• Proceedings of the Korean Society of Precision Engineering Conference
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• 2008.11a
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• pp.3-4
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• 2008

• Nutrition Research and Practice
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• v.17 no.4
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• pp.789-802
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• 2023

BACKGROUND/OBJECTIVES: Habitual coffee consumption was inversely associated with type 2 diabetes (T2D) and hyperglycemia in observational studies, but the causality of the association remains uncertain. This study tested a causal association of genetically predicted coffee consumption with T2D using the Mendelian randomization (MR) method. SUBJECTS/METHODS: We used five single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) associated with habitual coffee consumption in a previous genome-wide association study among Koreans. We analyzed the associations between IVs and T2D, fasting blood glucose (FBG), 2h-postprandial glucose (2h-PG), and glycated haemoglobin (HbA1C) levels. The MR results were further evaluated by standard sensitivity tests for possible pleiotropism. RESULTS: MR analysis revealed that increased genetically predicted coffee consumption was associated with a reduced prevalence of T2D; ORs per one-unit increment of log-transformed cup per day of coffee consumption ranged from 0.75 (0.62-0.90) for the weighted mode-based method to 0.79 (0.62-0.99) for Wald ratio estimator. We also used the inverse-variance-weighted method, weighted median-based method, MR-Egger method, and MR-PRESSO method. Similarly, genetically predicted coffee consumption was inversely associated with FBG and 2h-PG levels but not with HbA1c. Sensitivity measures gave similar results without evidence of pleiotropy. CONCLUSIONS: A genetic predisposition to habitual coffee consumption was inversely associated with T2D prevalence and lower levels of FBG and 2h-PG profiles. Our study warrants further exploration.

• 한국전산유체공학회:학술대회논문집
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• 1995.10a
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• pp.82-89
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• 1995

In the present paper, a method of nearly orthogonal grid generation in an arbitrary simply-connected 3D domain will be presented. The method is a new direct and non-iterative scheme based on the concept of the decomposition of the global orthogonal transformation into consecutive mapping of a conformal mapping and an auxiliary orthogonal mapping, which was suggested by King and Leal [4]. In our numerical scheme. Kang and Leal's method is extended from 2D problems to 3D problems while the advantage of the non-iterative algorithm is maintained. The essence of the present mapping method is that an iterative scheme can be avoided by introducing a preliminary step. This preliminary step corresponds to a conformal map and is based on the boundary element method(BEM). This scheme is applied to generate several nearly-orthogonal grid systems which are orthogonal at boundaries.

• Journal of Pharmaceutical Investigation
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• v.18 no.1
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• pp.15-21
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• 1988

An inclusion complex of phenytoin (PT) with ${\beta}-cyclodextrin\;({\beta}-CyD)$ in molar ratio of 1 : 1 was prepared, and the interaction between host and guest molecules was confirmed by infrared spectrometry, differential scanning calorimetry and X-ray diffractometry. Suppositories were prepared by the fusion method. PT and $PT-{\beta}-CyD$ complex were added to PEG 1540 and Witepsol H-15 under the vigorous stirring at $40^{\circ}C$. Content uniformity was tested for different formulations of the PT suppositories. The release rates were dependent on the K.P. V dissolution apparatus and the dialyzing tubing method. Then, the release rates were increased in the following order: $PT-{\beta}-CyD$ complex in PEG 1540>PT in PEG 1540>$PT-{\beta}-CyD$ complex in Witepsol H-15>PT in Witepsol H-15. The area under the curve and maximum blood concentration after rectal administration were increased in the following order: $PT-{\beta}-CyD$ complex in PEG 1540>PT in PEG 1540>$PT-{\beta}-CyD$ complex in Witepsol H-15>PT in Witepsol-15.

• Journal of the Korea institute for structural maintenance and inspection
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• v.3 no.1
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• pp.171-178
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• 1999

Despite of decrease in shear and moment strengths, most steel structural designers use web openings in beams because of economical benefit and requirement. The purpose of this study is to suggest the method of reinforcement of H-shape steel beams with a rectangular web opening. If shear predominates over bending, it is necessary to consider all possible combinations of shear force and bending moment acting at the opening. In this paper, the ultimate strength and behavior of perforated beams have been investigated according to parameters (ratio of M/V, opening width within opening height ratio D/h, various reinforcing types A/B/C/D/M/N/W). The results of this study are as follows ; 1. Deformation of H-shape steel beams with a rectangular web opening was greatly affected by not only bending but also shear. 2. SB1-2/3 series have little difference in the reinforced efficiency, but SB1-2E/3E series have difference in the reinforced efficiency according to the reinforcement type. 3. Efficiency of SB1-2E/3E series is determined by reinforcing types, which RB1-2E-B/M/C and RB1-3E-M/D/C specimens have good efficient. Reinforcing type of perforated beams chooses efficient method according to ratio of M/V and D/h.

• Korean Journal of Food Science and Technology
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• v.33 no.1
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• pp.12-18
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• 2001

The water-soluble extracts of plants used as tea materials were investigated for their antioxidant activities and active components(total phenolics, ascorbate and selenium). Antioxidant activities of the plant extracts were determined by measuring the changes in both peroxide values(POV method) during storage(36 day, $55^{\circ}C$) and conductivity of soybean oil at $110^{\circ}C$(Rancimat method). Soybean oil without any additive was used as a control. Soybean oil treated with 0.02% BHT was used as a positive control. The test samples were prepared by mixing the plant extracts with soybean oil in 0.02% concentration by weight. The water-soluble extracts of lycii fructus(23 d), oolong tea(23 d), orange peel(23 d), citron(22 d), and apricot(22 d) showed longer induction periods, compared to control(21 d) and BHT(21 d) by POV method. Also water-soluble extracts of oolong tea(12 h), instant coffee(11 h), citron(10 h), cinnamomi cortex(10 h), schizandrae fructus(10 h), lycii fructus(10 h) and apricot(10 h) demonstrated longer induction periods, compared to control(8 h) and BHT(8 h) by Rancimat method. The contents of total phenolic compounds were observed to be high in water-soluble extracts of oolong tea, green tea, black tea, coffee, cinnamomi cortex, and cassiae semen. Ascorbate contents were found to be high in coffee, eucommiae cortex, black tea, ganoderma, cinnamomi cortex, persimmon leaf, chicory, green tea and oolong tea extracts. The selenium contents were not detected in all the extracts. The antioxidative effects of some plant extacts were seemed to be the combined effects of various antioxidant components such as phenolics and ascorbate.

• Proceedings of the KIEE Conference
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• 2001.07b
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• pp.650-652
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• 2001

The permanent magnet in hybrid step motor is magnetized to the axial direction. Accordingly the 2D analysis method such as 2D finite element method cannot guarantee the analysis accuracy. In this paper, the characteristics of hybrid type step motor are analyzed by using 3D equivalent magnetic circuit network method(3D EMCNM). 3D EMCNM supplements magnetic equivalent circuit by numerical technique using distributive magnetic circuit parameter and 3D EMCNM is used for the accurate and efficient analysis. The validity of the analysis results is confirmed by comparing with the experimental ones.

• Proceedings of the KIEE Conference
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• 1987.07b
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• pp.947-949
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• 1987

This paper describes the design of echo cancslling method(ECM) for transmission with full-duplex which ie transmitted on "2B+D"(144kbps)data through two-wire loop plants. The design objective is 40dB attenuation with a signal-to-noise ratio of $10{\sim}20dB$. Since the transhybrid loos can be as low as $6{\sim}10dB$, the required attenuation of the echo signal is on the order of $50{\sim}55dB$. The used algorithms based on the sign algorithm, and have been improved by using adoptive reference voltage level algorithm.

• International conference on construction engineering and project management
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• 2009.05a
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• pp.1161-1165
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• 2009

Safety of workers and productivity in construction site are affected according to the conflict status of work spaces which are performed at a time. The interference among the work spaces in construction site should be minimized because it becomes a blocking factor that causes construction delay and low productivity. Those factors can be managed by reasonable H&S (Health & Safety) practice. This research suggests the requirements of H&S practice and rules to establish the strategy of H&S management based on the literature reviews related to H&S rule. The suggested H&S rule can be visualized for searching space conflict point if the rule is linked with visual simulation tool. Accordingly the research results can be used for improving and visualizing construction productivity by work space control in 4D/nD CAD system.

• Journal of Broadcast Engineering
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• v.16 no.2
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• pp.274-292
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• 2011

This paper proposes an efficient coding method of the depth-map which is different from the natural images. The depth-map are so smooth in both inner parts of the objects and background, but it has sharp edges on the object-boundaries like a cliff. In addition, when a depth-map block is decomposed into bit planes, the characteristic of perfect matching or inverted matching between bit planes often occurs on the object-boundaries. Therefore, the proposed depth-map coding scheme is designed to have the bit-plane unit coding method using the adaptive XOR method for efficiently coding the depth-map images on the object-boundary areas, as well as the conventional DCT-based coding scheme (for example, H.264/AVC) for efficiently coding the inside area images of the objects or the background depth-map images. The experimental results show that the proposed algorithm improves the average bit-rate savings as 11.8 % ~ 20.8% and the average PSNR (Peak Signal-to-Noise Ratio) gains as 0.9 dB ~ 1.5 dB in comparison with the H.264/AVC coding scheme. And the proposed algorithm improves the average bit-rate savings as 7.7 % ~ 12.2 % and the average PSNR gains as 0.5 dB ~ 0.8 dB in comparison with the adaptive block-based depth-map coding scheme. It can be confirmed that the proposed method improves the subjective quality of synthesized image using the decoded depth-map in comparison with the H.264/AVC coding scheme. And the subjective quality of the proposed method was similar to the subjective quality of the adaptive block-based depth-map coding scheme.