• Proceedings of the Korean Society of Medical Physics Conference
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• 2006.08a
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• pp.91-91
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• 2006

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1311-1315
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• 2012

Objectives: Thrombotic risk is increased in patients with cancer and there are important implications for those who suffer a venous thromboembolism (VTE). We undertook this study to determine the frequency, clinical patterns, and outcome of VTE in Saudi patients with cancer. Methods: Cancer (solid tumors and lymphoma) patients who developed VTE from January 2004 to January 2009 were studied retrospectively. Demographics and clinical characteristics related to thrombosis and cancer were evaluated. Results: A total of 701 patients with cancer were seen during the study period. VTE was diagnosed in 47 (6.7%) patients (median age 52, range 18-80 years). Lower limb DVT was the most common type, seen in 47% patients, followed by PE in 19%, and 19% patients had both DVT & PE. Thrombosis was symptomatic in 72% patients while it was an incidental finding on routine workup in 28%. Cancer and VTE were diagnosed at the same time in 38% of patients, and 47% patients developed VTE during the course of disease after the cancer diagnosis. The majority of VTE post cancer diagnoses occurred during the first year (median 4 months, range 1-14). Additional risk factors for VTE were present in 22 (47%) patients and 14 (30%) of these patients were receiving chemotherapy at the time of thrombosis. Only 5 (10.6%) patients were receiving thrombo-prophylaxis at the time of VTE diagnosis. Most common types of tumors associated with thrombosis were breast cancer, non-Hodgkin's lymphoma and lung cancer. The majority of the affected patients (79%) had advanced stage of cancer. After a median follow-up of 13 (range 0.5-60) months, 38 (81%) patients had died. There was no difference in the mortality of patients with symptomatic or asymptomatic thrombosis (82% vs 78.6%). Conclusions: Thrombotic complications can develop in a significant number of patients with cancer, and almost half of the patients have additional risk factors for VTE. Thrombosis is usually associated with advanced disease and can be asymptomatic in more than a quarter of cases. Thromboprophylaxis in cancer patients is under-utilized. Community based studies are needed to accurately define the extent of this problem and to develop effective prophylactic strategies.

• Archives of Pharmacal Research
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• v.25 no.3
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• pp.381-386
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• 2002

The objective of this study was to link conformational changes of proteins at a water/methylene chloride interface to their destabilization upon emulsification. When 4 aqueous protein solutions (bovine serum albumin, $\beta$-lactoglobulin, ovalbumin, or ribonuclease) were emulsified in methylene chloride, considerable proportions of all the proteins became water insoluble aggregates. There were also noticeable changes in the compositions of their water-soluble species. A series of water/methylene chloride interfacial reactions upon the proteins was considered a major cause of the phenomena observed. Based on this supposition, the interfacial tension was determined by a Kruss DVT-10 drop volume tensiometer under various experimental conditions. It substantiated that the interfacial tension was high enough to cause the adsorption of all the proteins. Under our experimental conditions, their presence in the aqueous phase resulted in reductions of the interfacial tension by the degrees of 8.5 - 17.1 mN $m^{-1}$. In addition, dynamic changes in the interfacial tension were monitored to compare relative rates at which the adsorbed proteins underwent conformational, structural rearrangements at the interface. Such information helped make a prediction about how easily proteins would denature and aggregate during emulsification. Our study indicated that emulsifying aqueous protein solutions in organic solvents should be handled with care, due to adverse interfacial effects.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.50 no.10
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• pp.494-501
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• 2001

In this study, the effects of vascular parameter changes and electrodes on VOP measurement based on IPG were simulated mathematically. For the evaluation of the effects of hemodynamic changes on VOP, a mathematical model, which consists of cardiovascular system model and venous occlusion model, was developed and the model solution representing the blood flow and pressure in measuring point was found by 2nd order Runge-Kutta method. And, with sensitivity coefficients obtained from finite element solution of electric field in measuring point, the effects of electrode system on measurement were evaluated. As increasing the resistance, the venous capacitance was not changed but the venous outflows were decreased and the decreased compliance reduced the venous capacitance. And, for several configurations of round electrodes and band electrodes, the sensitivity coefficients were computed using the electric field distribution along deep vein. In conclusion, the proposed mathematical cardiovascular model could be applied to the simulation study on the effects of hemodynamic parameters on DVT diagnosis with IPG. And, also the sensitivity coefficients could provide effective electrode configuration for exact measurement of VOP.

• Proceedings of the Korean Society of Tobacco Science Conference
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• 2001.05a
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• pp.35-43
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• 2001

일대잡종육종이란 현대의 다양한 육종기술 중 하나로 교배 제1세대의 잡종강세현상을 곧바로 이용하는 것으로 여러 작물에서 실용적으로 이용되고 있다. F$_1$잡종종자를 생산하려면 자가수분을 통제해야 하는데 웅성불임을 이용하면 자친의 화분제거 노력이 생력되어 경제적인 종자생산이 가능하다. 연초는 자식성 작물로 잡종강세는 높지 않으나 종간 교잡에 의한 cms가 만들어진 이후 버어리종 등에서는 60년대부터 직적형질에 가깝게 유전되는 우성 단일유전자의 지배를 받는 N. logniflora의 역병(race 0)저항성을 도입한 웅성불임(cms) F$_1$잡종이 활발하게 이용되어 왔다. 최근에는 cms F$_1$잡종의 이용영역이 넓어져 우리나라의 경우 N. glutinosa에서 유래한 우성 단일인자 TMV저항성을 도입한 황색종 cms F$_1$잡종 KF 114가 주 재배품종이 되었고 버어리종에서는 VAM에서 유래한 열성단일유전자의 지배를 받는 PVY저항성이 도입된 KB 111의 확대재배가 예상되고 있다. 본 글에서는 cms F$_1$잡종의 국내외 이용 사례를 살펴보고 cms F$_1$잡종의 육성과 이용방향, cms F$_1$잡종 종자생산에 관하여 기술하였다. 그리고 병저항성뿐 아니라 알칼로이드함량, 염록소함량, DVT나 챤-abienol 및 SE함량 등 질적형질에 가깝게 유전되고 유전양식이 명확하게 밝혀진 화학성분에 대해서도 F$_1$잡종 육성의 대상 형질로 논의하였다.

• Journal of Biomedical Engineering Research
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• v.37 no.1
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• pp.39-45
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• 2016

A pressure measurement system was developed to verify magnitude and position of transferred pressure on the body surface during the intermittent pneumatic compression (IPC) which is one of the most well-known methods for the prevention of deep vein thrombosis (DVT). Eighty force sensing resistors (FSR) were arranged on a mannequin leg and a hardware controller sensed, digitized, and transferred pressure data every second while IPC was being applied. Finally, sensed pressure data were color coded and visualized on the 3D model with lab-developed software. The pressure data were also saved to files for further analysis. Using this measurement system, the changing pattern of pressure was measured on the mannequin leg by changing both chamber pressure and cuff tightness. As a result, net pressure transferred onto the body surface is dependent on chamber pressure and cuff tightness. Under the same chamber pressure, the tighter a cuff was worn, the wider compressed area was and the shorter compression cycle was. Also transferred pressure was proportional to both chamber pressure and cuff tightness.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2003.10a
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• pp.527-531
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• 2003

Previous researches on scalability problem of distributed virtual environment (DVE) have been mainly focused on spatial partitioning of area of interest (AOI). Congestion phenomena by avatar groups in AOI have been neglected relatively. However, AOI congestion is highly related to scalability of DVT because it exhausts system resources such as network bandwidth and rendering time, and could be a bar to perform collaboration among participants. In this paper, this will be defined as the problem that must be solved for the realization of the scalable DVE, and a model will be proposed to measure and control congestion situation in AOI. The purposes of the proposed model are to prevent high density of participants in AOI, and to protect stable collaboration in DVE. For evaluation of the performance it is compared with a previous method by defining the resource cost model which is dynamically activated to AOI congestion.

• Imaging Science in Dentistry
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• v.48 no.3
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• pp.167-176
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• 2018

Purpose: In the age of X-ray computed tomography (CT) and digital volume tomography (DVT), with their outstanding post-processing capabilities, indications for planar radiography for the study of the dentition of ancient Egyptian mummies may easily be overlooked. In this article, the advantages and limitations of different approaches and projections are discussed for planar oral and maxillofacial radiography using portable digital X-ray equipment during archaeological excavations. Furthermore, recommendations are provided regarding projections and sample positioning in this context. Materials and Methods: A total of 55 specimens, including 19 skeletonized mandibles, 14 skeletonized skulls, 18 separate mummified heads, and 4 partially preserved mummies were imaged using portable digital X-ray equipment in the course of archaeological excavations led by the University of Basel in the Valley of the Kings between 2009 and 2012. Images were evaluated by 2 authors with regard to the visibility of diagnostically relevant dental structures using a 4-point grading system(Likert scale). Results: Overall, the visibility of diagnostically relevant dental structures was rated highest by both authors on X-ray images acquired using a dental detector. The tube-shift technique in the lateral projections of mandibular dentition achieved the second-best rating, and lateral projections achieved the third-best rating. Conclusion: Conventional planar digital X-ray imaging, due to its ubiquity, remains an excellent method-and often the only practicable one-for examining the skulls and teeth of ancient Egyptian mummies under field conditions. Radiographic images of excellent diagnostic quality can be obtained, if an appropriate methodology regarding the selected projections and sample placement is followed.

• The Journal of Internal Korean Medicine
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• v.39 no.2
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• pp.165-175
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• 2018

Purpose: To report on a patient with subarachnoid hemorrhage and deep vein thrombosis treated with a combination of Korean and Western medicine. Methods: A patient diagnosed with subarachnoid hemorrhage and deep vein thrombosis was treated with herbal medicine (加減淸熱瀉濕湯 (Gagam-cheongyeolsaseub-tang)), acupuncture (GV2, GB20, LI11, LI4, TE5, GB34, ST36, SP9, ST38, GB39, SP6, LR3), moxibustion (CV6, CV9), and Western medicine for deep vein thrombosis and subarachnoid hemorrhage. To evaluate edema, one of the classic symptoms of deep vein thrombosis, we measured leg circumference at a specified time. Results: After taking Gagam-cheongyeolsaseub-tang and being treated with acupuncture, moxibustion, and Western medicine, the patient showed improvement in leg edema. The left calf circumference decreased from 37.5 cm to 34.5 cm. Conclusions: Korean medicine, acupuncture, moxibustion, and Western medicine may provide effective treatment for deep vein thrombosis in patients with subarachnoid hemorrhage, but further study is needed.

• Journal of Chest Surgery
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• v.41 no.5
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• pp.591-597
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• 2008

Background: Pulmonary endarterectomy is widely accepted as a treatment for chronic thromboembolic pulmonary hypertension. Based on our experiences, we sought to find ways to reduce perioperative complications and to improve surgical outcomes in patients undergoing pulmonary endarterectomy. Material and Method: This study was designed as a retrospective analysis of 20 patients with pulmonary hypertension who underwent pulmonary endarterectomy between January 1998 and March 2008. All patients presented with chronic dyspnea. Deep vein thrombosis (DVT) was the major cause of chronic pulmonary thromboembolism (55%). Seventeen patients (85%) underwent inferior vena cava (IVC) filter placement. Thirteen patients underwent surgery under total circulatory arrest, while the others underwent surgery while on low flow cardiopulmonary bypass. Concomitant tricuspid annuloplasty was done in 6 patients (66%) whose tricuspid regurgitation was as severe as grade IV/IV. The mean follow-up duration was $45{\pm}32$ months. Result: Using of University of California, San Diego (UCSD), thromboembolism classification, 4 patients (20%) were type 1, 8 patients (40%) were type II, and 8 patients (40%) were type III. Right ventricular systolic pressure was reduced significantly from $77{\pm}29$ mmHg to $37{\pm}19$ mmHg after pulmonary endarterectomy (p<0.001). The degree of tricuspid regurgitation and the NYHA functional class were all improved postoperatively. Reperfusion edema occurred in 7 cases (35%). The incidence of reperfusion edema was higher in the UCSD type III group than in the other group (25% vs 50%, p=0.25) and the length of postoperative intensive care unit stay was longer in type III group ($5{\pm}2$ days vs $9{\pm}7$ days, p=0.07). The early mortality rate was 10%, and the late mortality rate was 15% (n=3); one death was due to progression of underlying non-Hodgkin's lymphoma, and the other deaths were related to recurrent thromboembolism and persistent pulmonary hypertension, respectively. Conclusion: Pulmonary endarterectomy, as a curative surgical method for treating chronic thromboernbolic pulmonary hypertension, should be performed aggressively in patients diagnosed with chronic thromboembolic pulmonary hypertension, and an effort should be made to reduce the frequency of perioperative complications and to improve surgical outcomes.