• 한국주거학회논문집
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• 제27권5호
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• pp.55-63
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• 2016

This study intended to establish a direction for the revitalization of youth culture centers by examining the current status of youth centers operated in Daejeon and how they have been used. Four youth centers in Daejeon were visited and a survey was conducted targeting 180 people using the centers. Frequency, Mean, and ${\chi}^2$ analysis were performed by using SPSS statistics package, and major research outcomes are as follows; There were 6 youth culture centers in Daejeon and showed a lower construction rate of 7.4% on the basis of 81 up, myun and dong. Most youth centers were small, around $300-500m^2$ in total floor area, and accommodated 100-200 people, and the space comprised multipurpose hall, cafeteria, open space, club space, multimedia space, information service room, and guide booth. There were no sports spaces among the target facilities. So, it has created the need for physical activity space to promote health & development. Most users visited centers with their friends and simply to use the facilities, and the satisfaction with the facilities was relatively high at 4.32. The role of the local community and financial support of the government is required to activate the youth culture. Also, for the role of youth culture center, it was suggested that the youth culture center should develop program which corresponds with the level of the youth and boast the interest of the youth.

• Mycobiology
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• 제42권3호
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• pp.256-261
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• 2014

A ${\beta}$-glucosidase producing yeast strain was isolated from Korean traditional rice wine. Based on the sequence of the YCL008c gene and analysis of the fatty acid composition, the isolate was identified as Saccharomyces cerevisiae strain HJ-014. S. cerevisiae HJ-014 produced ginsenoside Rd, $F_2$, and compound K from the ethanol extract of red ginseng. The production was increased by shaking culture, where the bioconversion efficiency was increased 2-fold compared to standing culture. The production of ginsenoside $F_2$ and compound K was time-dependent and thought to proceed by the transformation pathway of: red ginseng extract ${\rightarrow}Rd{\rightarrow}F_2{\rightarrow}$ compound K. The optimum incubation time and concentration of red ginseng extract for the production of compound K was 96 hr and 4.5% (w/v), respectively.

• 건축사
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• 통권516호
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• pp.46-47
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• 2012

• 한국학연구
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• 제49호
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• pp.123-154
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• 2018

이 글은 해방 이후 강화문화관을 시작으로 전국에 걸쳐 등장한 문화원의 사회사적 성격을 문화냉전의 맥락에서 규명한 것이다. 문화원은 미국의 해외 공보 업무를 담당한 미국 공보원(United States Information Service, Korea)의 적극적인 지원으로 개관했으며 한국전쟁을 계기로 급격히 증가하였다. 문화원은 미국 공보원이 지향한 '자유 동아시아' 국가 형성을 목표로 미국적 가치와 문화를 전파했지만, 해당 지역 공동체의 현실적인 이해관계를 반영하면서 문화원 사업의 방점에 차이를 두었다. 1962년 설립된 한국문화원연합회는 전국적인 연결망을 형성하고 미국식 민주주의와 공산주의 이념의 강화 그리고 박정희 주도의 산업화와 근대화의 선전과 홍보에 앞장섰다. 1960년대 중후반 대전문화원의 활동에 관한 사례 분석을 통해 확인한 바와 같이, 문화원은 지역의 행정과 경찰 및 교육 그리고 흥행업자와 긴밀한 관계를 형성하면서 지역의 모든 문화 관련 활동을 수렴하는 기관으로서 위상을 지녔다. 또한, 냉전 시기 후방 군사도시이자 대규모 노동자 집결 도시인 대전의 문화원은 미군의 주둔과 연관된 사업을 수행하는 한편으로 베트남전쟁 참전과 관련된 정치적 긴장에 적극적으로 대응하는 모습을 보였다. 대전문화원 강당에서의 상설 영화 상영을 비롯해 대전 시내와 충남 일대 지역에서 조직적으로 전개한 이동영화 상영은 이를 보여준다. 따라서 1947년 한국사회 최초로 등장한 강화문화관이 과거 일본 제국과의 단절을 강조했다면, 1960년대 중후반 대전문화원은 동아시아 지역의 문화냉전 벨트의 형성을 위하여 '새로운 일본'을 소개하는 데 적극적이었다. 이는 일국 차원에서 전개된 대전문화원 활동이 동아시아 국가의 문화냉전의 형성과 중첩되었음을 증명하였다.

• 대한약침학회지
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• 제10권2호통권23호
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• pp.31-40
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• 2007

Objective : The aim is to examine the effect of Soyeum Pharmacopuncture (SPP) on collagen-induced arthritis (CIA) in DBA/1OlaHsd mice. Methods : To determine the effect of SPP on chronic IFNlammatory joint disease, we induced CIA in DBA/1OlaHsd mice by immunization with bovine type II collagen. Animals were treated with intraperitoneal injection doses of 2 mg/kg of SPP, beginning 3 days before the expected onset of disease symptoms. Inhibitory Effects of SPP were observed by serum levels of TNF-${\alpha}$, and IFN-${\gamma}$,,, or cell proliferation in the spleen cell culture and histological examination of knee joint. Results : In the CIA Mice, serum levels of TNF-${\alpha}$, and IFN-${\gamma}$,, production in the spleen cell culture were reduced. At the histopathological examination of knee joint, chondropathy of cartilage in the synovial joint in the SP group was repaired while compared with control group. Conclusion : These results suggest that the SPP may be effective for the prevention and treatment of rheumatoid arthritis disease.

• 가족자원경영과 정책
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• 제13권3호
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• pp.85-101
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• 2009

The Multi-cultural Family Support Center provides various educational programs and services for multi-cultural families. However, there are controversies regarding integration and assimilation, ethnic identity and ethnocentrism, and state-sponsored multi-culturalism. From the home economist's perspective, it was necessary to explore the direction of integration of family life culture in the multi-cultural society. This study concluded that there is a necessity to accept foreign culture and create a new culture while still maintaining their and our own cultural identity respectively. For this purpose, integration and assimilation must progress side by side to maintain the cultural identity and stability of multi-cultural families. But, women migrants are to adapt in their everyday life, they need to attend a Korean-language course and take part in a traditional Korean culture program such as having an assimilational characteristics. Also for the happiness of multi-cultural families ultimately not for the confronted problems, it requires sometimes education of changing migrants' own traditional customs and life culture partly. In this sense, educational and cultural programs held by Multi-Cultural Family Support Center are meaningful and their importance in adapting into everyday life must be recognised by all of us.

• 혜화의학회지
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• 제25권1호
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• pp.71-86
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• 2016

Objective : Hongyi (Formica yessensis) is the dried insect of fomicidae. In previous studies, it appeared possibilities on anti-thrombosis, preventing atherosclerosis, treating rheumatoid disease, and inhibiting hela cell. In this study, we investigated anti-inflammatory effects and mechanism of Hongyi. Methods : Hongyi A was extracted by water and made dried powder. Hongyi B was extracted by ethanol and made dried powder. We measured Nitric Oxide (NO) production on the mouse macrophages (RAW 264.7), mouse vascular endothelial cell (MOVAS) and human vascular endothelial cell (HUVEC) for anti-inflammatory effect. In addition, we conducted reverse transcription reaction (RT-PCR) for investigating the mechanism. Results : In RAW 264.7 macrophages stimulated by LPS, Hongyi A ($100{\mu}g/m{\ell}$) decreased NO production compared with LPS $2{\mu}g/ml$ control group with statistical significance (p<0.05). Hongyi A (50, $100{\mu}g/m{\ell}$) also decreased NO production compared with LPS $4{\mu}g/ml$ control group with statistical significance (p<0.01). Hongyi B (50, $100{\mu}g/m{\ell}$) decreased NO production compared with LPS $2{\mu}g/ml$ control group with statistical significance (p<0.01). Hongyi B (10, 50, $100{\mu}g/m{\ell}$) also decreased NO production compared with LPS $4{\mu}g/ml$ control group with statistical significance (p<0.01, p<0.001, p<0.001). In the MOVAS, Hongyi A and B increased NO production compared with control group. In the HUVEC, Hongyi B increased NO production compared with control group. The expression of NF-${\kappa}B$ in 12-hours MOVAS culture was decreased by Hongyi A and B (10, $50{\mu}g/ml$) compared with control group, but expression of $I{\kappa}B$ was increased. In the 24-hours MOVAS culture, expression of $I{\kappa}B$ was significantly increased. The expression of NF-${\kappa}B$ in 12-hours HUVEC culture was decreased by Hongyi A and B compared with control group, but expression of $I{\kappa}B$ was increased. Hongyi B also increased eNOS mRNA gene expression. Conclusions : Hongyi A and B showed anti-inflammatory effect in mouse macrophages with the activation of vascular endothelial cell through NO production in MOVAS and HUVEC repectively. Honyi B showed superior effect than Hongyi A, but additonal mechanism study should be conducted.

• 한국콘텐츠학회논문지
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• 제18권7호
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• pp.262-271
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• 2018

최근 대전시는 4차 산업혁명과 더불어 자연과 과학, 문화의 도시로 변모하고자 대덕특구를 중심으로 미래형 도시를 계획하고 있다. 따라서 본 연구는 대전시 도룡동의 과학 공원 네거리부터 (구)대덕과학문화센터에 이르는 1.5km 거리를 특성별로 구획하고 특색에 맞는 IT기술을 접목한 공간디자인 컨셉을 제안함으로써 향후 대덕과학문화의 거리 조성 추진 과정의 기본 방향을 제시하는 가이드라인의 역할을 수행할 수 있도록 공간 현황을 분석, 사용자 중심의 계획을 위한 체험 중심의 공간디자인 컨셉을 도출하고자 한다. 본 연구는 현장조사를 통해 도출된 문제점을 통해 개선이 필요한 인프라를 중심으로 IT기술을 접목하고, 스마트스트리트(Smart Street)로써 대덕과학문화의 거리를 탈바꿈할 수 있는 방법을 모색하고자 한다. 현장조사를 통해 얻은 시사점으로 (1)쾌적성과 안전성 문제의 지속성, (2)통일성 및 효율성 문제, (3)아이덴티티 결여 문제의 경험성과 연계하여 사용자 중심의 스마트시티의 방향성을 활용하여 해결 목표를 설정하였다. 사용자 중심의 거리 조성을 위해 인프라만을 기준으로 하는 획일적인 조닝을 지양하고 사용자 행위를 중심으로 하는 조닝을 시도하였다.

• International Journal of Oral Biology
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• 제49권1호
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• pp.18-25
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• 2024

Despite advancements in therapeutic approaches, radiotherapy and cisplatin-based chemotherapy remain primary noninvasive treatments for patients with oral squamous cell carcinoma (OSCC). Moreover, the 5-year survival rate for patients with OSCC has remained almost unchanged for several decades, and many side effects of chemotherapy still exist. In this study, three-dimensional (3D) models of OSCC were established using fibroblasts, and the efficacy of various biological inhibitors was evaluated. A culture of epithelial cells with two types of fibroblasts (hTERT-hNOFs and cancer-associated fibroblasts) within a type I collagen matrix resulted in the formation of a continuous layer of tightly packed cells compared to models without fibroblasts. Furthermore, the effects of biological chemicals, including Y27632, latrunculin A, and verteporfin, on these models were investigated. The stratified formation of the epithelial layer and invasion in OSCC 3D-culture models were effectively inhibited by verteporfin, whereas invasion was weakly inhibited by Y27632 and latrunculin. Collectively, the developed OSCC 3D-culture models established with fibroblasts demonstrated the potential for drug screening, with verteporfin showing promising efficacy.

• 한국콘텐츠학회논문지
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• 제11권3호
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• pp.230-240
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• 2011

갤러리는 미술작품을 소통을 목적으로 생산 공급자인 작가와 중개자인 기획자, 경영자 그리고 수요자인 소장자, 대중의 만남을 이루고 소통의 장을 제공하는 공간으로써의 기능을 제공하고 있다. 이러한 역할을 수행하고 있는 갤러리에 대한 대전지역의 현황을 원도심을 중심으로 한 현황분석과 그들의 기능적 역할을 심층면접 및 3차에 걸친 델파이 방법을 통해 분석하였다. 대전지역의 원도심에서 운영되고 있는 갤러리들은 열악한 환경 속에서도 그들의 사명감과 자부심으로 지역의 젊은 작가와 미술트랜드를 형성해 나가고 있다. 델파이 조사의 결과 갤러리의 역할은 지역작가 발굴과 미술 트렌드와 패러다임에 대한 제공 및 사회적, 문화적 책임을 수행하는 문화공간으로 인식하고 있다. 갤러리 측면에서 작품의 선정요인으로는 작품성, 시장성 및 갤러리와의 조화를 중요한 요인으로 인식하고 있으며, 작가의 측면에서는 갤러리의 전문성, 갤러리의 인지도 및 작품 판매 능력을 중요한 능력으로 인식하고 있다. 따라서 이제 갤러리들도 수동적이고 1차원적인 기능에만 머물 것이 아니라 다양한 문화 체험의 공간으로써, 문화 서비스 공간으로써의 기능을 고려해야 해야 할 것이다.