• Journal of the Korean housing association
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• v.27 no.5
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• pp.55-63
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• 2016

This study intended to establish a direction for the revitalization of youth culture centers by examining the current status of youth centers operated in Daejeon and how they have been used. Four youth centers in Daejeon were visited and a survey was conducted targeting 180 people using the centers. Frequency, Mean, and ${\chi}^2$ analysis were performed by using SPSS statistics package, and major research outcomes are as follows; There were 6 youth culture centers in Daejeon and showed a lower construction rate of 7.4% on the basis of 81 up, myun and dong. Most youth centers were small, around $300-500m^2$ in total floor area, and accommodated 100-200 people, and the space comprised multipurpose hall, cafeteria, open space, club space, multimedia space, information service room, and guide booth. There were no sports spaces among the target facilities. So, it has created the need for physical activity space to promote health & development. Most users visited centers with their friends and simply to use the facilities, and the satisfaction with the facilities was relatively high at 4.32. The role of the local community and financial support of the government is required to activate the youth culture. Also, for the role of youth culture center, it was suggested that the youth culture center should develop program which corresponds with the level of the youth and boast the interest of the youth.

• Mycobiology
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• v.42 no.3
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• pp.256-261
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• 2014

A ${\beta}$-glucosidase producing yeast strain was isolated from Korean traditional rice wine. Based on the sequence of the YCL008c gene and analysis of the fatty acid composition, the isolate was identified as Saccharomyces cerevisiae strain HJ-014. S. cerevisiae HJ-014 produced ginsenoside Rd, $F_2$, and compound K from the ethanol extract of red ginseng. The production was increased by shaking culture, where the bioconversion efficiency was increased 2-fold compared to standing culture. The production of ginsenoside $F_2$ and compound K was time-dependent and thought to proceed by the transformation pathway of: red ginseng extract ${\rightarrow}Rd{\rightarrow}F_2{\rightarrow}$ compound K. The optimum incubation time and concentration of red ginseng extract for the production of compound K was 96 hr and 4.5% (w/v), respectively.

• Korean Architects
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• s.516
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• pp.46-47
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• 2012

• 한국학연구
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• no.49
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• pp.123-154
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• 2018

이 글은 해방 이후 강화문화관을 시작으로 전국에 걸쳐 등장한 문화원의 사회사적 성격을 문화냉전의 맥락에서 규명한 것이다. 문화원은 미국의 해외 공보 업무를 담당한 미국 공보원(United States Information Service, Korea)의 적극적인 지원으로 개관했으며 한국전쟁을 계기로 급격히 증가하였다. 문화원은 미국 공보원이 지향한 '자유 동아시아' 국가 형성을 목표로 미국적 가치와 문화를 전파했지만, 해당 지역 공동체의 현실적인 이해관계를 반영하면서 문화원 사업의 방점에 차이를 두었다. 1962년 설립된 한국문화원연합회는 전국적인 연결망을 형성하고 미국식 민주주의와 공산주의 이념의 강화 그리고 박정희 주도의 산업화와 근대화의 선전과 홍보에 앞장섰다. 1960년대 중후반 대전문화원의 활동에 관한 사례 분석을 통해 확인한 바와 같이, 문화원은 지역의 행정과 경찰 및 교육 그리고 흥행업자와 긴밀한 관계를 형성하면서 지역의 모든 문화 관련 활동을 수렴하는 기관으로서 위상을 지녔다. 또한, 냉전 시기 후방 군사도시이자 대규모 노동자 집결 도시인 대전의 문화원은 미군의 주둔과 연관된 사업을 수행하는 한편으로 베트남전쟁 참전과 관련된 정치적 긴장에 적극적으로 대응하는 모습을 보였다. 대전문화원 강당에서의 상설 영화 상영을 비롯해 대전 시내와 충남 일대 지역에서 조직적으로 전개한 이동영화 상영은 이를 보여준다. 따라서 1947년 한국사회 최초로 등장한 강화문화관이 과거 일본 제국과의 단절을 강조했다면, 1960년대 중후반 대전문화원은 동아시아 지역의 문화냉전 벨트의 형성을 위하여 '새로운 일본'을 소개하는 데 적극적이었다. 이는 일국 차원에서 전개된 대전문화원 활동이 동아시아 국가의 문화냉전의 형성과 중첩되었음을 증명하였다.

• Journal of Pharmacopuncture
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• v.10 no.2 s.23
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• pp.31-40
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• 2007

Objective : The aim is to examine the effect of Soyeum Pharmacopuncture (SPP) on collagen-induced arthritis (CIA) in DBA/1OlaHsd mice. Methods : To determine the effect of SPP on chronic IFNlammatory joint disease, we induced CIA in DBA/1OlaHsd mice by immunization with bovine type II collagen. Animals were treated with intraperitoneal injection doses of 2 mg/kg of SPP, beginning 3 days before the expected onset of disease symptoms. Inhibitory Effects of SPP were observed by serum levels of TNF-${\alpha}$, and IFN-${\gamma}$,,, or cell proliferation in the spleen cell culture and histological examination of knee joint. Results : In the CIA Mice, serum levels of TNF-${\alpha}$, and IFN-${\gamma}$,, production in the spleen cell culture were reduced. At the histopathological examination of knee joint, chondropathy of cartilage in the synovial joint in the SP group was repaired while compared with control group. Conclusion : These results suggest that the SPP may be effective for the prevention and treatment of rheumatoid arthritis disease.

• Journal of Family Resource Management and Policy Review
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• v.13 no.3
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• pp.85-101
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• 2009

The Multi-cultural Family Support Center provides various educational programs and services for multi-cultural families. However, there are controversies regarding integration and assimilation, ethnic identity and ethnocentrism, and state-sponsored multi-culturalism. From the home economist's perspective, it was necessary to explore the direction of integration of family life culture in the multi-cultural society. This study concluded that there is a necessity to accept foreign culture and create a new culture while still maintaining their and our own cultural identity respectively. For this purpose, integration and assimilation must progress side by side to maintain the cultural identity and stability of multi-cultural families. But, women migrants are to adapt in their everyday life, they need to attend a Korean-language course and take part in a traditional Korean culture program such as having an assimilational characteristics. Also for the happiness of multi-cultural families ultimately not for the confronted problems, it requires sometimes education of changing migrants' own traditional customs and life culture partly. In this sense, educational and cultural programs held by Multi-Cultural Family Support Center are meaningful and their importance in adapting into everyday life must be recognised by all of us.

• Journal of Haehwa Medicine
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• v.25 no.1
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• pp.71-86
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• 2016

Objective : Hongyi (Formica yessensis) is the dried insect of fomicidae. In previous studies, it appeared possibilities on anti-thrombosis, preventing atherosclerosis, treating rheumatoid disease, and inhibiting hela cell. In this study, we investigated anti-inflammatory effects and mechanism of Hongyi. Methods : Hongyi A was extracted by water and made dried powder. Hongyi B was extracted by ethanol and made dried powder. We measured Nitric Oxide (NO) production on the mouse macrophages (RAW 264.7), mouse vascular endothelial cell (MOVAS) and human vascular endothelial cell (HUVEC) for anti-inflammatory effect. In addition, we conducted reverse transcription reaction (RT-PCR) for investigating the mechanism. Results : In RAW 264.7 macrophages stimulated by LPS, Hongyi A ($100{\mu}g/m{\ell}$) decreased NO production compared with LPS $2{\mu}g/ml$ control group with statistical significance (p<0.05). Hongyi A (50, $100{\mu}g/m{\ell}$) also decreased NO production compared with LPS $4{\mu}g/ml$ control group with statistical significance (p<0.01). Hongyi B (50, $100{\mu}g/m{\ell}$) decreased NO production compared with LPS $2{\mu}g/ml$ control group with statistical significance (p<0.01). Hongyi B (10, 50, $100{\mu}g/m{\ell}$) also decreased NO production compared with LPS $4{\mu}g/ml$ control group with statistical significance (p<0.01, p<0.001, p<0.001). In the MOVAS, Hongyi A and B increased NO production compared with control group. In the HUVEC, Hongyi B increased NO production compared with control group. The expression of NF-${\kappa}B$ in 12-hours MOVAS culture was decreased by Hongyi A and B (10, $50{\mu}g/ml$) compared with control group, but expression of $I{\kappa}B$ was increased. In the 24-hours MOVAS culture, expression of $I{\kappa}B$ was significantly increased. The expression of NF-${\kappa}B$ in 12-hours HUVEC culture was decreased by Hongyi A and B compared with control group, but expression of $I{\kappa}B$ was increased. Hongyi B also increased eNOS mRNA gene expression. Conclusions : Hongyi A and B showed anti-inflammatory effect in mouse macrophages with the activation of vascular endothelial cell through NO production in MOVAS and HUVEC repectively. Honyi B showed superior effect than Hongyi A, but additonal mechanism study should be conducted.

• The Journal of the Korea Contents Association
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• v.18 no.7
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• pp.262-271
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• 2018

Recently, Daejeon Metropolitan City is planning a futuristic city with Daedeok Special District at the center of its transformation into a city of nature, science and culture along with the fourth industrial revolution. Therefore, this research will divide the 1.5 km distance from the in Doryong-dong, Daejeon, science park intersection to the (Former)Daedeok Science and Culture Center, and propose a space design concept that incorporates IT technologies that fit the characteristics. The center will analyze the space status and derive an experience-oriented space design concept for user-centered planning so that it can serve as a guideline that will provide the fundamental direction for the promotion of the Daedeok Science Culture. Through the field survey, we will look for ways to integrate IT technology with infrastructure that needs improvement and change the distance of Daedeok Science culture as a smart street. The results of the field survey were : (1) made by connecting the persistence of comfort and safety issues, (2) uniformity and efficiency issues, and (3) the experience of identity problems and the orientation of the smart city. To create user-centered distances, we attempted to avoid uniform zoning based solely on infrastructure and zoning focusing on user behavior.

• International Journal of Oral Biology
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• v.49 no.1
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• pp.18-25
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• 2024

Despite advancements in therapeutic approaches, radiotherapy and cisplatin-based chemotherapy remain primary noninvasive treatments for patients with oral squamous cell carcinoma (OSCC). Moreover, the 5-year survival rate for patients with OSCC has remained almost unchanged for several decades, and many side effects of chemotherapy still exist. In this study, three-dimensional (3D) models of OSCC were established using fibroblasts, and the efficacy of various biological inhibitors was evaluated. A culture of epithelial cells with two types of fibroblasts (hTERT-hNOFs and cancer-associated fibroblasts) within a type I collagen matrix resulted in the formation of a continuous layer of tightly packed cells compared to models without fibroblasts. Furthermore, the effects of biological chemicals, including Y27632, latrunculin A, and verteporfin, on these models were investigated. The stratified formation of the epithelial layer and invasion in OSCC 3D-culture models were effectively inhibited by verteporfin, whereas invasion was weakly inhibited by Y27632 and latrunculin. Collectively, the developed OSCC 3D-culture models established with fibroblasts demonstrated the potential for drug screening, with verteporfin showing promising efficacy.

• The Journal of the Korea Contents Association
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• v.11 no.3
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• pp.230-240
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• 2011

A gallery provides the function to make opportunities for artist to meet the customers who would buy the products from them. And there was performed the place where artist who production provider, planner, managers and private collectors met to distribute artworks and to educate fine art for public and provide a chance sending leisure time. We investigated this galleries at old urban center in daegeon region by the deep interview and Delphi method. A galleries was operated by a sense of duty and pride. Though its environment is poor, it grows up the young artist and art trends. By delphi results, the role of gallery is recognized as the discovery of an unknown young artist and provider of art trend and paradigm. Also they was recognized as the space for social and cultural responsibility operation culture. Galleries was recognized as key factors as literary value, marketability and harmony between gallery and artworks. Artist was known as a key factors as gallery's expertise, gallery awareness and capacity for artworks selling. Gallery will be considered the functions as the various cultural experience space and culture service space. Although galleries are passive and one dimensional functions.