• Title/Summary/Keyword: Cytochrome P-450 dependent aryl hycrocarbon hydroxylase(AHH)

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Combinatory Effects of Benzene, Toluene and Xylene on the Induction of Rat Liver Microsomal Enzymes and Their Metabolites (흰쥐 간의 microsomal enzymes의 유도에 있어서 benzene, toluene과 xylene의 복합적인 영향과 그들의 대사산물)

  • 김기웅;박상신;김태균;문영한;장성근
    • Toxicological Research
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    • v.12 no.1
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    • pp.9-15
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    • 1996

  • We studied the effects of a single, combined and mixed exposure of benzene, toluene and xylene on the activities of rat liver microsomal AHH, ADH and ALDH, and the excretion of their metabolites in urine. The AHH activities of the rats treated in combination and mixture were slightly higher and/or similar to those rats treated with single solvent, while the reverse effects were observed for ADH and ALDH. Similar effects were observed when the metabolites were examined in urine (p < 0.01). These results suggest that each solvent might interJkre the induction and action of ADH and ALDH, and decrease the excretion of their metabolites into urine.

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