• Journal of Microbiology and Biotechnology
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• v.26 no.4
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• pp.693-699
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• 2016

Clostridium difficile toxin A is known to cause deacetylation of tubulin proteins, which blocks microtubule formation and triggers barrier dysfunction in the gut. Based on our previous finding that the Clostridium difficile toxin A-dependent activation of histone deacetylase 6 (HDAC-6) is responsible for tubulin deacetylation and subsequent microtubule disassembly, we herein examined the possible effect of potassium acetate (PA; whose acetyl group prevents the binding of tubulin to HDAC-6) as a competitive/false substrate. Our results revealed that PA inhibited toxin A-induced deacetylation of tubulin and recovered toxin A-induced microtubule disassembly. In addition, PA treatment significantly decreased the production of IL-6 (a marker of inflamed tissue) in the toxin A-induced mouse enteritis model. An in vitro HDAC assay revealed that PA directly inhibited HDAC-6-mediated tubulin deacetylation, indicating that PA acted as a false substrate for HDAC-6. These results collectively indicate that PA treatment inhibits HDAC-6, thereby reducing the cytotoxicity and inflammatory responses caused by C. difficile toxin A.

• Journal of the Korean Society of Radiology
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• v.83 no.4
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• pp.951-957
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• 2022

Meningiomas are the most common intracranial tumors. However, microcystic and angiomatous meningiomas are very rare subtypes that present unusual imaging findings. Hence, radiological diagnosis of these tumors can be challenging. We herein describe a case of mixed angiomatous and microcystic meningioma in an 81-year-old male. MRI revealed an extra-axial mass with high T2 signal intensity, measuring 1.5 cm in diameter, with multiple tiny intralesional cysts and entrapped peritumoral cyst formation. After tumor resection, a histopathological diagnosis of mixed angiomatous and microcystic meningioma was made.

• Journal of Gastric Cancer
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• v.7 no.4
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• pp.254-260
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• 2007

Purpose: The purpose of this study is to compare the clinicopathological characteristics of stomach and small bowel gastrointestinal stromal tumors and to determine the risk factors and treatment guidelines. Materials and Methods: Among 38 patients who were diagnosed with a gastrointestinal stromal tumor from August 1998 to May 2006, 29 patients at the Pundang Jesaeng General Hospital, Daejin Medical Center were evaluated. The clinicopathological characteristics of gastrointestinal stromal tumors arising from stomach and small bowel were compared. Immunohistochemical staining for CD117, CD34, smooth muscle actin, desmin, and S-100 protein was performed and classified according to NIH criteria. Prognosis between groups was analyzed according to NIH criteria. Results: There was no significant difference in the clinicopathological characteristics and prognosis between gastrointestinal stromal tumors arising from the stomach and small bowel. Recurrence of the disease occurred in four (13.8%) patients. Classification of gastrointestinal stromal tumors according to NIH criteria was predictive of recurrence (P=0.030). Conclusion: NIH criteria were predictive of recurrence, but the location of the primary site was not predictive of recurrence. A further study involving multi center data and a long-term follow-up will be needed for formulating diagnostic and therapeutic guidelines.

• Clinics in Shoulder and Elbow
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• v.9 no.1
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• pp.96-104
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• 2006

Purpose: To evaluate and compare the results of children with displaced supracondylar fractures of humerus treated with open reduction and pinning with closed reduction and pinning. Materials and Methods: From March 2002, we treated 17 patients with completely displaced supracondylar fractures under the age of 7 with a minimal follow up period of 6 months. 9 patients were treated with closed reduction and pinning and 8 patients were treated with open reduction and pinning. The clinical results were evaluated with Flynn's criteria. Time to bone union was also analyzed for these two set of patients. Results: The group treated with open reduction had 6 excellent and 2 good results for change in carrying angles, 5 excellent, 2 good and 1 fair results for motion loss evaluated by Flynn's criteria. The average time to bony union for this group was 5.8 weeks. The group treated with closed reduction had 6 excellent, 2 good, and 1 fair results for change in carrying angles and 7 excellent, 1 good and 1 fair results for motion loss. The average time to bony uinon for this group was 3.7 weeks. Conclusion: In treating completely displaced supracondylar fractures of humerus in children, the closed reduction method and open reduction method all showed good results. But the operation time, duration of hospital stay and time to union was somewhat shorter for the patients treated with closed redution and pinning.

• Proceedings of The KACE
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• 2017.08a
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• pp.113-116
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• 2017

현대 사회는 4차 산업혁명을 통해 빠르게 발달하고 있다. 이러한 사회에서는 새로운 지식과 기술이 끊임없이 만들어지고 기존의 지식과 기술이 도태되고 지식과 기술의 생명주기가 점차적으로 빨라지고 있다. 이에 따라 새롭게 제시되는 지식과 기술을 적합한 문제에 적용하여 문제를 해결하는 능력의 중요성이 커지고 있다. 특히 차세대 기술로 평가받는 인공지능, 로봇, 자율 자동차, 사물 인터넷 등의 기술과 연관된 문제를 해결하는 방법은 컴퓨터를 활용한 문제 해결방법과 밀접하게 연관돼있기 때문에 컴퓨터를 활용하여 주어진 문제를 표현하고 해결하는 능력은 매우 중요하다. 본 연구에서는 운영체제에서 기본적으로 제공되는 파일 관리 프로그램에 대한 문제점을 제기하고 문제 해결을 위해 컴퓨팅 사고력을 활용해서 문제에 대한 조사 단계, 분석 단계, 그리고 자동화 단계를 거쳐 문제를 해결한다.

• Journal of Korean Foot and Ankle Society
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• v.23 no.3
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• pp.139-142
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• 2019

Pigmented villonodular synovitis (PVNS) is a rare proliferative disease involving the synovial membranes. Complete excision with a total synovectomy is important for diffuse type PVNS because of its high recurrence rate. In the ankle, complete excision of diffuse type PVNS is difficult due to the anatomical structure of the ankle joint. This paper reports the author's experience of surgical treatment with combined open and arthroscopic synovectomy. In this manner, it is expected that the complications of the open procedure and the recurrence rate of arthroscopic procedure can be reduced.

• Proceedings of The KACE
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• 2018.01a
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• pp.125-128
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• 2018

오늘날 스마트폰, 태블릿과 같은 모바일 디바이스가 등장하고, 무선 네트워크의 기술이 향상되면서 모바일 쇼핑 이용률이 높아지고 있다. 이에 따라 택배의 사용률도 증가하고 있는데, 택배를 수령하는 일반적인 방법으로 직접 수령하는 것과 공동 택배 보관 장소를 통해 수령하는 것이 있다. 그러나 이러한 방법들은 택배기사와 시간을 정해야 하는 번거로움, 택배기사를 위장한 범죄, 그리고 공동 택배 보관 장소에서의 택배 분실 등과 같은 문제점이 존재한다. 따라서 본 연구에서는 1인 가구와 택배 수령에 어려움을 겪는 가구를 위한 개인 택배 보관 시스템을 개발하였다. 이 시스템은 안드로이드 어플리케이션에서 택배에 부착된 바코드를 스캔하여 그 정보를 아두이노와 블루투스 통신을 통해 전달한다. 이때, 아두이노는 미리 저장된 운송장 번호와 수신한 운송장 번호를 비교하여 택배 보관 시스템의 잠금 장치를 열고 닫는다.

• Annual Conference of KIPS
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• 2011.11a
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• pp.205-208
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• 2011

오늘날 기업 내 ERP(Enterprise Resource Planing)시스템 도입이 활발해지고 있는 가운데 그 역기능으로 ERP 시스템 도입 실패 사례 또한 증가하고 있다. 이로 인해 ERP 시스템이 올바르게 구축되었는가를 판단하는 ERP 시스템에 대한 완성도 혹은 하자여부를 판단하는 감정평가 활동이 증가하고 있다. ERP 시스템은 일반적으로 패키지 형태의 프로그램과는 달리 비즈니스 프로세스 분석 단계에서 계약의 내용이 수정 및 확정되어지며, 업종 및 국가별 비즈니스 프로세스 특성에 따라 일반화된 모듈 프레임 워크를 그대로 적용하기 어려운 점을 가지고 있다. 따라서 본 연구에서는 ERP 시스템 완성도 감정평가를 위해 국내외 ERP 시스템에 대한 기본구조와 함께 세부적인 (공통/상이)모듈에 대해 정리를 수행하고, 이를 대상으로 핵심적인 비즈니스 업무수행을 위한 세부적인 절차를 추출하고자 한다. 본 연구를 통하여 제시된 ERP 시스템 감정 절차는 ERP 시스템 감정을 위한 기초자료로 활용될 수 있다.

• Proceedings of the KIEE Conference
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• 2011.07a
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• pp.21-22
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• 2011

In this paper, considerations on correlation between partial discharge and breakdown using void-simulated defect, investigating the characteristics of void discharges. For the purpose, the relationship between PDIV(Partial Discharge Inception Voltage) and BDV(BreakDown Voltage) was analyzed. As a result, it is noticed that the higher PDIV, the higer BDV.

• Proceedings of the KIEE Conference
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• 2011.07a
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• pp.199-200
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• 2011

Load forecasting is very important for power system analysis and planning. This paper suggests yearly load forecasting of considering weekly normalization and seasonal load characteristics. Each weekly peak load is normalized and the average value is calculated. The new hourly peak load is seasonally collected. This method was used for yearly load forecasting. The results of the actual data and forecast data were calculated error rate by comparing.