• Korean Journal of Veterinary Service
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• v.29 no.4
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• pp.503-506
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• 2006

Cyclopia is a congenital ocular abnormality in which two orbits are fused together due to an arrest in the normal process of embryonic tissue development. Reported here is a case of cyclopia in a calf observed from the uterus of cow slaughtered in an abattoir in Korea on March 24, 2004. The calf possessed a spherical-shaped head and only one centrally placed eye. The one eyeball showed complete eyelashes on the defective eyelids. The nasal region and the anterior nares were absent along with a dorsally curved mandible extended beyond the defective maxillae.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2004.10a
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• pp.36-36
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• 2004

• BMB Reports
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• v.48 no.10
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• pp.577-582
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• 2015

Cyclopia subternata is a medicinal plant commonly used in traditional medicine to relieve pain. Here, the anticoagulant effects of scolymoside, an active compound in C. subternata, were examined by monitoring activated partial thromboplastin time (aPTT), prothrombin time (PT), and the activities of thrombin and activated factor X (FXa). The effects of scolymoside on plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (t-PA) expression were evaluated in tumor necrosis factor (TNF)-α-activated human endothelial cells. Treatment with scolymoside resulted in prolonged aPTT and PT and the inhibition of thrombin and FXa activities and production. In addition, scolymoside inhibited thrombin-catalyzed fibrin polymerization and platelet aggregation. Scolymoside also elicited anticoagulant effects in mice, including a significant reduction in the PAI-1 to t-PA ratio. Collectively, these findings indicate that scolymoside possesses anticoagulant activities and could be developed as a novel anticoagulant.