• Journal of Pharmaceutical Investigation
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• v.21 no.4
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• pp.215-222
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• 1991

The absorption characteristics of itraconazole, which is an antifungal agent, from intestinal segments in the anesthetized rat i1l situ were investigated in order to design an effective oral drug delivery system. The pH-solubility profile of itraconazole, the rate and extent of absorption of itraconazole, the optimal absorption site(s) of itraconazole and the absorption enhancing effect of sodium cholate on itraconazole were examined in the present study. In situ single-pass perfusion method and recirculating perfusion technique using duodenum(D), jejunum(J) and ileum(I) were employed for the calculation of apparent permeability(Pe) and apparent first-order rate constant(Kobs). respectively. The results of this study were as follows; (1) Itraconazole showed appreciable aqueous solubility only at pH values of below 2.0. (2) pe(cm/sec) decreased in the following order: $D(10.24{\pm}1.78{\times}10^{-4})>J(8.86{\pm}0.79{\times}10^{-4})>I(3.78{\pm}0.13 X 10^{-4})$. (3) $Kobs(min^{-1})$ decreased in the following order: $J(17.12{\pm}3.19{\times}10^{-3})>D(13.37{\pm}0.6{\times}10^{-3})>I(11.05{\pm}0.91{\times}10^{-3})$. (4) The solubility of itraconazole markedly increased with the increase of the concentration of sodium cholate. (5) The addition of 10 mM sodium cholate significantly increased the apparent first-order rate constant of itraconazole in the ileum by a factor of 6.8.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.30 no.1
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• pp.1-9
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• 2018

In present study, we suggested the quasi-linear model that linearizes the quadratic drag representing the energy loss across the porous plate. The quasi-linear model was solved by Boundary Element Method (BEM) for development of the porous wave absorber suitable for 2-D wave tank. The drag coefficient at the porous plate was newly obtained through comparison of experimental results. It is found that the porous wave absorber with porosity 0.1, submergence depth d/h = 0.1, and inclined angle $10^{\circ}{\leq}{\theta}{\leq}20^{\circ}$ shows the effective wave absorption. Using the developed quasi-linear numerical model, the optimal design of various types of a porous wave absorber will be applied.

• Journal of Microbiology and Biotechnology
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• v.18 no.5
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• pp.933-941
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• 2008

An extracellular $\beta$-glucosidase produced by Monascus purpureus NRRL1992 in submerged cultivation was purified by acetone precipitation, gel filtration, and hydrophobic interaction chromatography, resulting in a purification factor of 92-fold. A $2^2$ central-composite design (CCD) was performed to find the best temperature and pH conditions for enzyme activity. Maximum activity was observed in a wide range of temperature and pH values, with optimal conditions set at $50^{\circ}C$ and pH 5.5. The $\beta$-glucosidase showed moderate thermostability, was inhibited by $HgCl_2$, $K_2Cr_O_4$, and $K_2Cr_2O_7$, whereas other reagents including $\beta$-mercaptoethanol, SDS, and EDTA showed no effect. Activity was slightly stimulated by low concentrations of ethanol and methanol. Hydrolysis of p-nitrophenyl-$\beta$-D-glucopyranoside (pNPG), cellobiose, salicin, n-octyl-$\beta$-D-glucopyranoside, and maltose indicates that the $\beta$-glucosidase has broad substrate specificity. Apparently, glucosyl residues were removed from the nonreducing end of p-nitrophenyl-$\beta$-D-cellobiose. $\beta$-Glucosidase affinity and hydrolytic efficiency were higher for pNPG, followed by maltose and cellobiose. Glucose and cellobiose competitively inhibited pNPG hydrolysis.

• The KIPS Transactions:PartD
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• v.16D no.5
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• pp.755-766
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• 2009

Software architecture allows us to make many decisions about a software system and analyze it even before it exists in order to make systematic and planned development possible. Similarly, architecture-based software evolution planningmakes planned evolution possible by allowing us to make many decisions about evolution of a software system and analyze its evolution at the level of architecture design before software evolution is realized. In this paper, we develop a framework for architecture-based software evolution planning for the class of deterministic evolution plans by defining and relating various essential concepts and developing its valuationmechanism so that a plan with the greatest value among candidate plans can be selected as an optimal plan. A case study is conducted for explicating the framework and exemplifying its usage.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.247-247
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• 2019

수력발전 사업에 있어 Desander 구조물은 주로 고산지대 수력발전댐의 Run-of-river 형식의 발전방식에서 유사로 인한 터빈의 손상을 방지하기 위한 목적으로 설치된다. Desander의 적정 규모는 터빈의 손상을 일으킬 수 있는 유사 입경에 대해 안정적으로 침전을 시킬 수 있는 폭/길이/깊이로 평가할 수 있으며 상대적으로 Desander의 규모가 크게 설계된 경우 초기 공사비 증가하고 반대로 규모가 작게 설계된 경우 터빈의 교체 주기 단축으로 인한 유지관리비가 증가된다. 현재까지 일반적인 Desander 구조물의 설계 방식은 제거 입경의 침전 속도, 유입유량 및 깊이를 변수로 사용하여 경험식(L. Sudry method, Guicciardis method 및 Rouse method)을 통해 규모를 결정해 왔다. 하지만, 3-D 전산유체해석을 통해 유속 흐름 분석으로 직 간접적 Desander 규모의 적정성을 평가할 수 있는 현 시점에서 경험식으로부터 도출된 결과의 신뢰성과 객관성을 검증할 필요가 있다고 판단된다. 본 연구에서는 노르웨이 NSTU에서 개발한 유사의 이송 및 확산해석 기능이 내장된 범용 소프트웨어인 SSIIM을 이용하였다. SSIIM(Simulation of Sediment movements In water Intakes with Multiblock)은 개수로 흐름 상태에서 유사 이동 및 하상 변동을 분석할 수 있도록 개발된 3-D 해석 프로그램이다. SSIIM은 수치해석 방법으로 유한체적법(Finite Volume Method)를 채택하였으며 Navier-Stokes equations을 통해 유체의 흐름을 해석한다. 입력 자료는 유입 유량($m^3/sec$), 유입 유사량(kg/sec), 유출부 수위 및 해당 Desander Structure grid 자료가 사용되며 해석 결과로 Desander 내 grid 별 유속, 수위, 유사 농도 변화 등을 제공한다. 본 연구에서는 SSIIM을 이용하여 제거 목표 유사 입경의 차집 효율(Trap efficiency)로 Desander의 적정 규모를 평가 할 수 있는 설계법을 제안하며 설계 단계에서 결정되는 최소 제거유사 입자와 차집 효율에 의한 Desander의 적정 규모 평가 분석을 파키스탄 A 프로젝트를 대상으로 수행하였다. 연구 성과로 (1)SSIIM을 통해 해석된 차집 효율을 기초로 Desander의 적정 규모를 계획할 경우 경험적 방식에 비해 설계의 객관성과 신뢰성을 제고할 수 있으며 (2)3-D 수치해석을 통해 grid 별 유사농도를 확인 할 수 있어 Desander 형상과 규모에 대한 평가가 가능하다.

• Geomechanics and Engineering
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• v.32 no.6
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• pp.583-600
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• 2023

The resilient modulus (M_R) of various pavement materials plays a significant role in the pavement design by a mechanistic-empirical method. The M_R determination is done by experimental tests that need time and money, along with special experimental tools. The present paper suggested a novel hybridized extreme gradient boosting (XGB) structure for forecasting the M_R of modified base materials subject to wet-dry cycles. The models were created by various combinations of input variables called deep learning. Input variables consist of the number of W-D cycles (WDC), the ratio of free lime to SAF (CSAFR), the ratio of maximum dry density to the optimum moisture content (DMR), confining pressure (σ₃), and deviatoric stress (σ_d). Two XGB structures were produced for the estimation aims, where determinative variables were optimized by particle swarm optimization (PSO) and black widow optimization algorithm (BWOA). According to the results' description and outputs of Taylor diagram, M1 model with the combination of WDC, CSAFR, DMR, σ₃, and σ_d is recognized as the most suitable model, with R² and RMSE values of BWOA-XGB for model M1 equal to 0.9991 and 55.19 MPa, respectively. Interestingly, the lowest value of RMSE for literature was at 116.94 MPa, while this study could gain the extremely lower RMSE owned by BWOA-XGB model at 55.198 MPa. At last, the explanations indicate the BWO algorithm's capability in determining the optimal value of XGB determinative parameters in M_R prediction procedure.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.44 no.1
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• pp.117-124
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• 2024

The objective of Value Engineering (VE) is to derive the optimal value at the most efficient life cycle cost, comprising three stages: Pre-Study, Study, and Post-Study. In this study, we propose a method for information collection and analysis during planned site visit surveys in the preparation stage of VE. The 3D spatial model, created using a drone, facilitated observation and analysis of the study area from various angles, both from the center and the outside. Additionally, through the utilization of drones, we conducted on-site investigations of the research area's 3D spatial model, enabling a macroscopic perspective previously only feasible through a microscopic viewpoint during planned site visits in the pre-study phase. Furthermore, the utilization of actual spatial data obtained from observations allowed for real-time information verification during Design VE workshops, enhancing the efficiency and reliability of the VE project.

• Asian-Australasian Journal of Animal Sciences
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• v.13 no.7
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• pp.974-979
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• 2000

A total of 80 weaned piglets (Landrace $\times$ Yorkshire $\times$ Large White) were used in a 28-day growth assay to detennine the optimal inclusion level of sodium sulfite ($Na_{2}SO_{3}$) as an extrusion enhancer of soybean meal for nursery piglets. piglets (21 d of age, 6.04 kg of BW) were grouped into 4 treatments in a completely randomized block design. Treatments were: 1) Extruded SBM (Control), 2) Extruded SBM with 0.5% $Na_{2}SO_{3}$ (0.5 ESBM), 3) Extruded SBM with 1.0% $Na_{2}SO_{3}$ (1.0 ESBM) and 4) Extruded SBM with 1.5% $Na_{2}SO_{3}$ (1.5 ESBM). Each treatment has 4 replicates of 5 heads per pen. In phase I (d 0 to 14), diets supplied 3,400 kcal ME/kg, 23% crude protein, 1.65% lysine, 0.50% methionine, 0.9% Ca and 0.8% P. Phase II (d 14 to 28) diets contained 3,300 kcal ME/kg, 21% crude protein, 1.45% lysine, 0.45% methionine, 0.9% Ca and 0.8% P. For d 0 to 14, piglets fed 1.5 ESBM had greater ADG, ADFI and FCR compared to piglets fed control and 0.5 ESBM diet. ADG was significantly higher in piglets fed 1.5 ESBM diet than other groups (p<0.05) except 1.0 ESBM. In phase II (d 14 to 28), there was no significant differences in production traits among treatments. For overall period (d 0 to 28), piglets fed diets with high sodium sulfite grew faster than piglets fed control and 0.5 ESBM diets. The highest ADG and the best FeR were obtained in piglets fed diets with 1.5 ESBM during the entire period. Piglets fed 1.5 ESBM diet showed significantly higher crude protein digestibility than 0.5 ESBM (p<0.05) at d 14 post-weanling, but not at d 28 post-weanling. There were no significant differences in digestibilities of total amino acids. In conclusion, the addition level of 1~1.5% sodium sulfite for SBM extrusion could be favorable for rate and efficiency of growth in weaning pigs.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.24 no.12A
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• pp.1883-1890
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• 1999

Wireless communication in an urban area, the accurate prediction of wave propagation characteristics are very important to determine communication service areas, select optimal base-stations, and design cells, etc. The CCIR model is a propagation prediction model using a shadowing by the buildings in an urban area. This model represent the shadowing rate by the means of the effect of shadowing between base-station and mobile unit in a shaped linear plane. But, This one occurred a lot of prediction error because it did not consider that density area by the buildings and terrain configurations by the hill and mountain on Line-Of-Sight. In this thesis, an improved propagation prediction model is proposed to reduce prediction error. We presents a new equation, which is using the SAS. This equation is associated with the shadow height by the buildings that considers the topology and the number of blocks that can affect the building shadow in the Line-Of-Sight. We measure the received electrical field level of base-station that high density area, medium density area, and low density area, and then compare and analysis the result to prediction of CCIR model and proposed model. The result compared with the measurement, the proposed model has the improvement of 9.71dB in a high density area, 9.66dB in a medium density area, and 4.02dB in a low density area better than the CCIR model. The result compared with the measurement, the proposed model has the improvement of 9.71dB in a high density area, 9.66dB in a medium density area, and 4.02dB in a low density area better than the CCIR model.

• Journal of Korean Society of Disaster and Security
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• v.14 no.2
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• pp.61-75
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• 2021

Recently, as the occurrence frequency of sudden floods due to climate change increased and the aging of the existing spillway, it is necessary to establish a plan to utilize an auxiliary spillway to minimize the flood damage of downstream rivers. Most studies have been conducted on the review of flow characteristics according to the operation of auxiliary spillway through the hydraulic experiments and numerical modeling. However, the studies on examination of flood damage in the downstream rivers and the stability of the revetment according to the operation of the auxiliary spillway were relatively insufficient in the literature. In this study, the stability of the revetment on the downstream river according to the outflow conditions of the existing and auxiliary spillway was examined by using 3D numerical model, FLOW-3D. The velocity, water surface elevation and shear stress results of FLOW-3D were compared with the permissible velocity and shear stress of design criteria. It was assumed the sluice gate was fully opened. As a result of numerical simulations of various auxiliary spillway operations during flood season, the single operation of the auxiliary spillway showed the reduction effect of maximum velocity and the water surface elevation compared with the single operation of the existing spillway. The stability of the revetment on downstream was satisfied under the condition of outflow less than 45% of the design flood discharge. However, the potential overtopping damage was confirmed in the case of exceeding the 45% of the design flood discharge. Therefore, the simultaneous operation with the existing spillway was important to ensure the stability on design flood discharge condition. As a result of examining the allocation ratio and the total allowable outflow, the reduction effect of maximum velocity was confirmed on the condition, where the amount of outflow on auxiliary spillway was more than that on existing spillway. It is because the flow of downstream rivers was concentrated in the center due to the outflow of existing spillway. The permissible velocity and shear stress were satisfied under the condition of less than 77% of the design flood discharge with simultaneous operation. It was found that the flood damage of downstream rivers can be minimized by setting the amount allocated to the auxiliary spillway to be larger than the amount allocated to the existing spillway for the total outflow with simultaneous operation condition. However, this study only reviewed the flow characteristics around the revetment according to the outflow of spillway under the full opening of the sluice gate condition. Therefore, the various sluice opening conditions and outflow scenarios will be asked to derive more efficient utilization of the auxiliary spillway in th future.