• Safety and Health at Work
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• v.2 no.2
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• pp.97-104
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• 2011

N,N-Dimethylformamide (DMF) is globally used as an organic solvent in the production of synthetic leather and resins because of its low volatility, making it an attractive industrial material. Despite its excellent property as a chemical solvent, utilization of DMF is somewhat controversial nowadays due to its hazardous effects on exposed workers in work places. Many toxification cases are being reported globally and the number of cases of liver damage is still increasing in developing countries. On account of this, a series of epidemiologic surveys are being conducted to understand the degrees of liver damage caused by DMF exposure. Furthermore, many investigations have been performed to clarify the mechanism of DMF-induced liver toxicity using both human and experimental animal models. This review summarizes the current occupational cases reported on liver damage from workers exposed to DMF in industrial work places and the research results that account for DMF-induced liver failure and possible carcinogenesis. The findings reviewed here show the synergistic toxicity of DMF exposure with other toxicants, which might occur through complicated but distinct mechanisms, which may extend our knowledge for establishing risk assessments of DMF exposure in industrial work places.

• Earthquakes and Structures
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• v.25 no.5
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• pp.325-342
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• 2023

The damping modification factor (DMF) is used to modify the 5%-damped response spectrum to produce spectral values that correspond to other necessary damping ratios for seismic design. The DMF has been the subject of numerous studies, and it has been discovered that seismological parameters like magnitude and distance can have an impact on it. However, DMF formulations incorporating these seismological parameters cannot be directly applied to seismic design because these parameters are not specified in the present seismic codes. The goal of this study is to develop a formulation for the DMF that can be directly applied in seismic design and that takes the effects of magnitude, distance, and site conditions into account. To achieve this goal, 16660 ground motions with magnitudes ranging from 4 to 9 and epicentral distances ranging from 10 to 200 km are used to systematically study the effects of magnitude, distance, and site conditions on the DMF. Furthermore, according to the knowledge that magnitude and distance affect the DMF primarily by changing the spectral shape, a spectral shape factor is adopted to reflect influences of magnitude and distance, and a new formulation for the DMF incorporating the spectral shape factor is developed. In comparison to the current formulations, the proposed formulation provides a more accurate prediction of the DMF and can be employed directly in seismic design.

• Toxicological Research
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• v.29 no.3
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• pp.187-193
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• 2013

The effects of toluene in dimethylformamide (DMF)-induced hepatotoxicity were investigated with respect to the induction of cytochrome P-450 (CYP) and the activities of related enzymes. The rats were treated intraperitoneally with the organic solvents in olive oil (Single treatment groups: 450 [D1], 900 [D2], 1,800 [D3] mg DMF, and 346 mg toluene [T] per kg of body weight; Combined treatment groups: D1+T, D2+T, and D3+T) once a day for three days, while the control group received just the olive oil. Each group consisted of 4 rats. The activities of the xenobiotic metabolic enzymes and the hepatic morphology were assessed. The immunoblots indicated that the expression of CYP2E1 was considerably enhanced depending on the dosage of DMF and the CYP2E1 blot densities were significantly increased after treatment with both DMF and toluene, compared to treatment with DMF alone. The activities of glutathione-S-transferase and glutathione peroxidase were either decreased or remained unaltered after treatment with DMF and toluene, whereas the lipid peroxide levels were increased with increasing dosage of DMF and toluene. The liver tissue in the D3 group (1,800 mg/kg of DMF) showed signs of microvacuolation in the central vein region and a large necrotic zone around the central vein, in rats treated with both DMF (1,800 mg/kg) and toluene (D3T). These results suggest that the expression of CYP2E1 is induced by DMF and enhanced by toluene. These changes may have facilitated the accelerated formation of N-methylformamide (NMF) from toluene, and the generated NMF may directly induce liver damage.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.32 no.2
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• pp.102-110
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• 2022

Objectives: The purpose of this study is to analyze the content of N,N-dimethylformamide(DMF) in polyurethane coated gloves(PU-gloves) and to assess the dermal exposure generated by wearing them. Methods: We analyzed the concentrations of DMF in 12 gloves by EN16778 standard. The samples cut into pieces of about 10 by 10 mm and extracted with methanol in flask in an ultrasonic bath at 70℃. An aliquot of the extract is analyzed with GC-MS. The dose of dermal exposure was calculated by ECETOC TRA consumer 3.1 and compared with derived no effect level(DNEL) for systemic effects due to long term exposure by workers. The extracted amount of DMF by saline solution was compared with that by EN16778 standard. Results: The mean concentration of DMF in PU-gloves was 1,377 mg/kg(range 13~3,948 mg/kg). The concentration of DMF showed significantly differences by packing type, manufacturer, and price(p<0.05). The dose of dermal exposure was 0.0007~0.572 mg/kg body weight/day when the DMF content was 10~4,000 mg/kg. The DMF extracted by saline solution was around 11% for 8 hours. Conclusions: The risk of dermal exposure due to the residual DMF in the PU-gloves was not signifiant. But, the limit of 1,000 mg/kg in PU-gloves can be recommended for international standard and trading systems.

• Analytical Science and Technology
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• v.26 no.5
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• pp.315-325
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• 2013

The possibility of acute hepatotoxicity caused by dimethylformamide (DMF) requires regular monitoring of the workers who are using DMF to prevent the occupational disease. The authors performed ambient and biological monitoring of workers involved in synthetic leather manufacturing processes using DMF to assess the correlation between the markers of ambient and biological monitoring of DMF. The authors monitored 142 workers occupationally exposed to DMF from 19 workshops in the synthetic leather and ink manufacturing industries located in northern region of Gyeonggi-do. The subjects answered questionnaire on work procedure and use of personal protective equipment to be classified by exposure type. DMF in air samples collected using personal air samplers, diffusive and active sampler, was analysed using gas chromatograph-flame ionization detector (GC-FID) with DB-FFAP column (length 30 m, i.d. 0.25 mm, film thickness 0.25 ${\mu}m$). Urinary N-methylformamide (NMF) was analysed using gas chromatograph-mass selective detector (GC-MSD) at selected ion monitoring (SIM) mode with DB-624 column (length 60 m, i.d. 0.25 mm, film thickness 1.40 ${\mu}m$). Geometric mean (GM) and geometric standard deviation (GSD) of the ambient DMF was $6.85{\pm}3.43$ ppm, and GM and GSD of urinary NMF was $42.3{\pm}2.7$ mg/L. The ratio of subjects with DMF level over 10 ppm was 44%, and those with urinary NMF over 15 mg/L was 87%. NMF in urine adjusted by DMF in air was $4.61{\pm}2.57$ mg/L/ppm and $9.50{\pm}2.41$ mg/L/ppm, respectively, with or without respirator. There was seasonal differences of NMF in urine adjusted by DMF in air, $7.63{\pm}2.74$ mg/L/ppm in summer and $4.53{\pm}2.29$ mg/L/ppm in winter. The urinary NMF concentration which corresponds to 10 ppm of ambient DMF was 52.7 mg/L (r=0.650, n=128). Considering the difference of the route of exposure which resulted from the compliance of wearing personal protective equipment, the estimated contribution of respiratory and dermal exposure route for DMF was 48.5% vs. 51.5%.

• Korean Journal of Ecology and Environment
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• v.41 no.4
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• pp.485-489
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• 2008

Algal chlorophyll-$\alpha$ is commonly determined by spectro-photometric method using 90% acetone as solvents. However, acetone has low extraction efficiency without grinding filters, and DMF (dimethyl formamide) was tested for the compatibility with acetone. Chlorophyll-$\alpha$ concentration was determined for samples from 5 reservoirs of different trophic states and phytoplankton composition, using acetone extraction with grinding and DMF without grinding. Chlorophyll-$\alpha$ measured by DMF and Acetone did not show a significant difference when using trichromatic method of UNESCO and Lorenzen, and therefore, DMF can substitute acetone. But when acidification method was applied, they showed significant difference of 8%. It can be concluded that DMF can extract chlorophylls more effectively without grinding and it can be a better alternative for the standard extraction solvent.

• Journal of the korean academy of Pediatric Dentistry
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• v.8 no.1
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• pp.15-19
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• 1981

As a pilot survey of Water Fluoridation in Chungju, Fluoride content in the water of that city was examined, and 1563 K primary school children aged from 7 to 13 were surveyed on their oral hygiene status. The results were as followings: 1. Fluoride content...0.1 ppm. 2. dmf rate...80.04 % DMF rate...45.17 % 3. dmf t rate/index...28.29 % / 2.18 dmf s rate/index...14.14 % / 5.44 4. DMF T rate/index...6.62 % / 1.07 DMF S rate/index...1.87 % / 1.51.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2002.05a
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• pp.986-990
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• 2002

Dual Mass Flywheel(DMF) is used in order to improve the vibration characteristics of drivetrain of manual transmission vehicles. Regardless of its complexity and high cost, application of DMF is keep increasing due to a trend of using Diesel engines in passenger cars and light weight design of drivetrains. Modeling and analysis of DMF is rather simple, but finding out optimum parameters of damper may not be easy. Furthermore, its realization in DMF has some limitations due to DMF's structure and its structure dependent damping characteristics. Requirements on spring-damper characteristics of DMF has been reviewed and investigations on structures and damping characteristics of currently Produced DMFs have been made in this paper. Also, ideal spring and damper characteristics has been proposed based on such investigations.

• Transactions of the Korean Society of Automotive Engineers
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• v.12 no.4
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• pp.146-153
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• 2004

This paper presents a discrete analysis approach to investigate the performance of dual mass flywheel (DMF). In the discrete analysis, arcspring installed between the flywheels is modeled as N- discrete elements. Each element consists of mass, spring and nonlinear friction element. LuGre friction model is used to describe nonlinear friction characteristic. Based on the dynamic models of the DMF, clutch, engine, manual transmission and vehicle, a DMF performance simulator is developed using MATLAB Simulink. Simulation results of the engine speed, driveshaft torque and vehicle velocity are compared with test results. It is found that the discrete DMF model describes the vehicle behavior closely, especially during the clutch actuation period.

• Bulletin of the Korean Chemical Society
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• v.30 no.12
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• pp.2921-2926
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• 2009

Cu-BTC[$Cu_3(BTC)_2(H_2O)_3$, BTC = 1,3,5-benzenetricarboxylate], one of the most well-known metal-organic framework materials (MOF), has been synthesized under atmospheric pressure and room temperature by using ultrasound. The Cu-BTC can be obtained in 1 min in the presence of DMF (N,N-dimethylformamide), suggesting the possibility of continuous production of Cu-BTC. Moreover, the surface area and pore volume show that the concentration of DMF is important for the synthesis of Cu-BTC having high porosity. The morphology and phase also depend on the concentration of DMF : Cu-BTC cannot be obtained at room temperature in the absence of DMF and aggregated Cu-BTC (with low surface area) is produced in the presence of high concentration of DMF. It seems that the deprotonation of benzenetricarboxylic acid by base (such as DMF) is inevitable for the room temperature syntheses.