• Steel and Composite Structures
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• v.22 no.1
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• pp.1-12
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• 2016

Severe fatigue and noise problems of modular bridge expansion joints (MBEJs) are often induced by vehicle loads. However, the dynamic characteristics of single-support MBEJs have yet to be further investigated. To better understand the vibration mechanism of single-support MBEJs under vehicle loads, a 3D finite element model of single-support MBEJ with five center beams is built. Successive vehicle loads are given out and the vertical dynamic responses of each center beams are analyzed under the successive loads. Dynamic amplification factors (DAFs) are also calculated along with increasing vehicle velocities from 20 km/h to 120 km/h with an interval 20 km/h. The research reveals the vibration mechanism of the single-support MBEJs considering coupled center beam resonance, which shows that dynamic responses of a given center beam will be influenced by the neighboring center beams due to their rebound after the vehicle wheels depart. Maximal DAF 1.5 appears at 120 km/h on the second center beam. The research results can be utilized for reference in the design, operation and maintenance of single-support MBEJs.

• The Korean Society of Law and Medicine
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• v.8 no.1
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• pp.35-57
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• 2007

Hier zu behandelndes Thema ist ein altes Problem beim Recht, das seinen Ursprung sogar im romischen Recht finden kann. Aber wegen der medizinischen und naturwissenschaftlichen Entwicklung $t\ddot{a}ucht$ es wieder mit anderen Konstellationen auf. Dabei geht es besonders darum, ob sich die Patienten an der kommerziellen Nutzung seiner $K\ddot{o}rpersubstanzen$ von anderen-z. B. $\ddot{A}rzten$ oder Forschern-beteiligen $k\ddot{o}nnen$. $Daf\ddot{u}r$ gibt es in Bezug auf Gesetz keine besonderen Regelungen in Deutschland. Und nach zivilrechtlicher Theorie stellt Nutzung menschlicher $K\ddot{o}rpersubstanzen$ eine Personlichkeitsverletzung des fruheren $Tr\ddot{a}gers$ und/oder eine Verletzung des Arzt-Patienten-Vertrages dar. $Au{\beta}erdem$ ist Anspruch des $fr\ddot{u}heren\;Tr\ddot{a}gers$ debkbar, der auf dessen Einwilligung basiert. Dabei sind diese Probleme $zun\ddot{a}chst$ unter $Pers\ddot{o}nlichkeitsverletzung$ zu subsumieren und damit zu $l\ddot{o}sen$.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.47 no.2
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• pp.24-33
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• 2015

This study aims to suggest wastewater treatment options for diaper recycling by identifying characteristic analysis of wastewater from diaper recycling process and efficiency evaluation of wastewater treatment units. The wastewater characteristic analysis showed that the concentration of organic pollutants and ionic materials were very high comparing to seawater. Through the investigation of similar wastewater treatment, six treatment units were identified to reduce pollutants. It is found UF(ultra-filtration), DAF(dissolved air flotation), fenton oxidation, electro-coagulation and chemical-coagulation are effective in reducing organic pollutants while membrane system and ion exchanger are effective in reducing ionic materials. Even though the target of water quality should be secured in terms of managing organic pollutants level, the application of treatment unit for reducing ionic material needs lots of considerations. This result suggests that reuse of pulping wastewater after controlling organic pollutants is better than direct discharge of pulping wastewater. To select the appropriate wastewater treatment unit, an economic analysis about operation condition, wastewater flow, cost, efficiency should be considered.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2011.04a
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• pp.743-746
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• 2011

본 연구에서는 유한요소해석을 이용하여 차량속도 및 긴장재의 설계에 따른 CFTA 거더의 동적거동 및 동적증폭계수를 분석하였다. 긴장재의 해석변수로서는 긴장재의 양과 긴장력을 고려하였으며 차량하중은 도로교설계기준의 DB-24 하중을 선택하였다. 차량하중은 3축-2트랙에 작용하는 등가절점하중으로 변환하여 속도에 따라 시간함수로 모델링하였다. 긴장재의 양은 외측 �� 내측 덕트의 유무에 따라 변화시켰으며 긴장력은 설계긴장력의 0%에서 100%까지 25%씩 증가시켰다. 차량속도는 40km/hr에서 100km/hr까지 20km/hr씩 증가시켰으며, 해석결과 긴장재의 긴장력 변화는 거더의 동적거동에 영향을 주지 않았으며 초기처짐에만 영향을 주었다. 긴장재의 양에 따라서는 거더의 동적거동이 다르게 나타났으며 긴장재의 양이 적을 수록 동적처짐은 증가하였다. 이를 바탕으로 거더의 동적증폭계수(DAF)를 산출하였으며, 이 결과 긴장재가 없는 경우에도 도로교표준시방서에서 정한 기준 값보다 매우 작은 거동을 보였다.

• Journal of Korean Society of Water and Wastewater
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• v.18 no.2
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• pp.222-227
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• 2004

Flotation processes involve the use of very small bubbles (micro-bubbles) to separate particles from water. The process has become a good alternative to sedimentation, especially where the particles are small or of low density. Although the flotation process commences with a collision between particles and bubbles, most research has been focused only on the characteristics of the particles. In this paper, recent theoretical and experimental research on the characteristics of bubbles is summarized. The effect on the collision efficiency of the size and charge of bubbles is calculated through trajectory analysis. The size and charge of bubbles are measured under different conditions and the ramifications of the results are discussed. The results may lead to a better understanding and optimization of the existing process. In particular, we discuss an idea that a new advanced flotation process might be possible by the modification of the characteristics of the bubble alone or of both bubble and particle.

• Journal of Environmental Science International
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• v.14 no.7
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• pp.691-697
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• 2005

Waste sludge may be used to recovery wastewater contaminated with heavy metals. The waste sludge is an inexpensive readily available source of biomass for biosorption with metal-bearing wastewater. The biosorption of heavy metals such as Pb(II), Cu(II), Cr(II), and Cd(II) onto waste sludge was investigated in batch ex­periments and waste sludge loaded heavy metals was separated by dissolved air flotation. The biosorption equi­bria of heavy metals could be described by Langmuir and Freundich isotherms. The adsorption capacity for waste sludge was in the sequence of Pb(II)>Cr(II)>Cu(II)>Cd(II). The system attained equilibrium about 20 min. The Langmuir and Freundlich adsorption model effectively described the biosorption equilibrium of Cu(II) and Cr(II) ions on waste sludge. Maximum adsorption capacity of Cu(II) and Cr(II) were 196.08 and 158.73 mg/g, respectively. Solid-liquid separation efficiencies were kept above $95\%$ on waste sludge loaded heavy metals, and were decreased with pH increasing.

• Genomics & Informatics
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• v.12 no.2
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• pp.64-70
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• 2014

Human papillomavirus (HPV) infection is the leading cause of cancer mortality among women worldwide. The life-threatening infection caused by HPV demands the need for designing anticancerous drugs. In the recent years, different compounds from natural origins, such as carrageenan, curcumin, epigallocatechin gallate, indole-3-carbinol, jaceosidin, and withaferin, have been used as a hopeful source of anticancer therapy. These compounds have been shown to suppress HPV infection by different researchers. In the present study, we explored these natural inhibitors against E6 oncoprotein of high-risk HPV-16, which is known to inactivate the p53 tumor suppressor protein. A robust homology model of HPV-16 E6 was built to anticipate the interaction mechanism of E6 oncoprotein with natural inhibitory molecules using a structure-based drug designing approach. Docking analysis showed the interaction of these natural compounds with the p53-binding site of E6 protein residues 113-122 (CQKPLCPEEK) and helped the restoration of p53 functioning. Docking analysis, besides helping in silico validation of natural compounds, also helps understand molecular mechanisms of protein-ligand interactions.

• Coupled systems mechanics
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• v.3 no.2
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• pp.147-170
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• 2014

In the recent times, dimensions of heavy load carrying vehicle have changed significantly incorporating structural flexibility in vehicle body. The present paper outlines a procedure for the estimation of bridge response statistics considering structural bending modes of the vehicle. Bridge deck roughness has been considered to be non homogeneous random process in space. Influence of pre cambering of bridge surface and settlement of approach slab on the dynamic behavior of the bridge has been studied. A parametric study considering vehicle axle spacing, mass, speed, vehicle flexibility, deck unevenness and eccentricity of vehicle path have been conducted. Dynamic amplification factor (DAF) of the bridge response has been obtained for several of combination of bridge-vehicle parameters. The present study reveals that flexible modes of vehicle can reduce dynamic response of the bridge to the extent of 30-37% of that caused by rigid vehicle model. However, sudden change in the bridge surface profile leads to significant amount of increment in the bridge dynamic response even if flexible bending modes remain active. The eccentricity of vehicle path and flexural/torsional rigidity ratios plays a significant role in dynamic amplification of bridge response.

• Genomics & Informatics
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• v.13 no.2
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• pp.60-67
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• 2015

The leading cause of cancer mortality globally amongst the women is due to human papillomavirus (HPV) infection. There is need to explore anti-cancerous drugs against this life-threatening infection. Traditionally, different natural compounds such as withaferin A, artemisinin, ursolic acid, ferulic acid, (-)-epigallocatechin-3-gallate, berberin, resveratrol, jaceosidin, curcumin, gingerol, indol-3-carbinol, and silymarin have been used as hopeful source of cancer treatment. These natural inhibitors have been shown to block HPV infection by different researchers. In the present study, we explored these natural compounds against E6 oncoprotein of high risk HPV18, which is known to inactivate tumor suppressor p53 protein. E6, a high throughput protein model of HPV18, was predicted to anticipate the interaction mechanism of E6 oncoprotein with these natural inhibitors using structure-based drug designing approach. Docking analysis showed the interaction of these natural inhibitors with p53 binding site of E6 protein residues 108-117 (CQKPLNPAEK) and help reinstatement of normal p53 functioning. Further, docking analysis besides helping in silico validations of natural compounds also helped elucidating the molecular mechanism of inhibition of HPV oncoproteins.

• Genomics & Informatics
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• v.11 no.4
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• pp.289-291
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• 2013

Human papillomavirus (HPV) infection is the leading cause of cancer mortality among women worldwide. The molecular understanding of HPV proteins has significant connotation for understanding their intrusion in the host and designing novel protein vaccines and anti-viral agents, etc. Genomic, proteomic, structural, and disease-related information on HPV is available on the web; yet, with trivial annotations and more so, it is not well customized for data analysis, host-pathogen interaction, strain-disease association, drug designing, and sequence analysis, etc. We attempted to design an online reserve with comprehensive information on HPV for the end users desiring the same. The Human Papillomavirus Proteome Database (hpvPDB) domiciles proteomic and genomic information on 150 HPV strains sequenced to date. Simultaneous easy expandability and retrieval of the strain-specific data, with a provision for sequence analysis and exploration potential of predicted structures, and easy access for curation and annotation through a range of search options at one platform are a few of its important features. Affluent information in this reserve could be of help for researchers involved in structural virology, cancer research, drug discovery, and vaccine design.