• Animal Bioscience
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• 제37권2호
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• pp.218-227
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• 2024

Objective: The aim of this research was to explore the effects of dietary substitution of alfalfa hay by amaranth hay on production performance, rumen fermentation, nutrient digestibility, serum biochemical parameters and antioxidant ability in dairy cows. Methods: A total of 45 healthy Holstein cows with same parity and similar milk yield and body weight were randomly divided into 3 groups: control diet without amaranth hay (CON) or 50% and 100% alfalfa hay replaced by an equal amount of amaranth hay (dry matter basis, AH1 and AH2, respectively). All the cows were fed regularly 3 times a day at 06:30, 14:30, and 22:30 and had free access to water. The experiment lasted for 60 d. Results: The dry matter intake of CON and AH1 groups was higher (p<0.05) than that of AH2 group. Compared with AH1 group, the milk yield of AH2 group was reduced (p<0.05). Moreover, dietary substitution of alfalfa hay by amaranth hay increased (p<0.05) milk fat, ammonia nitrogen and acetate concentrations. However, the crude protein digestibility of AH2 group was lower (p<0.05) than that of CON group, while an opposite tendency of serum urea nitrogen was found between two groups. The neutral detergent fiber digestibility of AH1 group was increased (p<0.05) when compared to AH2 group. Amaranth hay treatment increased (p<0.05) the serum concentration of glutathione peroxidase in dairy cows. Compared with CON group, the malonaldehyde activity of AH1 group was decreased (p<0.05). Conclusion: Dietary replacing alfalfa hay with amaranth hay (50% ratio) in dairy cows did not affect production performance but improved their antioxidant ability.

• Korean Journal of Radiology
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• 제24권8호
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• pp.807-820
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• 2023

Objective: To assess whether computed tomography (CT) conversion across different scan parameters and manufacturers using a routable generative adversarial network (RouteGAN) can improve the accuracy and variability in quantifying interstitial lung disease (ILD) using a deep learning-based automated software. Materials and Methods: This study included patients with ILD who underwent thin-section CT. Unmatched CT images obtained using scanners from four manufacturers (vendors A-D), standard- or low-radiation doses, and sharp or medium kernels were classified into groups 1-7 according to acquisition conditions. CT images in groups 2-7 were converted into the target CT style (Group 1: vendor A, standard dose, and sharp kernel) using a RouteGAN. ILD was quantified on original and converted CT images using a deep learning-based software (Aview, Coreline Soft). The accuracy of quantification was analyzed using the dice similarity coefficient (DSC) and pixel-wise overlap accuracy metrics against manual quantification by a radiologist. Five radiologists evaluated quantification accuracy using a 10-point visual scoring system. Results: Three hundred and fifty CT slices from 150 patients (mean age: 67.6 ± 10.7 years; 56 females) were included. The overlap accuracies for quantifying total abnormalities in groups 2-7 improved after CT conversion (original vs. converted: 0.63 vs. 0.68 for DSC, 0.66 vs. 0.70 for pixel-wise recall, and 0.68 vs. 0.73 for pixel-wise precision; P < 0.002 for all). The DSCs of fibrosis score, honeycombing, and reticulation significantly increased after CT conversion (0.32 vs. 0.64, 0.19 vs. 0.47, and 0.23 vs. 0.54, P < 0.002 for all), whereas those of ground-glass opacity, consolidation, and emphysema did not change significantly or decreased slightly. The radiologists' scores were significantly higher (P < 0.001) and less variable on converted CT. Conclusion: CT conversion using a RouteGAN can improve the accuracy and variability of CT images obtained using different scan parameters and manufacturers in deep learning-based quantification of ILD.

• Annals of Clinical Neurophysiology
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• 제7권2호
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• pp.65-74
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• 2005

Charcot-Marie-Tooth (CMT) disease was described by Charcot and Marie in France and, independently, by Tooth in England in 1886. CMT is the most common form of inherited motor and sensory neuropathy, and is a genetically heterogeneous disorder of the peripheral nervous system. Therefore, many genes have been identified as CMT-causative genes. Traditionally, subclassification of CMT have been divided into autosomal dominant inherited demyelinating (CMT1) and axonal (CMT2) neuropathies, X-linked neuropathy (CMTX), and autosomal recessive inherited neuropathy (CMT4). Recently, intermediate type (CMT-Int) with NCVs between CMT1 and CMT2 is considered as a CMT type. There are several related peripheral neuropathies, such as $D{\acute{e}}j{\acute{e}}rine$-Sottas neuropathy (DSN), congenital hypomyelination (CH), hereditary neuropathy with liability to pressure palsies (HNPP) and giant axonal neuropathy (GAN). Great advances have been made in understanding the molecular basis of CMT, and 17 distinct genetic causes of CMT have been identified. The number of newly discovered mutations and identified genetic loci is rapidly increasing, and this expanding list has proved challenging for physicians trying to keep up with the field. Identifying the genetic cause of inherited neuropathies is often important to determine at risk family members as well as diagnose the patient. In addition, the encouraging studies have been published on rational potential therapies for the CMT1A. Now, we develop a model of how the various genes may interact in the pathogenesis of CMT disorder.

• 한국토양비료학회지
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• 제31권2호
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• pp.197-203
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• 1998

생태계 내에서는 생명체에 의한 물질순환이 지속적으로 일어나기 때문에 이러한 일련의 과정이 차단된 조건 특히 시설재배지와 같은 폐쇄적인 시스템에서는 연작장해와 같은 복합적인 문제가 발생한다. 본 연구는 이러한 문제를 해결하는데 있어 필수적인 생물학적인 평가방법을 얻고자 우리 나라 중부지역 주요 시설재배지의 토양을 채취하여 작물종류, 재배년수등의 요인이 토양 미생물의 특성에 미치는 영향을 살펴보았다. 시설재배지의 토양전기전도도는 장미와 화훼재배지가 각각 $1.23dS\;m^{-1}$과 $1.32dS\;m^{-1}$으로 시금치 $3.59dS\;m^{-1}$와 참외 재배지 $3.46dS\;m^{-1}$인 원예작물 재배지보다 낮았다. 재배년수가 증가할수록 토양화학성중 유기물과 인산염의 함량이 증가하였다. 재배작물별 미생물서식밀도는 형광성 Pseudomonas 속이 배추, 상추 시금치 등의 엽채류 재배지에서 $40.7{\times}10^4{\sim}97.9{\times}10^4cfu\;g^{-1}$, 딸기, 수박, 오이, 참외 등의 과채류 재배지에서 $25.0{\times}10^4{\sim}91.7{\times}10^4cfu\;g^{-1}$ 이었으나 장미와 화훼재배지는 $113.8{\times}10^4{\sim}129.7{\times}10^4cfu\;g^{-1}$으로 원예작물 재배지역에 비해 높았다. Fusarium속은 장미와 화훼재배지의 $3.8{\times}10^2{\sim}4.0{\times}10^2cfu\;g^{-1}$에 비해 엽채류 $4.3{\times}10^2{\sim}16.3{\times}10^2cfu\;g^{-1}$, 과채류 $7.6{\times}10^2{\sim}30.0{\times}10^2cfu\;g^{-1}$으로 원예재배지가 상대적으로 높았다. 재배년수별 토양미생물수는 호기성세균, 중온성 Bacillus속, 고온성 Bacillus속 및 형광성 Pseudomonas속등이 11년 이상된 시설재배지에서 높았으나, 다양성 지수는 재배년수가 증가할수록 감소하였다. 토양 미생물체량인 Biomass 탄소는 호기성 세균, 방선균 및 중온성 Bacillus 속등의 미생물수와 정의 상관관계를 가지고 있었다.

• 셀메드
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• 제2권2호
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• pp.16.1-16.5
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• 2012

Fever in cancer patients is often due to the following causes: evil qi and toxity stagnancy, disorders of qi and blood, deficiencies of zang and fu organs, and the disorder of yin and yang. The treatments given to cancer patients with a fever are according to five: (a) Excessive inner heat and toxicants: remove heat and the toxicant, induce purgation. We use Cheng-Qi-Tang plus Qing-Wen-Bai-Du-Yin. (b) Tangle of damp and heat, and qi stagnancy: remove damp and heat, smooth the qi channel. We use Gan-Lu-Xiao-Du-Dan or San-Ren-Tang. (c) Obvious blood and heat stagnancy: remove heat and blood stasis. We use Xue-Fu- Zhu-Yu-Tang. (d) Deficiency of spleen qi, inner heat caused by a yin deficiency: nourish spleen qi and yin to remove the inner heat. We use Bu-Zhong-Yi-Qi-Tang or Xiao-Jian-Zhong-Tang. (e) Prominent yin deficiency and hectic fever: replenish yin and remove inner heat. We use Qing-Hao-Bie-Jia-Tang or Chai- Qian-Mei-Lian-San. The pathogenesis of fever in cancer patients is complicated. We can see both deficiency and excess in one differentiation. Therefore, we must make sure of it, then we can get the most effective treatment.

• 대한한의학회지
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• 제42권2호
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• pp.107-119
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• 2021

Objectives: This study was aimed to report changes in clinical symptoms and signs after treatment with Korean medicine in patients who suffered from calf edema due to deep vein thrombosis (DVT). Methods: A 46-year-old male patient, who discharged home after receiving standardized treatment for acute DVT in the right leg, suffered pain and heat sense due to edema of the affected calf. Oral administration of herbal medicine (Gyejibongnyeong-hwan 4 g, twice daily) and acupuncture therapy were given to him for 6 weeks. The change in chief complaints, Villalta score, the right and left side difference of the circumference and the skin surface temperature of both calves, and blood level of D-dimer were observed before and after treatment. Results: The patient's chief complaints began to significantly improve from 2 weeks after treatment, and disappeared completely within 4 weeks. At the end of the treatment, a substantial decrease in the difference between the right and left calves in the circumference and skin surface temperature was observed. This effect was maintained even at the time of follow-up 3 months after the end of treatment, and the patient completely recovered indoor and outdoor life to the level before onset. Conclusions: This case suggests that Korean medicine treatment, including Gyejibongnyeong-hwan administration and acupuncture therapy, can be a viable option to improve edema and related clinical problems in the affected limbs due to DVT.

• Journal of Acupuncture Research
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• 제23권3호
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• pp.177-190
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• 2006

Objectives : It has long been known about the anticancer effect of GRR-HAS, however, it has not been systemically determined the differentially regulated genes by GRR-HAS in cancer cells. The purpose of this study is to screen the GRR-HAS mediated differentially expressed genes in cancer cells such as HepG2 hepatoma cell lines. Oligonucleotide microarray and proteomic approaches were employed to screen the differential expression genes. Methods : GRR~HAS was prepared by boiling and stored at $-70^{\circ}C$ until use. Cells were treated with various concentrations of GRR-HAS (0.1, 0.5, 1.5, 10, $20mg/m{\ell}$) for 24 h. Cell toxicity was tested by MTT assay. To screen the differentially expressed genes in cancer cells, cells were treated with $1.5mg/m{\ell}$ of GRR-HAS. For oligonucleotide microarray assay, total RNA was used for gene expression analysis using oligonucleotide genechip (Human genome Ul33 Plus 2.0., Affimatrix Co.). For proteomic analysis, total protein was analyzed by 2D gel electrophoresis and Q-TOF mass spectrometer. Results : It has no cytotoxic effects on both HepG2 cells in all concentrations(0.1, 0.5, 1.5, 10,$20mg/m{\ell}$). In oligonucleotide microarray assay, the number of more than twofold differentially regulated known genes was 320 with 6 up-regulated and 314 down-regulated genes in HepG2 cells. In proteomic analysis, three spots were identified by 2D-gel electrophoresis and Q-TOF analysis. One down -regulated protein was protein disulfide isomerase and up-regulated proteins were fatty acid binding protein 1 and 14-3-3 gan1lTIa protein by $1.5mg/m{\ell}$ of CRR-HAS. Discussion : This study showed the comprehensive gene expression analysis using oligonucleotide microarray for the screening of GRR-HAS mediated differentially regulated genes. These results will provide a better application of GRR-HAS in cancer field and drug target development.

• 한국정밀공학회지
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• 제19권8호
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• pp.212-219
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• 2002

The pipe with a long-neck flange is widely used in power plants, chemical plants, and shipbuilding companies. Now the pipe with a long-neck flange is manufactured by welding a thick flange to a pipe. But this long-neck flange pipe has some defects in the welding region such as unfitting and local thermal fatigue, which weaken the strength around the neck of the flange. Moreover, after welding the flange, the contacting surfaces of the flange have to be machined flat. So, that is uneconomical. Therefore, to solve the above problems of the long-neck flange pipe, a new process, which has no defects around the flange neck, is required. In this study, three forming processes are suggested to get an enhanced long-neck flange. First suggested process consists of conical forming and flange forming. Second and third suggested processes consist of the bulging of a long pipe locally heated by induction coils and the flange forming. The differences between second and third suggestions are the thickness and local heating area of the pipe. That is, the thickness of the initial pipe of third suggestion is larger than that of the final product, and the local heating area is smaller than that of second suggestion. These three suggestions for forming a long-neck flange are simulated by FE analyses with a commercial code DEFORM 2D. Especially, the theoretical result of FE analysis on the first suggestion for forming a long-neck flange is verified by the experiment with aluminum 6063 pipes. From the theoretical and experimental results, it is concluded that three suggested processes are very useful in order to manufacture the pipe with a long-neck flange without any defects.

• 자원환경지질
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• 제4권2호
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• pp.77-90
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• 1971

About four hundred deposits of iron, talc, fluorite, tungsten, molybdenum, lead, zinc and other polymetallic mineral deposits were plotted on the Ore Distribution Map of the Ockcheon Geosynclinal Area. These mineral deposits plotted on the map can be divided into the several metallogenic zones by the consideration of their geologic background including the sedimentary and tectonic cycles and the igneous activities in the geosynclinal evolution, as follows: a. Chungju iron and talc zones. b. Cheong-san copper bearing iron sulphide zone c. Kumsan-Muju fluorite-polymetallic zones. d. Cheong-an Puyong and Ein Suckseong gold zone e. Hwang-gan Seolcheon and Sangju gold zones. Chungju iron zone originated in the iron bed in the Kemyongsan Series corresponding to the Pre-Ockcheon Cycle of evolution history. In early period of the Ockcheon Cycle, Hyangsanri quartzite and Munjuri phyllitic formation corresponding to the lower terrigenous sequence were not mineralized while the next sequence of the Samsungsan basic igneous-metamorphic formation and the Changri limestone formation were mineralized by the copper bearing iron sulphide and the fluorite-polymetallic deposits respectively. Two generations of the gold zones are recognized. The earlier generation distributes directionaly in the outside of the Ockcheon sedimentary belt was followed by the earlier grantitic invasion of Jurasic in age, while the later generation scatters at random which was related to the nondirectional Cretaceous granitic intrusion of the Post-Ockcheon Cycle. Conclusively speaking, it was disclosed that the endogenic mineralization in the Ockcheon geosyn clinal zone was not conspicuous in its inner sedimentary belt except its limestone area but in its outer peripheral granitic or gneissic zones, and the related igneous activities occured in the Post-Ockcheon Cycle of evolution history.

• 한국토양비료학회지
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• 제31권1호
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• pp.9-15
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• 1998

우리나라 시설재배지 토양화학성분 함량을 파악하기 위하여 과채류(果菜類) 350점, 엽채류(葉菜類) 119점, 화분류(花奔類) 44점 계 513점의 토양시료를 전국에서 채취하여 분석한 결과는 다음과 같다. 시설재배지 표토의 토양화학성분 함량의 평균함량은 pH 6.0, 유기물 35g/kg, 유효인산 1.092mg/kg, 전기 전도도 2.94dS/m이고, 치환성칼리, 석회, 고토함략은 각각 1.27, 6.0, 2.Scmol+/kg이며, 질산태질소 함량은 155.1mg/kg이었다. 작물별로는 엽채류(葉菜類) > 과채류(果菜類) > 화분류(花奔類)재배지 순으로 토양화학성분 함량이 많았다. 심토의 토양화학성분 함량은 pH 6.0, 유기물 27g/kg, 유효인산 761mg/kg, 염농도는 1.83dS/m이고. 치환성칼리, 석회, 고토함량은 각각 0.93. 5.3. 1.7cmol+/kg이며, 질산태질소 함량은 93.4mg/kg으로 pH를 제외하고 대부분의 성분들이 표토보다 낮았다. 토양의 화학성이 작물생육에 적정한 범위보다 낮은토양의 분포비율은 pH 46.4% 유효인산 12.7, 치환성칼리 23.4, 치환성석회 29.8, 치환성고토 27.9%, 유기물은 20.7%이었고, 적정범위보다 많은 토양은 pH 26.8% 유효인산 79.9, 치환성칼리 70.6, 치환성석회 52.4, 치환성고토 53.2, 유기물은 54.8%이었다. 토양화학성분들과 전기전도도와의 상관관계에서 상관계수는 질산태질소> 치환성고토> 치환성칼리> 치환성석회 순으로 감소하였다. 시설 재배지 토양화학성분 함량에서 년차의 경과에 따른 변동은 pH,치환성석회, 치환성고토함량은 변동폭이 크지 않았으나, 유기물, 유효인산, 치환성칼리함량은 점차 높아지는 경향이었다.