• Title/Summary/Keyword: DH

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Convenient Preparation of Tumor-specific Immunoliposomes Containing Doxorubicin

  • Nam, Sang-Min;Cho, Jang-Eun;Son, Byoung-Soo;Park, Yong-Serk
    • BMB Reports
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    • v.31 no.1
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    • pp.95-100
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    • 1998
  • Two innovative methods to prepare target-sensitive immunoliposomes containing doxorubicin by coupling monoclonal antibodies (mAb DH2, SH1) specific to cancer cell surface antigens ($G_{M3}$, $Le^X$) have been developed and are described here. Firstly, liposomes containing N-glutaryl phosphatidylethanolamine (NGPE) were prepared, followed by the encapsulation of doxorubicin, DH2 or SH1 antibodies were conjugated to NGPE in the liposomes (direct coupling). Secondly, liposomes were prepared with NGPE/mAb conjugates by the detergent dialysis method (conjugate insertion), and then doxorubicin was encapsulated by proton gradient. The immunoliposomes prepared by both methods were able to specifically bind to the surface of the tumor cells - B16BL6 mouse melanoma cells. The efficiencies of doxorubicin-entrapping into liposomes prepared by direct coupling and conjugate insertion was about 98% and 25%, respectively. These types of liposomal formulation are sensitive to target cells, which can be useful for various clinical applications.

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A study on the InGaAsP/InP MQW-LD fabrication by the liquid phase epitaxy (액상결정성장에 의한 InGaAsP/InP MQW-ND 제작에 관한 연구)

  • 조호성;홍창희;오종환;예병덕;이중기
    • Korean Journal of Optics and Photonics
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    • v.3 no.4
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    • pp.252-257
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    • 1992
  • In this study, InGaAsP/InP MQW-DH wafer was grown by a vertical type LPE system and 10$\mu$m stripe MQW-LD was fabricated with the wafer. The threshold current was about 200 mA and when the cavity length of the LD was 470$\mu$m the central wavelenth of gain spectra was 1.32$\mu$m the lasing wavelength was 1.302$\mu$m which corresponded to the gain center of the quantum well thickness of 300 $\AA$.

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A simple nonlinear model for estimating obturator foramen area in young bovines

  • Pares-Casanova, Pere M.
    • Korean Journal of Veterinary Research
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    • v.53 no.2
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    • pp.73-76
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    • 2013
  • The aim of this study was to produce a simple and inexpensive technique for estimating the obturator foramen area (OFA) from young calves based on the hypothesis that OFA can be extrapolated from simple linear measurements. Three linear measurements - dorsoventral height, craneocaudal width and total perimeter of obturator foramen - were obtained from 55 bovine hemicoxae. Different algorithms for determining OFA were then produced with a regression analysis (curve fitting) and statistical analysis software. The most simple equation was OFA ($mm^2$) = [3,150.538 + ($36.111^*CW$)] - [147,856.033/DH] (where CW = craneocaudal width and DH = dorsoventral height, both in mm), representing a good nonlinear model with a standard deviation of error for the estimate of 232.44 and a coefficient of multiple determination of 0.846. This formula may be helpful as a repeatable and easily performed estimation of the obturator foramen area in young bovines. The area of the obturator foramen magnum can thus be estimated using this regression formula.

Cloning and Base Sequence Determination of Replication Initiation Gene (rep) Isolated from Staphylococcus aureus DH1 R-plasmid pSBK203 (Staphylococcus aureus DH1에서 분리된 R-plasmid pSBK203의 복제 개시 유전자(rep) 분리 및 염기서열 결정)

  • Park, Seung-Moon;Kwon, Dong-Hyun;Byeon, Woo-Hyeon
    • Korean Journal of Microbiology
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    • v.31 no.1
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    • pp.44-47
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    • 1993
  • A replication initiation gene was identified and its nucleotide sequence has been determined from a 3.8 kb, chloramphenicol acethyltransferase conferring R-plasmid pSBK203 of Staphylococcus aures. Location of the replication related region of pSBK 203 was determined by interuption with pUC 119 at XBaI and MspI sites which resulted in inactivation of replication in Bacilius subtilis. Base sequence of this region revealed on open reading frame of 942 base pairs, which encoded a 314 amino acid protein. Base sequence homology with other rep of pT181 family plasmids such as pT181, pC221, pC223, pS194, pU112, and pCW7 was ranged from 78% to 97% and the predicted amino acid sequence homology was from 72% to 95%.

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Outdoor Testing and Degradation of EVA and POE Encapsulated Photovoltaic Modules (옥외 관측을 통한 EVA, POE PV모듈의 열화 연구)

  • Kim, Jeha
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.29 no.12
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    • pp.847-852
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    • 2016
  • Using both EVA and POE encapsulants, we fabricated polycrystalline Si PV modules and performed a set of reliability tests of PID, DH, TC, and Complex prior to outdoor installation. The power output with temperatures and insolation as well as I-V characteristics had been monitored under outdoor environments for 18 months. In the entire period, the total power of 3,576 kWh from POE PV modules was observed larger than 3,449 kWh from EVA PV modules by 3.5%. All the PV modules showed a 5.6~9.2% drop in the conversion efficiency. As for the solar power generation, the PV modules performed through PID, TC test revealed distinct difference in between EVA and POE for which the POE PV module produced more power by +11.4% and +6.6%, respectively, as measured in the 18th month. In addition, POE was proved to protect better the solar cells under PID influence.

An Algorithm for Secure key Exchange based on the Mutual Entity Authentication (상호 실체인증 기능을 갖는 안전한 키 교환 알고리즘)

  • Kang, Chang-Goo;Choi, Yong-Rak
    • The Transactions of the Korea Information Processing Society
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    • v.5 no.8
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    • pp.2083-2090
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    • 1998
  • In this paper, we propose two authentication exchange schemes which combine public key-based mutual authentication with a Diffie-Hellman key derivation exchange. The security of key exchange of the proposed schemes depends on the discrete logarithm problem. The ,securtly of the etity authentication depends on that of the signature mechanism to be used in the proposed scheme. In comparisun with the Kerberos, X.509 exchanges, and ISO 3-way authentication protocol, the proposed schemes are not only simple and efficient. but also are resistant to the full range of replay and interceptiun attacks.

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THE DEVELOPMENT OF FOAMING AGENTS USING SLES & DH-109EX

  • Hu Rui;Kim, Jeong-Hun;Kim, Min-Kyn;Kang, Young-Goo;Kim, Hong
    • Proceedings of the Korea Institute of Fire Science and Engineering Conference
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    • 1997.11a
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    • pp.582-589
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    • 1997
  • Experiments were conducted to develop foaming agents by using SLES and DH-l09EX as raw material. PG (Propylene glycol) and BC (Butyl cellusolve) were adopted as subsidiary material. The undiluted foam solution was produced with these materials. This solution determined the expansion ratio, viscosity, drainage time and extinguishing ability of the final product. The results indicate that the expansion ratio is over 16 and drainage time is over one minute. The extinguishing ability for SLES system was succeeded in the unit of B-0.5.

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SURFACE ROUGHNESS EFFECTS ON THE COERCIVITY OF THIN FILM HEADS

  • Kim, Hyunkyu;Horvath, M. Pardavi
    • Journal of the Korean Magnetics Society
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    • v.5 no.5
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    • pp.663-666
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    • 1995
  • The domain wall motion coercivity, $H_{c}$, of magnetic materials arises from the dependence of the wall energy on localized changes in material parameters (magnetization, anisotropy, exchange energy densities). However, in an otherwise perfectly homogeneous material, the domain wall energy might change due to the change in the volume of the wall versus the wall position. Thus, any surface roughness contributes to the coercivity. Assuming different two-dimensional surface profiles, characterized by average wavelengths ${\lambda}_{x}$ and ${\lambda}_{y}$, and relative thickness variations dh/h, the coercivity due to the surface roughness has been calculated. Compared to the one dimensional case, the 2D coercivity is reduced. Depending on the ratio of ${\lambda}$ to the domain wall width, $H_{c}$ has a maximum around 2, and increasing with dh/h. With the decreasing thickness of the thin film and GMR heads, it might be the domain factor in determining the coercivity.

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