• Journal of Microbiology and Biotechnology
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• v.29 no.9
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• pp.1478-1487
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• 2019

Ulcerative colitis (UC), a chronic inflammatory bowel disease, substantially impacts patients' health-related quality of life. In this study, an effective strategy for discovering high-efficiency probiotics has been developed. First, in order to survive in the conditions of the stomach and intestine, high bile salt-resistant and strong acid-resistant strains were screened out from the fecal flora of healthy adults. Next, the probiotic candidates were rescreened by examining the induction ability of IL-10 (anti-inflammatory factor) production in dextran sodium sulfate (DSS)-induced colitis mice, and Lactobacillus sakei 07 (L07) was identified and selected as probiotic P. In the end, fourteen bifidobacterium strains isolated from stools of healthy males were examined for their antimicrobial activity. Bifidobacterium bifidum B10 (73.75% inhibition rate) was selected as probiotic B. Moreover, the colonic IL-6 and $TNF-{\alpha}$ expression of the DSS-induced colitis mice treated with L. sakei 07 (L07) - B. bifidum B10 combination (PB) significantly decreased and the IL-10 expression was up-regulated by PB compared to the DSS group. Furthermore, Bacteroidetes and Actinobacteria decreased and Firmicutes increased in the DSS group mice, significantly. More interestingly, the intestinal flora biodiversity of DSS colitis mice was increased by PB. Of those, the level of B. bifidum increased significantly. The Bacteriodetes/Firmicutes (B/F) ratio increased, and the concentration of homocysteine and LPS in plasma was down-regulated by PB in the DSS-induced colitis mice. Upon administration of PB, the intestinal permeability of the the DSS-induced colitis mice was decreased by approximately 2.01-fold. This method is expected to be used in high-throughput screening of the probiotics against colitis. In addition, the L. sakei 07 - B. bifidum B10 combination holds potential in UC remission by immunomodulatory and gut microbiota modulation.

• Journal of Nutrition and Health
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• v.41 no.5
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• pp.391-401
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• 2008

Probiotics have emerged as a potential treatment modality for numerous gastrointestinal disorders, including IBD. However, few probiotics have undergone appropriate preclinical screening in vivo. Kefir is considered a probiotic, benefiting the host through its effects in the intestinal tract. Despite numerous studies examining the action of probiotics on the host organism, few have analyzed the effects on intestinal environment. We assessed the protective effect of kefir for three weeks before inducing colitis with 2% dextran sodium sulfate for five days. The DSS loads were similar in all DSS treatment group. The results of the experiment are as follows. Food intake and FER of experimental groups were not significantly different each other, but water consumption tended to be higher in all DSS treatment groups as compared with the normal control. And visual inspection of feces revealed mild diarrhea in rat given 2% DSS. The anti-inflammatory activity of kefir was determined by myeloperoxidase activity during the DSS treatment, and there was no significant difference in any group. The levels of thiobarbituric acid reactive substances (TBARS) as a colonic lipid peroxidation were significantly lower in the kefir intake groups than in rats treated with 2% DSS alone. The DNA % in tail and tail moment values as a DNA damage level of the blood lymphocytes in kefir intake groups tended to be lower than 2% DSS treatment alone, especially tail lengths were significantly diminished. According to the colonic histopathological assay, there were a severe inflammation of lamina propria and submucosa and mild edema in mucosa and sub mucosa in DSS alone treated group. We found a slight regenerative change in kefir treatment groups. In our experiments, this means that ulcerative colitis related to oxidative injury might be prevented by kefir as a probiotic. Further studies of the potential benefits of kefir as a probiotic in inflammatory condition are encouraged.

• Journal of Korean Society for Quality Management
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• v.18 no.2
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• pp.54-68
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• 1990

Contingency response in a FMS system requires that the system be able to identify and evaluate a number of alternatives. This paper is outlined that DSS completes with a problem processor in corporating Timed Petri Nets model, and a data base system. DSS enables the FMS user to get the maximum benefit from a FMS. The structure of this DSS parallels the organizational activities involved in running the FMS. In designing a shop floor controller for FMS, interactions between the different real time, discrete event functions must be established. The specification of the machine tool and material handling system functions working as a concurrent and cooperative system is given in terms of Timed Petri Nets. In addition, the basic concepts and uses of Petri Nets are surveyed. The system to be studied is first modelled by a Timed Petri Nets and then procedure for evaluating the FMS system performance are presented. Numerical examples are studied to illustrate a session of the FMS used-DSS interaction.

• Asia pacific journal of information systems
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• v.7 no.3
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• pp.1-21
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• 1997

본 논문에서는 인터넷 기반의 새로운 DSS 개념인 인터넷 DSS 개념적인 설계를 제안한다. 제안하는 인터넷 DSS는 인터넷 환경에서 효과적으로 구동될 수 있도록 지능형 에이전트(Intelligent Agent)를 주요 구성모듈로 하고 있으며, 네트웍 통신층, 문제해결층, 그리고 사용자 인터페이스층 등 다층구조를 갖고 있다. 인터넷 DSS 가능성을 구체적으로 보여주기 위하여 기업내에서 전략적으로 가장 첨예한 대립관계를 보이고 있는 마케팅 부서와 생산관리 부서간의 전략적 통합문제에 적용하여 그 의미를 분석하였다. 이는 최근 기업경영이 글로벌화 되어가면서 마케팅과 생산기능이 지리적으로 떨어져서 운영되는 것이 일반화되어 가고 있기 때문에 기존의 DSS보다는 인터넷 DSS가 이러한 경우에 훨씬 적용가능성이 높기 때문이다. 본 논문에서는 인터넷 DSS를 구성하는 모듈중에서 주로 모형에이전트의 모형결합 메카니즘을 중심으로 설명하였고 결론부분에서 향후 연구방향을 제시하였다.

• Biomedical Science Letters
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• v.21 no.2
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• pp.115-121
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• 2015

Ulcerative colitis (UC) is an inflammatory bowel disease, which is a chronic gastrointestinal disorder. Pulsatilla koreana (P. koreana) is a perennial plant that grows around Korea and it has various pharmacological effects such as anti-cancer and anti-inflammatory activity. However, the regulatory effects of P. koreana in intestinal inflammation are not yet understood. This study attempted to determine the effect of P. koreana in dextran sulfate sodium (DSS)-induced colitis in mice. The colitis mice were induced by drinking water containing 5% DSS for 7 days. The results showed that mice treated with DSS showed remarkable clinical signs, including weight loss, and reduced colon length. Administration of P. koreana attenuated DSS-induced the weight loss, colon shortening and Disease activity index in mice. Additionally, P. koreana inhibited the cyclooxygenase-2 and prostaglandin $E_2$ levels in DSS-treated colon tissues. These results provide experimental evidence that P. koreana might be a useful therapeutic medicine for patients with UC.

• Journal of the Korean Operations Research and Management Science Society
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• v.19 no.2
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• pp.129-151
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• 1994

Recently, Decision Support Systems (DSS) research has seen a more to combine Artificial Intelligence (AI) including neural network techniques with traditional DSS concepts and technologies to build an intelligent DSS or a knowledge-based DSS. This article proposes a Management Evaluation and its Support System (MESS) as a knowledge-based DSS. The management evaluation of a firm means the performance of all managerial operations is appraised by considering the situations of the firm. A neural network is used to represent the management evaluation structure as a suitable means of management knowledge representation. Finally a case study in a telecommunication corporation is presented.

• IE interfaces
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• v.7 no.2
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• pp.121-132
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• 1994

Despite extensive research on various factors affecting the effectiveness of decision support systems (DSS), considerable ambiguity still exists regarding the role and influence of the experience on the given task and the decision support system. Although researchers have advocated DSS effectiveness as a multi-dimensional construct, specific results regarding the effect of the familiarity in the task and the DSS on the problem-solving time is still lacking. The study reported here attempts to find the effect of the peculiarity of the problem-solving process on the problem-solving time. The results of the study highlight that the expertise in both the task and the DSS have made the shortage of the problem-solving time. However, more research about the generalized performance measure on the DSS is required.

• Natural Product Sciences
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• v.15 no.4
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• pp.185-191
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• 2009

Intestinal epithelial cells (IEC) play an important role in the mucosal immune system. IEC-derived mediators of inflammatory cascades play a principal role in the development of colon inflammation. The aim of this study was to investigate the inhibitory effect of aqueous extracts of Schizandra chinensis fruits (SC-Ex) on the production of inflammatory mediators by the human colonic epithelial cells. HT-29 cells were stimulated with dextran sulfate sodium in the presence or absence of SC-Ex to examine the cytoprotection and production of IL-8 and reactive oxygen species (ROS). It was shown that dextran sulfate sodium (DSS) caused the reduction of cell viability and production of IL-8 and ROS in DSS-treated HT-29 cells. We observed that the treatment of SC-Ex protected significantly cell proliferation from DSS-induced damage in dose-dependent manner. SC-Ex (10 and 100 ${\mu}g$/ml) also suppressed DSS-induced production of IL-8 mRNA and protein. Moreover, DSS-induced ROS production was inhibited markedly by the treatment of 100 ${\mu}g$/ml SC-Ex. These results suggest that SC-Ex has the protective effects on DSS-induced cell damage and the release of inflammatory mediators in the intestinal epithelial cells.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 1996.04a
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• pp.59-76
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• 1996

Vessels in the world merchant fleet generally operate in either liner or bulk trade. The supply and the demand trend of general cargo ship are both on the ebb however those trend of tankers and containers are ins light ascension. Oil tankers are so far the largest single vessel type in the world fleet and the tanker market is often cited as a texbook example of perfect competition. Some shipping statistics in recent years show that there has been a radical fluctuation in spot charter rate under easy charter's market. This implies that the proper scheduling of tankers under spot market fluctuation has the great potential of improving the owner's profit and economic performance of shipping. This paper aims at developing the TS-DSS(Decision Support System for Tanker Scheduling) in the context of the importance of scheduling decisions. TS-DSS is defined as a DSS based on the optimization models for tanker scheduling. The system has been developed through the life cycle of systems analysis design and implementation to be user-friendly system. The performance of the system has been tested and examined by using the data edited under several tanker scheduling has been tested and examined by using the data edited under several tanker scheduling scenarios and thereby the effectiveness of TS-DSS is validated satisfactorily. The authors conclude the paper with the comments of the need of appropriate support environment such as data-based DSS and network system for successful implementatio of the TS-DSS.

• Journal of the Korean Institute of Navigation
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• v.20 no.1
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• pp.27-46
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• 1996

Vessles in the world merchant fleet generally operate in either liner or bulk trade. The supply and the demand trend of general cargo ship are both on the ebb, however, those trend of tankers and containers are in slight ascension. Oil tankers are so far the largest single vessel type in the world fleet and the tanker market is often cited as a textbook example of perfect competition. Some shipping statistics in recent years show that there has been a radical fluctuation in spot charter rate under easy charterer's market. This implys that the proper scheduling of tankers under spot market fluctuation has the great potential of improving the owner's profit and economic performance of shipping. This paper aims at developing the TS-DSS(Decision Support System for Tanker Scheduling) in the context of the importance of scheduling decisions. The TS-DSS is defined as the DSS based on the optimization models for tanker scheduling. The system has been developed through the life cycle of systems analysis, design, and implementation to be user-friendly system. The performance of the system has been tested and examined by using the data edited under several tanker scheduling scenarios and thereby the effectiveness of TS-DSS is validated satifactorily. The authors conclude the paper with the comments on the need of appropriate support environment such as data-based DSS and network system for succesful implementation of the TS-DSS.