• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5895-5900
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• 2013

Dictamnine (Dic) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells and dihydroartemisinin (DHA) also has potent anticancer activity on various tumour cell lines. This report explores the molecular mechanisms by which Dic treatment and combination treatment with DHA and Dic cause apoptosis in human lung adenocarcinoma A549 cells. Dic treatment induced concentration- and time-dependent cell death. FCM analysis showed that Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (${\Delta}{\Psi}m$) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis. Combination treatment with DHA and Dic dramatically increased the apoptotic cell death compared to Dic alone. Interestingly, pretreatment with z-DQMD-fmk significantly attenuated DHA and Dic co-induced apoptosis, implying that caspase-3 plays an important role in Dic and DHA co-induced cell apoptosis. Collectively, we found that Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which mitochondria and caspase were not involved and DHA enhanced Dic induced A549 cell apoptosis via a caspase-dependent pathway.

• 인터넷정보학회논문지
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• 제19권1호
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• pp.105-111
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• 2018

건축 구조물의 상대적인 변위 계측을 위하여 2메가 픽셀 Full HD(FHD) 해상도의 카메라와 디지털 영상상관(DIC, Digital Image Correlation) 플랫폼을 설계하고, 계측에 영향을 주는 영상 품질을 분석하였다. DIC 플랫폼은 Freescale사의 I.MX6를 기반으로 설계하였다. 영상 상관을 이용한 계측은 영상의 품질에 따라 계측 정밀도에 영향을 줄 수 있는데, 이러한 영상 품질 요인으로 영상의 밝기(brightness), 대조(contrast), 신호대 잡음비(SNR, Signal to Noise Ratio)를 분석하였다. 관심 영역(ROI, Region Of Interest)으로 설정한 부분에서 추출한 영상을 기준 영상으로 삼고, 일정 시간 경과 후 디지털 영상 상관(DIC)을 이용하여 기준 영상의 이동을 화소 및 부화소 단위로 추적 계산하여 변위를 측정하였다. 더불어 DIC 기반의 비접촉 원격 계측의 유효성을 파악하기 위하여 25m, 35m, 50m의 계측 거리에서, 영상 품질 요인 및 ROI 의 크기를 조정하여 측정을 하고 정밀도를 분석하였다.

• Structural Engineering and Mechanics
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• 제69권4호
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• pp.467-477
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• 2019

Digital image correlation (DIC) is now a popular and extensively used full-field metrology technique. In general, DIC is performed by using a turnkey solution offered by various manufacturers of DIC. In this paper, a simple and economical set-up for DIC is proposed which uses easily accessible digital single-lens reflex (DSLR) camera rather than industrial couple-charged device (CCD) cameras. The paper gives a description of aspects of carrying a DIC experiment which includes experimental set-up, specimen preparation, image acquisition and analysis. The details provided here will be helpful to carry DIC experiments without specialized DIC testing rig. To validate the responses obtained from proposed DIC set-up, tension and fatigue tests on specimens made of IS 2062 Gr. E300 steel are determined. Tensile parameters for a flat specimen and stress intensity factor for an eccentrically-loaded single edge notch tension specimen are evaluated from results of DIC experiment. Results obtained from proposed DIC experiments are compared with those obtained from conventional methods and are found to be in close agreement. It is also noted that the high resolution of DSLR allows the use of proposed approach for fracture characterization which could not be carried out with a typical turnkey DIC solution employing a camera of 2MP resolution.

• 한국항공우주학회지
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• 제49권8호
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• pp.617-626
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• 2021

비행체의 초음속 비행 중 고온 환경에서의 열 거동은 비행체의 열 구조 설계에 중요하다. 본 연구에서는 전역-국부 다중 디지털 이미지 상관기법을 사용하여 노치 구조물의 전 영역의 열변형 및 응력집중 현상에 대해 관찰/분석하였다. 다중 DIC 시스템은 2D DIC 시스템과 3D DIC 시스템으로 구성되었다. 가열 챔버를 이용하여 노치 시편을 가열하였으며 여러 온도에서 다중 DIC 시스템을 사용하여 구조물의 변형 이미지를 촬영하고 분석하였다. 다중 DIC 기법을 사용하여 노치 시편의 전 영역 변형률과 노치 부위의 응력집중 현상을 계측/분석하였으며 ABAQUS^TM 프로그램을 이용하여 노치 시편에 대해 유한요소해석을 진행하고 실험결과와 비교 분석하였다. 본 연구를 통해 다중 DIC 시스템의 열변형 계측과 응력 집중 현상의 연구 분석에서의 활용 가능성을 보여주었다.

• 한국주거학회논문집
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• 제27권6호
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• pp.95-104
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• 2016

The purpose of this research is to compare housing wealth effects of home-owning single income couples (SIC) and dual income couples (DIC) on their non-durable consumption and to assess the effects by location, age groups, housing structure type, debt-to-asset ratio and employment status. Using the Korean Labor and Income Panel Study (KLIPS) of 2014, this empirical study identified 1,198 SIC households and 1,044 DIC households, and employed multiple regression analysis. The main results reveal that the difference of financial portfolios between SIC and DIC households was little but housing wealth effects were stronger among SIC households than DIC counterpart. It's evident that housing wealth effects were conspicuous for SIC and DIC households who were headed by wage earners aged over 40s, and resided in apartment outside the Seoul Metropolitan Area. However, household debt became a determinant in contradicting housing wealth effects of SIC and DIC households. While the household financial dimension was in proportion to income, DIC households didn't gain much financial security due to increasing expenditure. Further, this research imply that liquidity constraints explicitly posed a more serious threat to SIC households whose dependence on housing asset is larger than their counterpart.

• 한국안전학회지
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• 제29권5호
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• pp.15-21
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• 2014

The aim of this work is conduct the study on light weight and structural performance improvement of the composite wind power blade. GFRP (Glass Fiber Reinforced Plastic) pre-empted by CFRP(Carbon Fiber Reinforced Plastic), the major material of wind power blade, was identified the superiority of mechanical performance through the tensile and fatigue test. SENT(Single Edge Notched Tension) specimen fracture test was conducted on the specimen that laminated together 2 ply CFRP with 4 ply GFRP through DIC(Digital Image Correlation) analysis. The SENT specimen thickness and $a_0/W$ ratio is 1.45 mm and 0.2, respectively. The fracture test accomplished with displacement control with 0.1 mm/min at the room temperature. The experimental apparatus used for the fracture test consisted of a 50kN universal dynamic tester and CCD camera connected to a personal computer (PC), which was used to record images of the specimen surface. Following data acquisition, the images and load-displacements were transferred to the PC, on which the DIC software was implement. The experiment and DIC analysis results show that CFRP/GFRP laminated composite exhibits improvement of the strength, compared with that of the existing blade material. This study shows the result that the strength of CFRP rotor blade of wind turbine satisfies through the experimental and DIC method.

• 한국산학기술학회논문지
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• 제18권4호
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• pp.391-397
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• 2017

최근의 DIC (Digital Image Correlation) 기술은 인장 시험 중 동적 변형을 측정하는 데 사용되고 있다. 표준 인장 시험 방법은 진응력 - 진변형 곡선을 계산하기 위해 두 표점 거리 간 측정된 평균 변위를 사용한다. 따라서, 진응력 곡선은 균일 연신 구간, 즉 네킹 변형 시작점까지만 유효하다. 반면에, DIC를 사용한다면, 전체 측정 영역에서 국부 변형을 측정할 수 있기 때문에 변형률 및 변형률 속도의 유효한 범위가 인장 시편이 파단될 때까지 확장될 수 있다. 이러한 장점 때문에 연구 및 산업 분야에서 많은 광학 3D 측정 시스템이 도입되고 사용되었지만 기존의 3D 측정 시스템은 측정하기에 너무 비싸고 시간이 많이 소요된다. 또한 장비 크기로 인해 휴대가 불편한 단점이 존재한다. 본 논문에서는 기존의 스마트 폰을 이용한 2D DIC 측정 방법과 수치 해석 기법을 사용하여 2D 측정 영상 데이터의 오차를 개선한 2D 영상 보정 방법을 수행 하였다. 2D DIC 수정 제안 된 방법의 결과는 3D 측정 장비의 정확도에 비해 더 높은 정확도를 보였다. 결론적으로, 제안 된 2D DIC 및 보정 방법이 정확하고 신속한 측정 결과를 제공한다는 것이 입증되었다.

• Corrosion Science and Technology
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• 제23권2호
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• pp.113-120
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• 2024

An attempt was made to apply digital image correlation (DIC) strain analysis to in-situ scanning electron microscopy (SEM) observations of bending deformation to quantify local strain distribution inside a ZnMgAl-alloy coating in deformation. Interstitial-free steel sheets were hot-dipped in a Zn-3Mg-6Al (mass%) alloy melt at 400 ℃ for 2 s. The specimens were deformed using a miniature-sized 4-point bending test machine inside the SEM chamber. The observed in situ SEM images were used for DIC strain analysis. The hot-dip ZnMgAl-alloy coating exhibited a solidification microstructure composed of a three-phase eutectic of fine Al (fcc), Zn (hcp), and Zn2Mg phases surrounding the primary solidified Al phases. The relatively coarsened Zn₂Mg phases were locally observed inside the ZnMgAl-alloy coating. The DIC strain analysis revealed that the strain was localized in the primary solidified Al phases and fine eutectic microstructure around the Zn₂Mg phase. The results indicated high deformability of the multi-phase microstructure of the ZnMgAl-alloy coating.

• Computers and Concrete
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• 제17권6호
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• pp.831-848
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• 2016

This study aims to characterize the multiple cracking behavior of HTPP-ECC (High tenacity polypropylene fiber reinforced engineered cementitious composites) by Digital Image Correlation (DIC) Method. Digital images have been captured from a dogbone shaped HTPP-ECC specimen exhibiting 3.1% tensile ductility under loading. Images analyzed by VIC-2D software and ${\varepsilon}_{xx}$ strain maps have been obtained. Crack widths were computed from the ${\varepsilon}_{xx}$ strain maps and crack width distributions were determined throughout the specimen. The strain values from real LVDTs were also compared with virtual LVDTs digitally attached on digital images. Results confirmed that it is possible to accurately monitor the initiation and propagation of any single crack or multiple cracks by DIC at the whole interval of testing. Although the analysis require some post-processing operations, DIC based crack analysis methodology can be used as a promising and versatile tool for quality control of HTPP-ECC and other strain hardening composites.

• Structural Engineering and Mechanics
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• 제45권4호
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• pp.471-494
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• 2013

In this paper, identification of isotropic and orthotropic linear elastic material constitutive parameters has been demonstrated by a FEA-free energy-based inverse analysis method. An important feature of the proposed method is that it requires no finite element (FE) simulation of the tested material. Full-field displacements calculated using digital image correlation (DIC) are used to compute DIC stress fields enforcing the equilibrium condition and DIC strain fields using interpolation functions. Boundary tractions and displacements are implicitly recast into an objective function that measures the energy residual of external work and internal elastic strain energy. The energy conservation principle states that the residual should be zero, and so minimizing this objective function inversely identifies the constitutive parameters. Synthetic data from simulated testing of isotropic materials and orthotropic composite materials under 2D plane stress conditions are used for verification of the proposed method. When identifying the constitutive parameters, it is beneficial to apply loadings in multiple directions, and in ways that create non-uniform stress distributions. The sensitivity of the parameter identification method to noise in both the measured full-field DIC displacements and loadings has been investigated.