• BMB Reports
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• v.53 no.4
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• pp.191-205
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• 2020

The unexpected pandemic set off by the novel coronavirus 2019 (COVID-19) has caused severe panic among people worldwide. COVID-19 has created havoc, and scientists and physicians are urged to test the efficiency and safety of drugs used to treat this disease. In such a pandemic situation, various steps have been taken by the government to control and prevent the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). This pandemic situation has forced scientists to rework strategies to combat infectious diseases through drugs, treatment, and control measures. COVID-19 treatment requires both limiting viral multiplication and neutralizing tissue damage induced by an inappropriate immune reaction. Currently, various diagnostic kits to test for COVID-19 are available, and repurposing therapeutics for COVID-19 has shown to be clinically effective. As the global demand for diagnostics and therapeutics continues to rise, it is essential to rapidly develop various algorithms to successfully identify and contain the virus. This review discusses the updates on specimens/samples, recent efficient diagnostics, and therapeutic approaches to control the disease and repurposed drugs mainly focusing on chloroquine/hydroxychloroquine and convalescent plasma (CP). More research is required for further understanding of the influence of diagnostics and therapeutic approaches to develop vaccines and drugs for COVID-19.

• Journal of Korean society of Dental Hygiene
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• v.9 no.3
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• pp.229-247
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• 2009

The purpose of this study is to provide the improvement basis for Dental Hygiene education program by analyzing the current implement status of Dental Hygiene curriculum in Korea and comparing the status with the US ADA standard. The researcher analyzed the Dental Hygiene syllabus limiting "Dental prophxis", "Comprehensive dental hygiene" subjects only from 31 universities which offer 3 years program. The main interest was to figure the implementing status of the curriculum and to compare the actual teaching content with the CODA 2-17 standard. The results show that there are a number of problems in implementing the Dental Hygiene courses among different universities. First, there is a significant inconsistence among schools in terms of course title, total credit, hours, the ratio for theory and practice, etc. In addition, there is a big gap between the actual content of Dental Hygiene courses and the essential/required content of CODA 2-17 standard. For instance, most of the Dental Hygiene programs in Korea cover the overall assessment stage content and some of implementation stage content. However, very few programs deal with the planning and evaluation stage content. To improve these problematic circumstance a number of suggestions were made. Developing the standardized curriculum for the Dental Hygiene program might be one of the major solutions. Next, the regular accreditation and/or assessment system for the Dental Hygiene program should be developed. This research can provide the basis for the need to assess and improve the Dental Hygiene curriculum.

• Journal of Korean Society of Water and Wastewater
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• v.30 no.4
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• pp.449-457
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• 2016

In this study, the effectiveness of electrodialysis in removing inorganic arsenic from groundwater was investigated. To evaluate the feasibility of the electrodialysis, operating parameters such as treatment time, feed concentration, applied voltage and superficial velocity were experimentally investigated on arsenic removal. The higher conductivity removal and arsenic removal efficiency were obtained by increasing applied voltages and operation time. An increase of salinity concentrations in arsenic polluted groundwater exerted no effects on the arsenic separation ratios. Arsenic polluted waters were successfully treated with stack voltages of 1.8 ~ 2.4 V/cell-pair to approximately 93.4% of arsenic removal. Increase flow rate in diluate cell gave positive effect to removal rate. However, increase of superficial velocity in the concentrated cell exerted no effects on either the conductivity reduction or on the separation efficiency. Hopefully, this paper will provide direction in selecting appropriate operating conditions of electrodialysis for arsenic removal.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.335-335
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• 2011

Instability of a thin film attached to a compliant substrate often leads to emergence of exquisite wrinkle patterns with length scales that depend on the system geometry and applied stresses. However, the patterns that are created using the current techniques in polymer surface engineering, generally have low aspect ratio of undulation amplitude to wavelength, thus, limiting their application. Here, we present a novel and effective method that enables us to create wrinkles with a desired wavelength and high aspect ratio of amplitude over wavelength as large as to 2.5:1. First, we create buckle patterns with high aspect ratio of amplitude to wavelength by deposition of an amorphous carbon film on a surface of a soft polymer poly(dimethylsiloxane) (PDMS). Amorphous carbon films are used as a protective layer in structural systems and biomedical components, due to their low friction coefficient, strong wear resistance against, and high elastic modulus and hardness. The deposited carbon layer is generally under high residual compressive stresses (~1 GPa), making it susceptible to buckle delamination on a hard substrate (e.g. silicon or glass) and to wrinkle on a flexible or soft substrate. Then, we employ glancing angle deposition (GLAD) for deposition of a high aspect ratio patterns with amorphous carbon coating on a PDMS surface. Using this method, pattern amplitudes of several nm to submicron size can be achieved by varying the carbon deposition time, allowing us to harness patterned polymers substrates for variety of application. Specifically, we demonstrate a potential application of the high aspect wrinkles for changing the surface structures with low surface energy materials of amorphous carbon coatings, increasing the water wettability.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.23 no.6
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• pp.1602-1609
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• 1998

In this paper, the design and implementation of the novel RF front end circuit for CDMA based PCS phone is described. This novel scheme is realized by building the power amplifier module combined with duplexer. The dielectric filters which are parts of duplexer are broken up and relocated into the module. Electromagnetic analysis for via holes and coupling between narrow transmissio lines is icluded to design a circuit. The combined moule has been minimaturized to be as small as 1.5CC. It has satisfied IS-95 requirements for linearity performances of CDMA signal at 24-dBm output power as well as played apart as a duplexer. The operating current of about 95mA has been saved owing to both rearranging dielectric filters and limiting operating point to class-B by considering real working power range of CDMA phones.

• ALGAE
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• v.23 no.4
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• pp.277-288
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• 2008

The relationship between nutrients and phytoplankton dynamics was investigated daily from 12 April to 22 July 2003 in Sagami Bay, Japan. According to multidimensional scaling (MDS) and cluster analysis, phytoplankton community was divided into four distinct groups. The first group was consisted of centric diatom species, such as Guinardia spp., Detonula spp., Letocylindrus danicus, Skeletonema costatum, Eucampia zodiacus and Chaetoceros spp.. The second and third clusters comprised mainly diatoms and dinoflagellates, respectively. The other cluster was restricted to the samples collected during the last sampling period when the rainfall and river discharge was frequently recorded. Canonical correspondence analysis (CCA) was applied to analyze four groups respectively, which focused on the effects of nutrients concentration and ratio on phytoplankton variations. Based on CCA analysis, most species of centric diatom were negatively correlated with DSi concentrations and Si/N ratio. Nutrients were strongly limited phytoplankton growth during the summer when the rainfall was not observed, whereas river discharge by rainfall and counterclockwise coastal currents (although the surface circulation pattern is often altered by Kuroshio Current, the counterclockwise coastal currents are generally dominant) has brought phytoplankton population accumulation and triggered the micoalgae growth in western part of the bay. Phosphorous (P) was strongly limited after significantly increases in the phytoplankton abundances. However, silicate (Si) was not a major limiting factor for phytoplankton production, since Si/DIN and Si/P ratio did not create any potential stoichiometric limitation. This indicates that high Si availability contributes favorably to the maintenance of diatom ecosystems in Sagami Bay.

• Nuclear Engineering and Technology
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• v.47 no.3
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• pp.380-387
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• 2015

A lead slowing-down spectrometer (LSDS) system is a promising nondestructive assay technique that enables a quantitative measurement of the isotopic contents of major fissile isotopes in spent nuclear fuel and its pyroprocessing counterparts, such as $^{235}U$, $^{239}Pu$, $^{241}Pu$, and, potentially, minor actinides. The LSDS system currently under development at the Korea Atomic Energy Research Institute (Daejeon, Korea) is planned to utilize a high-flux ($>10^{12}n/cm^2{\cdot}s$) neutron source comprised of a high-energy (30 MeV)/high-current (~2 A) electron beam and a heavy metal target, which results in a very intense and complex radiation field for the facility, thus demanding structural shielding to guarantee the safety. Optimization of the structural shielding design was conducted using MCNPX for neutron dose rate evaluation of several representative hypothetical designs. In order to satisfy the construction cost and neutron attenuation capability of the facility, while simultaneously achieving the aimed dose rate limit (< $0.06{\mu}Sv/h$), a few shielding materials [high-density polyethylene (HDPE)eBorax, $B_4C$, and $Li_2CO_3$] were considered for the main neutron absorber layer, which is encapsulated within the double-sided concrete wall. The MCNP simulation indicated that HDPE-Borax is the most efficient among the aforementioned candidate materials, and the combined thickness of the shielding layers should exceed 100 cm to satisfy the dose limit on the outside surface of the shielding wall of the facility when limiting the thickness of the HDPE-Borax intermediate layer to below 5 cm. However, the shielding wall must include the instrumentation and installation holes for the LSDS system. The radiation leakage through the holes was substantially mitigated by adopting a zigzag-shape with concrete covers on both sides. The suggested optimized design of the shielding structure satisfies the dose rate limit and can be used for the construction of a facility in the near future.

• The Journal of the Korea Contents Association
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• v.10 no.12
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• pp.1-9
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• 2010

Diabetes is a type of metabolic disease presented by high blood sugar and that leads to significantly decrease the quality of life causing various symptoms. It is essential to manage a systematic menu for preventing such diabetes even though there are some ways for it including diet, physical exercise, medicinal prescription, and so on. This study proposes a smart phone based personalized menu management system for achieving the systematic diabetes management. At the present time almost menu systems for diabetes patients are subjectively prescribed by dietitians or doctors and that does not reflect current situations and personal preferences. The system proposed in this study provides the menu for diabetes patients according to season, weather, time, and personal preferences. In particular, the recipe and personalized menu for patients can be provided without limiting any time and location based on smart phone services, and its menu can easily be changed or selected by the phone.

• Journal of the Korea institute for structural maintenance and inspection
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• v.19 no.6
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• pp.72-79
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• 2015

An efficient and practical reliability evaluation method is proposed for the coastal structures in this paper. It is capable of evaluating reliability of real complicated coastal structures considering uncertainties in various sources of design parameters, such as wave and current loads, resistance-related design variables including Young's modulus and compressive strength of the reinforced concrete, soil parameters, and boundary conditions. It is developed by intelligently integrating the Latin Hypercube sampling (LHS), Monte Carlo simulation (MCS) and the finite element method (FEM). The LHS-based MCS is used to significantly reduce the computational effort by limiting the number of simulation cycles required for the reliability evaluation. The applicability and efficiency of the proposed method were verified using a caisson-type breakwater structure in the numerical example.

• Journal of the Korean Chemical Society
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• v.9 no.2
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• pp.67-70
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• 1965

Polarographic studies of reduction of Ni(Ⅱ)-CN complex on Hg-electrode have indicated that $Ni(CN)_4^{2-}$ is reduced by two paths, via one electron process Ni(CN)42- + e [1]↔[2] Ni(CN)43- =(eq) Ni(CN)2- + 2CN- and via two electron process Ni(CN)42- + 2e [3]→ 1/2[Ni(CN)33-]2 + CN- of which reduction [1] must be faster than reduction [3]. At very dilute cyanide concentration (0.004 to 0.01 M) cathodic wave is practically responsible for reaction [1] and two cyanide ions appear to contribute to the reaction. As increasing cyanide ion concentration the rate of oxidation reaction [2] catalysed by Hg increases and reaction [1] and [2] approach to equilibrium. Therefore, reaction [3] represents the cathodic wave at high concentration of cyanide (above 0.2 M). This mechanism can also explain the fact that limiting current at $[CN^-]$ = 8 M is approximately twice of that at 0.004 M CN.