Purpose: Acellular human dermis is very useful implant for use in plastic and reconstructive surgery. However, the volume of acellular human dermis graft is known to decrease for a long time. Basic fibroblast growth factor (bFGF) is a polypeptide that enhances the collagen synthesis and angiogenesis. In the current study we examined whether bFGF could improve the survival of acellular human dermis ($SureDerm^{(R)}$) by increasing angiogenesis of the graft. Methods: Forty rats were divided into two groups (control and bFGF). A 2-mm thick piece of $SureDerm^{(R)}$ was cut into smaller pieces that were $15{\times}5$ mm in size. Two subcutaneous pockets were made on the back of each rat. Grafts sprayed with bFGF were implanted in the bFGF group and injected with bFGF after transplantation every 3 days for 2 weeks. In the control group, the grafts were treated with phosphate-buffered saline (PBS) instead of bFGF. Four days, and 1, 4, and 12 weeks after the implantation, the grafts were harvested and gross and histologic examinations were performed. Inflammation grade, graft thickness, neocollagen density, and neocapillary count were measured. Results: The bFGF group displayed more rapid accumulation of inflammatory cells with a higher density of neocapillaries, and increased active collagen synthesis. After 12 weeks, the thickness of the grafts in the control and bFGF groups was $75.15{\pm}4.80%$ and $81.79{\pm}5.72%$, respectively, in comparison to the thickness before transplantation. There was a statistically significant difference between both groups ($p$ <0.05). Conclusion: bFGF was effective in reducing the absorption of acellular human dermal grafts by increasing angiogenesis and accelerating engraftment. In conclusion, bFGF may be a good tool for use in acellular human dermal graft transplantation for reconstructive surgery involving soft-tissue defects.
Proceedings of the Korean Vacuum Society Conference
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2010.02a
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pp.322-322
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2010
For boron doping on n-type silicon wafer, around $1,000^{\circ}C$ doping temperature is required, because of the relatively low solubility of boron in a crystalline silicon comparing to the phosphorus case. Boron doping by fiber laser annealing and lamp furnace heat treatment were carried out for the uniformly deposited p-a-Si:H layer. Since the uniformly deposited p-a-Si:H layer by cluster is highly needed to be doped with high temperature heat treatment. Amorphous silicon layer absorption range for fiber laser did not match well to be directly annealed. To improve the annealing effect, we introduce additional lamp furnace heat treatment. For p-a-Si:H layer with the ratio of $SiH_4:B_2H_6:H_2$=30:30:120, at $200^{\circ}C$, 50 W power, 0.2 Torr for 30 min. $20\;mm\;{\times}\;20\;mm$ size fiber laser cut wafers were activated by Q-switched fiber laser (1,064 nm) with different sets of power levels and periods, and for the lamp furnace annealing, $980^{\circ}C$ for 30 min heat treatment were implemented. To make the sheet resistance expectable and uniform as important processes for the $p^+$ layer on a polished n-type silicon wafer of (100) plane, the Q-switched fiber laser used. In consequence of comparing the results of lifetime measurement and sheet resistance relation, the fiber laser treatment showed the trade-offs between the lifetime and the sheet resistance as $100\;{\omega}/sq.$ and $11.8\;{\mu}s$ vs. $17\;{\omega}/sq.$ and $8.2\;{\mu}s$. Diode level device was made to confirm the electrical properties of these experimental results by measuring C-V(-F), I-V(-T) characteristics. Uniform and expectable boron heavy doped layers by fiber laser and lamp furnace are not only basic and essential conditions for the n-type crystalline silicon solar cell fabrication processes, but also the controllable doping concentration and depth can be established according to the deposition conditions of layers.
H-beam used for stiffening the upper structure of ocean plant is cut in the various shapes. The cutting process of the H-beam is done manually and requires a long time and high cost. Therefore, automation of H-beam cutting is an important task. This research aims to develop a 3-D simulator to build the automatic H-beam cutting system and to determine the optimal cutting method. The automatic H-beam cutting system composes of 6 robots including 2 cutting robots hang to a crane and 1 conveyer. The appropriate system layout for covering the various sizes and types of H-beam was tested and determined using the simulator. The H-beam cutting system uses a hybrid type of plasma and gas cutting because of special cutting shapes of H-beam. The cutting area of each cutting method should be properly divided according to the size and shape of H-beam to shorten the total cutting time. Additionally the collision between a robot and a robot or a robot and H-beam should be avoided. The optimal cutting method for the shortest cutting time without the collision could be found for the various cutting conditions by use of the simulator. 2 simulation samples shows the availability of the simulator to find the optimal cutting method.
Sim, Sung Im;Nam, Jin Soo;Park, In Sook;Yoo, Eun Ha;Lim, Ki Byung
FLOWER RESEARCH JOURNAL
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v.18
no.1
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pp.66-72
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2010
This experiment was conducted to examine the treatment conditions for single-color dyeing using the variety 'Akito' which was selected based on the flower size, density, blooming shape, elegance, expression of the dying color. The optimal conditions of dyeing rose flower were pH 3.5 under the $20-25^{\circ}C$, in which the vase life showed 15 days as longest after dyeing. The most suitable flower stage for dyeing was identified as second or third stage at which three petals of flower are opened. $10g{\cdot}L^{-1}$ concentration of dyeing solution with $2mL{\cdot}L^{-1}$ treatment of spreader for rose dyeing gave the best color performance.
Laser plasma was generated by a 1GW iodine photodissociation laser ($\lambda$=1.315$\mu\textrm{m}$, E=12.7J) whose output beam was focused on a molybdenum target surface. The experiment was conducted in a vacuum chamber under 1D-sTorr and several tens of laser shooting were necessary for sufficient exposure for the PBS resist of 111m thickness. Aluminium was coated on the top of the resist by 0.1$\mu\textrm{m}$ thickness which acts as an X-ray filter to cut off the visible and the ultraviolet lights. A bio-specimen was put directly on the aluminium coated resist and located at a distance of 3 cm from the X-ray source. The replicas of a steel mesh, spider's web. and a red blood cell were obtained by this technique and were observed by Nomarski microscope and SEM. The limitation of its resolution is determined by the X-ray source size and Fresnel diffraction effect, and its theoretical prediction is well matched with the experimental results. In this experiment, a resolution better than 0.1$\mu\textrm{m}$ could be obtained. ained.
Thinned, small larch logs have small diameters and no value-added final use, except as wood chips, pallets, or fuel wood, which are products with very low economic value; however, their mechanical strength is suitable for structural applications. In this study, small larch logs were sawed, dried, and cut into square timbers (with a $90mm{\times}90mm$ cross section) that were laterally glued to form core panels used to manufacture cross-laminated timber (CLT) wall panels. The surface and back of these core panels were covered with 12-mm-thick structural plywood panels, used as cross bands to obtain three-ply CLT wall panels. This attachment procedure was conducted in two different ways: gluing and pressing (CGCLT) or gluing and nailing (NGCLT). The size of the as-manufactured CLT panels was $1,220mm{\times}2,440mm$, the same as that of the plywood panels. The final wall panels were tested under lateral shear force in accordance with KS F 2154. As the lateral load resistance test required $2,440mm{\times}2,440mm$ specimens, two CLT wall panels had to be attached in parallel. In addition, the final CLT panels had tongued and grooved edges to allow parallel joints between adjacent pieces. For comparison, conventional light-frame timber shear walls and midply wall systems were also tested under the same conditions. Shear walls with edge nail spacing of 150 mm and 100 mm, the midply wall system, and the fabricated CGCLT and NGCLT wall panels exhibited maximum lateral resistances of 6.1 kN/m (100%), 9.7 kN/m (158%), 16.9 kN/m (274%), 29.6 kN/m (482%), and 35.8 kN/m (582%), respectively.
BACKGROUND/OBJECTIVES: Myocardial infarction (MI) is caused by extensive myocardial damage attributed to the occlusion of coronary arteries. Our previous study in a rat model of ischemia/reperfusion (I/R) demonstrated that administration of arabinoxylan (AX), comprising arabinose and xylose, protects against myocardial injury. In this study, we undertook to investigate whether psyllium seed husk (PSH), a safe dietary fiber containing a high level of AX (> 50%), also imparts protection against myocardial injury in the same rat model. MATERIALS/METHODS: Rats were fed diets supplemented with PSH (1, 10, or 100 mg/kg/d) for 3 d. The rats were then subjected to 30 min ischemia through ligation of the left anterior descending coronary artery, followed by 3 h reperfusion through release of the ligation. The hearts were harvested and cut into four slices. To assess infarct size (IS), an index representing heart damage, the slices were stained with 2,3,5-triphenyltetrazolium chloride (TTC). To elucidate underlying mechanisms, Western blotting was performed for the slices. RESULTS: Supplementation with 10 or 100 mg/kg/d of PSH significantly reduces the IS. PSH supplementation (100 mg/kg/d) tends to reduce caspase-3 generation and increase BCL-2/BAX ratio. PSH supplementation also upregulates the expression of nuclear factor erythroid 2-related factor 2 (NRF2), and its target genes including antioxidant enzymes such as glutathione S-transferase mu 2 (GSTM2) and superoxide dismutase 2 (SOD2). PSH supplementation upregulates some sirtuins ($NAD^+$-dependent deacetylases) including SIRT5 (a mitochondrial sirtuin) and SIRT6 and SIRT7 (nuclear sirtuins). Finally, PSH supplementation upregulates the expression of protein kinase A (PKA), and increases phosphorylated cAMP response element-binding protein (CREB) (pCREB), a target protein of PKA. CONCLUSIONS: The results from this study indicate that PSH consumption reduces myocardial I/R injury in rats by inhibiting the apoptotic cascades through modulation of gene expression of several genes located upstream of apoptosis. Therefore, we believe that PSH can be developed as a functional food that would be beneficial in the prevention of MI.
Park, Youngjun;Choi, Yun-Young;Moon, Yong-Jae;Park, Eunsu;Lim, Beomdu;Kim, Taeyoung
The Bulletin of The Korean Astronomical Society
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v.44
no.1
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pp.54.2-54.2
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2019
Removing noise which occurs inevitably when taking image data has been a big concern. There is a way to raise signal-to-noise ratio and it is regarded as the only way, image stacking. Image stacking is averaging or just adding all pixel values of multiple pictures taken of a specific area. Its performance and reliability are unquestioned, but its weaknesses are also evident. Object with fast proper motion can be vanished, and most of all, it takes too long time. So if we can handle single shot image well and achieve similar performance, we can overcome those weaknesses. Recent developments in deep learning have enabled things that were not possible with former algorithm-based programming. One of the things is generating data with more information from data with less information. As a part of that, we reproduced stacked image from single shot image using a kind of deep learning, conditional generative adversarial network (cGAN). r-band camcol2 south data were used from SDSS Stripe 82 data. From all fields, image data which is stacked with only 22 individual images and, as a pair of stacked image, single pass data which were included in all stacked image were used. All used fields are cut in $128{\times}128$ pixel size, so total number of image is 17930. 14234 pairs of all images were used for training cGAN and 3696 pairs were used for verify the result. As a result, RMS error of pixel values between generated data from the best condition and target data were $7.67{\times}10^{-4}$ compared to original input data, $1.24{\times}10^{-3}$. We also applied to a few test galaxy images and generated images were similar to stacked images qualitatively compared to other de-noising methods. In addition, with photometry, The number count of stacked-cGAN matched sources is larger than that of single pass-stacked one, especially for fainter objects. Also, magnitude completeness became better in fainter objects. With this work, it is possible to observe reliably 1 magnitude fainter object.
In this paper, we propose a deep neural network which extracts SIFT feature points by determining whether the center pixel of a cropped image is a SIFT feature point. The data set of this network consists of a DIV2K dataset cut into $33{\times}33$ size and uses RGB image unlike SIFT which uses black and white image. The ground truth consists of the RobHess SIFT features extracted by setting the octave (scale) to 0, the sigma to 1.6, and the intervals to 3. Based on the VGG-16, we construct an increasingly deep network of 13 to 23 and 33 convolution layers, and experiment with changing the method of increasing the image scale. The result of using the sigmoid function as the activation function of the output layer is compared with the result using the softmax function. Experimental results show that the proposed network not only has more than 99% extraction accuracy but also has high extraction repeatability for distorted images.
Sim, Jungbo;Shim, Youngbo;Kim, Kyung Hyun;Kim, Seung-Ki;Lee, Ji Yeoun
Journal of Korean Neurosurgical Society
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v.64
no.4
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pp.585-591
/
2021
Objective : Filum transection is one of the most commonly performed operative procedure in pediatric neurosurgery. However, the clinical and pathological features as well as the surgical indication are not well-established. This study aimed to analyze the characteristics of patients who underwent transection of the filum during the last 10 years in a single institute. Methods : A total of 82 patients underwent transection of the filum during the period. As a general rule, we performed the transection in patients who are symptomatic or have abnormality in the urologic or neuromuscular evaluations. There were exceptions as asymptomatic patients who only fit the definition of thickened filum (width greater than 2.0 mm or conus level below L3 vertebral body) were operated by parent's wish or surgeon's preference according to radiological findings, etc. Results : Seventy-six out of 82 patients had fibrous tissue in the pathologic specimen of filum. Interestingly, patients who had glial cells were more correlated with no preoperative syrinx, and no progression of syrinx even for those who did have syrinx initially. Also, larger percentage of symptomatic patients had peripheral nerve twigs than asymptomatic patients. No difference in conus level or thickness of filum was found between patients with or without preoperative syrinx. Significantly more patients with syrinx (56%) were chosen to be operated without any symptom or abnormality in study i.e., solely based on radiological findings than those without syrinx (21%). The surgical outcome for syrinx was favorable, as all but one patient had either improved or static syrinx. The exceptional case had increase in size due to the upward displacement of the proximal end of the cut filum. Conclusion : This study evaluated the pathological, clinical, radiological features of patients who underwent transection of the filum. Interesting correlations between pathological findings and clinical features were found. Excellent outcome regarding preoperative syrinx was also shown.
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