• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2005년도 춘계학술발표회
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• pp.1020-1021
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• 2005

• Journal of Radiation Protection and Research
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• 제26권3호
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• pp.231-236
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• 2001

A brief introduction is presented on the radiation safety studies at Tohoku University Cyclotron & Radioisotope Center. Studies on two subject are described; (1) measurement of the thick target neutron yield and radioisotope production / activation cross section for ten's of MeV neutrons and ions using K=110 Tohoku University cyclotron to provide basicdata for accelerator shielding, and (2) development of techniques for high sensitive radiation detection and profile measurement using an Imaging Plate which is a high sensitive two-dimensional radiation sensor. Application of the Imaging Plate techniques to localization of very weak radioactivity and to neutron profile measurement is described.

• 대한핵의학회지
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• 제29권3호
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• pp.350-354
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• 1995

한국 원자력 연구소 부설 원자력병원에 설치된 AVF 싸이클로트론을 이용하여 요즈음 핵의학에 널리 사용되는 PET 용 싸이클로트론의 에너지를 검정 할 수 있고 양성자 과잉 핵종인 싸이클로트론 동위원소의 생산 수율에 중요한 변수인 양성자에너지를 탄소에 입사시켜 입사빔의 Range와 에너지를 측정하는 방법을 제시하였다. 본 실험에서 사용된 양성자 빔의 양성자 에너지는 35 MeV와 50 MeV 사이였으며, 탄소 막은 두께 6.3mm, 밀도 $1.712 g/cm^3$를 사용하였다. 탄소 표적물을 $0.9^{\circ}$씩 스텝 모터를 사용하여 회전시킴으로 두께를 변화 시켜 공칭 에너지에 대한 Range를 측정함으로써 입사된 양성자의 에너지를 구하였고 이를 인출반경과 RF주파수를 바탕으로 상대론 적으로 계산된 에너지와 비교하였다.

• 대한핵의학회지
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• 제39권1호
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• pp.1-8
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• 2005

상용 PET사이클로트론의 기술적인 변화는 PET의 수요와 밀접한 관계가 있다. PET활용이 일반화 되어 미국을 중심으로 PET의 수요가 급증하게 됨에 따라 사이클로트론의 수요도 증가 하였다. 기존의 사이클로트론은 크기와 무게로 병원에 설치에 공간과 전원 공급 등 여러 문제가 있어 각 사이클로트론 제작사들은 새로운 모델을 출시하게 되었다. 새로운 모델의 특징은 다음과 같다. 첫째 기존의 모델이 양성자와 중양자 등의 2가지 이온을 인출 하였으나 시스템의 복잡성 등의 문제와 양성자로 O-15 생산이 가능하여 양성자 빔만을 인출 하거나 중양자는 선택 사양으로 전환 하였다. 둘째 기존 모델의 경우 양성자의 빔 에너지는 약 16 MeV 이상 가속 시킬 수 있으나 신 모델은 13 MeV 이내로 대폭 낮추어 PET 용 Rl생산에 최적화하였다. 셋째 전자석, RF 장치등의 최적화를 이룩하여 전력소모를 대폭 개선하였으며 외양도 대폭 작아져 무게를 20톤 이내로 대폭 낮추었다. 넷째 새로운 모델 사이클로트론들은 자체 차폐기능이 일반화 되었으나 IBA제품이나 삼영유니텍 제품은 사용자의 견지에 따라 선택 사양이 가능하다.

• 대한디지털의료영상학회논문지
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• 제16권1호
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• pp.61-67
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• 2014

The demand of cyclotron for PET (positron emission tomography) has rapidly grown as the more use of PET or PET-CT equipment requires the increased amount of radioactive isotopes for clinical positron emission. While research on failure statistics of medical equipment used in medical centers has continued to be done, the analysis and study on failure statistics of cyclotron have rarely been conducted. However, the growing demand shows the urgency of systematical management guideline and countermeasures for device failure to minimize any supply delay of radiopharmaceuticals occurred by such failure and complains from waiting patients for PET-CT diagnosis. Therefore, this study aims to analyze the failure report from Minitrace equipped in cyclotron which is owned by the department of nuclear medicine at Yeungnam University Medical Center and draws on the data to build effective management system for cyclotron.

• 대한전기학회논문지:시스템및제어부문D
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• 제49권1호
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• pp.10-17
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• 2000

Recently, as the field of cyclotron application is to be wider, to inject the beam whree the user want to is getting more important. But since it is not the easy way to describe the model equation of cyclotron, it could be operated by only operator's experiences. In this paper, we suggest the cyclotron controller using the fuzzy logic and the genetic algorithm. The proposed controller was verified in useful by applying to the cyclotron's beam line. In the experiment the measured results were obtained by VXIbus and the control algorithm was performed by LabWindows/CVI.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2004년도 추계학술발표회 발표논문집
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• pp.1113-1114
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• 2004

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제44회 동계 정기학술대회 초록집
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• pp.537-537
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• 2013

Cyclotron-accelerated ion beams are used for various researches, such as nuclear physics, nuclear chemistry, biotechnology, and material sciences including radio-isotope production. Recently considerable applications are asked to the cyclotron development undertaken to meet user requirements of various ions'energies, intensities, and their pulsed beams. For instance, a cocktail beam acceleration technique rapidly changing the ion species and energies was developed to irradiating integrated circuit chips. Also a chopping system in a cyclotron injection line is considered for producing a pulsed ion beam with a relatively long period compared with that generated by the resonance frequency. For the research in neutron time-of-flight measurement, a single-pulsed beam with a repetition interval of the order of mili-seconds or longer is necessary to have a good resolution and to remove background events. In this paper a feasibility of pulsed beam with an external ion source is simulated by adopting a combination system of a chopper accompanying with a bunching stage in the injection line and an additional chopper after the exit of the cyclotron in order to produce beam pulses with a range of $1{\mu}s{\sim}1ms$ periods from a resonance RF cycle. The pulseperiod will be adjusted by chopping the number of beam bunches from the injected pulses in the injection line. However, the longer pulses will have reduced number of beam pulses and sacrificed beam currents. Because the beam users need an intense single pulsed beam, a careful tuning of the acceleration phase and a high-intense external ion source are necessary to achieve an intense single-pulsed beam from the cyclotron. It is essential to strictly match the acceleration phase of injected beams in the central region of the cyclotron to improve its efficiency. An effect of space charge at each pulse from the ion source will be also considered.

• 방사선산업학회지
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• 제10권1호
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• pp.37-41
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• 2016

The recent prevalence of PET examinations in Korea has led to an increase in the number of cyclotrons. The medical isotope $^{18}F$ produced in most cyclotron facilities currently operating in Korea is emitted into the environment during the production of [$^{18}F$]FDG, a cancerdiagnosis reagent. The amount of [$^{18}F$]FDG synthesized determines the radioactive concentration of $^{18}F$ in the exhaust. At some facilities, this amount temporarily exceeds the emission limit. In this study, we evaluated the $^{18}F$ radioactivity concentration in the exhaust from the cyclotron facility at Chosun University. The $^{18}F$ radioactivity concentration was measured using an air sampler and a HPGe semiconductor detector. The measurements showed that the radioactive concentration of $^{18}F$ in the exhaust at the cyclotron facility at Chosun University was the highest during [$^{18}F$]FDG synthesis but remained under the legal limit of $2,000Bq\;m^{-3}$.

• Bulletin of the Korean Chemical Society
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• 제25권8호
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• pp.1147-1150
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• 2004

Hypericin (1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione), an antidepressant which is also known to be a potent protein kinase C (PKC) inhibitor was synthesized as a precursor for radioiodine labeling via two step reactions. Malignant glioma cells express higher PKC activity compared to untransformed glial cell. Here we report the synthesis and radioiodine labeling of hypericin as a potential brain tumor imaging radiopharmaceutical. The reference compound, 2-iodohypericin, and its radiolabelled analogues, 2-[$^{123}I$]iodohypericin and 2-[$^{124}I$]iodohypericin have been prepared by the reaction of hypericin with NaI or [$^{123}I$]NaI or [$^{124}I$]NaI. The labeling yield was 60-65% for each analogue and the optimal reaction time was 10 min. The purification and isolation of the labelled products were achieved by a reversed-phase HPLC.