• Genomics & Informatics
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• v.18 no.1
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• pp.6.1-6.9
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• 2020

Acute leukemia represents the most common pediatric malignancy comprising diverse subtypes with varying prognosis and treatment outcomes. New and targeted treatment options are warranted for this disease. Patient-derived xenograft (PDX) models are increasingly being used for preclinical testing of novel treatment modalities. A novel approach involving targeted error-corrected RNA sequencing using ArcherDX HemeV2 kit was employed to compare 25 primary pediatric acute leukemia samples and their corresponding PDX samples. A comparison of the primary samples and PDX samples revealed a high concordance between single nucleotide variants and gene fusions whereas other complex structural variants were not as consistent. The presence of gene fusions representing the major driver mutations at similar allelic frequencies in PDX samples compared to primary samples and over multiple passages confirms the utility of PDX models for preclinical drug testing. Characterization and tracking of these novel cryptic fusions and exonal variants in PDX models is critical in assessing response to potential new therapies.

• Journal of Energy Engineering
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• v.5 no.2
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• pp.193-197
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• 1996

A study was conducted on the oxidation behavior of U-0.75 wt% Ti chips (Depleted Uranium, DU chips) using an XRD and a thermogravimetric analyzer in the temperature range from 250 to 500$^{\circ}C$ in air. At the temperature lower than 400$^{\circ}C$, DU chips were converted to UO$_2$, U$_3$O$\_$7/, and U$_3$O$\_$8/ whereas at the temperature higher than 400$^{\circ}C$, DU chips were completely converted to U$_3$O$\_$8/, the most stable form of uranium oxide. The activation energy for the oxidation of DU chips is found, 44.9 kJ/mol and the oxidation rate in terms of weight gain (%) can be expressed as; dW/dt8.4${\times}$10$^2$e(equation omitted) wt%/min (250$\leq$T($^{\circ}C$) $\leq$ 500) where W=weight gain (%), t=time and T=temperature.

• Journal of Pharmacopuncture
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• v.21 no.1
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• pp.7-13
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• 2018

Objective: Hwa-byung is one of the cultural concept of distress in Korea resulted from chronic accumulated anger. It is characterized by various symptoms like stuffy in the chest, hot or heat sensation, something pushing up in the chest, feeling of mortification, and a flush of anger. This protocol aims to explore the efficacy and safety of Huanglian-jie-du decoction on various somatic symptoms and insomnia in patients with Hwa-byung. Methods: This is study protocol for a randomized, double-blind, placebo-controlled trial. A total of 44 patients will be randomly assigned to the experimental group or the placebo group in a 1:1 ratio. All medications will be taken orally 3 times per day for 7 consecutive days. The primary outcomes are the mean changes in Patient Health Questionnaire of physical symptoms (PHQ-15) and Insomnia Severity Index (ISI) after the 7 days of administration. The secondary outcomes include the scales to assess stress response, symptoms of Hwa-byung, and state anger. Conclusion: The results of this study will provide high quality and explorative evidence to investigate the effect of Huanglian-jie-du decoction on Hwa-byung.

• Transactions of the Korean hydrogen and new energy society
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• v.27 no.1
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• pp.22-28
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• 2016

It is necessary to store and supply hydrogen isotopes for Tokamak operation. A storage and delivery system (SDS) is used for storing hydrogen isotopes as a metal hydride form. We designed and fabricated a depleted uranium (DU) bed to store hydrogen isotopes. The rapid storage of hydrogen isotopes is very important not only for safety reasons but also for the economic design and operation of the SDS. The delivery rate at the desorption temperatures without the operation of a dry pump was analyzed in comparison with that with the operation of the dry pump. The effect of the initial desorption temperatures on the dehydriding of the DU without the operation of the dry pump was measured. The effect of the initial desorption temperatures on the dehydriding of DU with the operation of the dry pump was also measured and analyzed. The primary pressure on the desorption temperatures without the operation of the dry pump was analyzed in comparison with that with the operation of the dry pump. The temperature gradient of the coil heater and the primary vessel was also analyzed. Our results will be used to develop pilot scale hydrogen isotope processes. It was confirmed that dehydriding of a medium-scale DU bed has enabled without the operation of the dry pump.

• International Journal of Costume and Fashion
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• v.6 no.1
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• pp.30-47
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• 2006

La $d\'{e}marche$ et l'objet de cette recherche sont d'analyser, psychiquement, $th\'{e}oriquement$, les marques de $l'intersexualit\'{e}$ $pr\'{e}sentent$ en Orient et les $\'{e}l\'{e}ments$ intersexuels, binaires dans le $v\hat{e}tement$, et $\'{e}galement$ de comprendre $l'ambiguit\'{e}$ ou encore la fusion des $identit\'{e}s$ $sexu\'{e}es$, qui $pr\'{e}sente$ symboliquement a travers le $v\hat{e}tement$, dans la $soci\'{e}t\'{e}$ moderne. La base fondamentale dans la $th\'{e}orie$ de l'Orient est que l'univers se divise en Yin ($caract\`{e}re\;f\'{e}minin$) et Yang ($caract\`{e}re$ masculin) et que tout individu $poss\`{e}de$ $\'{e}galement$ ce couple, en quelque sorte un intersexuel qui s'ignore, avec des variations selon l'individu. En $d\'{e}finitive$, les compositions doubles des $\'{e}l\'{e}ments$ dans le $v\hat{e}tement$ oriental montraient $embl\'{e}matiquement$ nos $qualit\'{e}s$ doubles, masculins et $f\'{e}minins$, et les trois $\'{e}l\'{e}ments$ semblent primordiaux pour $l'\'{e}lucidation$ de la $pr\'{e}disposition$ du porteur : la couleur du tissu, sa forme et la texture du $v\hat{e}tement$. La mode d'auiourd'hui oscille entre masculin et $f\hat{e}minin$. Cette fusion de la mode semble le reflet d'une tendance intersexuelle et d'une fusion du genre. Ainsi, cette recherche est, $\grave{a}$ travers $l'\'{e}l\'{e}ment$ masculin ou $f\'{e}minin$ des $v\hat{e}tements$, pour tenter de discerner lesprit, l'intention et le $caract\`{e}re$ sexuel dominant du porteur.

• Journal of Microbiology
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• v.44 no.6
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• pp.632-640
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• 2006

In this study, the biodegradative activities of monocyclic aromatic compounds were determined from the multi-drug resistant (MDR) Acinetobacter baumannii, which were studied in the form of clinical isolates from a hospital in Korea. These bacteria were capable of biodegrading monocyclic aromatic compounds, such as benzoate and p-hydroxybenzoate. In order to determine which pathways are available for biodegradation in these stains, we conducted proteome analyses of benzoate, and p-hydroxybenzoate-cultured A. baumannii DU202, using 2-DE/MS analysis. As genome DB of A. baumannii was not yet available, MS/MS analysis or de novo sequencing methods were employed in the identification of induced proteins. Benzoate branch enzymes [catechol 1,2-dioxygenase (CatA) and benzoate dioxygenase $\alpha$ subunit (BenA)] of the $\beta$-ketoadipate pathway were identified under benzoate culture condition and p-hydroxybenzoate branch enzymes [protocatechuate 3,4-dioxygenas $\alpha$ subunit (PcaG) and 3-carboxy-cis,cis-muconate cycloisomerase (PcaR)] of the $\beta$-ketoadipate pathway were identified under p-hydroxybenzoate culture condition, respectively, thereby suggesting that strain DU202 utilized the $\beta$-ketoadipate pathway for the biodegradation of monocyclic aromatic compounds. The sequence analysis of two purified dioxygenases (CatA and PcaGH) indicated that CatA is closely associated with the CatA of Acinetobacter radiresistance, but PcaGH is only moderately associated with the PcaGH of Acinetobacter sp. ADPI. Interestingly, the fused form of PcaD and PcaC, carboxymuconolactone decarboxylase (PcaCD), was detected on benzoate-cultured A. baumannii DU202. These results indicate that A. baumannii DU202 exploits a different $\beta$-ketoadipate pathway from other Acinetobacter species.

• The Research Journal of the Costume Culture
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• v.7 no.3
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• pp.1-16
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• 1999

This study in concerned with the costume accessories appeared in Sam Kuk Sa ki. The accessories of both sexes were analized. Results of this research can be summarized as follows : It was appeared that names of accessories of men were fewer in number than those of women. Men\`s accessories such as a hat, bok-du, a belt,boots, shoes, and sock were mentioned in Sam Kuk Sa Ki. Women\`s accessories appeared such as a hat, a comb, a hair pin, a belt, shoes, and sock. A bok-du, boots, and a hared belt were used exclusively by men, while a hat, kwan(冠), a comb, a hair pin, a scarf, pyo( ) were worn exclusively by women. All men from different classes including true bone class as well as the common class wore bok-du, a hat, a hard belt, boots, sock ; however, class distinctions were made from materials used for those items. Also women\`s accessories were used as means of differentiating social status of the wearer by means of materials employed for each item. Especially, woman\`s hat and scarf were a symbol of the noble class. Only two classes of women from the true-bone class and women from the sixth du-pum class entited to wear hats. Wearing a scarf was not allowed to women from the common class. Class dirrernetiations were made by the materials used for hats and scarves. Materials for a scarf such as gold and silver leaf, pecock tail, and king fisher fly feather were restricted to women from true-bone class. Such as man\`s hat bok-du( 頭), use of women\`s comb and hair pin, scarf, leggings were items drived from Tang China. It clearly showed that costume accessories of Silla were heavily influenced by the Chinese. At the same time the costume accessories were sued to make sex difference among the people of Silla. Woman wore a soft belt made of cloth while man wore a hard belt. Woman\`s hat, a scarf, a comb, a hair pin, a belt or sash for a shirt, and leggings were woman\`s sex symbol. Thus, costume accessories of Silla appeared in Sam Kum Sa Ki functioned as means of differentiating social status of the wearer such as sex,class and rank in the society. Also, they showed that Silla kingdom had close cultural relationship with Tang China.

• Natural Product Sciences
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• v.19 no.2
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• pp.192-200
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• 2013

As part of the research for the natural products about prostate-related disease, this study screened 159 plant species from 46 families, which included a total of 213 different kinds of local native plants and these plants were tested for the ability to inhibit LNCaP proliferation, an androgen-sensitive prostate cancer cell line, and DU145 proliferation, which is a more aggressive androgen-insensitive prostate cancer cell line. The results indicated that nineteen of 213 types of plants exhibited antiproliferative activity (cell viability < 30%, $500{\mu}g/mL$) on the growth of androgen-sensitive LNCaP cell lines, and five of them exhibited DU145 cell antiproliferative activity (cell viability < 30%, $500{\mu}g/mL$). The methanol extracts of Eurya emarginata (stems), Gleditsia japonica var. koraiensis (leaves), Photinia glabra (leaves) and Elaeagnus macrophylla (leaves) showed antiproliferative activity on both the androgen-sensitive LNCaP cells (cell viability < 30%) and androgen-insensitive DU145 cells (cell viability > 100%). The study also found that the methanol extracts of Styrax japonica (fruits), Aralia continentalis (leaves), Fagus crenata var. multinervis (stems), Thuja orientalis (stems) and Poncirus trifoliate (branches) presented the strongest activity and demonstrated potent antiproliferative activity on both cell lines (LNCaP and DU145 cell viability < 30%).

• Journal of the Korean Society of Costume
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• v.19
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• pp.175-194
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• 1992

Le Proche-Orient est le pays de la Bible, Le peuple He breu ancien, appartenant la race des S mits s mi-nomades, est venu avec Abraham, de m sopotamie en Palestine, terre de Canaan. Nous avons consid r les v tements du peuple des anciens H breux en nous basant sur la Bible et en observant des peintures murales et des bas-reliefs des divers payes de l'ancienne poque, Pour comprendre l' volution des v tements des gens de la pr sente r gion palestinienne, nous avons tudi les v tements traditionnels de la race b douine qui m nent jusqu' maintenant une vie nomade dans le m nent jusqu' maintenant une vie nomade dans le d sert, parce que nous n'avons pas pu connaitre le processus d' volution des v tements apr s l'ancienne poque la suite d' v nements historiques compliques. En conclusion, nous pouvons nous r sumer comme suit: 1) Nous pensons que la kimlah, costume important du peuple h breu ancien est devenu abajeh, manteau des B douins, puisque ces v tements servent prot ger le corps lors des changments de temps, et la nuit on les utilise comme couverture et comme sac pour y mettre des objets, et comme tente lors su travail. en un mot, les fonctions de la Simlah et celles de l'abajeh sont les memes l' poque ancienne et maintenant. 2) Nous pensons que la forme et l'utilisation de la Kethoneth ayant une forme de tunique et de la thob des B douins sont presque semblable. La kethoneth et la thob sont la tuniqu importante que portent jusqu' maintenant tous les peuples du Proche-Orient. 3) Comme on le voit dans la Bible, les femmes du peuple h breu et celles des B douins utilisent le voile pour couvrir la e te, et se servent d'accessoires pour d corer leur corps. A l'avenir, les vVtements des Palestiniens, dans une recherche pous approfondie, feront l'objet de a 2 me partie de l' tude des costumes du Proche-Orient.

• Journal of the Korean earth science society
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• v.26 no.3
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• pp.199-217
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• 2005

Using monthly total ozone data obtained from a Total Ozone Mapping Spectrometer (TOMS) onboard the Nimbus-7 and Earth Probe satellite, this study examined the trend in the total amount of global ozone during two periods: from 1979-1992 [Early period] and 1997-2002 [Latter period]. The Annual average of total ozone during the Early period was globally reduced by about 10 DU compared to the amount during the Latter, except in some areas between the equator and 20 N. Global trends of total ozone showed a decrease of -6.30 DU/decade during 1979-1992, and an increase of 0.12 DU/decade during 1997-2002. Its enhancement during the Latter period was especially noticeable in tropical areas. The EOF analyses of total ozone from this period indicated signs of temporal/spatial variability, associated with the phenomena of Quasi-Biennial Oscillation (QBO), Quasi-Triennial Oscillation (QTO), El Nino Southern Oscillation (ENSO), and volcanic eruption. Seasonal profiles of tropospheric ozone in the tropics obtained from ozonesondes, showed the spatial pattern of zonal wavenumber one. Overall, this study may be useful in analyzing possible causes in the variations of statospheric and tropospheric ozone.