• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1807-1810
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• 2014

Background: It is known that inducible nitric oxide synthase (iNOS)/nitric oxide (NO) plays an integral role during intestinal inflammation, an important factor for colon cancer development. Natural compounds from Curcuma longa L. (Zingiberaceae) have long been a potential source of bioactive materials with various beneficial biological functions. Among them, a major active curcuminoid, demethoxycurcumin (DMC) has been shown to possess anti-inflammatory properties in lipopolysaccharide (LPS)-activated macrophages or microglia cells. However, the role of DMC on iNOS expression and NO production in an in vitro inflamed human intestinal mucosa model has not yet been elucidated. This study concerned inhibitory effects on iNOS expression and NO production of DMC in inflamed human intestinal Caco-2 cells. An in vitro model was generated and inhibitory effects on NO production of DMC at 65 ${\mu}M$ for 24-96 h were assessed by monitoring nitrite levels. Expression of iNOS mRNA and protein was also investigated. DMC significantly decreased NO secretion by 35-41% in our inflamed cell model. Decrease in NO production by DMC was concomitant with down-regulation of iNOS at mRNA and protein levels compared to proinflammatory cytokine cocktail and LPS-treated controls. Mechanism of action of DMC may be partly due to its potent inhibition of the iNOS pathway. Our findings suggest that DMC may have potential as a therapeutic agent against inflammation-related diseases, especially in the gut.

• Journal of Electrical Engineering and Technology
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• 제6권3호
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• pp.423-430
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• 2011

Multi-input multi-output (MIMO) dynamic matrix control (DMC) technique is applied to control steam temperatures in a large-scale ultrasupercritical once-through boiler-turbine system. Specifically, four output variables (i.e., outlet temperatures of platen superheater, finish superheater, primary reheater, and finish reheater) are controlled using four input variables (i.e., two spray valves, bypass valve, and damper). The step-response matrix for the MIMO DMC is constructed using the four input and the four output variables. Online optimization is performed for the MIMO DMC using the model predictive control technique. The MIMO DMC controller is implemented in a full-scope power plant simulator with satisfactory performance.

• Korean Chemical Engineering Research
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• 제46권3호
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• pp.550-554
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• 2008

메탄올과 초임계 이산화탄소를 이용하여 $K_2CO_3/ZrO_2$ 촉매상에서 디메틸 카보네이트(dimethyl carbonate, DMC)를 합성하였다. $K_2CO_3$를 함침법으로 지르코니아에 담지시켜 촉매를 제조하였다. 673 K에서 소성했을 때, 칼륨 성분이 지르코니아 표면에 최대한 고르게 분산되었다. 단사정계(monoclinic)의 결정 구조를 갖는 지르코니아 자체는 DMC 생성에 대한 활성이 없었지만 $K_2CO_3$를 담지시켰을 경우 촉매 성능이 향상되었다. 촉매 외에 촉진제로 $CH_3I$를 사용하였다. 촉매와 촉진제의 사용은 DMC 생성을 향상시키는데 중요한 역할을 하였다. 촉매와 촉진제를 적정량 사용하였을 경우 DMC 생성량을 향상시킬 수 있었지만 과량으로 사용했을 경우 DMC 생성 외에 다른 부반응에도 영향을 미쳤다. 메탄올과 초임계 이산화탄소로부터 DMC 생성에 대한 촉매와 촉진제의 영향 및 그 반응 메카니즘을 제시하였다.

• 대한전자공학회논문지TC
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• 제46권10호
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• pp.14-27
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• 2009

Polar code는 터키 Erdal Arikan교수가 2006년 입력된 채널을 나누면 Cutoff Rate이 향상되는데 착안하여 Polar code를 제안했다. 채널분극은 주어진 B-DMC(Binary-input Discrete Memoryless Channel) W에서 대칭 용량의 높은 비율을 가진 연속적인 code로 이루어져 있다. 대칭 용량은 동등한 확률을 가진 채널의 입력을 이용하여 높은 비율을 얻는데 채널분극은 주어진 B-DMC W의 N개의 독립적인 출력을 모은 것이다. 즉, N은 Binary입력 채널 {$W^{(i)}_N\;:\;1{\leq}\;i\;{\leq}\;N$} 일 때, N이 커지게 되고, I{WN(i)}에서 값이 1에 가까워지면 그 값은 I(W)로 접근되고, I{WN(i)} 값이 0에 가까워지면 1-I(W)에 접근된다. 여기에서 I(W)는 신뢰성 있는 통신상에서의 동등한 주파수를 가진 W의 입력으로 높은 비율을 나타낸다. 이로써 {WN(i)}는 결국 채널코딩을 위한 적합한 상태라고 볼 수 있다. Polar code를 바탕으로, 본 논문은 Arikan의 Polar code의 부호화와 복호화를 분석하고 새롭게 Radix4의 Polar code 부호화를 제안했다.

• Asian-Australasian Journal of Animal Sciences
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• 제15권11호
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• pp.1568-1572
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• 2002

A 152 day trial was conducted to see the effect of feeding naturally fermented wheat straw (FWS) with either energy, protein or energy protein supplements on the growth of buffalo calves. Twenty four male buffalo calves (10-12 months old) divided in 6 equal groups were individually offered FWS as sole roughage along with either conventional concentrate mixture (conc), maize grains (M), solvent extracted mustard cake (DMC), M-DMC mixture (50:50), deoiled rice bran (DRB) or uromol bran mixture (UBM) in 70:30 ratio. The digestibility of nutrients, nitrogen retention and nutritive value was maximum in FWS:UBM followed by FWS:DMC and FWS:Conc groups. Almost, all the blood parameters were observed well within the normal range except that of blood urea (FWS:UBM) and creatinine (FWS:DMC and FWS:DRB). The dietary combination in which FWS was supplemented with only conventional protein supplement like DMC proved to be highly efficient as far as live weight gain was concerned. FWS supplemented with energy-protein combination i.e. MDMC could also be used as complete feed for growing calves in comparison to conventional feeding system.

• Asian-Australasian Journal of Animal Sciences
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• 제15권9호
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• pp.1307-1311
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• 2002

Twelve dietary combinations were prepared using 70 parts of fermented wheat straw (FWS) as the sole roughage supplemented with 30 parts of either the low protein concentrate mixture (Conc.-I), high protein concentrate mixture (conc.-II), maize grains (M), solvent extracted mustard cake (DMC), deoiled rice bran (DRB), uromol bran mixture (UBM), deep stacked poultry litter (DSPL), dried poultry droppings (DPD), M-DMC mixture (50:50), M-UBM mixture (50:50), M-DPD mixture (50:50) or M-UBM-DPD mixture (50:25:25) and evaluated by in-sacco technique. The above dietary combinations were also evaluated by changing the roughage to concentrate ratio to 60:40. The digestion kinetics for DM and CP revealed that FWS:DPD had the highest, whereas, the FWS:M-DMC had the lowest rapidly soluble fraction. The potentially degradable fraction was found to be maximum in FWS:M and minimum in FWS:DPD dietary combinations. The higher degradation rate of FWS:DRB and FWS:UBM combinations was responsible for their significantly (p<0.05) higher effective degradability as compared to other combinations. The highest undegradable fraction noted in FWS:M-UBM-DPD followed by FWS:DMC was responsible for high rumen fill values. The FWS:DRB, FWS:UBM and FWS:DPD combinations had higher potential for DM intake. The dietary combination with higher concentrate level (60:40) was responsible for higher potentially degradable fraction, which was degraded at a faster rate resulting in significantly higher effective degradability as compared to the corresponding dietary combination with low concentrate level (70:30). The low undegradable fraction in the high concentrate diet was responsible for low rumen fill values, which predicted of high potential for DM intake. Out of 24 dietary combinations, FWS with either of UBM, DRB, DMC, Maize, M-DMC or DPD in 70:30 ratio supplemented with minerals and vitamin A in comparison to conventional feeding practice (roughage and concentrate mixture) could be exploited as complete feed for different categories of ruminants.

• Journal of Applied Biological Chemistry
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• 제61권2호
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• pp.187-190
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• 2018

Two curcumin derivatives, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), isolated from Curcuma longa were analyzed for their inhibitory activities against two isoforms of monoamine oxidase (MAO), which is involved in the catalysis of neurotransmitting monoamines. In the study, DMC and BDMC potently inhibited human MAO-B, with $IC_{50}$ values of 2.45 and $2.59{\mu}M$, respectively, and both compounds showed effective inhibitory activities against human MAO-A, with $IC_{50}$ values of 3.24 and $3.09{\mu}M$, respectively. The inhibitory activities of the two compounds were higher than those of curcumin. The removal of the methoxy or dimethoxy groups in curcumin might increase the inhibitory activities against human MAO-A and MAO-B. The inhibited activities were recovered to almost the values of the reversible references in the dialysis experiments with DMC and BDMC. DMC and BDMC showed competitive inhibition for MAO-A and MAO-B, respectively, with $K_i$ values of 0.91 and $0.80{\mu}M$, respectively. These results suggest that the two curcumin derivatives may be useful or lead compounds in the treatment of related disorders as potent reversible MAO inhibitors.

• 생약학회지
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• 제15권1호
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• pp.15-23
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• 1984

To find antimicrobial strains of the soil microorganisms in Korea, they were isolated from the soil samples of different locations and screened for antibiotic activity against several standard microbes. An isolate among them had an antibacterial activity against gram-positive bacteria. The examination of its morphological and biochemical characteristics according to the International Streptomyces Project methods showed that it belongs to the genus Streptomyces. The strain was named DMC-72. The strain appears to be a new strain when it was compared with the species within the genus which have been so far reported. The antibiotic metabolite of the strain was produced in submerged culture method. It was found to be a quinone compound and was named soulomycin. This strain was also found to produce an ${\alpha}-amylase$ inhibitor in the submerged culture.

• 한국측량학회:학술대회논문집
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• 한국측량학회 2005년도 추계학술대회
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• pp.303-334
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• 2005

• 공업화학
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• 제10권4호
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• pp.620-627
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• 1999

리튬이온전지용 Al 집전체와 비수용성 전해질의 전기화학적 특성을 연구하기 위하여 1 M $LiBF_4$ EC : DMC, 1 M $LiBF_4$ EC : EMC. 1 M $LiPF_6$ EC : DMC. 1 M $LiPF_6$ EC : EMC의 4가지 전해질에서 전압전류 및 임피던스 특성을 조사하였다. Al 집전체는 비교적 넓은 전위창(0.5~4.1 V)에서 안전하지만, 첫 싸이클의 저 전위에서(<2.0 V vs. $Li/Li^{+}$)에서 전해질 내 미량 존재하는 불순물($H_2O$, $O_2$ 등)과 반응하여 계면물질을 생성하며, 리튬염 및 유기용매 또한 일정 전위 범위(<1.5 V vs. $Li/Li^{+}$)에서 Al 집전체와 반응하였다. 특히 전해질내 존재하는 미량의 불순물로 인하여 고 전위에 노출된 Al 집전체의 국부부식이 진행되었다.