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A clinical study of systemic lupus erythematosus in children (소아에서 전신성 낭창의 임상적 고찰)

  • Kim, Ji Tae;Nam, Young Mee;Lee, Jae Seung;Kim, Dong Soo
    • Clinical and Experimental Pediatrics
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    • v.50 no.1
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    • pp.74-78
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    • 2007
  • Purpose : Systemic lupus erythematosus (SLE) is a chronic multisystemic autoimmune disease with complex clinical manifestations. It probably involves genetic, environmental and immunologic factors. In this study, we investigated the clinical manifestations, laboratory findings and prognosis of pediatric SLE to aid clinical care of pediatric SLE. Methods : The data of 45 patients who were diagnosed as pediatric SLE in Severance Children's Hospital from Jan. 1996 to Dec. 2005 were analysed retrospectively. Results : The mean age at diagnosis was 10.8 (0-15) years old. And the ratio of male to female patients was 1:4. The initial manifestations were facial edema (51.1 percent), malar rash (44.4 percent), and fever (28.9 percent). The ANA (97.8 percent), anti-ds DNA antibody (82.2 percent), lupus nephritis (71.1 percent), malar rash (71.1 percent), and cytopenia (66.7 percent) were the most common findings among the classification criteria by ACR (American College of Rhematology, 1997). Conclusion : Clinical manifestations and prognosis are various in pediatric SLE. Intensive studies of SLE in children should be continued for more effective treatment.

Fabrication of Polycrystalline Si Films by Silicide-Enhanced Rapid Thermal Annealing and Their Application to Thin Film Transistors (Silicide-Enhanced Rapid Thermal Annealing을 이용한 다결정 Si 박막의 제조 및 다결정 Si 박막 트랜지스터에의 응용)

  • Kim, Jone Soo;Moon, Sun Hong;Yang, Yong Ho;Kang, Sung Mo;Ahn, Byung Tae
    • Korean Journal of Materials Research
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    • v.24 no.9
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    • pp.443-450
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    • 2014
  • Amorphous (a-Si) films were epitaxially crystallized on a very thin large-grained poly-Si seed layer by a silicide-enhanced rapid thermal annealing (SERTA) process. The poly-Si seed layer contained a small amount of nickel silicide which can enhance crystallization of the upper layer of the a-Si film at lower temperature. A 5-nm thick poly-Si seed layer was then prepared by the crystallization of an a-Si film using the vapor-induced crystallization process in a $NiCl_2$ environment. After removing surface oxide on the seed layer, a 45-nm thick a-Si film was deposited on the poly-Si seed layer by hot-wire chemical vapor deposition at $200^{\circ}C$. The epitaxial crystallization of the top a-Si layer was performed by the rapid thermal annealing (RTA) process at $730^{\circ}C$ for 5 min in Ar as an ambient atmosphere. Considering the needle-like grains as well as the crystallization temperature of the top layer as produced by the SERTA process, it was thought that the top a-Si layer was epitaxially crystallized with the help of $NiSi_2$ precipitates that originated from the poly-Si seed layer. The crystallinity of the SERTA processed poly-Si thin films was better than the other crystallization process, due to the high-temperature RTA process. The Ni concentration in the poly-Si film fabricated by the SERTA process was reduced to $1{\times}10^{18}cm^{-3}$. The maximum field-effect mobility and substrate swing of the p-channel poly-Si thin-film transistors (TFTs) using the poly-Si film prepared by the SERTA process were $85cm^2/V{\cdot}s$ and 1.23 V/decade at $V_{ds}=-3V$, respectively. The off current was little increased under reverse bias from $1.0{\times}10^{-11}$ A. Our results showed that the SERTA process is a promising technology for high quality poly-Si film, which enables the fabrication of high mobility TFTs. In addition, it is expected that poly-Si TFTs with low leakage current can be fabricated with more precise experiments.

A PN-code Acquisition method Using Array Antenna Systems for CDMA2000 1x (CDMA2000 1x용 배열 안테나 시스템에서 PN 동기 획득 방법)

  • Jo, Hee-Nam;Yun, Yu-Suk;Choi, Seung-Won
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.42 no.8 s.338
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    • pp.33-40
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    • 2005
  • This paper presents a structure of the searcher using a diversity in array antenna systems operating in the cdma2000 1x signal environments. The new technique exploits the fact that the In-phase and quadrature components of interferers can respectively be viewed as an independent gaussian noise at each antnna element in most practical cdma signal environments. The proposed PN acquisition scheme is a singles-dwell PN acquisition system consisting of two stages, that is, the searching stage and the verification stage. The searching stage independently correlates the receiver multiple signals with PN generator of each antenna element for obtaining the synchronous energy at the entire region. Then, the searching results of each antenna element are non-coherently combinind. The verification stage compares the searching energy with the optimal threshold, which is predesigned in the lock detector, and decides whether the acquisition is successful or fail. In this paper, we analyzed the effect of tile diversity order to determine the mean acquisition time. In general, it is known that the mean acquisition time significantly decrease as the number of antenna elements increases. But, as the diversity order goes up, the enhancement of the performance is saturated. Therefore, to decrease the mean acquisition time of the searcher, we must design the optimal array antenna systems by considering the operating SNR range of the receiver, the probability of detection $P_D$ and that of false alarm $P_{FA}$ . The Performance of the proposed PN acquisition scheme is analyzed in frequency selective Rayleigh fading channels. In this paper, the effect of the number of antenna elements on PN acquisition scheme is shown according to the probability of detection $P_D$ and that of false alarm $P_{FA}$.

Manufacturing artificial lightweight aggregates using coal bottom ash and its application to the lightweight-concretes (석탄 바닥재를 이용한 인공경량골재의 제조 및 경량 콘크리트에 적용)

  • Kim, Kang-Duk;Kang, Seung-Gu
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.18 no.5
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    • pp.211-216
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    • 2008
  • The artificial lightweight aggregate (ALA) was manufactured in a rotary kiln at $1125^{\circ}C$ using green body formed by pelletizing the batch powder composing of coal bottom ash (CBA) produced from power plant, clay and dredged soil (DS). The TCLP (Toxicity characteristic leaching procedure) results showed that the dissolution concentration of heavy metal ions of ALA fabricated in this study was below the limitation defined by the enforcement regulations of wastes management law in Korea. The ALA containing 60$\sim$70 wt% CBA had a bulk density of 1.45$\sim$1.49 and a water absorption of 17.2$\sim$18.5 %. The impact values for oven-dry state and saturated-surface dry state of ALA were 27.4$\pm$1.3 and 23.4$\pm$2.6 % respectively. The 28-days compressive strength of concrete made with various ALA was $22.7\sim27.8 N/mm^2$. The slump of concrete with ALA containing CBA 60 and 70 wt% were 7.9 and 14.3 cm respectively. The unit weight of concrete made with any ALA fabricated in this study was satisfied with the standard specifications of lightweight concrete for the civil engineering and construction presented by Korea as below $1.84 ton/m^3$.

The Study of Reliability Based Optimization Design for Connection (불확실성을 고려한 접합부의 최적설계에 관한 연구)

  • Shin, Soo-Mi;Yun, Hyug-Gee;Kim, Hye-Min
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.6
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    • pp.26-32
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    • 2016
  • Usually, there are many uncertainties regarding the error of an assumed load, material properties, member size, and structure analysis in a structure, and it may have a direct influence on the qualities of optimal design of structures. Probabilistic analysis has developed rapidly into a desirable process and structural reliability analysis is an increasingly important tool that assists engineers to consider uncertainties during the design, construction and life of a structure to calculate its probability of failure. This study deals with the applications of two optimization techniques to solve the reliability-based optimization problem of structures. The reliability-based optimization problem was formulated as a minimization of the structural volume subject to the constraints on the values of componential reliability index determined by the AFOSM approach. This presented method may be a useful tool for the reliability-based design optimization of structures.

Quantitative Analysis of Artifactual Perfusion Defects due to the Cutoff Frequencies of Reconstruction Filters in Tc-99m-MIBI Myocardial SPECT Images (Tc-99m-MIBI 심근 SPECT에서 재구성필터의 차단주파수에 의한 인위적 관류결손의 정량적 평가)

  • Kwark, Cheol-Eun;Chung, June-Key;Lee, Myung-Chul
    • Journal of Biomedical Engineering Research
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    • v.16 no.2
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    • pp.231-238
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    • 1995
  • Tc-99m-MIBI (Sestamibi) myocardial SPECT along with TI-201 tomographic Imaging has demonstrated wide application and high image quality sufficient for the diagnosis of myocardial perfusion defect, which consequently reflects regional myocardial blood flow. The qualitative values of myocardial SPECT with Tc-99m-MIBI as well ds the quantitative cases depend in some degree on the reconstruction techniques of multiple projections. Filtered backprojection (FBP) Is the common standard method for reconstruction rather than the complicated and time-consuming arithmetic methods. In FBP it is known that the distribution of radioactivity in reconstructed transverse slices varies with the selected litter parameters such as cutoff frequencies and order (Butterworth case) The cutoff frequencies used in clinicAl practice partially remove and decrease the true radioactive distribution and alter the pixel counts, which lead to underestimation of true counts in specific myocardial regions. In this study, we have investigated the effect of cutoff frequencies of reconstruction filter on the artifactually induced perfusion defects, which are often demonstrated near inferior and/or inferoseptal cardiac walls due to the intense hepatic uptake of Tc-99m-MIBI. A computerized method for Identifying the relative degree of artifactual perfusion defect and for comparing those degrees along with the relative amount of hepatic uptake to myocardium was developed and patient images were studied to observe the quantitative degree of underestimation of myocardial perfusion, and to propose some reasonable threshold of cutoff frequency in the diagnosis of perfusion defect quantitatively. We concluded that from the quantitative viewpoint cutoff frequencies may be used as high as possible with the sacrifice of homogeneity of image quality, and those frequencies lower than the common 0.3 Wyquist frequency would reveal severe degradation of radioactive distribution near inferior and/or inferoseptal myocardium when applying Butterworth or low pass filter.

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Wet-end Monitoring Experience in Liner Paper Mill (라이너지 제지공장의 습부공정 모니터링 경험)

  • 신종호;류정용;김용환;송봉근
    • Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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    • 2001.11a
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    • pp.57-58
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    • 2001
  • 용수 다소비 산업으로 분류되는 제지공업의 특성 상, 용수사용의 억제 및 용수의 무방류화에 대한 압력이 증가되고 있는 반면, 초지환경은 날로 열악해지고 있는 실정이다. 한 예로써, 용지의 재활용율 및 재사용 비율이 증가함에 따라 원료의 저급화가 심 각한 수준에 이르고 있으며, 이러한 초지환경의 변화는 각질화되고 극도로 미세화된 다량의 미세섬유 발생 및 잡고지로부터 유입되는 점착성 이물질과 무기 충진제의 도입 등을 유발함으로서 제품의 물리적 성질 저하, 탈수부하 증가로 인한 생산성 저하, 약품사용량 증가 등을 초래하여, 결과적으로는 폐수처리장의 부하를 증대시킴과 동시에 청수사용량 및 폐수방류량을 증가시키는 악순환을 되풀이하게 된다. 국내 제지산업이 국제적 경쟁력을 갖추기 위해서는 제품의 증대가 필수적이나, 원료와 설비의존도를 감안할 때, 제품특성과 공정 분을 결정하는 습부공정을 정확히 파악하여 최적 운전조건을 확립하는 것이 가장 경제적이고 용이한 방법일 뿐만 아니라 전체 제지공정의 정정화에도 기여할 수 있을 것으로 판단된다. 일정규모이상의 종이를 생산하는 제지공장은 거의 대부분 컴퓨터로 처리되는 온라인 공정조절 시스템(On-line process control system)을 구비하고 료의 도입에서부터 설비운전 및 제품의 기본적인 품질관리까지 실시간의 자동화되고 안정적인 운전과 관리시스템을 유지하고 있다. 그러나 전체 제지공정 중, 제품 물성과 운전조건의 대부분을 결정하는 습부공정만큼은 아직도 주기적인 분석이 행해지고 있지 않을 뿐만 아니라, 슬러리의 농도나 보류도 정도를 제이하면 분석항목 조차도 변변히 확립되어 있지 않을 실정이다. 이는 다량의 물 속에 존재하게 되는 용전물질(Dissolved solids, DS), 부유물질(Suspended solids, SS), 섬 유(Fibers), 무기 미 세분(Inorganic f fines), 그리고 투입되는 약품간에 발생하는 계면동전현상 및 이러한 현상과 최종 지제 품의 물성간의 상관관계에 대한 이해 정도나 경험 부족에서 기인하는 것으로 생각된다. 1 1983년 미국제지기술연합회(T APpI)의 제지용 첨가제 분과위원회(Papermaking A Additive Committee)에서는 습부공정의 적절한 조절을 위해 어떤 항목들이 필요하며 그 중요도는 어떠한가를 조사하였으며, 그 결과로 전하밀도, 제타전위, 보류도 및 여수 도, 무기 미세분 함량 등이 중요하다고 보고하였다. 그러나 지료의 전기적 특성을 실시 간으로 측정하는 기자재류가 최근에 이르러서야 도입되고 있는 실정이기 때문에 충분 한 현장적용 사례가 보고되지 못하고 있으며, 결과적으로 얻어진 정보와 최종 지제품의 물성 및 초지기 운전조건과의 상관관계를 확립하는 작업결과는 더욱 찾아보기 어렵다. 따라서, 본 연구에서는, 라이너지 제조공장의 습부공정에 투입되는 약품이 지료 의 전기적 성질, 즉 전하밀도와 제타전위에 미치는 영향을 모니터링함으로서 지료의 전기적 성질들과 습부 공정상태와의 상관관계를 살펴보고자 하였다. 본 연구는 다음과 같은 순서로 진행하였다.

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The ptimum temperatures during cultivation period of Gastrodia elata according to growth stages (천마 생육단계별 변온에 의한 최적온도 및 재배기간)

  • Kim, Chang-Su;Kim, Hyo-Jin;Seo, Sang-Young;Kim, Hee-Jun;Lee, Wang-Hyu
    • Journal of Mushroom
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    • v.16 no.2
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    • pp.90-95
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    • 2018
  • This study was carried out to investigate the optimum temperature and the cultivation period according to the different growth stages of Gastrodia elata (G. elata). The growth period for the indoor cultivation of G. elata is divided into four stages that require specific temperatures during the enlargement of the tuber. The optimum temperatures and cultivation periods during the growth stages of G. elata were observed to be $20^{\circ}C$ for 30 days during the mycelial growth stage (MGS), $25^{\circ}C$ for 120 days during the tuber formation stage (TFS), $6-24^{\circ}C$ for 60 days during the tuber enlargement stage (TES), and $5^{\circ}C$ for 30 days during the dormant stage (DS). The total cultivation period was shortened by 120 days in the indoor cultivation facilities by reduction of 30 days from the mycelial growth stage, addition of 30 days to the tuber formation stage, and reduction of 120 days from the dormancy stage as compared to the outdoor field cultivation. These results provide a basis for a growth model that permits year-round cultivation of G. elata.

Electrochemical Behavior of Bis(2,2'-Bipyridyl) Copper(II)-Sodium Dodecyl Sulfate Solution in the Presence of $MgCl_2$ (염화마그네슘이 있을 때 비스(2,2'-비피리딜)구리(II)-도데실황산나트륨 용액의 전기화학적 거동)

  • Ko, Young Chun;Chung, Keun Ho
    • Analytical Science and Technology
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    • v.10 no.2
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    • pp.126-130
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    • 1997
  • Electrochemical behavior of 1.0mM bis(2,2'-bipyridyl)copper( II )(${Cu(bpy)_2}^{2+}$) in 100mM NaCl+27mM $MgCl_2$ solution with and without sodium dodecyl sulfate(SDS) is investigated. In the presence of SDS, $E_{pa}$ and $E_{1/2}$ of ${Cu(bpy)_2}^{2+/1+}$ shifts to the positive direction compared to the SDS free. Teh intersection of two lines on ${\Delta}E_p$ vs. -log[SDS] plot for 1.0mM $Cu(bpy)_2(NO_3)_2$ in 100mM NaCl+27mM $MgCl_2$ solution is a critical micelle concentration(CMC). Reduced form ${Cu(bpy)_2}^{1+}$ in the presence of $MgCl_2$ is more easily associated to dodecyl sulfate anion($DS^-$) than oxidized ${Cu(bpy)_2}^{2+}$. As the ionic strength is increased by the addition of multiply charged cations($MgCl_2$), the double layer becomes more compact and micelle formation is more difficult.

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Sorption Characteristics of Binary Mixture of Sugar and Sodium Chloride (저장상대습도(貯藏相對濕度)에 따른 당(糖)과 소금 이상혼합물(二相混合物)의 흡습특성(吸濕特性))

  • Oh, Hoon-Il;Kim, Woo-Jung;Park, Nae-Jung
    • Korean Journal of Food Science and Technology
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    • v.15 no.1
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    • pp.19-26
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    • 1983
  • A study was designed to investigate the sorption characteristics of binary mixtures of NaCl and sucrose or glucose stored at various relative humidities ranging from 46% to 92%. At low relative humidity below RH 65%, the sorption equilibrium was easily achieved, whereas at higher relative humidity values over 73%, all of the mixtures tended to cintinously absorb moisture with increase in storage time. A linear equation of log $({\frac{dw}{dt}})$ = a log(t) + log(b) was found to be valid between the sorption rate and storage time with respect to storage humidities. In sucrose-NaCl mixture, the slope showed a increasing tendency as the percentage of NaCl increased in the mixture, while that of glucose-NaCl mixture failed to show a definite trend. Plateaus were obtained when the amount of water absorbed was plotted on the X axis and the percent composition of mixture on the Y axis at different storage time. The shape of plateau was varied with respect to the kind of sugar-NaCl mixture, composition of the mixture and relative humidities. A linearity was found between log(1-Aw) and the amount of water absorbed over the Aw range 0.73-0.92 and the slope was affected by the kind and composition of sugar-NaCl mixtures.

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