• Title/Summary/Keyword: DEVS Modeling

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The estimation of Draize score by in vitro cytotoxicity using continuous cell lines (In Vitro cytotoxicity에 의한 Draize score 측정 체계 수립)

  • 정민석;최종완
    • Proceedings of the SCSK Conference
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    • 1996.07a
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    • pp.33-51
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    • 1996
  • 화장품의 변질요인은 크게 물리적 또는 화학적 변화에 의한 요인과 미생물오염으로 인한 각종 문제점으로 대별될 수 있다. 이 중에서 미생물 오염문제는 제품의 상품가치에 미치는 영향 뿐만 아니라 지속적인 사용에 의한 피부의 위생적 측면때문에 그 중요성에 대한 인식이 높아지고 있다. 따라서, 제품개발시는 화장품 처방중의 영양성분의 배합, pH, 유화형태, 방부제의 혼합, 분배계수 및 그 안정성을 고려하여야 함은 물론이고 처방중의 모든 원료의 각각에 대한 항균능 및 피부자극여부를 사전에 미리 조사하여 각 제품별로 적당한 방부체계를 선택하는 것은 매우 중요한일이다. 독성실험방법에 있어서 in vivo 실험에 대체할 수 있는 새로운 in vitro 실험방법 수립 즉, 동물실험을 하지 않고 in vitro 실험결과로부터 in vivo 결과를 예측할 수 있도록 새로운 in vitro 실험체계의 가능성을 실험하였다. 4종의 cell line중 transformed mouse fibroblast L929가 본 실험에서 사용하기에 배양상의 용이성과 안정성, 재현성의 관점에서 가장 알맞은 cell line이었다. transformed mouse fibroblast L929를 사용한 NR$_{50}$ assay와 Draize score간의 regression coefficient ${\gamma}$값은 0.91이었다. 혈청은 시험물질의 세포에 대한 민감성에 영향을 주었다. 따라서, modified serum-free method를 이용함으로써 regression coefficient가 증가된 즉, 상관성 및 재현성이 높은 결과를 얻을 수 있었다. 이러한 기술은 독성실험에 실험동물을 사용하지 않고 in vivo test에 대체 할 수 있고, 또한 화학물질에 대한 prescreening으로 이용할 수 있을 것으로 판단된다.원과 섭식장소, 수중생물의 경우는 특히 수온, 수량 영양원등이다.(중략). 본 연구의 접근방법으로는 ASRS의 개념적인 Reference Model을 수립하고 이 Reference Model에 대한 Formal Model로 DEVS(Discrete Event System Specification)을 이용하여 시스템을 Modeling하였다. 이의 Computer Simulation을 위하여 DEVS형식론 환경에서의 Simulation Language인 DEVSim ++ⓒ를 이용하여 시스템을 구현하였다.. 실형 결과로는 먼저 선형 상미분방정식의 예로 mass-damper-spring system, 비선형 상미분방정식의 예로는 van der Pol 방정식, 연립 상미분방정식의 예로는 mixing tank problem 등을 보였으며, 그의 공학에서 일어나는 여러 가지 문제들도 다루었다.화물에 대한 방어력이 증가되어 나타난 결과로 여겨지며, 또한 혈청중의 ALT, ALP 및 LDH활성을 유의성있게 감소시키므로서 감잎 phenolic compounds가 에탄올에 의한 간세포 손상에 대한 해독 및 보호작용이 있는 것으로 사료된다.반적으로 홍삼 제조시 내공의 발생은 제조공정에서 나타나는 경우가 많으며, 내백의 경우는 홍삼으로 가공되면서 발생하는 경우가 있고, 인삼이 성장될 때 부분적인 영양상태의 불충분이나 기후 등에 따른 영향을 받을 수 있기 때문에 앞으로 이에 대한 많은 연구가 이루어져야할 것으로 판단된다.태에도 불구하고 [-wh]의미의 겹의문사는 병렬적 관계의 합성어가 아니라 내부구조를 지니지 않은 단순한 단어(minimal $X^{0}$ elements)로 가정한다. 즉, [+wh] 의미의 겹의문사는 동일한 구성요 소를 지닌 병렬적 합성어([$[W1]_{XO-}$ $[W1]_{XO}$ ]

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Modeling Environment for Distributed Simulation with Hierarchical Animation (계층적 애니메이션이 가능한 분산 시뮬레이션 모델링 환경)

  • Yi, Mi-Ra;Kim, Hyung-Jong
    • Journal of the Korea Society for Simulation
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    • v.17 no.1
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    • pp.33-42
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    • 2008
  • In general, simulation is to predict or evaluate some systems that are hard to be executed in real world, and so usually the target systems to be modeled are large and complex. Trying to observe the dynamics of the systems results in similar level of animation complexity, the model and animation has the same complexity as the system. Trying to display all the graphic objects representing the dynamics of the models being simulated, however, causes the distraction of focus, which results in solving the above listed problems difficult. The redundant graphic objects also increase the computer computation overhead. To solve the problem, a research about a hierarchical animation environment has been proposed a few years ago. In the research, the users can have better focus on the dynamics of system components by selectively choosing the hierarchical level and components within a level of the hierarchically structured model. However, the research has not a modeling methodology for modelers to describe systematically animation part corresponding to dynamics of simulation in a model. This research has defined the modeling methodology of DESHA and defined DESHA-C++, improving the previous research output, as an execution environment of DESHA models. In addition, to use hierarchical animation environment in various problems, this research proposed and developed the distributed simulation modeling environment that connects DESHA environment and HLA.

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Design of ILS M&S for RAM Analysis in Guided Weapon System (유도무기체계 RAM분석을 위한 ILS M&S 설계)

  • Lee, Yong-Bin;Lee, Dong-Wook;Lee, Joo-Hyung;Um, Chun-Sup;Park, Jang-Won
    • Journal of the Korea Society for Simulation
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    • v.24 no.2
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    • pp.19-29
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    • 2015
  • M&S techniques are utilized for various purposes on the national defense, and its importance is increasing than ever. For analyzing RAM (Reliability, Availability and Maintainability) of weapon system, using M&S techniques can be more effective and practical way than deterministic approach, because M&S approach can consider uncertain variables and various constraints in the ILS (Integrated Logistics support) field. For design of ILS M&S, we first set up a purpose of M&S, attributes of real system and other similar ILS M&S tool. Then, we convert real system into model which consists of mathematical formula and logical expression. In this thesis, we introduce modeling procedures of M&S that describes total life cycle of 'OO guided weapon system' and the contents proposed in this paper can provide references for developing other M&S tool.

Web-based Distributed Experimental Frame for Discrete Event Simulation System (이산사건 시뮬레이션 시스템을 위한 웹 기반 분산 실험 틀)

  • Jung, Inho;Choi, Jaewoong;Choi, Changbeom
    • Journal of the Korea Society for Simulation
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    • v.26 no.2
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    • pp.9-17
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    • 2017
  • The problem of social phenomenon is getting more complicated than past decades, and the simulation engineers need more computation power to solve the problem. Therefore, the needs of the computational resources of the modeling and simulation environment are increasing. In the perspective of the simulation, it is necessary to allocate computational resources flexibly so that the simulation can be performed per the available budget range. As an alternative to the simulation environment to accommodate these requirements, cloud service has emerged as an environment in which computing resources can be used flexibly. This paper proposes a web-based simulation framework which consists of a front-end that reconstructs the simulation model using the web, and a back-end that executes the discrete event simulation. This paper also carried out a case study which shows web-based simulation framework has better overall runtime than standalone simulation framework.

Design of Scenario Creation Model for AI-CGF based on Naval Operations, Resources Analysis Model(I): Evolutionary Learning (해군분석모델용 AI-CGF를 위한 시나리오 생성 모델 설계(I): 진화학습)

  • Hyun-geun, Kim;Jung-seok, Gang;Kang-moon, Park;Jae-U, Kim;Jang-hyun, Kim;Bum-joon, Park;Sung-do, Chi
    • Journal of the Korea Institute of Military Science and Technology
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    • v.25 no.6
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    • pp.617-627
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    • 2022
  • Military training is an essential item for the fundamental problem of war. However, there has always been a problem that many resources are consumed, causing spatial and environmental pollution. The concepts of defense modeling and simulation and CGF(Computer Generated Force) using computer technology began to appear to improve this problem. The Naval Operations, Resources Analysis Model(NORAM) developed by the Republic of Korea Navy is also a DEVS(Discrete Event Simulation)-based naval virtual force analysis model. The current NORAM is a battle experiment conducted by an operator, and parameter values such as maneuver and armament operation for individual objects for each situation are evaluated. In spite of our research conducted evolutionary, supervised, reinforcement learning, in this paper, we introduce our design of a scenario creation model based on evolutionary learning using genetic algorithms. For verification, the NORAM is loaded with our model to analyze wartime engagements. Human-level tactical scenario creation capability is secured by automatically generating enemy tactical scenarios for human-designed Blue Army tactical scenarios.