• 대한본초학회지
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• 제39권3호
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• pp.69-76
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• 2024

Objectives : Hypertension (high blood pressure), one of the world's major chronic diseases, has a high mortality rate due to its high prevalence and complications, but its control rate is low. The proper management and control through appropriate exercise, diet management, and optimal drug choice can reduce the risk of death from hypertension. Although various antihypertensive drugs are used to treat hypertension, they also have numerous adverse effects. Alongside increased interest in the use of Traditional Herbal Formulas (THF) for hypertension treatment, the purpose of this study was to examine the vasodilative effects of 10 THF in the rat thoracic artery pre-contracted by potassiumchloride (KCl). Methods : THF were extracted with distilled water for 2 hours. The rat thoracic artery was suspended and contracted by KCl in the organ bath which contained 10 ml Krebs Henseleit (KH) buffer. THF extracts were added in a dose-dependent increase (10-1,000 ㎍/mL) to examine vasodilative effects. The vasodilative effects produced by THF were expressed as the percentage in response to KCl-induced contraction. Results : Among the 10 THF, Banhasasim-tang, Buhnsimgieum, Sagunja-tang, and Samul-tang showed vasodilative effects. And, Sipjeondaebo-tang, Ssanghwa-tang, Ojeok-san, Onkyung-tang, Yongdamsagan-tang, and Hyangsayukgunja-tang showed no significant vasodilative effects. Also, in co-administration with amlodipine, Banhasasim-tang showed higher vasodilative effects than amlodipine alone, and Buhnsimgieum showed greater vasodilative effects at low concentrations, but inhibited amlodipine's vasodilative effects at high concentrations. Conclusion : As a result of these studies, they will be expected to provide useful data to establish guidelines of combined administration of THF and western antihypertensive drugs for the treatment of hypertension.

• 대한본초학회지
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• 제39권2호
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• pp.11-18
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• 2024

Objectives : High blood pressure (also called Hypertension), which is the blood pressure that is higher than normal, is a chronic disease and causes various complications. Historically, Traditional Herbal Prescriptions (THP) have treated many diseases. However, there are not many studies on the treatment of hypertension with THP, very few studies have investigated the interactions between the co-administration of synthetic anti-hypertensives and THP. Therefore, the objective of the present study was to investigate the vasorelaxant activities of 10 THP in rat thoracic aortas pre-contracted with potassium chloride (KCl). Methods : An electric extractor was used to extract THP in distilled water for 2h. Rat thoracic aortas were isolated and pre-contracted using KCl in organ chambers containing 10 ml Krebs Henseleit (KH) buffer. THP extracts were added in increasing concentrations (10-1000 ㎍/mL) to investigate vasorelaxant activities. The vasorelaxant activities induced by THP were expressed as a percentage in response to contraction generated by KCl. Results : Among the 10 THP, Dangguisu-san, Mahwang-tang, Bulwhangeumjeonggi-san, Jakyakgamcho-tang, and Hyangsapyeongwi-san showed significant vasorelaxant activities. Maekmundong-tang, Bojungikgi-tang, Samryeongbaekchul-san, Yukmijihwang-tang, and Insampaedok-san showed no significant effect. Also, in co-administration with amlodipine, Mahwang-tang showed higher vasorelaxant activities than amlodipine alone, and Hyangsapyeongwi-san showed greater vasorelaxant activities at low concentrations but inhibited amlodipine's vasorelaxant activities at high concentrations. Conclusion : The results of these experiments are expected to provide useful data to establish guidelines for THPs and co-administration with western antihypertensive drugs to treat hypertension.

• 대한약침학회지
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• 제26권1호
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• pp.18-26
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• 2023

Objectives: Terminalia chebula, the main ingredient of Altan Arur 5, has been used for many years in traditional medicine. This medicine is more effective than other drugs and is used to treat chronic gastritis and gastrointestinal disorders such as peptic ulcers and esophageal reflux. Other ingredients of Altan Arur 5 are Punica granatum (pomegranate), tulip seeds, black balm, and excreta of Trogopterus xanthipes. The main ingredients of T. chebula are antibacterial and analgesic in traditional medicine. Despite having been used for many years and although many studies have been conducted on the beneficial effects of this medicine and its ingredients, the toxicity of Altan Arur 5 has not yet been elucidated. Therefore, we aimed to study the toxicity of Altan Arur 5 to ensure that it is safe to use. Methods: Acute and chronic toxicity of Altan Arur 5 were assessed in 10 Kunming mice and 8 Sprague-Dawley rats, respectively, in different doses. In the acute toxicity study, Altan Arur 5 was orally administered to Kunming mice in doses of 12 g/kg, 24 g/kg, and 48 g/kg for 14 days. In the chronic toxicity study, it was orally administered to Sprague-Dawley rats in doses of 1.25 g/kg, 2.5 g/kg, and 5 g/kg for 12 weeks. Results: No significant differences were observed in the relative organ weights for mice treated with Altan Arur 5 compared with those in the control group. Furthermore, no macro- or microstructural changes were noted in the organs of any group. Conclusion: Our toxicity testing revealed that the traditional medicine Altan Arur 5 has no toxic effects in vivo.

• 한국의학물리학회지:의학물리
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• 제20권4호
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• pp.324-330
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• 2009

본 연구에서는 정위방사선수술시 움직이는 목표점에 대한 사이버나이프 호흡동기추적장치의 위치 정확성 및 유용성을 평가하고자 한다. 본 연구를 위해 움직이는 목표점을 재현할 수 있는 동적팬톰을 사용하였으며 움직이는 목표점 추적을 위하여 사이버나이프의 호흡동기추적장치인 $Synchrony^{TM}$ 시스템을 사용하였다. 움직이는 목표점의 치료계획을 위하여 4D CT를 이용한 영상획득을 하였고 움직이는 목표점에서의 선량분포와 점선량 측정을 위하여 gafchromic EBT 필름과 0.62 cc 이온 전리함을 사용하였다. 호흡동기추적장치의 정확성을 평가하기 위하여 팬톰의 목표점을 움직였을 때와 정지 상태일 때 목표점에서의 선량분포(처방선량기준 선량분포의 80%)를 비교하였으며 목표점에서의 점선량을 측정하였다. 위치추적장치와 호흡동기추적장치 상호간의 동기화에 의한 정확성은 동기화 되지 않을 경우 평균 $11.5{\pm}3.09\;mm$였으며 동기화 되었을 경우 $0.14{\pm}0.08\;mm$의 차이를 나타내었다. 목표점 정지상태시의 영상과 4D CT를 이용한 움직이는 목표점에 대한 영상을 이용하여 치료계획상의 정확성은 평균 $0.18{\pm}0.06\;mm$의 차이를 나타내었다. 또한 호흡동기추적장치의 정확성은 1 mm 이하로 나타났다. 호흡동기추적장치의 유효성을 확인하기 위하여 움직이는 목표점에 대하여 호흡동기추적장치를 중지하여 측정한 결과 평균 $17.39{\pm}0.14\;mm$였으며 가동하였을 때 $1.37{\pm}0.11\;mm$로 나타났다. 목표점에서의 선량값을 비교한 결과 목표점이 정지상태일 때 $0.68{\pm}0.38%$, 호흡동기추적장치를 이용한 움직이는 목표점에서는 $1.31{\pm}0.81%$의 차이를 나타내었다. 위치추적장치와 호흡동기추적장치 상호간의 동기화에 의한 정확성 확인에서 장치사이에서 동기화가 매우 정확하게 수행됨을 확인하였다. 본 연구의 결과 움직이는 목표점에 대한 정위방사선수술시 호흡동기추적장치를 필수적으로 사용해야하며 본 연구에서 사용된 사이버나이프의 호흡동기추적장치인 Synchrony 시스템의 유용성과 정확성을 평가한 결과 매우 정확함을 확인하였다.