• 동의생리병리학회지
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• 제22권3호
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• pp.612-618
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• 2008

In the present study, the anti-inflammatory effect of Haepyoejin-tang plus antler water extract was tested in formalin-injected chronic inflammation model in mouse hind paw. The test articles-100, 250, 500 mg/kg- were dosed once a day for 10 days, and changes on the body weight, paw weights were observed with histopathology of induced paw dorsum pedis. In addition, histomorphometry was also monitored at sacrifice. 15 mg/kg/10 mL of dexamethasone (DEXA) and diclofenac (DICLO) intraperitoneally dosed groups were used as reference groups. A significantly decrease of both absolute and relative paw weights were observed in all dosing groups including DEXA and DICLO groups compared to that of control, and a significantly decrease of the differences between intact and induced paw weights were also observed Haepyoejin-tang plus antler dosing groups compared to that of control. These histological signs-hypertrophy of paw dorsum pedis tissues were detected results from edematous changes on the cutaneous and subcutaneous tissues with severe infiltration of chronic inflammatory cells-were dramatically decreased in all dosing groups including DEXA and DICLO dosing groups compared to that of control. Especially, dose dependently decreases were detected in Haepyoejin-tang plus antler dosing groups compared to that of control. Base on these aforementioned results, it is concluded that Haepyoejin-tang plus antler have clear anti-inflammatory effect on the chronic inflammation induced by formalin injection.

• Imaging Science in Dentistry
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• 제35권3호
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• pp.141-146
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• 2005

Purpose : The purpose of this study was to investigate the preliminary use of morphologic operation (MO) in analyzing trabecular pattern of alveolar bone for the predicting systemic osteoporosis. Materials and Methods : Study subjects consisted of 35 females (average age 48.5 years) and 25 males (average age 25.8 years). Bone mineral density BMD $(grams/cm^2)$ of lumbar spine and proximal femur of these subjects were measured by a dual energy X-ray absorptiometry (DEXA). Regions of interest (ROIs) were selected from the digitized periapical radiographs of subjects' posterior jaw. A custom computer program processed morphology operations of ROIs. We compared mean values of 11 MO variables according to the osteoporotic group divided by the T-scores of DEXA. We also studied correlation between radiographic density and these MO variables. Results : The mean radiographic densities insignificantly correlated with MO variables. There were statistically significant differences among the values of 9 MO variables according to the osteoporotic group. Conclusion Morphologic operation can be effective in analyzing trabecular pattern of alveolar bone for the predicting osteoporosis.

• 한국콘텐츠학회논문지
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• 제12권6호
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• pp.353-360
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• 2012

본 연구는 근위대퇴골 정면 영상에서 골다공증 측정을 위한 영상지표가 이중에너지흡수계측법(DEXA)으로 측정한 골밀도 결과와 관련성이 있는지 알아보고자 하였다. 총 112명을 대상으로 근위대퇴부 정면 영상을 촬영하였고, 영상 지표인 대퇴골관비(CCR)와 피질골 두께지표(CTI)를 측정하여 DEXA 골밀도 결과와 비교하였다. T-score를 이용하여 골다공증군과 비골다공증군으로 나누었고, 영상지표와 평균비교분석 및 상관관계분석, 진단일치도를 비교하였다. 영상계측에서 골다공증군의 골수강내 대퇴관과 골단 대퇴관 간격은 비골다공증군보다 유의하게 컸다. CCR은 골밀도와 음의 상관관계(r=-0.340)가 이었고, CTI는 양의 상관관계(r=0.624)가 있었다. 골다공증에 대한 CCR의 진단일치도는 63.4%이었고, kappa 값은 0.271이었다. CTI의 진단일치도는 67.0%이었고, kappa 값은 0.258 이었다. 결론적으로 근위대퇴골 영상에서 비골다공증군보다 골다공증군의 CCR이 더 크고, CTI는 더 좁게 나타났다. 이는 근위대퇴골 정면영상을 평가할 때 대퇴골의 골단간 피질의 두께가 얇은 환자는 골다공증에 대한 추가적인 검사를 추천할 수 있다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제27권5호
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• pp.403-414
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• 2005

The purpose of this study was to identify the effectiveness of the modified distraction osteogenesis (DO) method with the concept of overdistraction and compression stimulation which have been previously suggested by the authors in 2002 and to explore the optimal distraction-compression ratio and appropriate latency period for the compression force application during consolidation. The experimental specimens were assessed with radiography, histologic findings, and dual energy x-ray absorptiometry (DEXA) after the conventional DO method and the modified DO technique had been applied on rat mandibles. Total 60 rats were used for the study. In experimental group of 54 adult rats, mandibular osteotomies between the first and second molar areas were performed and customized external distractors were applied. The surgeries on 6 rats of control group also were done with same osteotomy technique and DO device application. Final amount of distraction was set-up as 2 mm on both groups. But, in a experimental group of 54 rats, distraction osteogenesis with a compression force were performed with the different distraction-compression ratio and variant latency periods for compression. The three ratio-subgroups were made as distraction 4 mm group with compression 2 mm, distraction 3 mm group with compression 1 mm, and distraction 2.5 mm group with compression 0.5 mm. In addition, The three subgroups with 3, 7, 11 days latency period prior compression were allocated on each ratio-subgroups. Total 9 subgroups consisted of 6 rats on each subgroup. In control group of 6 rats, conventional distraction technique were routinely performed. The rats of control groups were sacrificed on postoperative 3, 6 weeks after 2 mm distraction. The rats in the experimental groups also were sacrificed on the same euthanasia days of control groups to compare the wound healing. Final available specimens were 55 rats except 5 due to osteomyelitis, device dislodgement. Distraction-compression combined group on 6 weeks generally had showed increased bone mineral density than the same period group of conventional distraction technique on the DEXA study. More matured lamellar bone state and extended trabecular pattern in the combined group than those of control group were also observed in the histologic findings on 6 weeks. In the distraction-compression combined groups, the bone density of 2.5 mm distraction subgroups with 0.5 mm compression showed the highest value on the DEXA study among various force ratio groups. In the distraction-compression combined groups, the bone density of 3 day latency period subgroups showed the highest value on the DEXA study among various latency period groups for the compression application. From this study, we could deduce that 1/5 force ratio for the compression versus distraction, 3 day latency period prior compression application would be the most effective condition if modified distraction osteogenesis technique might be applicable. The modified DO method with a compression force may improve the quality of bone regenerate and shorten total treatment period in comparison with conventional DO technique clinically.

• 생명과학회지
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• 제33권12호
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• pp.1036-1045
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• 2023

골격근량과 근력의 점진적인 감소를 특징으로 하는 근감소증은 고령화 인구에서 중요한 문제이다. 본 연구는 콩잎 추출물(Soybean Leaf extracts, SL)의 덱사메타손으로 유도된 근위축에 대한 치료적 가능성을 세포 및 동물 모델에서 조사하였다. 세포 실험 결과, SL은 C2C12 근섬유의 형태, 밀도 및 크기가 보존되어 통계적으로 유의미한 수준으로 덱사메타손에 의해 유발된 근위축을 완화하는 것으로 나타났다. 또한, SL 처리는 주요 근육 위축 조절 인자인 muscle RING-finger protein-1 (MuRF1)과 muscle atrophy F-box (MAFbx)의 발현을 mRNA 및 단백질 수준 모두에서 유의하게 하향 조절하였다. 마우스 모델에서 SL 투여는 특히 덱사메타손으로 인한 체중 감소와 근육 소모를 상쇄하여 비복근과 전경골근의 근육량을 보존하는 것으로 나타났다. 기능적으로도 SL을 투여한 마우스는 악력과 트레드밀 지구력이 향상되어 근육 성능이 개선되었다. 또한 SL은 골격근에서 근위축 관련 단백질인 MAFbx의 발현을 억제하여 덱사메타손 유도 근위축에 대한 보호 역할을 보여주었다. 이러한 연구 결과를 종합해 볼 때 SL은 근감소증과 같은 근육 소모 질환을 개선할 수 있는 유망한 천연 치료제가 될 수 있음을 시사한다.

• The Journal of Korean Physical Therapy
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• 제15권4호
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• pp.466-478
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• 2003

This study was to evaluate the body composition and bone mineral density according to aging in adult and investigated the relationship between various parameters such as body mass index(BMI), bone mineral density(BMD), bone mineral content(BMC), lean body mass(LBM), fat mass(FM) and the value obtained from dual energy X-ray absorptiometry(DEXA). The subjects were composed of healthy adult male and female who were $20^{\sim}73$ years old and they were divided three group according to age (A group : 20-39 yrs., B group : 40-59 yrs., C group : more than 60 yrs.). The conclusion derived from statistical analysis was as follows : 1. Bone mineral content and density were significantly affected by lean body mass(relatively, R=0.85 - 0.63). 2. There was significant difference among age groups in total bone mineral density. 3. There was significant difference among age groups in bone mineral content of male and female. 4. Lean body mass is diminished according to age, but there was not significant difference among age groups. 5. Fat mass of A group in male had the highest mass and followed by C group and B group. In female groups, fat mass of A group had the highest mass and followed by B group and C group. Abdominal fat mass is increased according to age. This result suggest that aging was closely relation with loss of muscle mass, bone mineral density and bone mineral content.

• 대한한방내과학회지
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• 제43권4호
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• pp.503-513
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• 2022

Objectives: The antitussive, expectorant, and anti-inflammatory effects of Mahwangyounpae-tang (MHYPT) aqueous extracts were observed in appropriate animal models of various respiratory disorders. Methods: MHYPT aqueous extracts were orally administered once a day for 11 days at dose levels of 400, 200, and 100 mg/kg. The effect of MHYPT was determined by comparing its antitussive effect with theobromine (TB), its expectorant effect with ambroxol (AM), and its anti-inflammatory effect with dexamethasone (DEXA). Results: MHYPT aqueous extracts (400 mg/kg) showed favorable antitussive effects comparable to those of TB (50 mg/kg) in the NH₄OH-exposure coughing mouse model and expectorant effects comparable to those of AM (250 mg/kg) in the phenol red-secretion mouse model, but MHYPT (400 mg/kg) showed less anti-inflammatory activity compared to DEXA (1 mg/kg) in the xylene-induced acute inflammatory mouse ear model under the experimental conditions used. Conclusion: MHYPT aqueous extracts administered at dosage levels of 400, 200, and 100 mg/kg induced dose-dependent and favorable antitussive, expectorant, and anti-inflammatory activities that occurred by simultaneous modulation of the activity of mast cells and respiratory mucous production under the experimental conditions used in this study.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제28권2호
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• pp.95-102
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• 2002

DM is a systemic disease with many complications. One of them, diabetic osteopenia is important sequelae and many authors reported reduced bone mass in diabetic rats. However, in mandible, study has been rare because of its anatomical limits. So the objective of this study was to investigate bony change in mandible of diabetic rats. Thirty-two adult rats were used in this study. Half of them were male and female respectively. In sixteen rats, streptozotocin was injected intraperitoneally to induce DM and the serum glucose concentration was checked to ensure the induction of DM prior to the time of sacrifice. At 1, 2, 3, 4, 6, 8, 12, 16weeks, control group and diabetic group rats were sacrificed respectively. And then bone mineral density of mandibles and femurs of the rats was measured using dual energy X-ray absorptiometry(DEXA). In addition serum osteocalcin and urine deoxypyridinoline were measured as markers of bone formation and resoption respectively. Mandibular and femoral bone density in streptozotocin induced rats was decreased with significance statistically after 4 weeks from injection. In mandible, comparing with femur, bone density was moderately decreased. The alveolar bone in mandible was more decreased bone density than the whole body in the mandible From these results, bone mineral density decreased in uncontrolled diabetic group with time, and especially alveolar bone was more destructive in the mandible. So authors think that consideration of reduced bone mineral density is necessary in dental procedure.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 1993년도 제45차 추계 학술대회 연제집
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• pp.45-46
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• 1993

• The Journal of Korean Physical Therapy
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• 제18권2호
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• pp.17-24
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• 2006

Purpose: This study was aimed for service to clinical data of physical therapy necessity of bone complication through analysis method of BMD (bone mineral density) used DEXA (dual energy X-ray absorptiometry) to their skeletal system for physical therapy assesement and intervention program in type II diabetic patients. Methods: Experimental group of 75 subjects and comparison group of 62 subjects were participated in type II diabetic patients(40-80 ages). BMD was measured by DEXA. BMD change of BMI score and BMD comparison of age and sex would be known. Results: This study was found that decreased BMD and increased osteopenea in type II diabetes. In particular, women were lower BMD and higher incidence of osteopenea than men. Men showed significant difference in normal group. Influence of type II diabetes was great on change of BMD in men. however, it showed no significant difference from normal group. Conclusion: it was found that skeletal system complication by type II diabetes had some relations. Because reduction of BMD had a great danger to induce trauma by fall or degenerative disease of system, evaluation of proper physical therapy for its prevention and improvement and intervention program are needed. In addition, it would be important to divide type II diabetic patients into osteopenea and osteoporosis changes of skeletal system at comprehensive aspect of physical therapy.