• 한국발생생물학회지:발생과생식
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• 제22권4호
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• pp.341-350
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• 2018

Chemokines is a small protein that plays a major role in inflammatory reactions and viral infections as a chemotactic factor of cytokines involved in innate immunity. Most of the chemokines belong to the chemokine groups CC and CXC. To investigate the immune system of the olive flounder (Paralichthys olivaceus), an expression pattern specifically induced in the early developmental stages of analysis is examined using qRT-PCR. We also examined tissue-specific expression of both CC and CXC chemokine in healthy olive flounder samples. CC and CXC chemokine shows increased expression after immune-related organs are formed compared to expression during early development. CC chemokine was more highly expressed in the fin, but CXC chemokine showed higher expression in the gills, spleen, intestines, and stomach. Spatial and temporal expression analysis of CC and CXC chemokine were performed following viral hemorrhagic septicemia virus (VHSV) infection. CC chemokine showed high expression in the gills, which are respiratory organs, whereas CXC chemokine was more highly expressed in the kidneys, an immune-related organ. These results suggest that CC and CXC chemokine play an important role in the immune response of the olive flounder, and may be used as basic data for the immunological activity and gene analysis of it as well as other fish.

• 한국발생생물학회지:발생과생식
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• 제23권1호
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• pp.63-72
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• 2019

The head gap gene buttonhead (btd) is required for the patterning of head segments in the early Drosophila embryo. Mutant phenotypes of btd display a gap-like phenotype in which antennal, intercalary, mandibular and the anterior portion of the maxillary segments are eliminated. In agreement with the phenotypes, btd is expressed in a stripe covering the head segments at the blastoderm stage. During the early phase of the germband extension, btd is expressed in stripes with single segmental periodicity, which is required for the formation of the peripheral nervous system. In contrast to the key role of btd in Drosophila embryonic development, it has been suggested that Tribolium ortholog of btd (Tc-btd) is dispensable for embryonic head development. In order for better understanding of the requirement of Tc-btd in the early Tribolium embryo, we re-analyzed the expression patterns and functions of Tc-btd during embryonic segmentation. Tc-btd is expressed in segmental stripes at the stages of blastoderm and germband elongation. Up to 28.3% of embryos in which Tc-btd is knocked down displays the loss of antennal, mandibular and the pregnathal regions in the head, with abdominal segments being disrupted in the trunk. Our findings suggest that Tc-btd is required for the head and trunk development in the early Tribolium embryo.

• Computers and Concrete
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• 제17권6호
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• pp.801-814
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• 2016

An alternative type of building system with masonry units is extensively used nowadays to reduce the emission of CO2 and embodied energy. Long-term performance of such structures has become essential for sustaining the building technology. This study aims to assess the strength and durability properties of concrete prepared with unprocessed bagasse ash (BA) and silica fume (SF). A mix proportion of 1:3:3 was used to cast concrete cubes of size $100mm{\times}100mm{\times}100mm$ with various replacement levels of cement and tested. The cubes were cast with zero slump normally adopted in the manufacturing of hollow blocks. The cubes were exposed to acid attack, alkaline attack and sulphate attack to evaluate their durability. The mass loss and damages to concrete for all cases of exposures were determined at 30, 60, and 90 days, respectively. Then, the residual compressive strength for all cases was determined at the end of 90 days of durability test. The results showed that there was slight difference in mass loss before and after exposure to chemical attack in all the cases. Though the appearance was slightly different than the normal concrete the residual weight was not affected. The compressive strength of 10% bagasse ash (BA) as a replacement for cement, with 10% SF as admixture resulted in better strength than the normal concrete. Hence concrete with 10% replacement with BA along with 10% SF as admixture was considered to be durable. Besides solid concrete cubes, hollow blocks using the same concrete were casted and tested simultaneously to explore the possibility of production of masonry units.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제16권4호
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• pp.1224-1248
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• 2022

In various sensor network applications, such as climate observation organizations, sensor nodes need to collect information from time to time and pass it on to the recipient of information through multiple bounces. According to field tests, this information corresponds to most of the energy use of the sensor hub. Decreasing the measurement of information transmission in sensor networks becomes an important issue.Compression sensing (CS) can reduce the amount of information delivered to the network and reduce traffic load. However, the total number of classification of information delivered using pure CS is still enormous. The hybrid technique for utilizing CS was proposed to diminish the quantity of transmissions in sensor networks.Further the energy productivity is a test task for the sensor nodes. However, in previous studies, a clustering approach using hybrid CS for a sensor network and an explanatory model was used to investigate the relationship between beam size and number of transmissions of hybrid CS technology. It uses efficient data integration techniques for large networks, but leads to clone attacks or attacks. Here, a new algorithm called SBEA (Snowball Endurance Algorithm) was proposed and tested with a bow. Thus, you can extend the battery life of your WSN by running effective copy detection. Often, multiple nodes, called observers, are selected to verify the reliability of the nodes within the network. Personal data from the source centre (e.g. personality and geographical data) is provided to the observer at the optional witness stage. The trust and reputation system is used to find the reliability of data aggregation across the cluster head and cluster nodes. It is also possible to obtain a mechanism to perform sleep and standby procedures to improve the life of the sensor node. The sniffers have been implemented to monitor the energy of the sensor nodes periodically in the sink. The proposed algorithm SBEA (Snowball Endurance Algorithm) is a combination of ERCD protocol and a combined mobility and routing algorithm that can identify the cluster head and adjacent cluster head nodes.This algorithm is used to yield the network life time and the performance of the sensor nodes can be increased.

• 한국발생생물학회지:발생과생식
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• 제26권4호
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• pp.135-144
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• 2022

As the number of coronavirus disease 2019 (COVID-19) vaccinations increases, various side effects are being reported, and menstrual abnormalities have been reported as a side effect in women. However, it is still unclear whether the COVID-19 vaccine has detrimental effects on the female reproductive system. Therefore, we investigated the effect of excessive immune response on reproductive function by administering Lipopolysaccharides (LPS) instead of the COVID-19 vaccine. The immune response in mice was induced by injection of LPS. Mice injected with saline 5 times were used as a control group, and mice injected with LPS 5 times were used as an experimental group. Repeated administration of LPS significantly reduced the number of corpus luteum (CL). On the other hand, the injection of LPS did not affect the development of follicles leading before the CL. The expression of the apoptosis-related genes Fas and Fas-L increased in the experimental group. In addition, the expression of the inflammation-related genes increased in the experimental group. In this study, we confirmed that LPS had detrimental effects on the uterus and ovaries in mice. These results suggest that injection of LPS can cause immune reactions within the uterus and ovaries and cause hormonal changes, which can have adverse effects such as abnormal operation or bleeding of the menstrual cycle. These results are expected to help determine the cause of decreased reproductive function, infertility, or physiological disorders caused by the COVID-19 vaccine.

• 한국방사선학회논문지
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• 제3권2호
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• pp.27-31
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• 2009

현재 의료용 엑스선 장비는 기존의 아날로그 방식의 필름, 카세트를 대신하여 디지털 방식인 CR, DR 이 널리 사용되면 그에 관한 연구개발이 활발히 진행되고 있다. 본 연구 에서는 디지털 엑스선 장비의 변환물질로 $BiI_3$(Bismuth tri-iodide)를 적용하여 실험하였으며 기존 선행연구에 비해 만족할만한 결과 값은 얻을 수 없었지만 가장 많이 사용되고 있는 a-Se(Amorphous Selenium)의 단점인 고전압인가와 제작방식의 어려움을 보완할 수 있는 새로운 가능성을 제시해 주었다. 본 연구에서 사용되어진 변환 물질은 순도 99.99%의 $BiI_3$가 이용되었으며 $3cm{\times}3cm$의 크기와 200um의 두께를 가지는 변환물질 층이 제작되었다. 변환 물질의 상하부에는 Magnetron Sputtering system장비를 이용한 ITO 전극이 형성되었다. 형성된 $BiI_3$ 엑스선 변환 물질의 특성 평가를 위해 구조적 분석과 전기적 분석이 이루어 졌다. SEM 측정을 통해 제작된 필름의 표면 및 단면적, 구성 성분을 관찰하였고, 전기적 분석을 위해서는 누설전류, 엑스선에 대한 신호량 및 잡음 대 신호비의 관찰이 이루어졌다. 실험 결과 $BiI_3$는 $1.6nA/cm^2$의 누설전류와 $0.629nC/cm^2$의 신호량을 측정할 수 있었으며, 이렇게 Screen print method로 제작된 엑스선 검출 물질은 PVD방법을 이용해 제작된 물질과 비슷하거나 더 나은 전기적 특성을 가지고 있었고 이는 제작 방법의 간소화 및 수율을 향상 시킬 수 있어 BiI3도 a-Se를 대체하기 위한 변환물질로 적합하다고 사료된다.

• 대한장애인치과학회지
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• 제14권1호
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• pp.11-16
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• 2018

In order to increase the accessibility of dental care for people with disabilities, National Health Insurance Service has implemented an additional point system of National Dental Insurance for dental treatment of patients with a special health care need (AID). The purpose of this study is to investigate the types and status of AID in Korea using data of the Health Insurance Review and Assessment Service from 2011 to 2017. The basic consultation fee is increased by 9.03 points (713 won) for brain disorder, intellectual disability, mental disability, or autistic disorder. From 2011 to 2015, the number of claims with a basic consultation fee increased from 90,456 to 141,179. Dental treatment and surgical treatment fee is increased by 100% of the defined insurance score for each of the 15 items. During the five years from 2012 to 2016, the number and amount of claims for each item increased steadily. Of the total claims for 5 years, endodontic treatment was highest, with 107,477 cases, followed by 51,641 cases of scaling. There are two types of dental safety observation fee, simple and complex. The simple safety observation fee is 10,370 won per day, and the complex safety observation fee is 20,750 won per day. Dental safety observation fees were charged 34 times in 2015, 14 times in 2016, and 41 times through May 2017. From 2011 to 2017, the number and amount of claims using AID for dental care for people with disabilities increased. However, considering that the number of registered dental users with disability was about 560,000 in 2016, the number of claims using AID is 1-20,000, which is less than 2% of registered dental users with disability. Therefore, it is necessary to expand dental services for people with disabilities including AID.

• 한국토양비료학회지
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• 제34권1호
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• pp.64-70
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• 2001

전보에서 개발한 질소질 비료의 적정시비량 산정을 위한 전문가체계 모델인 NES 를 일리노이주 옥수수 포장에 적용하여 검증하였다. 본 검증에는 Howard 박사와 5개의 일리노이주 농업 시험장에서 수행한 옥수수에 대한 질소질 비료의 시용 결과를 각각 이용하였고, 현행 일리노이주 옥수수 포장의 질소시비 추천량, Hoeft 추천량, 이론적 최대이익산출 추천량 및 NES 추천량 등 각각의 추천기준에 대한 예상수량, 질소회수율 및 질소유실량을 산정 비교하였다. 생산성 지표(PI), 토양 유기물함량(SOM) 및 시비전 질산태질소 함량(PSNT) 등 3개의 토양특성을 고려한 NES의 추천량이 타 추천량에 비해 가장 적었으며, 이에 따른 질소의 회수율도 가장 높았다. 그러나, 수익면에 있어서는 NES 추천량이 이론적 최대이익산출 추천량에 미치지 못했는데, 이는 환경 비용을 고려하지 않은 결과로 생각된다. 따라서 경작 형태나 경운, 환경 비용 등에 따른 질소의 효율성을 고려한 보다 발전된 시비량 모델의 개발이 요구된다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제30권1호
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• pp.52-59
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• 2008

The geometric design of an implant surface may play an important role in affecting early osseointegration. It is well known that the porous surfaced implant had much benefits for the osseointegration and the early stability of implant. However, the porous surfaced implant had weakness from the transgingival contamitants, and it resulted in alveolar bone loss. The other problem identified with porous surface implant is the loss of physical properties resulting from the bead sintering process. In this study, we developed the new bead coating implant to overcome the disadvantages of porous surfaced implant. Ti-6Al-4V beads were supplied from STARMET (USA). The beads were prepared by a plasma rotating electrode process (PREP) and had a nearly spherical shape with a diameter of 75-150 ${\mu}m$. Two types of titanium implants were supplied by KJ Meditech (Korea). One is an external hexa system (External type) and the other is an internal system with threads (Internal type). The implants were pasted with beads using polyvinylalcohol solution as a binder, and then sintered at 1250 $^{\circ}C$ for 2 hours in vacuum of $10^{-5}$ torr. The resulting porous structure was 400-500 ${\mu}m$ thick and consisted of three to four bead layers bonded to each other and the implant. The pore size was in the range of 50-150 ${\mu}m$ and the porosity was 30-40 % in volume. The aim of this study was to evaluate the osseointegration of the newly developed dental implant. The experimental implants (n=16) were inserted in the unilateral femur of 4 mongrel dogs. All animals were killed at 8 weeks after implantation, and samples were harvested for hitological examination. All bead coated porous implants were successfully osseointegrated with peripheral bone. The average bone-implant contact ratios were 84.6 % (External type) and 81.5 % (Internal type). In the modified Goldner's trichrome staining, new generated mature bones were observed at the implant interface at 8 weeks after implantation. Although, further studies are required, we could conclude that the newly developed vacuum sintered Ti-6Al-4V bead coating implant was strong enough to resist the implant insertion force, and it was easily osseointegrated with peripheral bone.

• 대한한방내과학회지
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• 제39권4호
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• pp.662-675
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• 2018

Objective: The aim of this study was to establish the developmental history of hospice palliative care (HPC) with Korean medicine (KM). Methods: We compared the developmental history of HPC in Korea with that of Britain, the United States, Taiwan, Japan, and China. The articles in English or Korean published until Feb. 2017 were searched using 'Hospice' or 'Palliative care' with the name of each nation in the PubMed, MEDLINE, ScienceDirect, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) databases for foreign articles and OASIS (Oriental Medicine Advanced Searching Integrated System) for domestic articles. Books and gray literature were searched on the same databases and websites of the Ministry of Health and Welfare and related organizations in each country. Results: Modern palliative care began with the hospice movement led by Dr. Cicely Saunders. HPC in Korea started earlier than in other countries but it took considerable time for social consensus, so Korean policies have only been published recently. In this process, KM was excluded from HPC. For this reason, western medicine in Korea does not fully accept the spirit of HPC, the government does not take an aggressive stance with KM, and the institutes of KM do not have any interest in HPC. The World Health Organization recommends the establishment of policies and programs connected with a country's own health care system. In 2015, the Korean government made the third comprehensive plan for the development of KM. It included critical pathway guidelines about cancer-related fatigue and anorexia. More effort is required to set up HPC than other care types because Korea has two medical systems. Conclusions: Each nation has been trying to improve systems of HPC. We need to overcome the problems and bring out the best by making our own model of HPC with KM.