was well tolerated and did not produce significant changes in body temperature or blood pressure. The plasma concentrations of Rb1, Rb2, and Rc were stable and showed similar area under the plasma concentration-time curve (AUC) values after 15 days of repeated administration. Their AUC values after repeated administration of red ginseng extract for 15 days accumulated 4.5- to 6.7-fold compared with single-dose AUC. However, the plasma concentrations of Rd and compound K showed large interindividual variations but correlated well between AUC of Rd and compound K. Compound K did not accumulate after 15 days of repeated administration of red ginseng extract. Conclusion: A good correlation between the AUC values of Rd and compound K might be the result of intestinal biotransformation of Rb1, Rb2, and Rc to Rd and subsequently to compound K, rather than the intestinal permeability of these ginsenosides. A strategy to increase biotransformation or reduce metabolic intersubject variability may increase the plasma concentrations of Rd and compound K.