• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8559-8561
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• 2016

Purpose: To evaluate efficacy of radiofrequency ablation (RFA) in treating colorectal cancer patients with liver metastases. Methods: During January 2010 to April 2012, 56 colorectal cancer patients with liver metastases underwent RFA. CT scans were obtained one month after RFA for all patients to evaluate tumor response. (CR+PR+SD)/n was used to count the disease control rates (DCR). Survival data of 1, 2 and 3 years were obtained from follow up. Results: Patients were followed for 10 to 40 months after RFA (mean time, $25{\pm}10months$). Median survival time was 27 months. The 1, 2, 3 year survival rate were 80.4%, 71.4%, 41%, 1 % respectively. 3-year survival time for patients with CR or PR after RFA was 68.8% and 4.3% respectively, the difference was statistically significant. The number of CR, PR, SD and PD in our study was 13, 23, 11 and 9 respectively. Conclusions: RFA could be an effective method for treating colorectal cancer patients with liver metastases, and prolong survival time, especially for metastatic lesions less than or equal to 3 cm. But this result should be confirmed by randomized controlled studies.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5699-5703
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• 2013

Objective: To investigate the clinical effects of whole brain radiotherapy concomitant with targeted therapy for brain metastasis in non-small cell lung cancer (NSCLC) patients with chemotherapy failure. Materials and Methods: Of the 157 NSCLC patients with chemotherapy failure followed by brain metastasis admitted in our hospital from January 2009 to August 2012, the combination group (65 cases) were treated with EGFR-TKI combined with whole brain radiotherapy while the radiotherapy group (92 cases) were given whole brain radiotherapy only. Short-term effects were evaluated based on the increased MRI in brain 1 month after whole brain radiotherapy. Intracranial hypertension responses, hematological toxicity reactions and clinical effects of both groups were observed. Results: There were more adverse reactions in the combination group than in radiotherapy group, but no significant differences were observed between the two groups in response rate (RR) and disease control rate (DCR) (P>0.05). Medium progression free survival (PFS), medium overall survival (OS) and 1-year survival rate in combination group were 6.0 months, 10.6 months and 42.3%, while in the radiotherapy group they were 3.4 months, 7.7 months and 28.0%, respectively, which indicated that there were significant differences in PFS and OS between the two groups (P<0.05). Additionally, RPA grading of each factor in the combination group was a risk factor closely related with survival, with medium PFS in EGFR and KRAS mutation patients being 8.2 months and 11.2 months, and OS being 3.6 months and 6.3 months, respectively. Conclusions: Whole brain radiotherapy concomitant with target therapy is favorable for adverse reaction tolerance and clinical effects, being superior in treating brain metastasis in NSCLC patients with chemotherapy failure and thus deserves to be widely applied in the clinic.

• International Journal of Naval Architecture and Ocean Engineering
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• 제11권2호
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• pp.699-722
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• 2019

It is difficult to observe the potential risks of lifting or turn-over operations in the early stages before a real operation. Therefore, many dynamic simulations have been designed to predict the risks and to reduce the possibility of accidents. These simulations, however, have usually been performed for predetermined and fixed scenarios, so they do not reflect the real-time control of an operator that is one of the most important influential factors in an operation; additionally, lifting or turn-over operations should be a collaboration involving more than two operators. Therefore, this study presents an integrated method for a collaborative simulation that allows multiple workers to operate together in the virtual world. The proposed method is composed of four components. The first component is a dynamic analysis that is based on multibody-system dynamics. The second component is VR (virtual reality) for the generation of realistic views for the operators. The third component comprises the control devices and the scenario generator to handle the crane in the virtual environment. Lastly, the fourth component is the HLA (high-level architecture)-based integrated simulation interface for the convenient and efficient exchange of the data through the middleware. To show the applicability of the proposed method, it has been applied to a block turn-over simulation for which one floating crane and two crawler cranes were used, and an offshore module installation for which a DCR (dual-crane rig) was used. In conclusion, the execution of the proposed method of this study is successful regarding the above two applications for which multiple workers were involved.

• 한국전산구조공학회논문집
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• 제30권5호
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• pp.397-404
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• 2017

본 연구의 목적은 트러스의 형태를 바꿔가며 엇갈린 트러스(STF) 시스템의 내진성능을 평가하는 것이다. 예제 구조물은 10층의 철골조 사무실 건물이며, 시스템별로 각각 프랫트러스, 하우트러스, 와렌트러스, 케이트러스와 비렌딜트러스를 적용하였다. 중력하중, 풍하중, 지진하중을 고려한 구조해석을 실시하여 부재에 높은 DCR을 만족하는 단면을 산정한 후 고유주기, 밑면전단력과 층간변위를 산출하였다. 그 후, 역량스펙트럼법을 통해 1.2배의 설계지진(DE)과 최대고려지진(MCE)에 대한 성능점을 산정하고, STF 시스템의 항복여부 및 소성힌지의 분포를 파악하여 구조기준에서 제시한 목표성능수준을 만족하는지 살펴보았다. 평가 결과, 모든 시스템이 해당 목표성능수준을 만족하였으며, 시스템의 경제성 및 효율성을 따져보았을 때, PR10이나 VR10이 가장 적합한 것으로 나타났다.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2017년도 제48회 춘계학술대회논문집
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• pp.258-265
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• 2017

고속추진체계의 시험평가에는 많은 비용과 시간이 필요하므로 시험자료의 양은 항상 부족하고, 설사 있더라도 지상시험 환경이 실제 비행조건과 일치하는 경우가 드물다. 이러한 이유로 설계자들은 설계결과에 대한 불확실성을 정량적인 확률로 제시하는데 어려움을 가지고 있다. 본 논문에서는 Evidence 기법을 이용하여, 시험자료 대신 개발자들의 경험과 공학적인 지식을 바탕으로 불확실성을 모델링하는 방법을 연구하였다. 연소효율은 이중연소램제트 엔진의 초기설계단계에서 가장 예측하기 어려운 변수중의 하나이다. 유사분야의 경험을 가진 설계자들이 이 값을 제시하는 것으로 가정하여 이중연소램제트 엔진의 설계결과에 대한 불확실성을 산출하였다. 나아가 흡입구와 연소기 출구면적으로 설계변수로, 추력성능과 thermal choking의 가능성을 제약함수로 하는 신뢰성 최적설계를 수행함으로써 시스템의 안전성을 확보하면서 최적의 성능을 얻을 수 있는 설계기법을 탐색하였다.

• 한국전자파학회논문지
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• 제18권1호
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• pp.15-23
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• 2007

본 논문에서는 six-port 위상 상관기와 신호 검파부 그리고 I 및 Q 채널 신호를 복조하는 간단한 구조를 갖는 six-port 직접 변환 QPSK 수신기를 설계하고 제작하였다. Six-port 위상 상관기의 출력 단자간 출력 위상 신호를 해석하고, 출력 단자 신호 간 $90^{\circ}C$ 위상 관계로부터 QPSK신호를 복조하는 간단한 회로의 직접 변환 수신기 구조를 갖는다. Six-port 위상 상관기는 $90^{\circ}C$ 하이브리드 branch line 및 전력 분배기를 가지며, $11.7{\sim}12.0\;GHz$ 주파수 대역에서 설계된 six-port 위상 상관기의 출력 신호는 $^{\circ}$ 이내의 양호한 위상 오차 특성을 갖는다. 또한 직접 변환 수신기 구성 소자간 양호한 정합도 및 진폭 특성에 의해 약 $5^{\circ}$ 이내의 위상 오차를 갖는 I, Q 데이터를 복원하였다.

• 한국정보통신학회논문지
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• 제14권5호
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• pp.1071-1077
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• 2010

본 논문에서는 집중 소자형 6단자 위상 상관기 구조를 설계 제작하고, 이를 바탕으로 집중 소자형 6단자 위상 상관기를 이용한 L-대역 직접변환 수신 성능을 분석하였다. 제작된 L-대역 집중 소자형 6단자 위상 상관기 소자는 저항형 전력 분배기와 twist-wire 동축케이블을 사용하였으며, 낮은 대역에서 소형화 구조가 가능하고, 광역 특성을 갖는다. 집중 소자형 6단자 위상 상관기를 사용한 L-대역 직접변환 수신 성능은 집중 소자형 6단자 위상 상관기의 LO 단자와 RF 입력 단자에 각각 중심 주파수가 1.69 GHz이고 전력이 -20 dBm인 LO 신호와 QPSK 신호를 입력하여 측정하였다. 집중 소자형 6단자 위상 상관기를 사용한 직접변환 구조는 양호한 I/Q 디지털 신호를 복원할 수 있었다.

• 한국정보통신학회논문지
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• 제13권10호
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• pp.2039-2044
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• 2009

본 논문에서는 다층형 결합 선로를 이용한 PSK 반송파 신호 복원 회로를 해석하고 설계 제작한다. 다층형 결합 선로 구조의 coupled line으로 구성되는 반송파 복원 6단자 소자는 다층형 구조를 가지며, 수신 전처리부의 6 단자 위상 상관기 구조와 동일한 구조를 갖는 일원화된 수신 구조 구현이 가능하다. 아울러 다층 결합 선로 6 단자 위상 상관기를 이용한 RML 기반 다중 모드 동기 복조형 반송파 신호 복원이 가능한 다층형 결합 선로 반송파 복원 회로 구조를 제안한다. 설계 제작된 다층형 결합 선로 구조 반송파 복원회로에 의한 직교 위상편이 방식 신호의 반송파 신호는 일정한 위상값과 반사 소자에 의해 발생되는 ${\pm}3o$ 이내인 위상차를 갖는 양호한 PSK 반송파 신호 특성을 나타내었다.

• 방사선산업학회지
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• 제9권3호
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• pp.143-151
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• 2015

A PET-MR system is particularly useful in diagnosing brain diseases. We have developed a prototype positron emission tomography (PET) system which can be inserted into the bore of a whole-body magnetic resonance imaging (MRI) system that enables us to obtain PET and MRI images simultaneously with a reduced cost. Silicon photomultipliers (SiPM) are appropriated as a PET detector at PET/MR system because detectors have a high gain and are insensitive to magnetic fields. Despite of its improved performance compared to that of PMT-based detectors, there is a problem of the photo-peak channel shift which is due to the increase of the temperature inside the ring detector. This problem will occur decreasing sensitivity of the PET and image distortion. In this paper, I quantitative analyze parameters of the KAIST SiPM depending on temperature by experiments. And I designed cooling methods in consideration of the degradation of sensors for correction of the temperature in the PET gantry. According to this research, we expect that distortive images and degradation of the sensitivity will not be occurred with using the above idea to reduce heat even if the PET system operates for a long time.

• 한국지진공학회논문집
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• 제26권5호
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• pp.211-217
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• 2022

New buildings have been designed using different seismic design standards that have been revised. However, the seismic performance of existing buildings is evaluated through the same performance evaluation guidelines. Existing buildings may not satisfy the performance targets suggested in the current guidelines, but there are practical limitations to discriminating the existing buildings with poor seismic performance through a full investigation. In this regard, to classify buildings with poor seismic performance according to the applied standard, this study aimed to evaluate performance-based investigation of the seismic design proposals of buildings with different design standards. The target buildings were set as RC ordinary moment frames for office occupancy. Changes in seismic design criteria by period were analyzed, and the design spectrum changes of reinforced concrete ordinary moment resisting frames were compared to analyze the seismic load acting on the building during design. The seismic design plan was derived through structural analysis of the target model, compared the member force and cross-sectional performance, and a preliminary evaluation of the seismic performance was performed to analyze the performance level through DCR. As a result of the seismic performance analysis through the derived design, the reinforced concrete ordinary moment frame design based on AIK 2000 has an insufficient seismic performance level, so buildings built before 2005 are likely to need seismic reinforcement.