• Journal of Advanced Marine Engineering and Technology
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• v.32 no.8
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• pp.1185-1191
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• 2008

The core design technology for the multi-effect desalination plant using the thermo compressor (MED-TVC) was investigated by the performance test of multi effect desalination plant in this paper. The final G.O.R (gain of output ratio) of MED-TVC type desalination plant is strongly affected by the performance of thermo-vapor compressor. The present experiments for the desalinating capacity and G.O.R were obtained for the range of the motive steam pressure, 266.0, 250.0, 230.0 and 200.0 kPa. And as a practical problem, to investigate the influence of the sea water temperature to the G.O.R, the inlet steam temperature of the suction water vapor was changed in the range of $311.2{\sim}324.2$ K in the present experiment. Through the experiments, the maximum value of G.O.R was 8.5 at the condition of the motive steam pressure, 136.0 kPa and the minimum value of G.O.R was 8.1 at the condition of the motive steam pressure, 266.0 kPa. And it was confirmed that the range of desalination capacity was $355.2{\sim}264.0$ ton/day in the normal operation condition.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.12
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• pp.1829-1836
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• 2010

The district heating system distributes the heat generated from a cogeneration plant to wider locations. In this process, the district heating pipe (DHP) is subjected to internal and external loadings. The internal loadings are generally caused by the operating conditions such as water temperature and internal pressure. Frictional interactions between the pipes and the soil contribute to the external loadings. Thus, investigation of the mechanisms of failure of DHPs will help to guarantee both mechanical stability and heating efficiency. In this study, we investigate the local buckling of DHPs using limit state design (LSD). Two methods are considered: the use of the limit state for the width-thickness ratio and the use of the limit state for the strain. The results are used to confirm that the DHP is stable under local buckling. Finally, we suggest a minimum preheating temperature for avoiding local buckling.

• Microbiology and Biotechnology Letters
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• v.34 no.4
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• pp.352-356
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• 2006

CW-270031, an injectable carbapenem, is a novel synthesized pyrrolidinyl-thio carbapenems. It was evaluated for its in vitro antibacterial activities in comparison with those of imipenem and meropenem against standard strains and clinical isolated strains, CW-270031 was more active than imipenem against gram-negative (E. coli and Klebsiella oxytoca) clinical isolates, but it was slightly active than meropenem. Against Klebsiella aeruginosa CW-118 MIC were 0.048 $\mu$g/ml for CW-270031, 0.19 $\mu$g/ml for imipenem. Against clinical E. coli MIC range were 0.012$\sim$0.195 $\mu$g/ml for CW-270031, 0.097$\sim$0.39 $\mu$g/ml for imipenem. Against clinical Klebsiella oxytoca MIC$_{50}$ were 0.09 $\mu$g/ml for CW-270031, 0.39 $\mu$g/ml for imipenem. Against gram-positive standard strains and clinical CW-270031 was slightly more activity than meropenem, but CW-270033 was less active than imipenem against these tested isolates. The subcutaneous injection of CW-270031 in mice revealed that the half-life of CW-270031 in serum was about 13 min, long than that of meropenem (10.6 min). CW-270031. was stable to hydrolysis by dog renal dehydropeptidase I (DHP-l) enzyme, to an more stabilities shown by meropenem.

• Animal cells and systems
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• v.11 no.2
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• pp.117-124
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• 2007

The present study demonstrates the changes in body weight (BW) and plasma sex steroid hormone profiles during artificial maturation induced by human chorionic gonadotropin (HCG) or salmon pituitary extract (SPE) injections in cultured eel, Anguilla japonica, kept in seawater for 3 months. In the weekly SPE-injected female group, BW was relatively stable during vitellogenesis. Following induction of vitellogenesis, females exhibited a rapid increase of BW, and the oocytes were observed to be in the migratory nucleus stage at the end of the experiment. Plasma testosterone (T) and $estradiol-17{\beta}$ ($E_2$) levels increased slightly during vitellogenesis and peaked at an average of 5.82 ng/mL and 4.76 ng/mL, respectively, at the end of the experiment. In the weekly control and HCG-injected female groups, BW slowly decreased during the experimental period, and the oocytes of the two groups were observed to be at the primary yolk globule stage. In the weekly HCG-injected female group, plasma T and $E_2$ levels increased slightly during vitellogenesis and decreased afterward. In the control female group, however, plasma T and $E_2$ levels were not altered during the experimental period. Furthermore, plasma $17{\alpha},20{\beta}-dihydroxy-4-pregnen-3-one$ (DHP) was not detected in all experimental groups. Fertility and hatching rates of SPE-injected females were significantly higher in those that ovulated 15 h after DHP injection than 18 h. These results indicate that long rearing in seawater increases responsiveness to SPE in ovarian maturation of the Japanese eel, resulting in shortened period from completion of vitellogenesis by sex steroid hormone production.

• Journal of Advanced Marine Engineering and Technology
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• v.32 no.6
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• pp.893-900
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• 2008

The heat exchangers in the ships have been changed from the conventional shell & tube type to the plate type due to some merits as a compactness, a high thermal efficiency and a light-weight. In recent. it is reported that the vacuum phenomena were occurred in the seawater outlet piping of a main central cooler (MCC) on the ships. From the viewpoints of a common sense, the vacuum pressure in the seawater piping is rare event and difficult to be convinced because the seawater is pumped into the piping by a seawater pump with a high discharge head. However, the occurrence of a vacuum pressure in the seawater line of an MCC is real situation and often gives a severe damage to a rubber gasket of an MCC with a plate type heat transfer area. In this study, we analyzed the vacuum pressure in the seawater line of an MCC by using the simpl Bernoulli's equation and found that the vacuum pressure in the seawater line of an MCC is inevitable untill the installation postion of an MCC is not lowered.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.39 no.6
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• pp.466-471
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• 2006

We investigated the changes in body weight (BW), plasma sex steroid hormone profiles, and testicular development of cultured male eel Anguilla japonica during an artificial maturation process. Eels that received weekly intraperitoneal injections of eel's ringer solution containing human chronic gonadotropin (HCG) were examined. In the ringer-treated control, BW changes decreased slowly during the experimental period. Plasma testosterone (T), 11-ketotestosterone (11-KT) and $17{\alpha},\;20{\beta}$-dihydroxy-4-pregnen-3-one (DHP) levels In the control remained low and did not show significant changes. Moreover, all germ cells in the testes of the control were spermatogonia. In the HCG-treated male eels, however, BW changes increased gradually from the fifth week and then decreased slowly. The plasma T level increased rapidly (p<0.05) in the second week and then decreased slowly. The plasma 11-KT level increased dramatically (p<0.05) in the second week and was maintained until the end of the experiment. The plasma DHP level increased progressively from the second week and peaked in the eighth week (p<0.05). The testes of HCG-treated male eels were more developed than those of the control; most were at the spermatozoa and spermatid stages and showed active spermiation. Thus, spermatogenesis and spermiation in the cultured eel can be induced by repeated injections of HCG.

• Biomolecules & Therapeutics
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• v.15 no.3
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• pp.156-161
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• 2007

Rapid advances in pharmacogenomic research have provided important information to improve drug selection, to maximize drug efficacy, and to minimize drug adverse reaction. The SNPs that are the most abundant type of genetic variants have been proven as valid biomarkers to give information on the prediction of pharmacokinetic/pharmacodynamic properties of drugs based on genotype. In order to elucidate a correlation between SNPs of calcium channel encoding gene and adverse reactions of calcium channel blockers, we investigated SNPs in CACNA1C gene known as a binding site of calcium channel blocker. 96 patients with hypertension who had taken or are taking an antihypertensive drug, 1,4-dihydropyridine (DHP) were included for analysis. These patients were composed of 47 patients with adverse drug reactions (ADR) such as edema from calcium channel blockers and 49 patients without ADR as a control group. The exons encoding the drug binding sites were amplified by PCR using specific primers, and SNPs were analyzed by direct sequencing. We found that there was no SNP in the exons encoding DHP binding site, but four novel SNPs in the exon-intron junction region. However, four novel SNPs were not associated with the ADR of calcium channel blockers. In conclusion, this study showed that ADR from calcium channel blockers may not be caused by SNPs of the binding sites of calcium channel blockers in CACNA1C gene.

• Journal of Ocean Engineering and Technology
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• v.32 no.6
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• pp.419-426
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• 2018

Recently, in an effort to reduce the energy efficiency design index (EEDI), studies on energy saving devices (ESDs) have been conducted. In this study, we designed a post-device suitable for a KRISO container ship (KCS) using computational fluid dynamics (CFD). In order to increase the efficiency of the post-device, a twisted rudder was used, which has a proven performance (showing a 1.34% reduction in DHP compared to the bare hull at 24 knots) in previous research at Pusan National University. In addition, an increase in efficiency was expected by the use of a rudder bulb, including the discontinuous section of the twisted rudder and a divergent propeller cap to prevent the contraction of the wake. The optimization criterion was the case where the delivery power was the least compared with the bare hull. We analyzed the cause of the efficiency increase through an analysis of the self-propulsion factor. The case study for optimization was divided into 4 types (1. clearance of the bulb and cap, 2. shape of the bulb, 3. size of the bulb and cap, and 4. asymmetric bulb). Finally, with a clearance of 50 mm from the ship, a spherical bulb with the cap having an angle of $5^{\circ}$, and an asymmetric rudder bulb with a bulb diameter of 1.2HH/1.4H (horizontal/vertical) showed a 2.05% reduction in DHP compared to the bare hull at 24 knots. We will fabricate a post-device that will be optimized in the future and verify the performance of the post-device through model tests.

• Journal of Broadcast Engineering
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• v.27 no.2
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• pp.174-184
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• 2022

3D human pose estimation models can be classified into a multi-view model and a single-view model. In general, the multi-view model shows superior pose estimation performance compared to the single-view model. In the case of the single-view model, the improvement of the 3D pose estimation performance requires a large amount of training data. However, it is not easy to obtain annotations for training 3D pose estimation models. To address this problem, we propose a method to generate pseudo ground-truths of multi-view human pose data from a multi-view model and exploit the resultant pseudo ground-truths to train a single-view model. In addition, we propose a multi-view consistency loss function that considers the consistency of poses estimated from multi-view images, showing that the proposed loss helps the effective training of single-view models. Experiments using Human3.6M and MPI-INF-3DHP datasets show that the proposed method is effective for training single-view 3D human pose estimation models.

• Journal of Aquaculture
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• v.19 no.4
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• pp.267-274
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• 2006

To understand the changes in plasma levels of sex steroids in the wild Japanese eel Anguilla japonica during artificially maturing process, eels received weekly intraperitoneal injections of a water-in-oil (W/O) type emulsion with Freund`s incomplete adjuvant containing salmon pituitary extract (SPE; 20 mg pituitary powder/fish) were examined. In the weekly Eel's Ringer-treated control wild eels, the body weight (BW) changes of fish decreased slowly during the experiment period. Plasma testosterone (T), $estradiol-17{\beta}\;(E_2)$ and $17a,20{\beta}-dihydroxyprogesterone$ (DHP) levels did not change significantly at the end of the experiment. In the weekly SPE-treated silver eels, however, rapid increase in BW changes occurred after 6 to 10 weeks, and the oocytes of all fish were observed to be in the migratory nucleus stage. Furthermore, significant increase in sex steroid hormones (T and $E_2$) levels occurred from 6 weeks. In the weekly SPE-treated yellow eels, the BW changes of fish increased slowly at 6 weeks and then increased. In these fish, the oocytes were at the tertiary yolk globule stage even at the end of the experiment. Plasma sex steroid hormones profiles revealed individual variability in SPE-treated yellow eels. Plasma T and $E_2$ levels significantly increased at 8 weeks and after 6 weeks, respectively, in SPE-treated yellow eels. In the weekly SPE-treated wild eels (silver and yellow eels), however, plasma DHP levels did not change significantly during the experiment period. In silver eel, final maturation could be induced by weekly administration of SPE using W/O type emulsion.