• Herbal Formula Science
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• v.15 no.2
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• pp.127-137
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• 2007

The purpose of this study was to investigate the effect of Yong-dam-sa-gan-tang (YST) on apoptosis in HepG2 cells, First of all. to study the cytotoxic effect of methanol extract of YST on HepG2 cells, the cells were treated with various concentrations of YST and then cell viability was determined by XTT reduction method and trypan blue exclusion assay. YST reduced proliferation of HepG2 cells in a dose-dependent manner. To confirm the induction of apoptosis, HepG2 cells were treated with various concentrations of YST. The cleavage of poly AD P-ribose polymerase (P ARP), a substrate for caspase-3 and a typical sign of apoptosis, and the activation of caspase-3, procaspase-8 and procaspase-8 were examined by western blot analysis. YST decreased procaspase-3, procaspase-8 and procaspase-9 levels in a dose-dependent manner and induced the clevage of PARP. YST triggered the mitochondrial apoptotic signaling by increasing the release of cytochrome c from mitochondria to cytosol. Furthermore, YST also downregulated the anti-apoptotic Bcl-2 and upregulated the pro-apoptotic-Bax. Therefore, this result suggest that YST induced HepG2 cell death through the mitochondrial pathway. Sustained activation of the Ras/Raf/MEK/ERK cascade in cells results in a cell cycle arrest and has been implicated in the differentiation of certain cell types, in many cases acting to promote differentiation. YST decreased the activation of Ras/Raf/MEK/ERK cascade in a dose-dependent manner. These results suggest that YST is potentially useful as a chemo-therapeutic agent in HepG2.

• Journal of Korean Medical classics
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• v.13 no.1
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• pp.102-116
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• 2000

In Cheon Won Gi Dae Ron(天元紀大論), Cheon(大) means Nature, Won(元) means sources, Gi(紀) is Gang Gi(綱紀) that means rules or regulations, so Cheon Won Gi(天元紀) means sources and rules of change that make Nature phenomenons. This volume treats of cause that weather change of Nature caused by, and its general rules, and presents fundamental notions and systems of measuring of 'Five elements' evolutions and Six kinds of natural factors(五運六氣)'. So named Cheon Won Gi Dae Ron(天元紀大論). This article of the research on the Cheon Won Gi Dae Ron(天元紀大論) can be divided into 3 chapters. Chapter 1 presents a theory that the principle of changes of creations' birth, groth and extinction is complished by sympathizing with Hyeong(形) of Ji(地) and Gi(氣) of Cheon(大) by rules of movement of O Un Yum Yang(五運陰陽). Chapter 2 presents theories that Tae Heo(太虛) makes Won Gi(元氣), and this Won Gi(元氣) makes the change of creations' birth, groth and extinction, and movement of O Un(五運) controls creation of nature. And treats of that 'excessive and short(太過不及)' that is made by a quality of Gi(氣) and ups and dons of Hyeong(形) controls weather of year. In Chapter 3, Cheon O Ji Yuk(天五地六) regard six and five as Yong(用). And A Cycle that movment that sympathizing with O Un(五運) and Yuk Gi(六氣) is Il Gi(一氣) as 30 years, and Il Ju(一周) as 60 years. And presents that O Un(五運) and Yuk Gi(六氣) that Gan Ji(干支) control.

• Journal of Korea Multimedia Society
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• v.25 no.1
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• pp.1-9
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• 2022

Ship detection in synthetic aperture radar (SAR) images is an important application in marine monitoring for the military and civilian domains. Over the past decade, object detection has achieved significant progress with the development of convolutional neural networks (CNNs) and lot of labeled databases. However, due to difficulty in collecting and labeling SAR images, it is still a challenging task to solve SAR ship detection CNNs. To overcome the problem, some methods have employed conventional data augmentation techniques such as flipping, cropping, and affine transformation, but it is insufficient to achieve robust performance to handle a wide variety of types of ships. In this paper, we present a novel and effective approach for deep SAR ship detection, that exploits label-rich Electro-Optical (EO) images. The proposed method consists of two components: a data augmentation network and a ship detection network. First, we train the data augmentation network based on conditional generative adversarial network (cGAN), which aims to generate additional SAR images from EO images. Since it is trained using unpaired EO and SAR images, we impose the cycle-consistency loss to preserve the structural information while translating the characteristics of the images. After training the data augmentation network, we leverage the augmented dataset constituted with real and translated SAR images to train the ship detection network. The experimental results include qualitative evaluation of the translated SAR images and the comparison of detection performance of the networks, trained with non-augmented and augmented dataset, which demonstrates the effectiveness of the proposed framework.

• Journal of Korean Medical classics
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• v.12 no.2
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• pp.56-71
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• 1999

1. In the recohnition of cosmos true form, It is compared to the Boundless(無極) the Great Absolute(太極),Yin and Yang(兩儀) throungh the fertilazation process of spermatozoon and ovum. 2. It is explained that principle of unchange through the Form and Action(體 用) relation of the outer appearances and Number (象數) with matching the number of nine and ten to HaDoo(河圖) and RakSye(洛書). 3. Eigth divinations(八卦) being compared to the human body, Care presevation of pregnancy(養胎) is explained that head forms firstly(Gun-I 1乾一), secondly lung(Tae-E 兌二), heart(E-Sam 離三), liver(Jin-Sa 震四), gall bladder(Son-Oo 巽五), kidney(Gam-Yuk 坎六), intestines and stomach(Gan-Chill 艮七), lastly flesh forms(Gon-Pal 坤八). 4. It is explained that process of physiological change of $\ll$Nei Ching The Natural Truth in Ancient Times$\gg$(內經 上古天眞論) by matching boy at the age of 8 to Gan-divination(艮卦), and girl at the age of 7 to Tae-divination(兌卦). 5. The theory of six sons from Gun-Gon(乾坤六子論) is explained by relation of Apriority Eight-divination(先天八卦) obedience and disobedience-left and right. 6. It is explained that form of the human-body and the relationship of the Heart - the Kidney through the Gam(坎) Li(離) - divination 7. The effort of interpretating time and space of the Twelve Horary signs is explanined by season, direction, Five elements(五行), rise and decline, the Three Sum(三合), the Six Sum (六合), the six crash(六衡)'s relation. 8. the process of change from apriority(先天) to postery(後天) in the book of Changes(周易) is explanined by comparing to the phenomenum of nature and the human body. 9. The Energy Satus(氣位) are different from the direction of Eight-divination(八卦) and the properties of the good or bad of herb-drugs are differnt from the place of production. 10. The rightness of realizating the Overlapping-divinations(重卦) are compared to the phenomenum of nature through the Divination Virture(卦德). 11. The dependence-relations of The Twelve Meridians(十二經脈) are explained by-matching January with liver meridian, February with gall bladder meridian, march with heart pericardium meridiam, April with small intestine meridkan, August with lung spleen meridian, jury with stomach meridian, August with lung meridian, September with large intestine meridian, October with urinary bladder meridianm November with kidney meridian. December with triple energizer meridian throng The Twelve Byuk-divination. 12. The process of menstration cycle is explained by The Month symbolizing-divination(月候卦). 13. Through The Trade(交易) prove the reason of feverish sympotoms to use feverish Drug, mill sympotoms to use mill drug of prescription and Heart-Kidneys Consensus(心賢相交) and through The Change(變易), prove the chill and feverish consensus of forechill after feverish, fore feverish after chill and through. The Non-Change(不易) explain the reason of chill sympotoms to use feverish drug, feverish sympotoms to use chill drug of prscription. 14. Ho-divination(互卦) applicate Jxa Sa(佐使) herb drug match of Kun Sin Jwa Sa() theory. 15. According to the Hyo-position(爻位) match the ages, body form and drug by matching Ehight-divination(八卦) to the human body form and function in medicine and the book of Changes(周易) application emphasize the human body Ehight-divination(人身八卦). 16. Throgh the Order-divination(序卦) explain the rightness of Divination Image(卦象) arrangement and all things take shape by cosmo-energy conseusus(宇宙氣交). 17. Throgh the Mixing-divination(難卦) supply the vacancy of medicine and the book of Changes(周易) relationship in the foreword explian the human energy movements, sleep, vomitting, the energy arrival(逮氣), heart pericardium(心包), lung membrane(肺膜) etc.... Like the above sentence medicine and the book of Changes(周易) theory of scholar Tang on the viewpoint of easten-the way Western appliance(東道西器) researching abyss of medicine impart to descendants, so I think that the achievement of medicine and the book of Changes(周易) study is very excellant and I expect that the study Korean Oriental Medicine(韓醫學) theory by means of medicine the book of Changes(周易) reference, will be accelarated.