• Title/Summary/Keyword: Cyano triphenylphosphorane

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A Convergent Synthesis of Bis-2-oxo Amide Triacylglycerol Analogues as Potent Lipase Inhibitors Using Acyl Cyanophosphorane Methodology

  • Lee, Kie-Seung
    • Bulletin of the Korean Chemical Society
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    • v.23 no.2
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    • pp.351-354
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    • 2002

  • A number of bis-2-oxo amide triacylglycerol analogues, a recently reported potent human gastric lipase inhibitor and its new analogues, have been prepared starting from 1,3-dibromo-2-propanol utilizing acyl cyanophosphorane methodology as a key step in a convergent manner. The key coupling reaction has been accomplished at -$78^{\circ}C$ between 1,3-diamino-2-propanol derivative and the labile diketo nitriles, derived from acyl cyanotriphenylphosphoranes upon oxidizing with $O_3$, under mild condition in moderate yields.

  • https://doi.org/10.5012/bkcs.2002.23.2.351 인용 PDF KSCI