• 기술혁신학회지
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• 제6권1호
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• pp.41-59
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• 2003

Daedeok Valley, located in the Daejon Metropolitan City, Korea, has around 1,000 start-ups. There is no comprehensive study for the valley except Seol et al.(2002), because the valley is a new one. There was no such valley four years ago, in 1998. This paper defines the spatial boundary, origins and characteristics of the valley. The core area of the valley is Daedeok Science Town. This valley is an outcome of so called the Venture Policy of DJ government and business restructuring after foreign exchange crisis of November, 1997.

• Journal of Information Technology Applications and Management
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• 제12권2호
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• pp.163-184
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• 2005

The purpose of this research is to examine the major determinants affecting the usage and performance of information technologies in Daedeok Valley and Zhongguancun venture firms. The development of the research model is based on the theoretical linkages of IDT (Innovation Diffusion Theory) and TAM(Technology Acceptance Model). Seven hypotheses are derived and tested using regression analysis. The results from regression analysis suggest that the usage of Information technologies is affected by innovation characteristics (perceived usefulness) as well as organizational characteristics (top management support, employee capability on information technology acceptance) in Daedeok Valley venture firms. But, The results from regression analysis suggest that the usage of Information technologies is affected by innovation characteristics (perceived usefulness), organizational characteristics (top management support, employee capability on information technology acceptance), and external pressure (environmental uncertainty, intensity of competition) in Zhongguancun venture firms.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 2007년도 춘계 학술대회
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• pp.9-9
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• 2007

• 기술혁신학회지
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• 제7권2호
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• pp.305-324
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• 2004

본 연구는 대덕벨리 벤처기업들의 현황 분석을 목적으로, 벤처 기업들의 CEO들을 대상으로 설문조사를 실시하였다. 이를 토대로 의미미분법을 적용하여 심층 분석해 본 결과, 대덕벨리의 벤처기업들은 대체로 자금조달, 마케팅 전략, 그리고 네트워크에 문제가 있는 것으로 나타났다. 특히, 제한된 자금조달 원천, R＆D에 치중한 기업 전략, 낮은 산학 연간 협력구도가 핵심 현안문제로 제기 되었다.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2004년도 추계 종합학술대회 논문집
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• pp.234-239
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• 2004

지역혁신발전 전략산업 가운데 하나로 대전시가 "대덕연구단지 영상타운 건립" 사업을 추진하고 있는 가운데, 대덕밸리가 보유한 관련기술의 현황을 파악하고 활용방안을 검토하기 위한 대덕밸리 디렉토리북의 제작이 검토되었다. 이 연구는 활용도높은 대덕밸리 디렉토리북의 제작을 위하여 기술현황 조사방안과 수집된 자료를 바탕으로 한 디렉토리북의 정보아키텍쳐 구성 방안을 정보디자인 관점에서 고찰하였다.

• 과학기술학연구
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• 제9권1호
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• pp.33-55
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• 2009

이 논문에서는 "과학기술거점의 일생"이란 관점에서 대덕연구단지의 진화과정을 분석 하였다. 이를 위하여 과학기술거점에 대한 이론적 논의를 살펴본 후 대덕연구단지의 진화과정을 개념 정립기($1968{\sim}1977$년), 단지 조성기($1978{\sim}1992$년), 클러스터 형성기(1993년 이후)로 구분하여 검토하였다. 대덕연구단지는 개념을 정립하고 단지를 조성하는 데 상당한 기간이 소요되었으며, 연구학원도시에서 출발한 후 전문연구단지를 거쳐 혁신클러스터로 진화해 왔다. 그러한 과정에서 대덕연구단지는 통제적 혁신체제에서 네트워크 혁신체제로, 국지적 혁신체제에서 상호작용적 혁신체제로, 대학 연구소 주도형에서 실리콘밸리형으로 변모할 가능성을 보이고 있다. 이러한 연구는 과학기술거점의 유형에 대한 분석이 한국의 특정한 사례에 대한 역사적 고찰에 의해서도 이루어질 수 있다는 점을 보여주고 있다.

• Journal of Information Technology Applications and Management
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• 제15권1호
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• pp.43-65
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• 2008

This study investigates the effects of business environment on the e-business strategy and performance of venture firms. The development of the research model is based on the empirical studies on the strategy literature. The data from the survey was analyzed using Partial Least Squares(PLS). For Daedeok Valley Venture Firms, product innovation differentiation strategy is affected by environmental uncertainty. And, cost leadership strategy tend to be influence by environmental uncertainty. Finally, venture firm's performance is effected by cost leadership strategy and marketing differentiation strategy. However, for in Hsinchu Science Park Venture Firms, product innovation differentiation strategy is affected by environmental uncertainty and heterogeneity. And, marketing differentiation strategy is enhanced by environment uncertainty and industry growth. In addition, cost leadership strategy tend to be influence by environmental uncertainty and heterogeneity. Finally, venture firm's performance is effected by cost leadership strategy and product innovation differentiation strategy.

• Nutrition Research and Practice
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• 제11권1호
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• pp.33-42
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• 2017

BACKGROUND/OBJECTIVE: This study aims to measure the in vitro antioxidant capacity of Korean diet (KD) with American diet (AD) as a control group and to examine the ex vivo DNA damage reduction effect on human lymphocytes. MATERIALS/METHODS: The KD applied in this study is the standard one-week meals for Koreans (2,000 kcal/day) suggested by 2010 Dietary Reference Intakes for Koreans. The AD, which is the control group, is a one-week menu (2,000 kcal/day) that consists of foods that Americans would commonly take in according to the National Health and Nutrition Examination Survey. The antioxidant capacity of each menu was measured by means of the total phenolic assay and 3 in vitro antioxidant activity assays (2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, trolox equivalent antioxidant capacity (TEAC), Oxygen radical absorbance capacity ($ORAC_{ROO{\cdot}}$)), while the extent of ex vivo lymphocyte DNA damage was measured by means of the comet assay. RESULTS: When measured by means of TEAC assay, the in vitro antioxidant capacity of the KD of the day was higher than that of the AD (P < 0.05) while there was no significant difference in total phenolic contents and DPPH and ORAC assays. The ex vivo lymphocyte DNA damage protective effect of the KD was significantly higher than that of the AD (P < 0.01). As for the one-week menu combining the menus for 7 days, the total phenolic assay (P < 0.05) and in vitro antioxidant capacity (P < 0.001, DPPH; P < 0.01, TEAC) of the KD menu were significantly higher than those of the AD menu. Likewise, the ex vivo DNA damage reduction rate of the Korean seven-day menu was significantly higher than that of the American menu (P < 0.01). CONCLUSION: This study demonstrates that the high antioxidant capacity and DNA damage protective effect of KD, which consists generally of various plant foods, are higher than those of typical AD.

• Preventive Nutrition and Food Science
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• 제12권4호
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• pp.197-201
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• 2007

Genistein is an active component of legumes and other related food shown to be associated with prevention of degenerative diseases such as cancer through inducing signaling pathways. Treatment of genistein resulted in the induction of apoptosis in the cultured cancer cells. This induction of apoptosis was demonstrated by the Tunel assay in these cells. Unveiling the potential of genistein in cytotoxicity via apoptosis when it is treated with estrogen can predict the therapeutic capability of genistein in breast cancers in the presence of endogenous estrogen. We have found that apoptosis induced by genistein treatment in the presence of estrogen is agonistic or antagonistic depending on the concentrations and treatment periods applied in MCF-7 breast cancer cells. For the suppression of cell survival, 24 hr of treatment was required to induce a synergistic agonistic response between estrogen and genistein at low concentrations of genistein. After this period, the agonistic pattern of genistein to estrogen disappeared. The decrement of COX-2 expression in MCF-7 cells treated with genistein was accompanied with the activation of AMPK only at a high concentration of genistein. This association between AMPK activation and down-regulation of COX-2 by genistein was dampened in the presence of estrogen. It was also demonstrated that genistein and estrogen regulate cell survival and apoptosis by modulating p53 and caspase-3 in the opposite direction. These results suggest that genistein has the potential to control breast cancer development, and co-treatment with estrogen can cause agonistic or antagonistic action on breast cancer cell control.

• Journal of Nutrition and Health
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• 제43권6호
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• pp.570-577
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• 2010

Water gets magnetically charged when it is contacted with a magnet. Although magnetic water products have been promoted since the 1930's, they have received very little recognition due to questionable effectiveness. Diethylnitrosamine (DEN) is a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver. In this study, the effect of magnetized water supplementation on lymphocyte DNA damage in ICR mice treated with DEN was evaluated using the Comet assay. Mice were divided into 3 groups: control, DEN, and DEN + magnetized water group. Fifteen mice were maintained in each group for the entire experimental period of 6, 12 and 18 weeks. Five mice in each group were sacrificed at 6, 12, and 18th weeks, followed by the Comet assay using the blood obtained from heart puncture of the mice. The level of lymphocyte DNA damage reflected by tail moment and other DNA damage indices of tail DNA (%) or tail length of the magnetized water group were significantly decreased after the 6th, 12th and 18th weeks of supplementation compared with the positive control, the DEN group. The relative DNA damage of the magnetized water groups compared to the DEN control group after 6th, 12th, and 18th weeks of supplementation were 42.2%, 40.8%, and 32.9% for DNA in tail, 31.2%, 32.6%, and 21.3% for tail length, and 33.8%, 33.8%, and 24.6% for tail moment, respectively. This is the first report demonstrating that magnetized water may be involved in the lowering effect of the DNA damage in DEN-treated ICR mice. This result suggests that the magnetized water might have minimized the DNA damage by improving the antioxidant status of the mice. However, further studies are needed to characterize the condition of the magnetization and examine the long-term effect of the water product.