• IMMUNE NETWORK
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• 제11권5호
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• pp.281-287
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• 2011

Background: Biodegradable polymers have increasingly been recognized for various biological applications in recent years. Here we examined the immunostimulatory activities of the novel poly(aspartic acid) conjugated with L-lysine (PLA). Methods: PLA was synthesized by conjugating L-lysine to aspartic acid polymer. PLA-nanoliposomes (PLA-NLs) were prepared from PLA using a microfluidizer. The immunostimulatory activities of PLA-NLs were examined in mouse bone marrow-derived dendritic cells (BM-DCs). Results: PLA-NLs increased the number of BM-DCs when added to cultures of GM-CSF-induced DC generation on day 4 after the initiation of cultures. Examination of the phenotypic properties showed that BM-DCs generated in the presence of PLA-NLs are more mature in terms of the expression of MHC class II molecules and major co-stimulatory molecules than BM-DCs generated in the absence of PLA-NLs. In addition, the BM-DCs exhibited enhanced capability to produce cytokines, such as IL-6, IL-12, TNF-${\alpha}$ and IL-$1{\beta}$. Allogeneic mixed lymphocyte reactions also confirmed that the BMDCs were more stimulatory on allogeneic T cells. PLA- NL also induced further growth of immature BM-DCs that were harvested on day 8. Conclusion: These results show that PLA-NLs induce the generation and functional activities of BM-DCs, and suggest that PLA-NLs could be immunostimulating agents that target DCs.

• Nuclear Engineering and Technology
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• 제49권7호
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• pp.1495-1504
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• 2017

In a previous study, a set of polygon-mesh (PM)-based skin models including a $50-{\mu}m-thick$ radiosensitive target layer were constructed and used to calculate skin dose coefficients (DCs) for idealized external beams of electrons. The results showed that the calculated skin DCs were significantly different from the International Commission on Radiological Protection (ICRP) Publication 116 skin DCs calculated using voxel-type ICRP reference phantoms that do not include the thin target layer. The difference was as large as 7,700 times for electron energies less than 1 MeV, which raises a significant issue that should be addressed subsequently. In the present study, therefore, as an extension of the initial, previous study, skin DCs for three other particles (photons, protons, and helium ions) were calculated by using the PM-based skin models and the calculated values were compared with the ICRP-116 skin DCs. The analysis of our results showed that for the photon exposures, the calculated values were generally in good agreement with the ICRP-116 values. For the charged particles, by contrast, there was a significant difference between the PM-model-calculated skin DCs and the ICRP-116 values. Specifically, the ICRP-116 skin DCs were smaller than those calculated by the PM models-which is to say that they were under-estimated-by up to ~16 times for both protons and helium ions. These differences in skin dose also significantly affected the calculation of the effective dose (E) values, which is reasonable, considering that the skin dose is the major factor determining effective dose calculation for charged particles. The results of the current study generally show that the ICRP-116 DCs for skin dose and effective dose are not reliable for charged particles.

• The Korean Journal of Physiology and Pharmacology
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• 제13권3호
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• pp.169-173
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• 2009

Ginsan, a Panax ginseng polysaccharide that contains glucopyranoside and fructofuranoside, has immunomodulatory effects. Although several biologic studies of ginsan have been performed, its effects on dendritic cells (DCs), which are antigen-presenting cells of the immune system, have not been studied. We investigated the immunomodulatory effects of ginsan on DCs. Ginsan had little effect on DC viability, even when used at high concentrations. Ginsan markedly increased the levels of production by DCs of IL-12 and TNF-${\alpha}$, as measured by ELISA. To examine the maturation-inducing activity of ginsan, we measured the surface expression levels of the maturation markers MHC class II and CD86 (B7.2) on DCs. It is interesting that ginsan profoundly enhanced the expression of CD86 on DC surfaces, whereas it increased that of MHC class II only marginally. In $^3H$-thymidine incorporation assays, ginsan-treated DCs stimulated significantly higher proliferation of allogeneic $CD4^+$ T lymphocytes than did medium-treated DCs. Taken together, our data demonstrate that ginsan stimulates DCs by inducing maturation. Because DCs are critical antigen-presenting cells in immune responses, this study provides valuable information on the activities of ginsan.

• Asian-Australasian Journal of Animal Sciences
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• 제18권3호
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• pp.314-319
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• 2005

To compare two different schemes, continuous scheme (CS) and discontinuous scheme (DCS), of once-weekly ovum pick up (OPU) with ultrasound-guided follicular puncture technique, Holstein heifers were randomly divided into two groups of five. After characterization of their two normal estrous cycles, the heifers were subjected to consecutive 20 weeks of once-weekly OPU under two schemes: the CS (one week interval between continuous OPU, total 100 OPU sessions performed) and the DCS (OPU fixed to the day 3 and day 10 of each estrus). Then, the status of ovaries and artificial insemination results were observed. On oocyte yield, the total number of punctured follicles using DCS was lower than that using CS, but the mean numbers of punctured follicles and recovered oocytes per session were higher in DCS than CS group. So the total number of recovered oocytes was similar in both groups. There were also no differences in the quality of recovered oocytes, nor in the developmental ability of oocytes fertilized in vitro between groups. The heifers in the DCS group showed regular estrous cycles with stable estrous signs through the periods of before, during, and after OPU, while those in CS group showed longer estrous cycles and less estrous signs during and/or after OPU compared with before period. Furthermore, the mean number of inseminations required for obtaining pregnancy after completion of the experiments was lower in DCS than CS group. The research demonstrates that similar quantity and quality oocytes can be achieved, and the side effects on donors are lower in DCS that needs fewer OPUs than CS group, and DCS is superior to CS.

• 한국전자파학회논문지
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• 제18권10호
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• pp.1189-1195
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• 2007

본 논문에서는 폴드형 GSM/DCS/USPCS 서비스용 휴대폰 단말기에 적용되는 3중 대역 폴디드 모노폴 안테나를 설계 제작한다. 안테나는 변형된 미앤더 구조이며, 접힌 형상을 갖도록 설계함으로써 GSM 주파수 대역에서는 길이를 늘리는 역할을 하고, DCS/USPCS 주파수 대역에서는 같은 방향으로 전류가 형성될 수 있도록 한다. 같은 방향의 다중 전류는 방사 저항과 이득을 동시에 높게 해 줌으로써 내장형 안테나로 성능 구현이 어려운 휴대폰에 적용될 수 있다. 설계된 안테나를 프레스 공법으로 제작하여 휴대폰에 적용한 결과 GSM/DCS/USPCS의 3중 대역에서 폴드 닫힘 상태에서 VSWR 3:1, 열림 상태에서 2:1 이내 특성을 만족하고 있으며, 최대 이득은 GSM 밴드에서 -0.02 dBi, DCS 밴드에서 +0.2 dBi, USPCS 밴드에서 +0.78 dBi을 가지고 전방향성 특성의 H면 방사 특성을 보인다.

• 한국콘텐츠학회논문지
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• 제12권7호
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• pp.21-28
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• 2012

데이터 중심 저장 기법(DCS)은 무선 센서 네트워크에서 수집된 데이터를 효율적으로 저장하고 관리하기 위한 대표적인 연구이다. DCS 기법에서는 발생하는 데이터를 값에 따라 저장을 담당하는 노드들이 할당되어 있다. 이러한 특성으로 인해 노드의 결함에 매우 취약하다는 문제점이 있다. 본 논문은 DCS 환경에서 노드 결함에 의한 데이터 소실이 발생하였을 경우, C-Point(Character-Point)기반 근사 복구 기법을 제안한다. 제안하는 기법은 물리 데이터의 공간 연속성을 이용하여 소실 데이터를 복구하여 질의 결과의 정확도를 높인다. 제안하는 기법의 우수성을 보이기 위해 결함이 발생하는 DCS 환경에서 시뮬레이션을 수행하였다. 성능평가 결과, 약 2.5%의 에너지 소모량 증가를 통해 정확도를 약 28% 향상시켰다.

• 한국전자파학회논문지
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• 제15권2호
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• pp.165-171
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• 2004

본 논문에서는 안테나 스위치 모듈 내에서 GSM/DCS 대역을 분리하는 적층형 다이플렉서를 설계하였고, LTCC 기술을 이용하여 제작한 후 그 특성을 고찰하였다. 다이플렉서를 구현하기 위해 소형의 L, C 집중 수동 소자를 사용하였으며, 또한 적층형 집중 수동 소자의 구조 모델링 및 등가 회로 모델을 제안함으로써 접지면 상에서 최적의 주파수 특성을 갖는 집중 수동 소자를 얻을 수 있었다. 이를 이용하여 RF 모듈에 적용 가능한 고품질의 다이플렉서를 구현하였다. GSM 저역 통과 필터는 0.55 dB 이하의 삽입 손실, 12 dB 이상의 반사 손실 그리고 DCS 통과 대역에서 26 dB 이상의 저지 특성을 나타내었다. DCS 고역 통과 필터는 0.82 dB 이하의 삽입 손실, 11 dB 이상의 반사손실 그리고 GSM 통과 대역에서 38 dB 이상의 저지 특성을 나타내었다.

• Nuclear Engineering and Technology
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• 제49권5호
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• pp.989-995
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• 2017

Distributed Control System (DCS) communication networks, which use Fast Ethernet with redundant networks for the transmission of information, have been installed in digitalized nuclear power plants. Normally, failover tests are performed to verify the reliability of redundant networks during design and manufacturing phases; however, systematic integrity tests of DCS networks cannot be fully performed during these phases because all relevant equipment is not installed completely during these two phases. In additions, practical verification tests are insufficient, and there is a need to test the actual failover function of DCS redundant networks in the target environment. The purpose of this study is to verify that the failover functions works correctly in certain abnormal conditions during installation and commissioning phase and identify the influence of network failover on the entire DCS. To quantify the effects of network failover in the DCS, the packets (Protocol Data Units) must be collected and resource usage of the system has to be monitored and analyzed. This study introduces the use of a new methodology for verification of DCS network failover during the installation and commissioning phases. This study is expected to provide insight into verification methodology and the failover effects from DCS redundant networks. It also provides test results of network performance from DCS network failover in digitalized domestic nuclear power plants (NPPs).

• Physical Therapy Rehabilitation Science
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• 제10권1호
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• pp.76-81
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• 2021

Objective: Smartphone addiction can cause forward head posture, carpal tunnel syndrome and depression, and anxiety. Various interventions have been proposed to resolve Smartphone addiction. However, research regarding the efficacy of these interventions remains lacking. This study was conducted to investigate the effect of tDCS (Transcranial Direct Current Stimulation) on smartphone addiction solution and stress reduction. Design: A randomized controlled trial. Methods: The participants were divided randomly into two group (tDCS vs. Control). tDCS was applied to 41 adults (22.95±2.76 years). The tDCS group was applied 2 mA, for 13 minutes twice over a 26 minute period (n₁ = 21). The control (n₂ = 20) was not applied after padding and was applied twice for 13 minutes over a 26 minute period. This study was conducted four times a week for a total of four weeks. Results: Smartphone addiction for tDCS showed significant improvement in the results in the S-score (p<0.05, 95% CI: 0.702, 4.922), and the result of heart rate (HR) and skin conductivity (SC) to stress. The tDCS group and control group showed no significant decrese in the results in the HR (p>0.05, 95% CI: -3.390, 8.332), but tDCS group showed significant decrese in the results in the SC (p<0.05, 95% CI: 0.060, 1.343) Conclusions: This study suggected that smartphone addiction treatment and decreses of stress. The use of tDCS will reduce the addiction rate of adults and reduce stress, so that possible side effects in society can be solved.

• 대한통합의학회지
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• 제10권2호
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• pp.105-113
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• 2022

Purpose: The purpose of this study is to investigate the effect of non-invasive transcranial direct current stimulation (tDCS) on muscle activity, including 10 m WT, TUG, and BBS, in hemiplegic stroke patients. Methods: This study was conducted on 42 inpatients diagnosed with hemiplegia due to stroke at hospital B in Daejeon for more than 6 months. Walking training was conducted for six weeks, five times a week for 30 minutes, with a general walking group (14 people), tDCS walking group (14 people), and tDCS (sham) walking group (14 people). Results: As a result of the study, the change in the muscle activity before and after tDCS intervention was significantly increased in the tibialis anterior muscle in the CG group. In the EG group, the erector spine (lumbar), rectus femoris, and tibialis anterior muscles significantly increased. In the SEG group, significant increases were observed in the rectus femoris and tibialis anterior muscles. Significant differences were found in the rectus femoris and tibialis anterior muscles in the comparison between groups after intervention according to tDCS application. Also, 10 m WT, TUG, and BBS were significantly increased in the CG, EG, and SEG groups after intervention, and there were significant differences in 10 m WT, TUG, and BBS in comparison between groups after intervention according to tDCS application. Conclusion: As a result, tDCS is an effective in improving the walking ability of stroke patients, and in particular, it effectively increases the muscle activity of the rectus femoris and tibialis anterior muscles, which act directly on walking, and also improves the speed and stability of walking. It is considered being an effective method to increase the gait of stroke patients by combining it with the existing gait training.