• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권10호
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• pp.4833-4848
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• 2019

This paper introduces the structure and effects of Kakao's news curation algorithm, which is created based on the Deep Reading Index (DRI). The DRI examines the extent of deep reading through content reading time, that is, the duration of reader engagement with an article. Current news curation algorithms focus on reader choice, with the click-through rate or pageviews as the gauge for consumption frequency. DRI is a product of the challenge of introducing and adopting a new factor called 'consumption time' instead of 'frequency of consumption', which is the basis of existing curation algorithms. The analysis of DRI-based services proves that the new algorithm can act as a curation system that is more effective in providing in-depth and quality news reports.

• Nutrition Research and Practice
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• 제11권1호
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• pp.51-56
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• 2017

BACKGROUND/OBJECTIVES: The purpose of this study was to assess the accuracy of a dietary reference intake (DRI) predictive equation for estimated energy requirements (EER) in female college tennis athletes and non-athlete students using doubly labeled water (DLW) as a reference method. MATERIALS/METHODS: Fifteen female college students, including eight tennis athletes and seven non-athlete subjects (aged between 19 to 24 years), were involved in the study. Subjects' total energy expenditure (TEE) was measured by the DLW method, and EER were calculated using the DRI predictive equation. The accuracy of this equation was assessed by comparing the EER calculated using the DRI predictive equation ($EER_{DRI}$) and TEE measured by the DLW method ($TEE_{DLW}$) based on calculation of percentage difference mean and percentage of accurate prediction. The agreement between the two methods was assessed by the Bland-Altman method. RESULTS: The percentage difference mean between the methods was -1.1% in athletes and 1.8% in non-athlete subjects, whereas the percentage of accurate prediction was 37.5% and 85.7%, respectively. In the case of athletic subjects, the DRI predictive equation showed a clear bias negatively proportional to the subjects' TEE. CONCLUSIONS: The results from this study suggest that the DRI predictive equation could be used to obtain EER in non-athlete female college students at a group level. However, this equation would be difficult to use in the case of athletes at the group and individual levels. The development of a new and more appropriate equation for the prediction of energy expenditure in athletes is proposed.

• International Journal of Oral Biology
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• 제30권4호
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• pp.143-148
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• 2005

Osteoclasts are multinucleated cells with bone resorbing activity and differentiated from hematopoietic cell lineages of monocyte/macrophages in the presence of receptor activator of NF-${\kappa}B$ ligand (RANKL) and M-CSF. However, the exact molecular mechanisms through which RANKL stimulates osteoclastogenesis remain to be elucidated. Here we report that activation of cAMP-response elementbinding protein (CREB) is not involved in osteoclastogenesis from osteoclast precursors in response to RANKL. RANKL induced CREB activation in osteoclast precursors. Using pharmacological inhibitors, we found that RANKL-induced CREB activation is dependent on p38 MAPK pathways. We also found that ectopic expressions of wild type and dominant negative forms of CREB in osteoclast precursors did not affect RANKL-induced osteoclast formation and bone resorbing activity. Furthermore, dominant negative forms of CREB did not alter the expression levels of osteoclast-specific marker genes. Taken together, these data suggest that CREB is dispensable for differentiation and resorbing activity of osteoclasts.

• Nutrition Research and Practice
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• 제11권4호
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• pp.300-306
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• 2017

BACKGROUND/OBJECTIVES: The doubly labeled water (DLW) method is considered the gold standard for the measurement of total energy expenditure (TEE), which serves to estimate energy requirements. This study evaluated the accuracy of predictive dietary reference intake (DRI) equations for determining the estimated energy requirements (EER) of Korean adults by using the DLW as a reference method. SUBJECTS/METHODS: Seventy-one participants (35 men and 36 women) aged between 20 and 49 years were included in the study. The subjects' EER, calculated by using the DRI equation ($EER_{DRI}$), was compared with their TEE measured by the DLW method ($TEE_{DLW}$). RESULTS: The DRI equations for EER underestimated TEE by -36.3 kcal/day (-1.3%) in men and -104.5 kcal/day (-4.9%) in women. The percentages of accurate predictions among subjects were 77.1% in men and 62.9% in women. There was a strong linear correlation between $EER_{DRI}$ and $TEE_{DLW}$ (r = 0.783, P < 0.001 in men and r = 0.810, P < 0.001 in women). CONCLUSIONS: The present study supports the use of DRI prediction equations to determine EER in Korean adults. More studies are needed to confirm our results and to assess the validity of these equations in other population groups, including children, adolescents, and older adults.

• Journal of Periodontal and Implant Science
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• 제34권4호
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• pp.781-790
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• 2004

골아세포의 생물학적 기능을 증진시키기 위해 키토산의 표면개질에 대하여 연구하였다. 생체적합성 천연고분자인 키토산은 1차 아미노기를 소유하고 있으므로 적정한 공유결합제를 사용하여 세포성장인자와 같은 생리활성을 지닌 단백질을 키토산의 표면에 고정시킬 수 있다. 본 연구에서는 키토산을 필름형태로 제조하여 세포성장인자 중 형질전환성장인자를 고정하고 골아세포의 부착, 성장 및 분화를 증가시키고자 하였다. 형태전환성장인자의 고정화 효율은 단순한 흡착방법에 비해 높았으며, 표면에 형성된 공유결합은 매우 안정하였다. 골아세포를 배양하여 초기세포부착능에 대한 영향을 연구한 결과, 배양 후 4시간, 1일째, 형질전환성장인자를 고정한 키토산 표면에서 고정하지 않은 키토산의 표면에 비해 더 많은 수의 골아세포가 부착되었고, 더 많이 신장된 부착형태를 보였다. 세포활성정도와 배양 후 4주일째의 칼슘축적량을 측정한 결과, 형질전환성장인자를 고정한 키토산 표면에서 고정하지 않은 키토산의 표면에 비해 더 높았다. 위의 결과는 키토산 표면에 형태전환성장인자의 고정이 성공적으로 이루어졌으며, 또한 실제로 활성이 있는 것이 증명되었다. 위의 연구 결과에서 형질전환성장인자로 고정된 키토산은 골아세포의 초기 부착 및 분화를 촉진시켰음을 알 수 있었던 바 성장인자의 표면고정은 임플란트 및 조직공학용 지지체에도 적용하여 생체적합성과 세포기능을 증진시키는데 이용할 수 있음을 알 수 있었다.

• Journal of the Korean Wood Science and Technology
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• 제46권6호
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• pp.627-636
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• 2018

This research was performed to supplement the previous research about the driving rain index (DRI) for Korea determined by using daily weather data for 30 years. The average annual driving rain index (AADRI) was calculated from the hourly weather data, and the magnitude of DRI was investigated according to wind directions. The hourly climate data were obtained from the Korea Meteorological Administration (KMA) for the period 2009 to 2017. Of 82 locations investigated, seven were classified into regions where the level of exposure of walls to rain was high. The result showed quite a difference from the previous results, in which no high exposure regions were observed. Since the hourly-based and the daily-based annual driving rain index (ADRI) values showed only a slight difference, the result may be explained by the length of the periods used in both studies. The change of DRI according to wind directions showed that there was a certain range of wind directions in which driving rain easily approached building walls. It suggests that the consideration of wind directions with high DRI would be useful to develop a good design of wooden buildings from the point of wood preservation and maintenance.

• 대한토목학회논문집
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• 제42권4호
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• pp.457-467
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• 2022

가뭄은 지역적 특성이 강하게 나타나므로 가뭄이 진행하는 상태나 심한 정도를 정의할 수 있는 객관적인 정의나 기준이 필요하다. 이를 위해 가뭄지수(drought index)란 개념은 증발산량을 정량적으로 제시하면서 시작되었으며, 현재까지 전 세계적으로 많은 가뭄 관련 연구가 수행되고 있다. 본 연구에서는 대표적인 기상학적 가뭄지수인 표준 강수 지수(SPI)를 산정하였고, 실질적인 가뭄을 고려할 수 있는 가뭄 위험 지수(DRI)를 가뭄 취약성 지수(DVI)와 가뭄 위험요소 지수(DHI)를 대상지역인 의령군에 적용하여 안정적인 용수공급 체계를 마련할 수 있는 실제적인 가뭄의 평가에 대한 방법을 제시하였다.

• Molecules and Cells
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• 제26권5호
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• pp.436-442
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• 2008

Osteoclasts are multinucleated cells with the unique ability to resorb bone. Elevated activity of these cells under pathologic conditions leads to the progression of bone erosion that occurs in osteoporosis, periodontal disease, and rheumatoid arthritis. Thus, the regulation of osteoclast apoptosis is important for bone homeostasis. In this study, we examined the effects of the Janus tyrosine kinase 2 specific inhibitor AG490 on osteoclast apoptosis. We found that AG490 greatly inhibited osteoclast apoptosis. AG490 stimulated the phosphorylation of Akt and ERK. Adenovirus-mediated expression of dominant negative (DN)-Akt and DN-Ras in osteoclasts inhibited the survival of osteoclasts despite the presence of AG490. Cytochrome c release during osteoclast apoptosis was inhibited by AG490 treatment, but this effect was inhibited in the presence of LY294002 or U0126. AG490 suppressed the pro-apoptotic proteins Bad and Bim, which was inhibited in osteoclasts infected with DN-Akt and DN-Ras adenovirus. In addition, constitutively active MEK and myristoylated-Akt adenovirus suppressed the cleavage of pro-caspase-9 and -3 and inhibited osteoclast apoptosis induced by etoposide. Taken together, our results suggest that AG490 inhibited cytochrome c release into the cytosol at least partly by inhibiting the pro-apoptotic proteins Bad and Bim, which in turn suppressed caspase-9 and -3 activation, thereby inhibiting osteoclast apoptosis.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2019년도 학술발표회
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• pp.364-364
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• 2019

최근 전세계적으로 기후변화로 인한 국내외 가뭄에 대한 피해 및 발생 빈도가 점차 증가하고 있으며, 우리나라의 경우 2000년대 이후 가뭄 주기가 점점 짧아져 2013년 이후 매년 가뭄이 발생하고 있다. 북한은 자연재해에 취약한 국가이며 특히 가뭄으로 인한 식량난 문제가 대두되고 있지만, 북한의 제한적인 정보로 인해 북한 지역에서의 가뭄의 발생과 피해 정보는 한정적이고, 활용할 수 있는 자료의 경우 외국 기관의 정보에 의존하는 실정이다. 향후 농업부문에 대한 대북한 지원과 통일 후를 대비한 농업정책의 수립을 위하여 북한의 가뭄에 대하여 독자적으로 신속한 정보를 취득, 분석할 수 있는 능력을 확보하는 것이 필요하다. 위성영상을 이용한 원격탐사 기술은 접근이 용이하지 못한 지역의 주기적인 관측이 가능하며, 동일한 정확도로 기상자료의 획득이 가능하다. Vegetation Drought Response Index (VegDRI)는 위성영상기반의 가뭄지수인 정규식생지수(Nomalized Difference Vegetation Index, NDVI), 기상학적 가뭄지수를 활용한 기후적 요소, 토지피복 및 생태지역 등의 생물물리학적 요소를 활용한 가뭄지표이다. 본 연구에서는 MODerate resolution Imaging Spectroradiometer (MODIS) 위성의 MOD13Q1 영상자료의 NDVI (2001~2018년)를 이용하였으며, 북한의 기상자료를 이용한 표준강수지수 (Standardized Precipitation Index, SPI)와 파머가뭄심도지수 (Palmer Drought Severity Index, PDSI), 그리고 북한 지역의 토지피복 및 생태지역 등의 요소들을 활용한 VegDRI를 통하여 북한의 가뭄 시기에 따른 시도별 가뭄 특성에 대하여 분석하고자 한다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2001년도 The 6th International Symposium of East Asian Resources Recycling Technology
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• pp.387-392
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• 2001

Kobe Steel, LTD. and Midrex Technologies Inc. jointly developed the FASTMET$\circledR$ process as a steel mill waste recycle technology in which the DRI product meets BF feed material or BOF/EAF feed material requirements. FASTMET(R) process turns value-less wastes into valuable DRI and sellable zinc oxide, and gives the solution for the steel mill wastes recycling from both economical and environmental viewpoints. During the development of the process, Laboratory, Pilot Plant and Demonstration Plant tests were carried out from 1990 to 1998. The first FASTMET(R) commercial plant began operation in April, 2000 and the second commercial plant started in April, 2001 Both commercial plants have proceeded successfully preying that FASTMET$\circledR$ is a suitable process for recycling steel mill waste and for producing DRI as an iron source.