• Microbiology and Biotechnology Letters
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• v.10 no.2
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• pp.109-115
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• 1982

A Corynebacterium sp. capable of utilizing diaminododecane (DAD) were isolated from the soil by enrichment culture. Among 9 different kinds of substituted alkanes containing CN, NH$_2$, Cl, and SH groups (monoteminally or diterminally substituted) tested as carbon source, the isolate, designated as DAD 2-2. utilized DAD, putrescine dihydrochloride, dodecanethiol, dodecane and lautylamine. Thioanisole, decanedithiol, dicyanooctane, laurylcyanide, and dichlorodecane were not utilized. When emulgen 950 was added to the medium, the growth of DAD 2-2 was greatly accelerated. Isolated DAD 2-2 grown in the medium with DAD as carbon source formed ethyl $\alpha$-ketoglutarate. Metabolic product of DAD 2-2 grown in a medium without nitrogen source was different from that of grown in a medium with NH$_4$NO$_3$. When glucose, putrescine, n-dodecane and other alkane derivatives were tested in place of DAD, isolate DAD 2-2 yielded products different from those they formed with DAD suggesting specificity of DAD as a carbon source.

• Journal of Korea Water Resources Association
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• v.37 no.5
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• pp.437-448
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• 2004

The traditional fixed areal DAD(rainfall Depth-Area-Duration) method, generally quoted in most hydrology texts, is a simple and useful procedure when watersheds are small and storm movement is not an important factor of consideration. However, it is difficult to obtain satisfactory results for the more apparent forms of storm movement such as typhoons, or for large watershed. In the latter case, especially the margin of error for the areal average rainfall increases proportionally to the area of study, causing biased result. To overcome these limitations, this study focuses on the storm-centered DAD analysis(moving area DAD method) developed and programmed by the isohyetal concept to obtain accurate and objective results. By comparing and analyzing the observed rainfall rates through both method, it was proved that the currently Proposed method more accurately reflected the average rainfall rate. In short, through this new method, approximately 130 storm events nationwide from 1969 to 1999 was analyzed and compared with the fixed areal method results.

• Korean Journal of Microbiology
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• v.21 no.4
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• pp.191-196
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• 1983

A Corynebacterium sp. capable of utilizing diaminododecane (DAD) were isolated from the soil by enrichment culture. Among 9 different kinds of substituted alkanes containing CN, $NH_2$, Cl, and SH groups (monoterminally or diterminally substituted) tested as carbon source, the isolate, designated as DAD 2-3, utilized DAD, putrescine dihydrochloride, dodecane and laurylamine. Dodecanethiol, thioanisole, decanedithiol, dicyanooctane, laurylcyanide,and dichlorodecane were not utilized. When emulgen 950 was added to the medium, the growth of DAD 2-3 was slightly accelerated. Isolate DAD 2-3 grown in the medium with DAD as carbon source formed .alpha.-ketoglutaric acid. Metabolic product of DAD 2-3 grown in a medium without nitrogen source was different from that of grown in a medium with $NH_4NO_3$. When glucose, putrescine, n-dodecane and other alkane derivatives were tested in place of DAD, isolate DAD 2-3 yielded products different from those they formed with DAD suggesting specificity of DAD as a carbon source.

• Journal of Cadastre & Land InformatiX
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• v.47 no.1
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• pp.191-211
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• 2017

Assessment of a storm is accomplished by the duration and storm area rather than a simple analysis given by the ground rain gauge stations. One of the best method for assessing storm is Depth-Area-Duration(DAD) of rainfall analysis. but existing DAD analysis method is likely to possible errors. Therefore, DAD analysis and its applicability were examined using a grid-based DAD analysis program that can reduce the possibility of errors in this study. Three spatial distribution techniques were used to analyze the applicability. Then, DAD analysis was performed using the converted grid-based rainfall data. As a result, it was possible to estimate the MAAR values by area for each duration, and showed high applicability in the rainfall data using ordinary kriging technique.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.236-236
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• 2017

본 연구에서는 강우의 시공간성을 파악할 수 있는 격자기반의 Average-point Tracking 프로그램을 이용하여 호우의 DAD(Depth-Area-Duration)를 분석하였다. IPCC 5차보고서에 따르면 1950년 이래로 다수의 극한 기상 및 기후 변화가 관측되었다. 그 중 일부는 인간의 활동과 관련된 것으로 많은 지역에서의 극한 호우 현상의 증가가 손꼽힌다. 이러한 극한 호우 현상 증가와 일부 저수지의 유출 증가 경향은 지역적 규모에서 홍수의 위험이 더 커졌음을 의미한다(Kim et al., 2016). 최근 이상기후 현상의 증가에 따른 강우양상의 변화로 게릴라성 집중 호우와 태풍의 빈도가 증가하고 있지만, 우리나라의 호우의 특성은 방위 및 진행방향에 따른 해석이 매우 복잡하여 강우를 정형화하기에 어려운 특징을 보인다. 또한 지속시간이 긴 호우의 경우에는 호우의 범위가 한반도 전체가 되는 특성 때문에 강우의 시 공간성과 관련된 관측 자료는 부족하며, 이러한 특성을 고려한 연구 또한 미진한 실정이다. 만약, 태풍과 같이 호우이동이 뚜렷한 경우, 기존의 적용되고 있는 유역중심의 DAD 분석 방법으로는 DAD 관계를 명확히 표현하기 어려우며 유역면적이 증가할수록 유역의 면적평균강우량의 오차도 증가하기 때문에 DAD 분석의 정확도는 낮아지게 된다. 따라서 본 연구에서는 호우의 형태와 이동을 고려하기 위해 시간에 따른 호우를 격자로 나누어 격자를 증가시키면서 면적평균최대강우량을 산정할 수 있는 Average-point Tracking 방법을 이용하여 DAD 분석을 실시하였다.

• Journal of the Korean Association of Geographic Information Studies
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• v.17 no.3
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• pp.68-81
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• 2014

This study aims to apply and evaluate the automatic DAD analysis method, which is able to establish the depth-area relationship more efficiently and accurately for point-to-areal rainfall conversion. First, the proposed automatic DAD analysis method tracks the expansion route of area from the storm center, and it is divided into Box-tracking, Point-tracking, Advanced point-tracking according to tracking method. After applying the proposed methods to 10 events occurred in Yongdam-watershed area, we confirmed that the Advanced point-tracking method makes it possible to estimate the maximum average areal rainfal(MAAR) more accurately with consideration of the storm movement and the multi-centered storm. In addition, Advanced point-tracking could reduce the errors of the estimated MAAR induced by increasing the area because it can estimate MAAR for each storm center and compare them at the same time. Finally, the DAD curve for the study area could be derived based on the DAD analysis of the selected 10 events.

• Korean Journal of Pharmacognosy
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• v.44 no.4
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• pp.332-335
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• 2013

Geographical classification of A. gigas was performed in the present study using UHPLC-DAD combined with multivariate data analysis techniques. Six active constituents were isolated from A. gigas; nodakenin, marmesin, decursinol, demethylsuberosin, decursin and decursinol angelate. One hundred sixty eight A. gigas samples were simultaneously determined using UHPLC-DAD. A principal component analysis (PCA) and partial least square discriminant analysis (PLS-DA) was used to classify the samples according to geographical origins (Korea and China). The origins of A. gigas from Korea and China were correctly classified by 81.6% and 93.8% using PLS-DA Y prediction. This result demonstrates the potential use of UHPLC-DAD combined with multivariate analysis techniques as an accurate and rapid method to classify A. gigas according to their geographical origin.

• Journal of Pharmaceutical Investigation
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• v.22 no.4
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• pp.301-306
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• 1992

The influence of phenobarbital (PB) pretreatment (75 mg/kg/day, i.p. for 4 days) on the metabolite kinetics of diltiazem (DTZ) was studied in rats in order to elucidate the effect of esterase induced by PB on the formation of DTZ to desacetyldiltiazem (DAD), DAD was injected via portal vein (3 mg/kg) to the control and PB-pretreated rats, The intrinsic hepatic clearance of DAD was significantly increased by PB pretreatment and the absolute bioavailability of DAD was significantly decreased in the PB-pretreated rats. According to the hepatic biotransformation model of DTZ, the fraction of systemic clearance of DTZ which forms DAD $(G_{mi})$ was different from that of DTZ which furnishes the available DAD to the systemic circulation $(F_{mi})$ in control rats. This result shows that DTZ was suspected of the sequential hepatic first-pass metabolism. On the other hand, PB pretreatment enhanced the $G_{mi}$ value of DTZ by 44%. It may be concluded that the deacetylation of DTZ to DAD in rats is increased by the esterase induced by PB but the transfer rate of DAD immediately formed from DTZ into systemic circulation is not affected by PB due to the 27% decreased absolute bioavailability of DAD resulting from PB pretreatment.

• Journal of Korea Water Resources Association
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• v.37 no.5
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• pp.425-435
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• 2004

Mainly, observed maximum rainfall has been evaluated by point rainfall, but actually it should be considered by means of average areal rainfall. Average areal rainfall is an estimated value computed through DAD(rainfall Depth-Area-Duration) analysis. By using this value, an average and maximum areal rainfall according to area-duration relationship could be computed. In this study, we assume that the whole Korea region is hydrologically homogeneous, and then analyze using the storm-centered DAD(moving-area DAD) method for the past century data. From this analysis, we evaluate the yearly variation of observed maximum areal rainfall through area-duration relationship. And we also construct an IDF(rainfall Intensity-Duration-Frequency) curve by using the annual time series data which is composed of maximum areal rainfall. The characteristics of IDF and observed maximum areal rainfall is also evaluated.

• Journal of Pharmaceutical Investigation
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• v.22 no.4
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• pp.317-321
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• 1992

A high-performance liquid chromatographic (HPLC) method was developed for the determination of diltiazem (DTZ) and its major metabolite, deacetyldiltiazem (DAD), in rat plasma. DTZ, DAD and imipramine, the internal standard, were selectively fractionated from plasma on a $C_{18}$ reversedphase column $({\mu}-Bondapak,\;10\;{\mu}m\;silica,\;300{\times}3.9\;mm\;ID)$. The composition of the mobile phase was methanol: acetonitrile: 0.04 M ammonium bromide: triethylamine (40:24:36:0.06 in volume). The pH of the mobile phase of their method was lowered to 6.4. The eluents from the column were detected for DTZ and DAD using a UV detector at 237 nm. The recovery was >85% for DTZ and DAD, and average intra-day and inter-day coefficients of variation were <6% for DTZ and DAD at the concentration ranges of 20-1000 ng/ml. Detection limit of DTZ and DAD in plasma was 20 ng/ml with signal-to-noise ratio of 3. This method would be applicable to practical pharmacokinetic studies without detriment to the HPLC column.