• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6435-6439
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• 2012

Chemoresistance to cancer therapy is a major obstacle to the effective treatment of human cancers with cisplatin (DDP), but the mechanisms of cisplatin-resistance are not clear. In this study, we established a cisplatin-resistant human ovarian cancer cell line (COC1/DDP) and identified differentially expressed proteins related to cisplatin resistance. The proteomic expression profiles in COC1 before and after DDP treatment were examined using 2-dimensional electrophoresis technology. Differentially expressed proteins were identified using matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry (MALDI-TOF-MS) and high performance liquid chromatography-electrospray tandem MS (NanoUPLC-ESI-MS/MS). 5 protein spots, for cytokeratin 9, keratin 1, deoxyuridine triphosphatase (dUTPase), aarF domain containing kinase 4 (ADCK 4) and cofilin1, were identified to be significantly changed in COC1/DDP compared with its parental cells. The expression of these five proteins was further validated by quantitative PCR and Western blotting, confirming the results of proteomic analysis. Further research on these proteins may help to identify novel resistant biomarkers or reveal the mechanism of cisplatin-resistance in human ovarian cancers.

• Journal of Biomedical Engineering Research
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• v.19 no.6
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• pp.623-629
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• 1998

To provide sufficient sound to the hearing-impaired person(HIP) who have many difficulty in communication with others using general telephone, big amplification is needed. But big amplification can occur howling as a side effect. In this study we developed the new technique of big amplification without howling, manufactured and estimated the new hearing aid telephone. Telephone speech is divided to three frequency band, amplified respectively and fitted to HIP's hearing ability. The telephone speech frequency is monitored by counter in time domain. The counter transfers the sinusoidal sound to rectangular wave using comparator and counts the number of rectangular wave in a certain time period, that is frequency, to monitor the howling. Telephone have microphone and speaker, which are fitted in a rigid structure and frequency band of telephone sound is limited, so howling occurs in the limited frequency band. If the counter notices that howling conditions happen, microprocessor decreases quickly the gain of the related frequency band. The result of test of our new hearing aid telephone showed that we can amplifiy the sound as much as 40dB, which is meaningful level to many HIP, and make HIP increase their perception ability from 20% to 60.8% in 1 syllable test and from 28.9% to 78% in 2 syllable test.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.32 no.6
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• pp.367-374
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• 2019

We investigate the effect of soil-structure interaction (SSI) on the response of LNG storage tanks to vertical seismic excitation depending on the type of foundation. An LNG storage tank with a diameter of 71 m on a clay layer with a thickness of 30 m upon bedrock, was selected as an example. The nonlinear behavior of the soil was considered in an equivalent linear method. Four types of foundation were considered, including shallow, piled raft, and pile foundations (surface and floating types). In addition, the effect of soil compaction within the group pile on the seismic response of the tank was investigated. KIESSI-3D, an analysis package in the frequency domain, was used to study the SSI and the stress in the outer tank was calculated. Based on an analysis of the numerical results, we arrived at three main conclusions: (1) for a shallow foundation, the vertical stress in the outer tank is less than the fixed base response due to the SSI effect; (2) for foundations supported by piles, the vertical stress can be greater than the fixed base stress due to the increase in the vertical impedance due to the piles and the decrease in radiation damping; and (3) soil compaction had a miniscule impact on the seismic response of the outer tank.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.32 no.3
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• pp.155-164
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• 2019

In this study, the soil-structure interaction(SSI) effect on the seismic response of LNG storage tanks was investigated according to the type of foundation. For this purpose, a typical of LNG storage tank with a diameter of 71m, which is constructed on a 30m thick clay layer over bedrock was selected, and nonlinearity of the soil was taken into account by the equivalent linearization method. Four different types of foundations including shallow foundation, piled raft foundation, and pile foundations(surface and floating types) were considered. In addition, the effect of soil compaction in group piles on seismic response of the tank was investigated. The KIESSI-3D, which is a SSI analysis package in the frequency domain, was used for the SSI analysis. Stresses in the outer tank, and base shear and overturning moment in the inner tank were calculated. From the comparisons, the following conclusions could be made: (1) Conventional fixed base seismic responses of outer tank and inner tank can be much larger than those of considering the SSI effect; (2) The influence of SSI on the dynamic response of the inner tank and the outer tank depends on the foundation types; and (3) Change in the seismic response of the structure by soil compaction in the piled raft foundation is about 10% and its effect is not negligible in the seismic design of the structure.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.19 no.3
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• pp.173-186
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• 2024

This paper analyzes a case of successful faculty entrepreneurship through a coupled process of open innovation in a university context, using the core competency theory perspective. Initially, the current state of faculty entrepreneurship is examined, and the effects of interdisciplinary coupled processes of open innovation are explored, focusing on the case of 'Omotion Inc.,' a startup utilizing generative AI technology for hyper-realistic 3D virtual human experiences. The research methodology involves in-depth interviews with Omotion Inc.'s co-founders, technology commercialization professionals, and experts in the field, followed by analysis based on foundational theories. Applying the core competency theory, this paper scrutinizes the process of integrating diverse expertise and technologies from various academic disciplines. The analysis goes beyond the limitations of faculty entrepreneurship confined to a single technology-centric research domain. Instead, it explores the possibilities of enhancement and value creation through coupled processes, providing practical implications for the university entrepreneurial ecosystem. The aim is to extend the traditional roles of education and research within the university, presenting a role in economic value creation beyond the boundaries of conventional faculty entrepreneurship. Through the collaboration of two faculty members, this study showcases the creation of novel technology and business models. It establishes that successful coupled processes of open innovation in faculty entrepreneurship, from a core competency theory perspective, require the entrepreneurial firm to possess (1) entrepreneurial capabilities, (2) technological capabilities, and (3) networking capabilities. The implications of this research highlight the positive impact of coupled processes of open innovation in faculty entrepreneurship, as evidenced by the Omotion Inc. case, offering guidance on entrepreneurial directions for university members preparing for entrepreneurship.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.25 no.2
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• pp.245-250
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• 2014

This paper introduces the inverse synthetic aperture radar(ISAR) imaging technique for rear view target of an automobile, which uses both linear frequency modulation-frequency shift keying(LFM-FSK) waveform and monopulse tracking. LFM-FSK waveform consists of two sequential stepped frequency waveforms with some frequency offset, and thus, can be used to generate ISAR images of rear view target of an automobile. However, ISAR images can often be blurred due to non-uniform change rate of relative aspect angle between radar and target. In order to address this problem, one-dimensional(1-D) Lagrange interpolation technique in conjunction with angle information obtained from the monopulse tracking is applied to generate uniform data across the radar's aspect angle. Simulation results show that the proposed method can provide focused ISAR images.

• The Korean Journal of Rehabilitation Nursing
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• v.6 no.2
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• pp.127-136
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• 2003

Purpose: This study is to assess the quality of life(QOL) of hematic cancer survivors after hematopoietic stem cell transplantation(HSCT) and received chemotherapy(RC) to prepare basic information for nursing interventions in order to improve the patients' QOL. Method: The data were collected by self-reporting questionnaire from January to March, 2003 intended for outpatients at the Cancer center of D university hospital in Busan. All 44 of them were diagnosed as hematic cancer and had spent 100 days after getting HSCT and complete remission(CR) throughout RC. The collected data were analyzed with descriptive statistics, t-test, ANOVA using SPSS/WIN 10.0 program. Results: The total mean score of the QOL was moderate. In case of survivors in HSCT, the total mean score of the QOL was $5.81{\pm}1.08$, and that of survivors in RC was $5.94{\pm}1.13$. The facts above has not been considered statistically as the result of analysis of differences in each domain of the QOL depending on the general characteristics of the objects of this study. Conclusion: The total mean score of the QOL was at moderate levels, indicating that the survivors after HSCT and RC were perceiving their QOL as moderate. In the nursing business aspect, the most important thing is to understand the QOL which the 2 groups of the survivors perceive, and the plans of nursing intervention that can be helpful to more qualitative life should be studied constantly.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.29 no.2
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• pp.109-117
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• 2018

In order to form focused inverse synthetic aperture radar(ISAR) images of a non-uniformly rotating target, rotational motion compensation(RMC) should be performed. Prominent point processing(PPP), one of the most representative RMC methods, is used to compensate nonlinear rotation motion by exploiting the phase signals of scatterers. In this paper, we propose a new RMC method based on the integrated cubic phase function(ICPF). The ICPF requires only one-dimensional(1-D) maximization to estimate the phases of multi-component signals. Simulation results using a point scatterers model in the absence of dominant scatterers validate that PPP based on ICPF can achieve well-focused ISAR images in real time.

• Toxicological Research
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• v.21 no.3
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• pp.209-218
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• 2005

We investigated effects of recombinant human erythropoietin (rHuEPO) on profiles of mRNA transcripts in 6 male cynomolgus (M. fascicularis) monkey's spleen for 4 weeks. Six monkeys, composed of control and treatment group (Control : M1, M2, M3: Treatment : M4, M5, M6) were intravenously administered 3 times per week without or with a dose of rHuEPO 2730 IU/0.1 ml/kg. After 4 weeks rHuEPO treatment, spleen was removed for RNA isolation. Splenic gene expression was assessed using Affymetrix U133A 2.0 arrays containing 18,400 transcripts and variants, including 14,500 well-characterized human genes. Gene expression pattern was very different between individuals even in same treatment. In rHuEPO treated groups showed number of genes were up- or down-regulated (M4: 79: M5: 48; M6: 73 genes). Six genes (epidermal growth factor receptor, calgranulin A, estrogen receptor binding site associated antigen, matrix metalloproteinase 19, zinc finger and BTB domain containing 16, progestin and adipoQ receptor) were commonly expressed in rHuEPO treated group. The different individual response could be major considering factor in monkey experiment. Further study is needed to clarify the different individual response to rHuEPO in molecular level. This study will be valuable in the fundamental understanding and validation of molecular toxicology for bio-generic drugs including rHuEPO in cynomolgus monkey.

• Journal of Information Science Theory and Practice
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• v.5 no.2
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• pp.62-74
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• 2017

This study examined the mechanical engineering research output from India, Japan, and South Korea on different parameters including growth, collaboration indices, and activity index. The purpose of the study is to understand the overall development of mechanical engineering through analytical approaches applied on the scholarly outcome of the countries considered for the study. The study focuses on analysing the articles published by India, Japan, and South Korea, and is restricted to articles indexed in the Science Citation Index - Web of Science for the period 2000 to 2014. The ratios of number of paper to citations for India, Japan, and Korea are 20,836: 1,97,679; 24,494: 2,04,393; and 30,578: 2,66,902 respectively for the period 2000-2014. The findings show that there is a decline in Japanese publications in mechanical engineering, whereas other two countries have recorded an increasing trend. While India has tripled its publications in a span of 15 years, South Korea, on the other hand, has doubled its publications in the same span of time. There has been an increasing trend towards collaboration in almost all fields of science and technology. However, the extent of collaboration and their rate of growth varied for one subject to another, one branch to another branch of the same subject, and from one country to another country. The present study analyses the growth of research publications of the mechanical engineering domain including authorship distribution, collaboration indices, prominent journals, and activity index.