• Title/Summary/Keyword: DM loss

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Medical-Nutrition-Therapy for Obese Patients with Type 2 Diabetes Mellitus Undergoing Metabolic Surgery (제2형 당뇨비만환자의 수술요법 시 임상영양치료 프로토콜 설정)

  • Kim, Hye-Jin;NamGung, Sin-A;Hong, Jeong-Im;Mok, Hee-Jung
    • Journal of the Korean Dietetic Association
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    • v.17 no.2
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    • pp.206-215
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    • 2011
  • Currently, metabolic surgery (Laparoscopic Roux-en-Y gastric bypass, LRYGB) has an important role and should be recommended as an intervention in the management of obese patients with type 2 diabetes mellitus (T2DM). A successful outcome of surgery requires medical nutrition therapy. Therefore, we performed a retrospective study on 25 patients with T2DM who underwent LRYGB at Yeouido St. Mary's Hospital from October 2008 to May 2010. The patients were followed up for an average of 6 months after surgery (range: 2~19 months). Diabetes was resolved in 80% of the patients. Percentage of excess weight loss was (%EWL) was 56.2%. After surgery, fasting blood sugar (FBS) and HbA1c were significantly reduced (123 mg/dl, A1c 6.7%, P<0.001) and triglyceride was also significantly reduced to 107.6 mg/dl (P<0.05). As diets of the patients progressed from liquid to soft to regular diet, energy, carbohydrates, and fat intakes increased significantly (P<0.001). But protein intake did not change significantly. Nutrient intake of the patients after the surgery was significantly lower than the recommended diet for the non-surgery group. Patients experienced side-effects related to the diets after surgery, including hair-loss (76%), smelly gas (52%), vomiting (48%), etc. A significantly positive correlation was observed between vomiting and FBS (P<0.001). There was a significant relationship between side effects and the amount of nutrient intakes. Therefore, guide patients to a diet progression with treatment to minimize side effects, especially vomiting. And monitor their dietary life to be healthy and not to regain weight until remission of T2DM.

Effects of Maturing Stage of Corn Hybrids on Silage Yield, Feeding Value for Dairy Cows and Milk Production in a Cold Region of Japan

  • Oshita, Tomoko;Takayama, Hideki;Otsuka, Hiroshi;Igarashi, Hiroaki;Nonaka, Kazuhisa;Kume, Shinichi
    • Asian-Australasian Journal of Animal Sciences
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    • v.20 no.4
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    • pp.511-516
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    • 2007
  • This experiment was conducted to evaluate the effects of differently maturing corn hybrids on silage production and milk production per unit area in the northern part of Japan, where grain development occurs under decreasing ambient temperature. Both hybrids were harvested at the same time. The stages of maturity for the early-maturing hybrids (EH; 80 d relative maturity) and the mid-maturing hybrids (MH; 93 d relative day) were early dent and late dough stage, respectively. The plant yields for MH were higher than those for EH. The dry matter (DM) content of MH was lower than that for EH, and the effluent loss for MH silage was greater than that for EH silage. Therefore, the DM yields of prepared silage per area were similar for both treatments. Twelve multiparous mid-lactation Holstein cows ($58{\pm}13$ days in milk) were fed diets based on EH or MH silage in a crossover design with two 3-week periods. Cows were fed 3 kg of hay crop silage (DM basis) and either EH or MH silage ad libitum, and concentrates were supplied to meet NRC requirement for dairy cows. Silage DM intake for EH was found to be higher (p<0.05) than that for MH (10.0 vs. 9.1 kg/day). Milk production and milk composition for EH were similar to those for MH. Feed efficiency per total feed intake was similar in both treatments, although the feed efficiency per concentrate intake tended to be higher for the EH than that for the MH diet. These results indicate that differences in maturation in corn hybrids affect the effluent production of silage and the silage intake of dairy cows. It may be advantageous to plant early hybrid corn with a reduction in effluent production of silage as well as a reduction in purchased feed costs for dairy cows under the climatic conditions of the northern part of Japan.

The Effect of Pre-Wilting Herbage on the Composition and Feeding Value of Silage (예건의 Silage의 품질에 미치는 영향)

  • 신정남;윤익석
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.3 no.2
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    • pp.92-99
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    • 1983
  • Experiment were conducted to study effect of pre-wilting on the quality of silage. Herbage samples were taken on November 11, 1981. Italian ryegrass and rye plant at grazing stage were taken and wilted to adjust their dry matter contents to the range of 15.8 to 53.2% and ensiled in order to evaluate the effect of pre-wilting on the chemical composition and nutrient loss of silage. Both prewilted and unwilted grass material were ensiled in small polyetylene film bag and stored under room temperature. 1. The formation of total acid decreased by increasing DM content, however, lactic acid content of the total organic acid increased. 2. In the silage, the loss of DM declined as DM content increased. 3. The quality of silage estimated by organic acid constituent was improved as DM content in the herbage increased. 4. The production of $NH_3-N$ decreased by increasing degree of prewilting. 5. In vitro dry matter digestibility was not affected by prewilting.

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Effect of Supplementary Feeding Strategies on the Performance of Stall Fed Dual-purpose Dairy Cows Fed Grass Hay-based Diets

  • Bwire, J.M.N.;Wiktorsson, H.
    • Asian-Australasian Journal of Animal Sciences
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    • v.16 no.3
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    • pp.359-367
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    • 2003
  • Supplementary feeding strategies were evaluated from pre-calving throughout lactation on 24 dual-purpose Mpwapwa breed cows in their second or greater lactation, weighing 246-455 kg. The Mpwapwa breed is an established breed of 4 Bos indicus breeds and 8% of Bos taurus. The cows were penned and stall-fed individually. Eight weeks before calving to eight weeks after calving, the cows were divided into two groups and offered hay ad libitum with either 2 kg DM (L) or 4 kg DM/day (H) concentrates. Nine weeks after calving half of the cows on L-level continued with 2 kg DM/day (L-L) while the remainder received 4 kg DM concentrate daily (L-H). Half of the cows on H-group continued with 4 kg DM/day (H-H) while the remainder received 2 kg DM/day (H-L). The concentrate mixture comprised of sunflower seed cake (33%) and maize bran (67%). The cows consumed all the concentrate offered. Hay DM intake was similar (6.8 kg/day) and tended to decrease the last two weeks before calving increased again after calving. Live weight change and body condition score were similar across treatments before calving but differed after calving (p<0.05). Heavier cows with higher condition score pre-calving had a higher body weight loss and regained weight later. After treatment reallocation, live weight change and condition differed between treatments (p<0.05). Calves were allowed to suckle milk from one quarter. The amount of milk suckled and calf weight gains were not significantly different between treatments. The cows were removed from the experiment when the milk yield was below 4 kg per day. Cows on treatment H produced 6.2 kg and on treatment L 5.0 kg saleable milk/day (p<0.05) during the first 8 weeks post partum. During the period 9-18 weeks post partum the saleable daily milk on H-H, L-H, H-L and L-L were 5.2, 4.8, 4.7 and 4.3 kg, respectively (p>0.05).

The Effects of Two Inoculants Applied to Forage Sorghum at Ensiling on Silage Characteristics

  • Guan, Wu-tai;Ashbell, G.;Hen, Y.;Weinberg, Z.G.
    • Asian-Australasian Journal of Animal Sciences
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    • v.15 no.2
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    • pp.218-221
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    • 2002
  • Whole forage sorghum (saccharatum) cultivar FS5 was harvested at the soft dough ($303{\pm}9g\;kg^{-1}$ DM) stage of maturity. The sorghum was chopped into approximately 20 mm pieces and ensiled under laboratory conditions in 1.5 L Weck glass jars. At ensiling, it was treated with two commercial silage inoculants: Pioneer 1188 (Inoculant A) and Eco-corn (Inoculant B). The inoculant A and B was applied at ca $2{\times}10^5$ or $2{\times}10^4$ colony forming units $g^{-1}$ DM., respectively. Silage with no additives served as a control. Three jars per treatment were opened on days 2, 4, 8, 15 and 60 post-ensiling to study fermentation dynamics. After 60 days of ensiling the silages were analyzed and subjected to an aerobic stability test lasting 5 days. Results showed that both inoculants caused a more rapid rate of pH decrease and a higher amount of lactic acid production. All the silages were well preserved and were stable upon exposure to air. Inoculants did not influence (p>0.05) the ash and total N contents, but tended to reduce acetic acid (p<0.05), butyric acid (p<0.01) and propionic acid (p<0.01) contents, and to increase the lactic acid content (p<0.01). The lower DM content of silages treated with Inoculant A agrees with the greater gas loss resulting from the DM loss, which was in good agreement with the higher yeast counts upon aerobic exposure. Silage treated with inoculant B had the highest DM (p<0.05) and lactic acid contents (p<0.01), and the lowest acetic acid content (p<0.05), which agrees with the rapid reduction of pH and smaller gas loss. Inoculant B reduced the ADF (p<0.01), ADL and NDF (p<0.05) contents, which also indicates smaller losses of organic soluble material. The control silages contained the highest levels of volatile fatty acids but no lactic acid, indicating secondary fermentation. It was concluded that both inoculants may improve the fermentation process, since silages from all treatments were stable upon aerobic exposure, noadvantage could be attributed to any of the inoculants used.

Multi-Criteria Decision Making Procedure under Incompletely Identified Preference Information

  • Ahn, Byeong-Seok;Kim, Jae-Kyeong;Kim, Soung-Hie
    • Journal of the Korean Operations Research and Management Science Society
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    • v.23 no.3
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    • pp.63-73
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    • 1998
  • The paper deals with interactive multiple criteria decision making procedure when decision maker (DM) specifies her or his preference in incomplete ways. Usually DM is willing or able to provide only incomplete information, because of time pressure and lack of knowledge or data. Under incomplete information on utility and attribute weight, the pairwise dominance checks result in strict or weak dominance values. Considering only strict dominance values sometimes fails to Prioritize alternatives because of fuzziness of preference information. Further there exists some information loss useful if used, otherwise. In this paper, we consider the outranking concept which implies the willingness of DM's taking some risk under the least favorable situation because she has enough reasons to admit the results. By comparing the magnitude of net preference degree of alternatives which is defined by difference between outrankings and outranked degree of each alternative, we can prioritize alternatives.

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Effects of Dietary Fiber on Water Balance, Blood Acid-Base Balance, Body Temperature, and Metabolic Rate of Adult Roosters under Heat Stress (사료 섬유질이 고온 스트레스를 받는 수탉 성계의 수분 출납, 혈액의 산-염기 평형, 체온 및 대사율에 미치는 영향)

  • 이지훈;이봉덕;이수기;유동조;현화진
    • Korean Journal of Poultry Science
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    • v.22 no.3
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    • pp.133-144
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    • 1995
  • One metabolism trial(Experiment I) and another respiration trial(Experiment II) were conducted to investigate the effects of dietary fiber supplementation(20% wheat bran) on the water balance, blood acid-base balance, body temperature, and metabolic rate of heat-stressed adult roosters. In Experiment I, twenty 20-wk-old SCWL roosters(BW 1.6 kg) were randomly alloted to 4 treatments with 5 birds per treatment and one per replicate. The 4 treatments were consisted of two temperature(21~22˚C vs. 34~35˚C) and two dietary fiber treatment(0% and 20% wheat bran), making Experiment I a 2x2 factorial. After 4 d of preliminary period, birds we subjected to 3-d collection period. Sixteen 20-wk-old SCWL roosters(BW 1.6 kg) were employed Experiment H, with two temperature(21~22˚C vs. 34~35˚C) and two wheat bran levels(0% and 20%). Brids were housed in individual metabolism cages under normal temperature(21~22˚C), at fed one of the experimental diet. After 4 d of preliminary period, a respiration trial with open-circuit gravimetric respiratory apparatus was carried out for each bird for 6 h, one by one, normal(20~21˚C) and hot(34~35˚C) temperatures. The ANOVA test and comparisons among treatment means were done at 5% probability level for both experiments. Results obtained from Experiment I and, II were summarized as follows, 1.The amounts of DM intake and excretion were significantly(P<.05) decreased by heat stress. The DM intake was not affected by the addition of 20% wheat bran, however, the amount of DM excretion was significantly increased by the high fiber diet. Thus, the DM metabolizability decreased significantly by the addition of 20% wheat bran. 2. The heat-stressed roosters increased the water intake and excreta moisture content significantly. Although not significant, the water intake tended to increase in roosters fed the 20% wheat bran diet. 3. The amounts of total water input and evaporative water loss were increased significantly by heat stress, and the addition of 20% wheat bran did not exert any influence on the total water input and evaporative water loss. However, roosters fed the 20% wheat bran diet increased the excreta water output significantly. 4. Neither the heat stress nor the dietary fiber did affect the blood pH, pCO2, and HCO$_3$- significantly. 5. The body temperature increased significantly by the heat stress. However, the high fiber deit failed to decrease the body temperature. 6. The heat-stressed roosters decreased the 02 consumption and C0$_2$ production, and increased the evaporative water loss significantly. However, the high fiber diet did not exert any infulence in this regard. It appears that the beneficial effect, if any, of high fibrous diet during heat stress episode may be due to the increased heat loss through the enhanced excreta water.

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Fermentative products and bacterial community structure of C4 forage silage in response to epiphytic microbiota from C3 forages

  • Wang, Siran;Shao, Tao;Li, Junfeng;Zhao, Jie;Dong, Zhihao
    • Animal Bioscience
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    • v.35 no.12
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    • pp.1860-1870
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    • 2022
  • Objective: The observation that temperate C3 and tropical C4 forage silages easily produce large amounts of ethanol or acetic acid has puzzled researchers for many years. Hence, this study aimed to assess the effects of epiphytic microbiota from C3 forages (Italian ryegrass and oat) on fermentative products and bacterial community structure in C4 forage (sorghum) silage. Methods: Through microbiota transplantation and γ-ray irradiation sterilization, the irradiated sorghum was treated: i) sterile distilled water (STSG); ii) epiphytic microbiota from sorghum (SGSG); iii) epiphytic microbiota from Italian ryegrass (SGIR); iv) epiphytic microbiota from oat (SGOT). Results: After 60 days, all the treated groups had high lactic acid (>63.0 g/kg dry matter [DM]) contents and low pH values (<3.70), acetic acid (<14.0 g/kg DM) and ammonia nitrogen (<80.0 g/kg total nitrogen) contents. Notably, SGIR (59.8 g/kg DM) and SGOT (77.6 g/kg DM) had significantly (p<0.05) higher ethanol concentrations than SGSG (14.2 g/kg DM) on day 60. After 60 days, Lactobacillus were predominant genus in three treated groups. Higher proportions of Chishuiella (12.9%) and Chryseobacterium (7.33%) were first found in silages. The ethanol contents had a positive correlation (p<0.05) with the abundances of Chishuiella, Acinetobacter, Stenotrophomonas, Chryseobacterium, and Sphingobacterium. Conclusion: The epiphytic bacteria on raw materials played important roles in influencing the silage fermentation products between temperate C3 and tropical C4 forages. The quantity and activity of hetero-fermentative Lactobacillus, Chishuiella, Acinetobacter, Stenotrophomonas, Chryseobacterium, and Sphingobacterium may be the key factors for the higher ethanol contents and DM loss in silages.

Evaluation of Y-Cap Capacitance in EMI Filter Design Using Measured S-Parameter (측정된 S-파라메터를 이용한 EMI 필터의 Y-캡 용량 산정에 대한 연구)

  • Kim, Jonghyeon;Jeon, Jiwoon;Kim, Taeho;Kim, Sungjun;Nah, Wansoo
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.25 no.3
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    • pp.319-332
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    • 2014
  • Insertion loss is used as the character to express the efficiency of EMI filter. In this paper, we studied the better method that can measure the insertion loss of EMI filter exactly than the original method. For the achievement of this, the method measuring both common mode(CM) and differential mode(DM) insertion loss with arbitrary input/output impedance is accomplished using a 4-ports S-parameters system for consideration of unbalanced factor. Using this method, when input/output used in specific system is known, CM/DM insertion loss of EMI filter inserted in the system can be calculated. Finally, we applied 4-ports modeling method to 'X/Y capacitor part' and suggested the algorithm for selecting suitable the value of Y-capacitor using mixed mode S-parameters and mixed mode chain S-parameters.

The Herbal Formula C-DM3 Improves the Changes of Diabetes-Related Biomarkers in High-Fat Diet-Induced Obese Mice through Regulation of the IRS1/PI3K/AKT and AMPK Signaling Pathways in the Liver and Pancreas (고지방식이를 통해 비만이 유발된 마우스에서 C-DM3 복합추출물의 항비만 및 항당뇨 효능 연구)

  • Yoon Yong Choi;Chenzi Lyu;Tong Zhang;Haifeng Shao;Xianglong Meng;Chu Duc Thanh;Jong-Seong Kang;Hyo Won Jung;Yong-Ki Park
    • Journal of Korean Medicine for Obesity Research
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    • v.24 no.1
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    • pp.25-40
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    • 2024
  • Objectives: In the present study, we investigated the effects of clean-diabetes mellitus 3 (C-DM3), a herbal formula with Trichosanthis Radix, Coptidis Rhizoma, Crataegi Fructus, and Cinnamomi Cortex, on the pathological and serological symptoms of diabetes and its related molecular mechanisms in diet-induced obese mice. Methods: We prepared an obese mouse model using a high-fat diet for 8 weeks and then administered the C-DM3 extract for 4 weeks. The changes of pathological and serological biomarkers for diabetes assessment were measured in the mice and histological changes were observed in the liver and pancreas tissues. We also identified the main compounds in the C-DM3 extract using high pressure liquid chromatography (HPLC) and analyzed the molecular mechanism of the disease condition by network pharmacological analysis. Results: In the in vivo, the administration of C-DM extract to obese mice significantly reduced body weight gain, fatty liver symptoms, and muscle loss, and decreased the levels of fasting blood glucose, insulin, aspertate aminotransferase, triglycerides, and low-density lipoprotein-cholesterol. In addition, C-DM extract significantly increased the phosphorylation of insulin receptor substrate 1, protein kinase b (AKT), phosphoinositide 3-kinase (PI3K), adenosine monophosphate-activated protein kinase, and glucose transporter 4 in all pancreatic and liver tissues, with inhibition of histopathological changes in obese mice. HPLC analysis identified hyperoside, berberine, epiberberine, columbamin, coptisine, coumarin, jatrorrhizine, and citric acid as the main compounds. In the network pharmacological analysis, the molecular targets of C-DM3 extract on obesity and diabetes were shown as the insulin, AKT, PI3K, and mitogen-activated protein kinase pathways with the regulation of inflammatory molecules interleukin 6 (IL-6), jun proto-oncogene, and IL-1β, which matched our in vivo targets. Conclusions: Based on these results, C-DM3 extract is expected to be effective in improving obesity and preventing diabetic progression.