• Journal of Microbiology and Biotechnology
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• 제29권9호
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• pp.1478-1487
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• 2019

Ulcerative colitis (UC), a chronic inflammatory bowel disease, substantially impacts patients' health-related quality of life. In this study, an effective strategy for discovering high-efficiency probiotics has been developed. First, in order to survive in the conditions of the stomach and intestine, high bile salt-resistant and strong acid-resistant strains were screened out from the fecal flora of healthy adults. Next, the probiotic candidates were rescreened by examining the induction ability of IL-10 (anti-inflammatory factor) production in dextran sodium sulfate (DSS)-induced colitis mice, and Lactobacillus sakei 07 (L07) was identified and selected as probiotic P. In the end, fourteen bifidobacterium strains isolated from stools of healthy males were examined for their antimicrobial activity. Bifidobacterium bifidum B10 (73.75% inhibition rate) was selected as probiotic B. Moreover, the colonic IL-6 and $TNF-{\alpha}$ expression of the DSS-induced colitis mice treated with L. sakei 07 (L07) - B. bifidum B10 combination (PB) significantly decreased and the IL-10 expression was up-regulated by PB compared to the DSS group. Furthermore, Bacteroidetes and Actinobacteria decreased and Firmicutes increased in the DSS group mice, significantly. More interestingly, the intestinal flora biodiversity of DSS colitis mice was increased by PB. Of those, the level of B. bifidum increased significantly. The Bacteriodetes/Firmicutes (B/F) ratio increased, and the concentration of homocysteine and LPS in plasma was down-regulated by PB in the DSS-induced colitis mice. Upon administration of PB, the intestinal permeability of the the DSS-induced colitis mice was decreased by approximately 2.01-fold. This method is expected to be used in high-throughput screening of the probiotics against colitis. In addition, the L. sakei 07 - B. bifidum B10 combination holds potential in UC remission by immunomodulatory and gut microbiota modulation.

• Journal of Nutrition and Health
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• 제41권5호
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• pp.391-401
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• 2008

캐피어 원말은 유산균, 효모, 다당 및 여러 영양성분을 다량 함유하고 있으며 장기능 개선 효능을 살펴보기 위하여 3주령의 수컷 흰쥐 (Sprague-Dawley)를 4군으로 나누어 정상대조군 (N군), DSS투여 대조군 (DC군)과 두 군의 캐피어 투여군으로 하여 대조군 사료와 캐피어 원말을 각각 1.5%와 3.0% 혼합한 사료로 3주간 사육하였다. 이 후 DSS투여 대조군과 캐피어 투여군들에 5일간 2% DSS 음용수 동일한 양을 투여하여 경미한 대장염을 유도하였다. 대장염 유도 후 희생하여 소장 단백질 및 DNA 함량, 혈장 및 결장의 조직검사와 결장조직에서 TBARS와 MPO 활성, 혈장 백혈구에서의 DNA 손상 정도를 측정하였다. 실험 자료는 Windows용 SPSS package program version12.0을 이용하여 통계 처리하였고, 네 군간의 평균값의 차이를 검증하기 위하여 일원배치 분산분석 (one-way ANOVA)을 한 후, Duncan's multiple range test로 변인간의 차이를 검증하였다. DSS 투여군 들에서 변 수분함량이 증가하고 음용수 섭취량이 증가하는 경향과 함께 결장의 조직검사 결과 DSS 투여군에서는 염증과 부종 증상을 관찰할 수 있었으며 식이무게의 3% 캐피어 원말 투여군에서는 재생성 변화를 볼 수 있었다. DSS를 투여받은 군들의 소장 점막 단백질 함량은 감소하는 경향을 보였으며 캐피어 3.0%식이섭취한 군들에서는 증가하는 경향을 보였으나 DNA함량에서는 차이를 볼 수 없었다. DSS 투여군에서는 결장조직의 TBARS 값이 유의적으로 증가하였으며 캐피어 투여군에서는 감소하였으나 캐피어 투여 용량에 따른 차이는 보이지 않았다. 혈장 TBARS와 결장조직의 MPO 활성은군 간에 유의한 차이가 없었다. DSS 투여군에서는 혈액 백혈구 DNA의 tail length가 유의하게 증가하였으며 캐피어 투여군에서는 감소하였다. 따라서 약 4주간 캐피어 원말의 투여는 2%의 DSS로 경미한 대장염을 유도한 흰쥐에서 결장 조직의 산화적 스트레스에 대한 저항력을 증가시켜 대장점막을 보호할 수 있는 기능이 있음을 확인할 수 있었다.

• 품질경영학회지
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• 제18권2호
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• pp.54-68
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• 1990

Contingency response in a FMS system requires that the system be able to identify and evaluate a number of alternatives. This paper is outlined that DSS completes with a problem processor in corporating Timed Petri Nets model, and a data base system. DSS enables the FMS user to get the maximum benefit from a FMS. The structure of this DSS parallels the organizational activities involved in running the FMS. In designing a shop floor controller for FMS, interactions between the different real time, discrete event functions must be established. The specification of the machine tool and material handling system functions working as a concurrent and cooperative system is given in terms of Timed Petri Nets. In addition, the basic concepts and uses of Petri Nets are surveyed. The system to be studied is first modelled by a Timed Petri Nets and then procedure for evaluating the FMS system performance are presented. Numerical examples are studied to illustrate a session of the FMS used-DSS interaction.

• Asia pacific journal of information systems
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• 제7권3호
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• pp.1-21
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• 1997

본 논문에서는 인터넷 기반의 새로운 DSS 개념인 인터넷 DSS 개념적인 설계를 제안한다. 제안하는 인터넷 DSS는 인터넷 환경에서 효과적으로 구동될 수 있도록 지능형 에이전트(Intelligent Agent)를 주요 구성모듈로 하고 있으며, 네트웍 통신층, 문제해결층, 그리고 사용자 인터페이스층 등 다층구조를 갖고 있다. 인터넷 DSS 가능성을 구체적으로 보여주기 위하여 기업내에서 전략적으로 가장 첨예한 대립관계를 보이고 있는 마케팅 부서와 생산관리 부서간의 전략적 통합문제에 적용하여 그 의미를 분석하였다. 이는 최근 기업경영이 글로벌화 되어가면서 마케팅과 생산기능이 지리적으로 떨어져서 운영되는 것이 일반화되어 가고 있기 때문에 기존의 DSS보다는 인터넷 DSS가 이러한 경우에 훨씬 적용가능성이 높기 때문이다. 본 논문에서는 인터넷 DSS를 구성하는 모듈중에서 주로 모형에이전트의 모형결합 메카니즘을 중심으로 설명하였고 결론부분에서 향후 연구방향을 제시하였다.

• 대한의생명과학회지
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• 제21권2호
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• pp.115-121
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• 2015

Ulcerative colitis (UC) is an inflammatory bowel disease, which is a chronic gastrointestinal disorder. Pulsatilla koreana (P. koreana) is a perennial plant that grows around Korea and it has various pharmacological effects such as anti-cancer and anti-inflammatory activity. However, the regulatory effects of P. koreana in intestinal inflammation are not yet understood. This study attempted to determine the effect of P. koreana in dextran sulfate sodium (DSS)-induced colitis in mice. The colitis mice were induced by drinking water containing 5% DSS for 7 days. The results showed that mice treated with DSS showed remarkable clinical signs, including weight loss, and reduced colon length. Administration of P. koreana attenuated DSS-induced the weight loss, colon shortening and Disease activity index in mice. Additionally, P. koreana inhibited the cyclooxygenase-2 and prostaglandin $E_2$ levels in DSS-treated colon tissues. These results provide experimental evidence that P. koreana might be a useful therapeutic medicine for patients with UC.

• 한국경영과학회지
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• 제19권2호
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• pp.129-151
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• 1994

Recently, Decision Support Systems (DSS) research has seen a more to combine Artificial Intelligence (AI) including neural network techniques with traditional DSS concepts and technologies to build an intelligent DSS or a knowledge-based DSS. This article proposes a Management Evaluation and its Support System (MESS) as a knowledge-based DSS. The management evaluation of a firm means the performance of all managerial operations is appraised by considering the situations of the firm. A neural network is used to represent the management evaluation structure as a suitable means of management knowledge representation. Finally a case study in a telecommunication corporation is presented.

• 산업공학
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• 제7권2호
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• pp.121-132
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• 1994

Despite extensive research on various factors affecting the effectiveness of decision support systems (DSS), considerable ambiguity still exists regarding the role and influence of the experience on the given task and the decision support system. Although researchers have advocated DSS effectiveness as a multi-dimensional construct, specific results regarding the effect of the familiarity in the task and the DSS on the problem-solving time is still lacking. The study reported here attempts to find the effect of the peculiarity of the problem-solving process on the problem-solving time. The results of the study highlight that the expertise in both the task and the DSS have made the shortage of the problem-solving time. However, more research about the generalized performance measure on the DSS is required.

• Natural Product Sciences
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• 제15권4호
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• pp.185-191
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• 2009

Intestinal epithelial cells (IEC) play an important role in the mucosal immune system. IEC-derived mediators of inflammatory cascades play a principal role in the development of colon inflammation. The aim of this study was to investigate the inhibitory effect of aqueous extracts of Schizandra chinensis fruits (SC-Ex) on the production of inflammatory mediators by the human colonic epithelial cells. HT-29 cells were stimulated with dextran sulfate sodium in the presence or absence of SC-Ex to examine the cytoprotection and production of IL-8 and reactive oxygen species (ROS). It was shown that dextran sulfate sodium (DSS) caused the reduction of cell viability and production of IL-8 and ROS in DSS-treated HT-29 cells. We observed that the treatment of SC-Ex protected significantly cell proliferation from DSS-induced damage in dose-dependent manner. SC-Ex (10 and 100 ${\mu}g$/ml) also suppressed DSS-induced production of IL-8 mRNA and protein. Moreover, DSS-induced ROS production was inhibited markedly by the treatment of 100 ${\mu}g$/ml SC-Ex. These results suggest that SC-Ex has the protective effects on DSS-induced cell damage and the release of inflammatory mediators in the intestinal epithelial cells.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 1996년도 The Korean Institute of Navigation 1996년도 춘계학술발표회 논문집
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• pp.59-76
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• 1996

Vessels in the world merchant fleet generally operate in either liner or bulk trade. The supply and the demand trend of general cargo ship are both on the ebb however those trend of tankers and containers are ins light ascension. Oil tankers are so far the largest single vessel type in the world fleet and the tanker market is often cited as a texbook example of perfect competition. Some shipping statistics in recent years show that there has been a radical fluctuation in spot charter rate under easy charter's market. This implies that the proper scheduling of tankers under spot market fluctuation has the great potential of improving the owner's profit and economic performance of shipping. This paper aims at developing the TS-DSS(Decision Support System for Tanker Scheduling) in the context of the importance of scheduling decisions. TS-DSS is defined as a DSS based on the optimization models for tanker scheduling. The system has been developed through the life cycle of systems analysis design and implementation to be user-friendly system. The performance of the system has been tested and examined by using the data edited under several tanker scheduling has been tested and examined by using the data edited under several tanker scheduling scenarios and thereby the effectiveness of TS-DSS is validated satisfactorily. The authors conclude the paper with the comments of the need of appropriate support environment such as data-based DSS and network system for successful implementatio of the TS-DSS.

• 한국항해학회지
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• 제20권1호
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• pp.27-46
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• 1996

Vessles in the world merchant fleet generally operate in either liner or bulk trade. The supply and the demand trend of general cargo ship are both on the ebb, however, those trend of tankers and containers are in slight ascension. Oil tankers are so far the largest single vessel type in the world fleet and the tanker market is often cited as a textbook example of perfect competition. Some shipping statistics in recent years show that there has been a radical fluctuation in spot charter rate under easy charterer's market. This implys that the proper scheduling of tankers under spot market fluctuation has the great potential of improving the owner's profit and economic performance of shipping. This paper aims at developing the TS-DSS(Decision Support System for Tanker Scheduling) in the context of the importance of scheduling decisions. The TS-DSS is defined as the DSS based on the optimization models for tanker scheduling. The system has been developed through the life cycle of systems analysis, design, and implementation to be user-friendly system. The performance of the system has been tested and examined by using the data edited under several tanker scheduling scenarios and thereby the effectiveness of TS-DSS is validated satifactorily. The authors conclude the paper with the comments on the need of appropriate support environment such as data-based DSS and network system for succesful implementation of the TS-DSS.