• Asian Pacific Journal of Cancer Prevention
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• 제16권1호
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• pp.345-349
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• 2015

Background: To determine the cut-off values of the preoperative risk of malignancy index (RMI) used in differentiating benign or malignant adnexal masses and to determine their significance in differential diagnosis by comparison of different systems. Materials and Methods: 191 operated women were assessed retrospectively. RMI of 1, 2, 3 and 4; cut-off values for an effective benign or malignant differentiation together with sensitivity, specificity, negative and positive predictive values were calculated. Results: Cut-off value for RMI 1 was found to be 250; there was significant (p<0.001) compatibility at this level with sensitivity of 60%, positive predictive value (PPV) of 75%, specificity of 93%, negative predictive value (NPV) of 88% and an overall compliance rate of 85%. When RMI 2 and 3 was obtained with a cut-off value of 200, there was significant (p<0.001) compatibility at this level for RMI 2 with sensitivity of 67%, PPV of 67%, specificity of 89%, NPV of 89%, histopathologic correlation of 84% while RMI 3 had significant (p<0.001) compatibility at the same level with sensitivity of 63%, PPV of 69%, specificity of 91%, NPV of 88% and a histopathologic correlation of 84%. Significant (p<0.001) compatibility for RMI 4 with a sensitivity of 67%, PPV of 73%, specificity of 92%, NPV of 89% and a histopathologic correlation of 86% was obtained at the cut-off level 400. Conclusions: RMI have a significant predictability in differentiating benign and malignant adnexal masses, thus can effectively be used in clinical practice.

• Nuclear Engineering and Technology
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• 제53권4호
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• pp.1157-1166
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• 2021

In this study, a numerical sensitivity analysis was performed to determine the fire suppression time for a large number of water mist nozzles in a large fire compartment. Fire simulations were performed using FDS (Fire dynamics simulator) 6.5.2 under the same condition as the test scenario 5 of the International Maritime Organization (IMO) 1165 test protocol. The sensitivities of input parameters including cell size, extinguishing coefficient (EC), droplets per second (DPS), and peak heat release rate (HRR) of fuel were investigated in terms of the normalized HRR and temperature distribution in the compartment. A new method of determining the fire suppression time using FDS simulation was developed, based on the concept of the cut-off time by cut-off value (COV) of the heat release rate per unit volume (HRRPUV) and the cooling time by the HRR cooling time criteria value (CTCV). In addition, a method was developed to determine the average EC value for the simulation input, using the cooling time and cut-off time.

• 대한간호학회지
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• 제50권6호
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• pp.787-798
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• 2020

Purpose: This study aimed to assign weights for subscales and items of the Post-Intensive Care Syndrome questionnaire and suggest optimal cut-off values for screening unplanned hospital readmissions of critical care survivors. Methods: Seventeen experts participated in an analytic hierarchy process for weight assignment. Participants for cut-off analysis were 240 survivors who had been admitted to intensive care units for more than 48 hours in three cities in Korea. We assessed participants using the 18-item Post-Intensive Care Syndrome questionnaire, generated receiver operating characteristic curves, and analysed cut-off values for unplanned readmission based on sensitivity, specificity, and positive likelihood ratios. Results: Cognitive, physical, and mental subscale weights were 1.13, 0.95, and 0.92, respectively. Incidence of unplanned readmission was 25.4%. Optimal cut-off values were 23.00 for raw scores and 23.73 for weighted scores (total score 54.00), with an area of under the curve (AUC) of .933 and .929, respectively. There was no significant difference in accuracy for original and weighted scores. Conclusion: The optimal cut-off value accuracy is excellent for screening of unplanned readmissions. We recommend that nurses use the Post-Intensive Care Syndrome Questionnaire to screen for readmission risk or evaluating relevant interventions for critical care survivors.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.497-501
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• 2016

Aim: To evaluate the relationship between pre-operative CA-125 levels and myometrial invasion in patients with early-stage endometrioid-type endometrial cancer. Materials and Methods: Two-hundred and sixty patients were diagnosed with endometrial cancer between January 2007 and December 2012. Of these, 136 patients with stage 1 endometrioid histologic-type and documented pre-operative serum CA-125 levels were included in the study. Age, preoperative CA-125 level, histologic grade, surgical grade, and presence of deep myometrial invasion were recorded. Additionally, 16, 20, and 35 IU/ml cutoff values were used and compared to evaluate the relationship between pre-operative CA-125 levels and myometrial invasion. Results: The average serum CA-125 level was $35.4{\pm}36.7$ in patients with deep myometrial invasion, and $21.5{\pm}35.8$ in cases without deep myometrial invasion. The relationship between the presence of deep myometrial invasion and CA-125 cut-off values (16, 20, 35 IU/ml) was statistically significant, although the correlation was weak (p<0.05). When the relationship between 16, 20 and 35 IU/ml CA-125 cut-off values and the presence of deep myometrial invasion was studied, specifity and sensitivity values were identified as: 0.60-0.68 for 16 IU/ml; 0.73-0.48 for 20 IU/ml; and 0.89-0.33 for 35 IU/ml. The sensitivity of 16 IU/ml cut-off value was higher when compared to other values. Conclusions: This study demonstrates that preoperative serum CA-125 values maybe used as a predictive test in patients with early stage endometrioid-type endometrium cancer, and as a prognostic factor alone. Further studies should be conducted to identify different CA-125 cut-off values in patients with low risk endometrial cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2507-2511
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• 2016

Purpose: To study the diagnostic accuracies of serum human epididymis protein 4 (HE-4) levels, virtual organ computer-aided analysis (VOCAL) parameters and endometrial volume in endometrial cancer cases. Materials and Methods: One hundred and seven patients (37 with endometrial cancer and 70 with benign endometrial pathology) were included in this study. VOCAL parameters and serum HE-4 levels were compared between the groups. Results: Area under the curve (AUC) values were 0.702, 0.658, 0.706 for vascularization index (VI), the flow index (FI) and the vascularization flow index (VFI), respectively. A cut off value of 0.568 for VI demonstrated 70% sensitivity, 72% specificity, 56% positive predictive value (PPV) and a81% negative predictive value (NPV). A cut off value of 25.8 for showed a senitivith of 70% and a specificity of 58% with aPPV of 46% and NPV of 78%, and with a cut off value of 0.12 for VFI 70%, 69%, 54% and 81%, respectively. The area under the curve for HE-4 was 0.814. A cut off value of 458 pmol/L was predictive of malignancy with 86% sensitivity and 63% specificity. Conclusions: VOCAL parameters and serum HE-4 levels were statistically significantly higher in the endometrial cancer patients. Serum HE-4 levels provided a greater sensitivity compared to power doppler angiography for predicting malignancy or benign endometrial pathology.

• 대한한방소아과학회지
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• 제37권4호
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• pp.1-14
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• 2023

Objectives This study aimed to evaluate the correlation between pediatric weakness scale scores and growth indices. Furthermore, we intended to calculate the cut-off values for diagnosing Kidney Weak Children through growth indices. Methods A total of 193 patients, aged 6 - 12 years, underwent both the pediatric weakness scale and bone age assessment, and the correlations between the pediatric weakness scale and growth indices were analyzed. Moreover, the cut-off values for diagnosing Kidney Weak Children were calculated. Differences in bone age and predicted height between the normal group and Kidney Weak Children, classified according to the calculated cut-off values, were analyzed. Results The weakness of the Shin or kidney system was significantly correlated with the height percentile, weight percentile, differences in current height percentile and mid parental height percentile, differences in predicted height and mid parental height, and differences in bone age and chronological age. When the criteria for diagnosing Kidney Weak Children is set at "height percentile of ≤25% and weight percentile of ≤25%", the sensitivity and specificity of the cut-off value were maximized. The cut-off values for weakness of the Shin or kidney system were 9 in children aged 6 - 9 years and 10 in children aged 10 - 12 years. Conclusions To diagnose Kidney Weak Children, the cut-off values of weakness of the Shin or kidney system were 9 in children aged 6 - 9 years and 10 in children aged 10 - 12 years.

• 한국방사선학회논문지
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• 제13권2호
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• pp.201-207
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• 2019

본 연구는 갑상샘 초음파에서 K-TIRADS 분류와 K-TIRADS 분류에 따른 Different risk group의 조합을 이용한 방법이 양성과 악성 결절의 감별진단에 유용한지를 평가하였다. 갑상샘 초음파를 시행한 210명을 대상으로 하였으며, 세침흡인세포검사 결과를 바탕으로 후향적인 분석을 하였다. 갑상샘 결절의 양성과 악성에 따른 K-TIRADS와 Different risk group의 점수체계의 차이 분석은 카이제곱 검정을 하였다. ROC 곡선 분석을 통해 악성 결절의 예측을 위한 K-TIRADS 점수와 Different risk group의 최적 cut off 값을 결정하였다. 양성과 악성 결절 군의 분류에 따른 K-TIRADS와 Different risk group의 차이검증 결과에서 각각 통계적으로 유의한 차이를 보였다(p=.001). ROC 곡선 분석에서 양성과 악성 결절의 예측을 위한 K-TIRADS에 따른 점수분류에서는 AUC 0.786, Cut-off value> 2를 나타내었으며, Different risk group에서는 AUC 0.640, Cut-off value> 2로 결정되었다(p=.001). 갑상샘 초음파에서 결절을 발견했을 때 양성과 악성 갑상샘 결절을 감별하는 데 도움을 주는 K-TIRADS에 따른 분류체계가 Different risk group에 따른 분류체계보다 갑상샘 결절의 감별진단에 도움을 줄 것으로 생각하며 K-TIRADS에 따른 분류체계를 적용하면, 불필요한 세포 검사를 줄일 수 있고, 악성 결절의 조기발견에 도움이 될 것으로 생각된다.

• 대한방사선기술학회지:방사선기술과학
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• 제42권5호
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• pp.345-350
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• 2019

Liver biopsy is the gold standard for diagnosing liver fibrosis, but it is invasive and has a risk for complications. For this reason, recently, study has been actively conducted on non-invasive liver fibrosis evaluation method. But, there is no established standard for the type of diffuse liver disease. Therefore, this study was suggest the usefulness and cut-off values of Fibroscan, FIB-4, APRI and AAR of patients with hepatitis C in Korea. According to the diagnosis, 240 people in hepatitis C are classified into fatty liver, chronic hepatitis, and liver cirrhosis. The statistical analysis was performed by ANOVA to verify difference between groups. The ROC curve was analyzed to determine the usefulness and practical cut-off value. As a result, for all diseases, the AUC value for Fibroscan was 0.8 over and the APRI was 0.7 over. Cut-off value of serum based liver fibrosis markers was increased in order of fatty liver, chronic hepatitis and liver cirrhosis. If Fibroscan and serological liver fibrosis markers are applied to predict liver fibrosis, it is expected that excessive liver biopsy can be reduced.

• 동의생리병리학회지
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• 제32권3호
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• pp.165-170
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• 2018

The aim of this study was to investigate the predictive validity of the five organ pattern identification questionnaire(FOPIQ). Data collection was conducted from 190 people who were randomly selected from the general population living in D city from October 2016 to June 2017, and the collected data were analyzed by SPSS 23.0 Statistics Program. Pearson correlation coefficient was used to know the relation between the expert's score and FOPIQ's one. The cut-off value, sensitivity and specificity were analyzed through ROC-curve. Significant p was <.05. The pearson correlation coefficient was .735, .756, .762, .736, and .513 between individual score of FOPIQ and that of the experts in liver, heart, spleen, lung, and kidney, respectively. The cut-off value of the FOPIQ was 46.209, 47.276, 45.336, 48.823, and 42.508 in liver, heart, spleen, lung, and kidney respectively. The AUC derived from the cut-off value of the FOPIQ was .907, .854, .888, .902, and .781 respectively. This study suggests that the FOPIQ could be valid to apply for general population in clinics as well as health checkups.

• 대한토목학회논문집
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• 제12권4_1호
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• pp.129-136
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• 1992

압력식(壓力式) 파고계(波高計)에서 측정(測定)되어진 압력파형(壓力波形)으로부터 수위변동(水位變動)을 추정(推定)하는 방법(方法)에 대해서 1) Fast Fourier Transform Method(FFTM), 2) Local Curvature Method(LCM), 3) Individual Wave Method(IWM)의 3가지 방법(方法)을 비교(比較)하여, 천해역(淺海域)에 있어서의 파랑측정(波浪測定)에 대한 압력식(壓力式) 파고계(波高計)의 적용성(適用性)에 대해 검토(檢討)했다. 그 결과(結果) 다음과 같은 결론(結論)을 얻었다. 1) 측정(測定)되어진 압력파형(壓力波形)으로부터 수위변동(水位變動)을 추정(推定)할 때에 사용(使用)되어지는 이론선형응답함수(理論線形應答函數)(Hp=coshkh/coshk(h+z)의 적용가능범위(適用可能範圍)(cut-off-frequency)는 $kh{\leq}3.0$이다. 그리고 kh > 3.0의 영역(領域)에 있어서의 이론선형응답함수(理論線形應答函數)는 일정치(一定値)를 부여함으로써 매우 정도높은 수위변동(水位變動)을 얻을 수 있다. 2) LCM에 의한 수위변동(水位變動)의 변환(變換)에 있어서는 측정(測定)된 압력파형(壓力波形)속에 포함되어 있는 단주기파(短週期波)들에 의해 크게 영향(影響)을 받는다. 그러므로, kh > 1.5인 영역(領域)의 압력변동(壓力變動)을 무시할 필요(必要)가 있다. 3) FFTM 및 IWM에 의해 추정(推定)되어진 통계량(統計量)의 재현성(再現性)은 양호하고, 특(特)히 평균주기(平均週期)의 재현성(再現性)으로부터 비선형성(非線型性)이 강한 영역(領域)에 있어서는 IWM이 유효(有效)한 수단이라고 사려되어진다.