• Biomedical Science Letters
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• v.2 no.2
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• pp.153-158
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• 1996

Verapamil, a potent calcium channel blocker, has been proved to be one of the modulators to overcome drug resistance in cancer chemotherapy. In the present experiment, the possibility of verapamil as a MDR modulator was investigated by using MTT assay. Sole treatment of verapamil on the HeLa and Caski cervical cancer cell line revealed dose dependent cytotoxicity within a range of tested dose. Combined treatment of verapamil with 5-FU, DDP on two human cervical cancer cell line led to a significant synergistic cytotoxicity. Therefore , these studies showed that verapamil had a possibility to be applicable to cancer chemotherapy in gynecological oncology.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3977-3982
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• 2012

Inhibitors of histone deacetylase activity are emerging as a potentially important new class of anticancer agents. In this study, we assessed the anticancer effects of valproic acid (VPA) on ovarian cancer in vitro and in vivo. Cultured SKOV3 cells were treated by VPA with different concentrations and time, then the effects on cell growth, cell cycle, apoptosis, and related events were investigated. A human ovarian cancer model transplanted subcutaneously in nude mice was established, and the efficacy of VPA used alone and in combination with diammine dichloroplatinum (DDP) to inhibit the growth of tumors was also assessed. Proliferation of SKOV3 cells was inhibited by VPA in a dose and time dependent fashion. The cell cycle distribution changed one treatment with VPA, with decrease in the number of S-phase cells and increase in G1-phase. VPA could significantly inhibit the growth of the epithelial ovarian cancer SKOV3 cells in vivo without toxic side effects. Treatment with VPA combined with DDP demonstrated enhanced anticancer effects. The result of flow cytometry (FCM) indicated that after VPA in vitro and in vivo, the expression of E-cadherin was increased whereas vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) were decreased. This study suggests that VPA could be a novel attractive agent for treatment of ovarian cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.1
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• pp.195-199
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• 2015

Background: This study was conducted to determine the influence of MACC1 expression on chemotherapy sensitivity in human U251 glioblastoma cells. Materials and Methods: Expression of the MACC1 gene in 49 cases of human brain glioma was determined by quantitative real-time PCR. Silencing effects of RNA interference on MACC1 was detected by Western-blotting. Flow cytometry methods and methyl thiazolyl tetrazolium assay (MTT) were used to determine the apoptosis and growth inhibitory rates of the U251 cells with MACC1 silencing. before and after treatment with cisplatin (DDP). Results: MACC1 mRNA in gliomas was up-regulated remarkably, to 158.8% of that in peri-cancerous tissues (P<0.05). The siRNA-MACC1 could inhibit the expression of MACC1 protein significantly (p<0.05), associated with an increase in apoptosis rate from 2.57% to 5.39% in U251 cells and elevation of the growth inhibitory rate from 1.5% to 17.8% (p<0.05 for both). After treatment with DDP at various concentrations (1, 3, $5{\mu}g/ml$), compared with control U251 cells, the apoptosis rate of MACC1-silenced U251 cells rose from 8.41%, 13.2% and 19.5% to 12.8%, 17.8% and 25.8%; the growth inhibitory rate increased from 16.2%, 19.3% and 24.5% to 23.7%, 28.4% and 36.3%. Conclusions: There is a notable relationship between over-expression of MACC1 and the characteristics of glioma cells. Silencing of MACC1 was found to enhance the apoptosis and growth inhibitory rates of U251 glioma cells, and thereby increase their sensitivity to DDP chemotherapy.

• International Journal of Computer Science & Network Security
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• v.23 no.9
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• pp.8-16
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• 2023

In Japan, high-speed ground transportation service using linear motors at speeds of 500 km/h is scheduled to begin in 2027. To accommodate 5G services in trains, a subcarrier spacing frequency of 30 kHz will be used instead of the typical 15 kHz subcarrier spacing to mitigate Doppler effects in such high-speed transport. Furthermore, to increase the cell size of the 5G mobile system, multiple base station antennas will transmit identical downlink (DL) signals to form an expanded cell size along the train rails. In this situation, the forward and backward antenna signals are Doppler-shifted in opposite directions, respectively, so the receiver in the train may suffer from estimating the exact Channel Transfer Function (CTF) for demodulation. In a previously published paper, we proposed a channel estimator based on Delay and Doppler Profiler (DDP) in a 5G SISO (Single Input Single Output) environment and successfully implemented it in a signal processing simulation system. In this paper, we extend it to 2×2 MIMO (Multiple Input Multiple Output) with spatial multiplexing environment and confirm that the delay and DDP based channel estimator is also effective in 2×2 MIMO environment. Its simulation performance is compared with that of a conventional time-domain linear interpolation estimator. The simulation results show that in a 2×2 MIMO environment, the conventional channel estimator can barely achieve QPSK modulation at speeds below 100 km/h and has poor CNR performance versus SISO. The performance degradation of CNR against DDP SISO is only 6dB to 7dB. And even under severe channel conditions such as 500km/h and 8-path inverse Doppler shift environment, the error rate can be reduced by combining the error with LDPC to reduce the error rate and improve the performance in 2×2 MIMO. QPSK modulation scheme in 2×2 MIMO can be used under severe channel conditions such as 500 km/h and 8-path inverse Doppler shift environment.

• International Journal of Computer Science & Network Security
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• v.23 no.7
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• pp.1-8
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• 2023

An Orthogonal Frequency Division Multiplexing (OFDM) based wireless communication system has drawn wide attention for its high transmission rate and high spectrum efficiency in not only radio but also Underwater Acoustic (UWA) applications. Because of the narrow sub-carrier spacing of OFDM, orthogonality between sub-carriers is easily affected by Doppler effect caused by the movement of transmitter or receiver. Previously, Doppler compensation signal processing algorithm for Desired propagation path was proposed. However, other Doppler shifts caused by delayed Undesired signal arriving from different directions cannot be perfectly compensated. Then Receiver Bit Error Rate (BER) is degraded by Inter-Carrier-Interference (ICI) caused in the case of Multi-path Doppler channel. To mitigate the ICI effect, a modified Delay and Doppler Profiler (mDDP), which estimates not only attenuation, relative delay and Doppler shift but also sampling clock shift of each multi-path component, is proposed. Based on the outputs of mDDP, an ICI canceling multi-tap equalizer is also proposed. Computer simulated performances of one-tap equalizer with the conventional Time domain linear interpolated Channel Transfer Function (CTF) estimator, multi-tap equalizer based on mDDP are compared. According to the simulation results, BER improvement has been observed. Especially, in the condition of 16QAM modulation, transmitting vessel speed of 6m/s, two-path multipath channel with direct path and ocean surface reflection path; more than one order of magnitude BER reduction has been observed at CNR=30dB.

• Journal of Korean Society of Forest Science
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• v.65 no.1
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• pp.80-91
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• 1984

The purposes of this study are to analyze and forecast the domestic demand for papers by regression models with time-series data (1965-81). For the period of 1965-81, the real GNP of Korea grew at annual average increase rate of 8.8 percent. On the other hand, the domestic demand of papers grew at annual average increase rate of 17.9 percent in this period. Especially, the annual average increase rate for board-papers accounted to 25.8 percent. To analyze domestic demand for papers, GNP, per capita GNP, price findex of papers, production activity index of the major papers consuming industries and price index of substitutive goods were selected as independent variables. The expected values of domestic demand for papers were computed by forecasting equations as follows. T-values are in parentheses. ${\ell}nDDP=2.452+1.986{\ell}nPG-0.844{\ell}nPWI$ $(33.397)^*\;(-6.149)^*\;R^2=0.997$ ${\ell}nDDP=6.468+0.827{\ell}nPDA$ $(17.403)^*\;R^2=0.950$ DDP : Domestic demand for papers PG : Real GNP per capita (1,000 won) PWI : Real price index of papers (1980 = 100) PDAV : Production activity index of the major papers consuming industries The results analyzed and forecasted by these models are summarized as follows: The domestic demand for papers had positive correlation toward per capita GNP and production activity index of the major papers consuming industries. Per capita GNP elasticity of the domestic demand for papers was the most elastic among independent variables. The price elasticity of domestic demand for papers had negative sign and inelastic. These were not only statistically significant but theoretically compatible. The domestic demand for papers was projected to be 3,152-4,470 thousand mit in 1991, representing at annual increase rate of 5.0-12.4 percent during the period of 1982-91. Domestic demand for papers per capita was projected to be 69.1-98.0 kg in 1991.

• Journal of Microbiology and Biotechnology
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• v.32 no.4
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• pp.405-418
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• 2022

Simotang oral liquid (SMT) is a traditional Chinese medicine (TCM) consisting of four natural plants and is used to alleviate gastrointestinal side effects after chemotherapy and functional dyspepsia (FD). However, the mechanism by which SMT helps cure these gastrointestinal diseases is still unknown. Here, we discovered that SMT could alleviate gastrointestinal side effects after chemotherapy by altering gut microbiota. C57BL/6J mice were treated with cisplatin (DDP) and SMT, and biological samples were collected. Pathological changes in the small intestine were observed, and the intestinal injury score was assessed. The expression levels of the inflammatory factors IL-1β and IL-6 and the adhesive factors Occludin and ZO-1 in mouse blood or small intestine tissue were also detected. Moreover, the gut microbiota was analyzed by high-throughput sequencing of 16S rRNA amplicons. SMT was found to effectively reduce gastrointestinal mucositis after DDP injection, which lowered inflammation and tightened the intestinal epithelial cells. Gut microbiota analysis showed that the abundance of the anti-inflammatory microbiota was downregulated and that the inflammatory microbiota was upregulated in DDP-treated mice. SMT upregulated anti-inflammatory and anticancer microbiota abundance, while the inflammatory microbiota was downregulated. An antibiotic cocktail (ABX) was also used to delete mice gut microbiota to test the importance of gut microbiota, and we found that SMT could not alleviate gastrointestinal mucositis after DDP injection, showing that gut microbiota might be an important mediator of SMT treatment. Our study provides evidence that SMT might moderate gastrointestinal mucositis after chemotherapy by altering gut microbiota.

• Product Safety
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• s.245
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• pp.52-53
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• 2014

BMW 코리아(대표 김효준)가 24일 서울동대문 디자인 플라자(DDP)에서 BMW 최초의 순수프리미엄 전기차 i3를 출시했다. BMW i3는 개인 이동수단의 혁명을 가져올 모델로 배기가스 제로의 지속가능한 미래의 이동수단이며 도시에서 드라이빙의 즐거움을 선보일 혁신적인 전기자동차다.

• 프린팅코리아
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• v.13 no.12
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• pp.105-105
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• 2014

앙리 카르티에-브레송의 '영원한 풍경'전(展)이 오는 12월 5일부터 2015년 3월 1일(74일간, 매주 월요일 & 구정 당일 휴관)까지 동대문 디자인플라자(DDP) 디자인전시관에서 개최된다. 이번 앙리 카르티에-브레송의 '영원한 풍경'전(展)에서는 우리나라 미공개 작품을 포함해 앙리 카르티에-브레송 생전에 제작된 오리지널 인쇄 작품 259점이 전시된다.

• Structural Engineering and Mechanics
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• v.49 no.2
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• pp.183-202
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• 2014

A new method of multiple damage detection in beam like structures is introduced. The mode shapes of both healthy and damaged structures are used in damage detection process (DDP). Multiple Damage Localization Index Based on Mode Shapes (MDLIBMS) is presented as a criterion in detecting damaged elements. A finite element modeling of structures is used to calculate the mode shapes parameters. The main advantages of the proposed method are its simplicity, flexibility on the number of elements and so the accuracy of the damage(s) position(s), sensitivity to small damage extend, capability in prediction of required number of mode shapes and low sensitivity to noisy data. In fact, because of differential and comparative form of MDLIBMS, using noise polluted data doesn't have major effect on the results. This makes the proposed method a powerful one in damage detection according to measured mode shape data. Because of its flexibility, damage detection process in multi span bridge girders with non-prismatic sections can be done by this method. Numerical simulations used to demonstrate these advantages.