• The KIPS Transactions:PartD
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• v.10D no.2
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• pp.211-220
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• 2003

As Geographic Information Systems represent three dimensional topological information, The Systems provide accurate and delicate services for users. In order to execute three dimensional topological operations, a dimensional transformation and heterogeneous spatial models should be used. However, the existing systems that use the dimensional transformation and the heterogeneous models, is not only difficult to operate the spatial operators, but also happened to support non-interoperability. Therefore, in order to solve the problems, we proposed three dimensional spatial object models that supported two dimensional object models and implemented them to show validity of the proposed models. When designing the three dimensional topological operators, we used 3DE-9IM which extended DE-9IM to support three dimensional concepts, and implemented operators on the component environment with object oriented concepts. The proposed three dimensional spatial object models and topological operators can support interoperability between systems, and execute spatial queries efficiently on three dimensional spatial objects.

• Spatial Information Research
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• v.13 no.2 s.33
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• pp.119-128
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• 2005

Most spatial data handled in GIS is two-dimensional. These two-dimensional data is established by selecting 2D aspects form 3D, or by projecting 3D onto 2D space. During this conversion, without user's intention, data are abstracted and omitted. This unwanted data loss causes disadvantages such as restrictingof the range of data application and describing inaccurate real world. Recently, three dimensional data is getting wide interests and demands. One of the examplesis Database Management System which can store and manage three dimensional spatial data. However, this DBMS does not support spatial query which is the essence of the database management system. So, various studies are needed in this field. This research designs spatial relationship that is defined in space database standard using the three-dimension space model. The spatial data model, which is used in this research, is the one defined in OGC for GMS3, and designing tool is DE-9IM based on Point-Set Topology blow as the best method for topological operation.

• Proceedings of the Korea Society of Information Technology Applications Conference
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• 2001.11a
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• pp.65-65
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• 2001

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.55 no.9
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• pp.452-455
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• 2006

The technology of wire explosion have been used to product nanopowders. A new concept was proposed to produce metallic nanosized powders, which is wire explosion in liquid media. We have exploded the Ag or Cu wires of diameter of O.3mm, 40mm long, in the de-ionized water or acetone, respectively. Electrical energy of 1.1kJ was stored in 10uF capacitor and released to the wires through a triggered spark gap switch. The process was observed by high-speed camera. Those images showed that the powders were generated by vapor condensation in the shell formed by shock wave in the water. The particles were directly dispersed into the water with collapse of the shell. The sizes of Ag and Cu nanopowders were evaluated to 35nm and 17nm, respectively.

• Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
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• 2004.03a
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• pp.31-37
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• 2004

GIS 분야에서 다루는 공간 데이터는 대부분 2차원의 데이터이다. 현실 공간에 존재하는 3차원 객체의 2차원 정보만을 취하거나 혹은 2차원 공간으로 투영하는 등의 방법으로 데이터를 저장한다. 이러한 방법은 정보의 손실로 인한 데이터 활용범위가 축소되고, 현실 공간을 정확하게 반영하지 못하는 문제가 있다. 최근 3차원 공간 데이터를 저장, 관리 가능한 DBMS가 개발되고, 3차원 데이터에 대한 관심과 요구가 높아가고 있다. 하지만 3차원 데이터를 단순 저장만 가능할 뿐 공간 연산에 대한 연구가 미흡한 실정이다. 본 연구에서는 3차원 공간 모델을 이용하여 공간 데이터베이스 표준에서 정의하고 있는 공간 관계 연산을 설계하였다. 공간 데이터 모델로는 OGC에서 제시한 GML3에서 정의하는 모델을 사용하였고, 공간 관계 연산에 대한 설계 도구로는 공간 관계를 연산하는데 가장 좋은 방법으로 알려진 DE-9IM을 이용하였다.

• KIISE Transactions on Computing Practices
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• v.20 no.9
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• pp.513-518
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• 2014

It has become possible for small scale laboratories to interpret large scale genomic DNA, thanks to the reduction of the sequencing cost by the development of next generation sequencing (NGS). De novo assembly is a method which creates a putative original sequence by reconstructing reads without using a reference sequence. There have been various study results on de novo assembly, however, it is still difficult to get the desired results even by using the same assembly procedures and the analysis tools which were suggested in the studies reported. This is mainly because there are no specific guidelines for the assembly procedures or know-hows for the use of such analysis tools. In this study, to resolve these problems, we introduce steps to finding whole genome of an unknown DNA via NGS technology and de novo assembly, while providing the pros and cons of the various analysis tools used in each step. We used 350Mbp of Toxocara canis DNA as an application case for the detailed explanations of each stated step. We also extend our works for prediction of protein-coding genes and their functions from the draft genome sequence by comparing its homology with reference sequences of other nematodes.

• Publications of The Korean Astronomical Society
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• v.32 no.1
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• pp.213-217
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• 2017

The recent updates of the North Ecliptic Pole deep ($0.5deg^2$, NEP-Deep) multi-wavelength survey covering from X-ray to radio-wave is presented. The NEP-Deep provides us with several thousands of $15{\mu}m$ or $18{\mu}m$ selected galaxies, which is the largest sample ever made at these wavelengths. A continuous filter coverage in the mid-infrared wavelength (7, 9, 11, 15, 18, and 24 µm) is unique and vital to diagnose the contributions from starbursts and AGNs in the galaxies out to z=2. The new goal of the project is to resolve the nature of the cosmic star formation history at the violent epoch (e.g. z=1-2), and to find a clue to understand its decline from z=1 to present universe by utilizing the unique power of the multiwavelength survey. The progress in this context is briefly mentioned.

• Journal of Microbiology and Biotechnology
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• v.17 no.6
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• pp.1045-1048
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• 2007

Two genes, dps encoding decaprenyl diphosphate synthase and dxs encoding 1-deoxy-D-xylulose 5-phosphate synthase, were isolated from Rhizobium radiobacter ATCC 4718. DNA sequencing analysis of the dps and dxs genes revealed an open reading frame of 1,077 bp and 1,920 bp, respectively. The heterologous expression in Escherichia coli BL21(DE3) was carried out in order to identify their functions. Recombinant E. coli BL21(DE3) harboring the dps gene produced $CoQ_{10}$ as well as $CoQ_8$ and $CoQ_9$, whereas E. coli harboring only the dxs gene produced more $CoQ_8$ compared with the wild-type E. coli. Additionally, the coexpression of dps and dxs genes in E. coli was carried out. The recombinant E. coli harboring only the dps gene produced $0.21{\pm}0.04\;mg/l$ of $CoQ_{10}$, whereas the coexpressed E. coli with dps and dxs genes produced $0.37{\pm}0.07\;mg/l$ of $CoQ_{10}$. HPLC analysis also showed that the $CoQ_{10}$ fraction (100% of the total CoQs distribution) was increased from $15.86{\pm}0.66%$ (only dps) to $29.78{\pm}1.80%$ (dps and dxs).

• Korean Journal of Radiology
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• v.21 no.9
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• pp.1095-1103
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• 2020

Objective: The present study aimed to investigate whether quantitative dual-energy computed tomography (DECT) parameters offer an incremental risk stratification benefit over the CT ventricular diameter ratio in patients with acute pulmonary embolism (PE) by using propensity score analysis. Materials and Methods: This study was conducted on 480 patients with acute PE who underwent CT pulmonary angiography (CTPA) or DECT pulmonary angiography (DE CT-PA). This propensity-matched study population included 240 patients with acute PE each in the CTPA and DECT groups. Altogether, 260 (54.1%) patients were men, and the mean age was 64.9 years (64.9 ± 13.5 years). The primary endpoint was all-cause death within 30 days. The Cox proportional hazards regression model was used to identify associations between CT parameters and outcomes and to identify potential predictors. Concordance (C) statistics were used to compare the prognoses between the two groups. Results: In both CTPA and DECT groups, right to left ventricle diameter ratio ≥ 1 was associated with an increased risk of all-cause death within 30 days (hazard ratio: 3.707, p < 0.001 and 5.573, p < 0.001, respectively). However, C-statistics showed no statistically significant difference between the CTPA and DECT groups for predicting death within 30 days (C-statistics: 0.759 vs. 0.819, p = 0.117). Conclusion: Quantitative measurement of lung perfusion defect volume by DECT had no added benefit over CT ventricular diameter ratio for predicting all-cause death within 30 days.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.217-223
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• 2013

Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and the outcomes for patients are still poor. It is important to determine the original type of synchronous multinodular HCC for preoperative assessment and the choice of treatment therapy as well as for the prediction of prognosis after treatment. Aims: To analyze clinicopathologic characteristics and prognoses in patients with multicentric occurrence (MO) and intrahepatic metastasis (IM) of synchronous multinodular hepatocellular carcinoma (HCC). Methods: The study group comprised 42 multinodular HCC patients with a total of 112 nodules. The control group comprised 20 HCC patients with 16 single nodular HCC cases and 4 HCC cases with a portal vein tumor emboli. The mitochondrial DNA (mtDNA) D-loop region was sequenced, and the patients of the study group were categorized as MO or IM based on the sequence variations. Univariate and multivariate analyses were used to determine the important clinicopathologic characteristics in the two groups. Results: In the study group, 20 cases were categorized as MO, and 22 as IM, whereas all 20 cases in the control group were characterized as IM. Several factors significantly differed between the IM and MO patients, including hepatitis B e antigen (HBeAg), cumulative tumor size, tumor nodule location, cirrhosis, portal vein and/or microvascular tumor embolus and the histological grade of the primary nodule. Multivariate analysis further demonstrated that cirrhosis and portal vein and/or microvascular tumor thrombus were independent factors differentiating between IM and MO patients. The tumor-free survival time of the MO subjects was significantly longer than that of the IM subjects ($25.7{\pm}4.8$ months vs. $8.9{\pm}3.1$ months, p=0.017). Similarly, the overall survival time of the MO subjects was longer ($31.6{\pm}5.3$ months vs. $15.4{\pm}3.4$ months, p=0.024). The multivariate analysis further demonstrated that the original type (p=0.035) and Child-Pugh grade (p<0.001) were independent predictors of tumor-free survival time. Cirrhosis (p=0.011), original type (p=0.034) and Child-Pugh grade (p<0.001) were independent predictors of overall survival time. Conclusions: HBeAg, cumulative tumor size, tumor nodule location, cirrhosis, portal vein and/or microvascular tumor embolus and histological grade of the primary nodule are important factors for differentiating IM and MO. MO HCC patients might have a favorable outcome compared with IM patients.